KEGG ORTHOLOGY: K07293

ORTHOLOGY: K07293

Entry

K07293                      KO

Symbol

PTPN11

Name

tyrosine-protein phosphatase non-receptor type 11 [EC:3.1.3.48]

Pathway

map04013

MAPK signaling pathway - fly

map04014

Ras signaling pathway

map04072

Phospholipase D signaling pathway

map04360

Axon guidance

map04625

C-type lectin receptor signaling pathway

map04630

JAK-STAT signaling pathway

map04650

Natural killer cell mediated cytotoxicity

map04670

Leukocyte transendothelial migration

map04722

Neurotrophin signaling pathway

map04920

Adipocytokine signaling pathway

map04931

Insulin resistance

map05120

Epithelial cell signaling in Helicobacter pylori infection

map05130

Pathogenic Escherichia coli infection

map05168

Herpes simplex virus 1 infection

map05205

Proteoglycans in cancer

map05208

Chemical carcinogenesis - reactive oxygen species

map05211

Renal cell carcinoma

map05220

Chronic myeloid leukemia

map05235

PD-L1 expression and PD-1 checkpoint pathway in cancer

Disease

H00523

Noonan syndrome and related disorders

H01018

Metachondromatosis

H01738

Noonan syndrome

H01984

Leopard syndrome

H02410

Myelodysplastic/myeloproliferative neoplasms

H02541

Juvenile myelomonocytic leukemia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04014 Ras signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04630 JAK-STAT signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04072 Phospholipase D signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04650 Natural killer cell mediated cytotoxicity
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   04670 Leukocyte transendothelial migration
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09152 Endocrine system
   04920 Adipocytokine signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09158 Development and regeneration
   04360 Axon guidance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
09160 Human Diseases
  09161 Cancer: overview
   05205 Proteoglycans in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05208 Chemical carcinogenesis - reactive oxygen species
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09162 Cancer: specific types
   05220 Chronic myeloid leukemia
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05211 Renal cell carcinoma
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
   05130 Pathogenic Escherichia coli infection
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Enzymes [BR:ko01000]
3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11
Protein phosphatases and associated proteins [BR:ko01009]
Protein tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Non-receptor PTPs
    K07293  PTPN11; tyrosine-protein phosphatase non-receptor type 11

Other DBs

GO:

0004726

Genes

HSA:	5781(PTPN11)

PTR:	748225(PTPN11)

PPS:	100967833 100970556(PTPN11)

GGO:	101133729(PTPN11)

PON:	100440983(PTPN11)

NLE:	100602671(PTPN11) 100605369

HMH:	116466981 116477894(PTPN11) 116813270

MCC:	712044(PTPN11)

MCF:	102129572(PTPN11)

MTHB:

126931454

MNI:	105493385(PTPN11)

CSAB:

103239151(PTPN11)

CATY:

105573167(PTPN11)

PANU:

101008549(PTPN11)

TGE:	112635452(PTPN11)

MLEU:

105552315(PTPN11)

RRO:	104674419(PTPN11)

RBB:	108540455(PTPN11)

TFN:	117089376(PTPN11)

PTEH:

111537181(PTPN11)

CANG:

105502317(PTPN11)

CJC:	100414905(PTPN11)

SBQ:	101031381(PTPN11) 101033019

CIMI:

108314188(PTPN11)

CSYR:

103276181(PTPN11)

MMUR:

105878675(PTPN11)

LCAT:

123626029(PTPN11)

PCOQ:

105825663(PTPN11)

OGA:	100955860(PTPN11)

MMU:	19247(Ptpn11)

MCAL:

110294055(Ptpn11)

MPAH:

110339175(Ptpn11)

RNO:	25622(Ptpn11)

MCOC:

116068338(Ptpn11)

ANU:	117697800(Ptpn11)

MUN:	110546380(Ptpn11)

CGE:	100771077(Ptpn11)

MAUA:

101833009(Ptpn11)

PROB:

127216041(Ptpn11)

PLEU:

114681906(Ptpn11)

MORG:

121444074 121445401 121445448 121445466 121445498 121445512 121445529 121445850(Ptpn11) 121446943

MFOT:

126495739 126511661

AAMP:

119805816 119805822 119805823 119805839 119805847 119805907 119819932 119824805(Ptpn11)

NGI:	103745559(Ptpn11)

HGL:	101701336(Ptpn11)

CPOC:

100732797(Ptpn11)

CCAN:

109696291(Ptpn11)

DORD:

105990684(Ptpn11)

