KEGG   ORTHOLOGY: K08041
Entry
K08041                      KO                                     

Name
ADCY1
Definition
adenylate cyclase 1 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01100  Metabolic pathways
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04020  Calcium signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04727  GABAergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05032  Morphine addiction
ko05142  Chagas disease
ko05146  Amoebiasis
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy
Disease
H00605  Deafness, autosomal recessive
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00230 Purine metabolism
    K08041  ADCY1; adenylate cyclase 1
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04371 Apelin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04020 Calcium signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04072 Phospholipase D signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04024 cAMP signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04022 cGMP-PKG signaling pathway
    K08041  ADCY1; adenylate cyclase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04114 Oocyte meiosis
    K08041  ADCY1; adenylate cyclase 1
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K08041  ADCY1; adenylate cyclase 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K08041  ADCY1; adenylate cyclase 1
   04062 Chemokine signaling pathway
    K08041  ADCY1; adenylate cyclase 1
  09152 Endocrine system
   04911 Insulin secretion
    K08041  ADCY1; adenylate cyclase 1
   04923 Regulation of lipolysis in adipocytes
    K08041  ADCY1; adenylate cyclase 1
   04912 GnRH signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04913 Ovarian steroidogenesis
    K08041  ADCY1; adenylate cyclase 1
   04915 Estrogen signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04914 Progesterone-mediated oocyte maturation
    K08041  ADCY1; adenylate cyclase 1
   04