DSP:	122098592(Ptpn11)

PLOP:

125349100(Ptpn11)

NCAR:

124990645

OCU:

100339517

OPI:	101529639(PTPN11)

TUP:	102485136(PTPN11) 102498455

GVR:	103593281(PTPN11)

CFA:	477488(PTPN11)

CLUD:

112676579(PTPN11)

VVP:	112926139 112935165(PTPN11)

VLG:	121475547(PTPN11)

NPO:	129507762(PTPN11)

AML:	100468867(PTPN11) 100471152

UMR:	103661289(PTPN11)

UAH:	113266983(PTPN11) 113270688

UAR:	123778834(PTPN11)

ELK:	111154862 111156454

LLV:

125081916

MPUF:

101678858(PTPN11) 101688002

NVS:	122903412(PTPN11)

ORO:	101368461(PTPN11) 101374328

EJU:	114213370 114219111(PTPN11)

ZCA:	113912429(PTPN11)

MLX:	118018488(PTPN11)

NSU:	110588209(PTPN11)

LWW:	102743189(PTPN11)

FCA:	101085500(PTPN11)

PYU:	121010320(PTPN11)

PCOO:

112870329(PTPN11)

PBG:	122470240(PTPN11)

LRUF:

124518188

PTG:	102951653(PTPN11) 102954137

PPAD:

109273906 109277629(PTPN11)

PUC:

125914556

AJU:	106982085 106988776

HHV:	120236974(PTPN11) 120242567

BTA:	533590(PTPN11)

BOM:	102276389(PTPN11)

BIU:	109570927(PTPN11)

BBUB:

102401129 102405817(PTPN11)

BBIS:

104980033(PTPN11)

CHX:	102177271(PTPN11)

OAS:	101114308(PTPN11)

BTAX:

128062064(PTPN11)

ODA:	120871132(PTPN11) 120880615

CCAD:

122422795(PTPN11)

SSC:	100170851(PTPN11) 100620540

CFR:	102523889(PTPN11)

CBAI:

105080590(PTPN11)

CDK:	105102551(PTPN11) 105105612

VPC:	102529754(PTPN11)

BACU:

103004467(PTPN11)

LVE:	103088783(PTPN11)

OOR:	101275685 101288182(PTPN11)

DLE:	111187198 111188123(PTPN11)

PCAD:

102979922(PTPN11) 102987506

PSIU:

116765123(PTPN11)

NASI:

112397307(PTPN11)

ECB:	100056857(PTPN11) 100146191

EPZ:	103557133(PTPN11) 103558567

EAI:	106842252(PTPN11) 106845198

MYB:	102251345(PTPN11)

MYD:	102755861(PTPN11)

MMYO:

118678341(PTPN11)

MLF:	102420806(PTPN11)

MNA:	107529574(PTPN11)

PKL:	118725234(PTPN11)

HAI:	109382264(PTPN11) 109391216

DRO:	112310448(PTPN11)

SHON:

118991117(PTPN11)

AJM:	119040448(PTPN11)

PDIC:

114509670(PTPN11)

PHAS:

123820995(PTPN11)

MMF:	118639877(PTPN11)

RFQ:	117017450(PTPN11)

PALE:

102889219(PTPN11)

PGIG:

120606707(PTPN11) 120614076

PVP:	105289236(PTPN11)

RAY:	107510717 107513271(PTPN11)

MJV:

108405695

TOD:	119244965(PTPN11)

SARA:

101552022(PTPN11) 101556236

LAV:	100674758(PTPN11)

TMU:

101348102

ETF:	101642693(PTPN11)

DNM:	101435063(PTPN11)

MDO:	100023824 100028991(PTPN11)

GAS:	123243044 123256872(PTPN11)

SHR:	100930062(PTPN11)

AFZ:	127545492 127556035

PCW:	110201173 110203391(PTPN11)

OAA:	100086381 100089978(PTPN11)

GGA:	395815(PTPN11) 419429

PCOC:

116228565(PTPN11) 116242713

MGP:	100541480 100550508(PTPN11)

CJO:	107321154(PTPN11) 107323557

TPAI:

128084678(PTPN11) 128084880

NMEL:

110406211(PTPN11) 110408529

APLA:

101789439

ACYG:

106031098(PTPN11) 106044308

AFUL:

116496024(PTPN11) 116497573

TGU:	100218949(PTPN11)

LSR:	110478178(PTPN11)

SCAN:

103818137(PTPN11)

PMOA:

120509573(PTPN11)

OTC:	121338859(PTPN11)

PRUF:

121364826(PTPN11)

GFR:	102033785(PTPN11)

FAB:	101811730(PTPN11)

PHI:	102103197(PTPN11)

PMAJ:

107211728(PTPN11)

CCAE:

111936431(PTPN11)

CCW:	104688668(PTPN11) 104693326

CBRC:

103616056(PTPN11) 103622297

ETL:	114062648(PTPN11) 114071019

ZAB:	102066384(PTPN11)

ACHL:

103804076(PTPN11) 103807112

SVG:	106852431(PTPN11)

FPG:	101914986(PTPN11) 101915334

FCH:	102054041 102058357(PTPN11)

CLV:	102084071(PTPN11) 102097440

EGZ:	104123916(PTPN11) 104133393

NNI:	104009062 104020567(PTPN11)

PLET:

104619667(PTPN11) 104626982

PCRI:

104028853 104030641(PTPN11)

PCAO:

104047711(PTPN11)

ACUN:

113485966(PTPN11) 113487880

TALA:

104359108(PTPN11) 104368318

PADL:

103917957 103925702(PTPN11)

AFOR:

103894741 103902765(PTPN11)

ACHC:

115343160 115345970(PTPN11)

HALD:

104316827 104323762

HLE:	104837927 104840853(PTPN11)

AGEN:

126038362 126041017

GCL:	127022721 127024767

CCRI:

104157593 104166771(PTPN11)

CSTI:

104555898 104562451(PTPN11)

EHS:	104505377(PTPN11) 104510400

CMAC:

104482511 104487534(PTPN11)

MUI:	104540223 104542976(PTPN11)

BREG:

104631433(PTPN11) 104634450

FGA:	104076761 104080799(PTPN11)

GSTE:

104261814 104263928(PTPN11)

LDI:

104345923

MNB:

103779254

OHA:	104335317(PTPN11) 104336064

NNT:	104407277 104410124(PTPN11)

SHAB:

115614193(PTPN11) 115617351

DPUB:

104305936 104308493(PTPN11)

PGUU:

104462347(PTPN11) 104465171

ACAR:

104524022(PTPN11) 104531019

CPEA:

104388006(PTPN11) 104395555

AVIT:

104271176(PTPN11) 104274600

CVF:	104282286(PTPN11) 104290548

CUCA:

104055615 104058901(PTPN11)

TEO:	104373420 104374791(PTPN11)

BRHI:

104495014 104498650(PTPN11)

AAM:	106492969(PTPN11) 106495554

AROW:

112963349(PTPN11) 112970089

NPD:	112945166(PTPN11) 112957413

TGT:	104569270 104570011(PTPN11)

DNE:	112983482 112991774(PTPN11)

SCAM:

104141899 104145765(PTPN11)

ASN:	102371778(PTPN11) 102386995

AMJ:	102562607 102570430(PTPN11)

CPOO:

109312671(PTPN11) 109314434

GGN:	109290555(PTPN11) 109293724

PSS:	102443910 102453333(PTPN11)

CMY:	102934329(PTPN11) 102934807

CPIC:

101941295 101949667(PTPN11)

TST:	117867923 117887968(PTPN11)

CABI:

116824594 116836789(PTPN11)

MRV:	120386082(PTPN11) 120387948

ACS:	100559345(ptpn11) 100564881

PVT:	110073274 110083443(PTPN11)

SUND:

121916573(PTPN11) 121937372

PBI:	103048752 103055536(PTPN11)

PMUR:

107286989(PTPN11) 107297989

CTIG:

120316660(PTPN11) 120319137

TSR:	106539364(PTPN11) 106556002

PGUT:

117658751 117672263(PTPN11)

PTEX:

113446178 113448671(PTPN11)

NSS:	113421267 113426790(PTPN11)

VKO:	123028618(PTPN11) 123031028

PMUA:

114602500 114602756(PTPN11)

ZVI:	118086429 118086624(PTPN11)

HCG:	128337930(PTPN11) 128338331

GJA:	107110836 107112180(PTPN11)

STOW:

125442510(PTPN11) 125445552

XLA:	108697240(ptpn11b.S) 108716965 399291(ptpn11.S) 444193(ptpn11b.L)

XTR:	548434(ptpn11b) 549586(ptpn11)

NPR:	108790634 108798021(PTPN11)

RTEM:

120915454 120933130(PTPN11)

BBUF:

120988535(PTPN11) 120997090

BGAR:

122924570(PTPN11) 122928690

DRE:	333979(ptpn11a) 393426(ptpn11b)

SRX:	107706767 107712100 107716115 107737552

SANH:

107665787 107673095 107687422 107704158

SGH:	107591094 107593936 107602222

CCAR:

109045050 109097251 109110513(ptpn11)

CAUA:

113045589 113068902 113076374 113099908 113101280 113110180

CGIB:

127944735 127966546 128011470 128020834

PTET:

122328740(ptpn11b) 122333836(ptpn11a)

LROH:

127154521(ptpn11b) 127172148(ptpn11a)

PPRM:

120463116(ptpn11b) 120482018(ptpn11a)

MAMB:

125259936(ptpn11b) 125262517(ptpn11a)

CIDE:

127504687 127520661

MASI:

127418998 127419692 127432581 127433684

IPU:	108276278(ptpn11b) 108277290(ptpn11a)

PHYP:

113530358 113544720(ptpn11)

SMEO:

124393652(ptpn11a)

TFD:	113638452(ptpn11a) 113658113(ptpn11b)

AMEX:

103022363(ptpn11) 103032744

CMAO:

118821954(ptpn11b) 118824554(ptpn11a)

EEE:	113580163 113591662(ptpn11)

TRU:	101068465(ptpn11) 101076633

TNG:	GSTEN00020571G001 GSTEN00025284G001

LCO:	104919515 104934925(ptpn11)

NCC:	104956326 104967981(ptpn11)

CGOB:

115010746 115016662(ptpn11)

ELY:	117258419(ptpn11b) 117269642(ptpn11a)

EFO:	125891641(ptpn11b) 125906059(ptpn11a)

PLEP:

121946887(ptpn11b) 121959592(ptpn11a)

SLUC:

116040746(ptpn11b) 116051029(ptpn11a)

ECRA:

117947049 117959143(ptpn11a)

ESP:	116692598 116703998(ptpn11)

PFLV:

114559065 114570677(ptpn11)

GAT:	120829464(ptpn11b) 120831714(ptpn11a)

PPUG:

119221895(ptpn11b) 119226376(ptpn11a)

MSAM:

119905928(ptpn11b) 119915161(ptpn11a)

SCHU:

122865353(ptpn11a) 122882941(ptpn11b)

CUD:	121518221(ptpn11b) 121524755(ptpn11a)

ALAT:

119023340(ptpn11b) 119029794(ptpn11a)

MZE:	101469361 101475609(ptpn11)

ONL:	100697902(ptpn11) 100700918

OAU:	116313166(ptpn11a) 116317376(ptpn11b)

OLA:	101156835(ptpn11) 101172160

OML:	112159720(ptpn11b) 112162955(ptpn11a)

XMA:	102223330 102232688(ptpn11)

XCO:	114147980 114149733(ptpn11)

XHE:	116720017 116724114(ptpn11)

PRET:

103467098 103473239(ptpn11)

PFOR:

103153507 103155575(ptpn11)

PLAI:

106938905 106947468(ptpn11)

PMEI:

106908907(ptpn11) 106932994

GAF:	122819708(ptpn11a) 122831403(ptpn11b)

CVG:	107086071(ptpn11) 107086704

CTUL:

119784762(ptpn11a) 119786496(ptpn11b)

GMU:	124866921(ptpn11b) 124872082(ptpn11a)

NFU:	107396142(ptpn11) 107397076

KMR:	108233149(ptpn11b) 108247149(ptpn11a)

ALIM:

106518899 106527575(ptpn11)

NWH:	119417149(ptpn11b) 119424655(ptpn11a)

AOCE:

111567360 111572898(ptpn11)

MCEP:

124996575(ptpn11a) 125020291(ptpn11b)

CSEM:

103384897 103389968(ptpn11)

POV:	109626354(ptpn11) 109630583

SSEN:

122758347(ptpn11a) 122776904(ptpn11b)

HHIP:

117765296(ptpn11b) 117771786(ptpn11a)

HSP:	118110882(ptpn11b) 118125646(ptpn11a)

LCF:	108882629(ptpn11b) 108897434(ptpn11a)

SDU:	111217827(ptpn11) 111227612

SLAL:

111656118 111666017(ptpn11)

XGL:	120804218(ptpn11b) 120806522(ptpn11a)

HCQ:	109507188(ptpn11) 109511800

SSCV:

125979383 125988843

BPEC:

110157366(ptpn11) 110157943

MALB:

109952842(ptpn11) 109967179

BSPL:

114858768(ptpn11b) 114866936(ptpn11a)

SASA:

106562610 106566948 106568295 106572187

STRU:

115149292 115159262 115166080 115168968

OTW:	112219594 112221573 112233022 112257482

OMY:	110491865 110523836 110532179 110536802(ptpn11a)

OGO:	123999166(ptpn11a) 124031854 124046194 124048692

ONE:	115102581 115118791 115126322 115132062

SALP:

111966362 111976610 111980032 112072408

SNH:	120025952 120044964(ptpn11a) 120059394 120060938

CCLU:

121538245(ptpn11b) 121545977 121573868 121582242

ELS:	105007638(ptpn11) 105013921

SFM:	108928156 108933903 108934731 108936064

PKI:	111842068 111850568 111853334

AANG:

118208610(ptpn11b) 118211692 118213242(ptpn11a)

LOC:	102682867(ptpn11) 102697778

PSPA:

121296985 121299572 121328588 121329018

ARUT:

117425918 117426726 117428180 117432426(ptpn11b)

PSEX:

120530867(ptpn11b) 120540494(ptpn11a)

LCM:	102352712 102357168(PTPN11)

CMK:	103184045(ptpn11a) 103187442(ptpn11b)

RTP:	109926577 109932773(ptpn11)

CPLA:

122540407(ptpn11b) 122562577(ptpn11a)

BFO:

BBEL:

CIN:

SCLV:

SPU:	578886 764175

APLC:

110984574

AJC:

117114235

SKO:

102803939

DME:	Dmel_CG3954(csw)

DER:

6555622

DSE:

6616088

DSI:	Dsimw501_GD24731(Dsim_GD24731)

DYA:	Dyak_GE16236

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15283

DAZ:

DNV:

DVI:

CCAT:

BOD:

RZE:	108364088 108380292

MDE:

SCAC:

LCQ:

LSQ:

HIS:

AGA:	AgaP_AGAP002438

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ014898

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

DSM:

NPT:

NFB:

NLO:

TCA:

DPA:	109536044 125505261

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:	111415900 111420455

BMOR:

101736863 101737822

BMAN:

114239743 114252833

MSEX:

115447264 115455205

DPL:	KGM_203407 KGM_211905

BANY:

NIQ:

PMAC:

PPOT:

PXU:	106113753 106123389

PRAP:

110998328 110999310

PBX:	123711878 123718933

PNAP:

125057656 125062743

ZCE:	119833218 119835841

CCRC:

123691617

HAW:	110374388 110381712

HZE:	124632279 124645143

TNL:	113504110 113508552

SLIU:

111358226 111360895

OFU:	114361338 114362488

PXY:

CFEL:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111045887 120355810

PHU:	Phum_PHUM498310

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

FCD:

DMK:	116918030 123470215

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

ISC:	IscW_ISCW012894

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

111633350 111639704 111640721

PTEP:

SDM:

LPOL:

PMEO:

CEL:	CELE_F59G1.5(ptp-2)

CBR:	CBG_02539(Cbr-ptp-2)

BMY:	BM_BM4610(Bma-ptp-2)

LOA:	LOAG_05248

NAI:	NECAME_14104

TSP:

Tsp_10590

HRO:	HELRODRAFT_87671

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105321845 105347587

MYI:

PMAX:

MCAF:

MMER:

DPOL:

OSN:

LAK:	106154086 106161520

SMM:	Smp_035390

SHX:	MS3_00005553(PTPN6)

OVI:	T265_06464

EGL:	EGR_03758 EGR_08145

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100204137 100210713 100211089

AQU:	100635856 100638429

SRE:	PTSG_00947

» show all

Reference

PMID:18829466

Authors

Jakob S, Schroeder P, Lukosz M, Buchner N, Spyridopoulos I, Altschmied J, Haendeler J

Title

Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase.

Journal

J Biol Chem 283:33155-61 (2008)
DOI:10.1074/jbc.M805138200

Reference

PMID:18559669

Authors

Lee HH, Chang ZF

Title

Regulation of RhoA-dependent ROCKII activation by Shp2.

Journal

J Cell Biol 181:999-1012 (2008)
DOI:10.1083/jcb.200710187

Reference

PMID:1281790

Authors

Adachi M, Sekiya M, Miyachi T, Matsuno K, Hinoda Y, Imai K, Yachi A

Title

Molecular cloning of a novel protein-tyrosine phosphatase SH-PTP3 with sequence similarity to the src-homology region 2.

Journal

FEBS Lett 314:335-9 (1992)
DOI:10.1016/0014-5793(92)81500-L

Sequence

[hsa:5781]

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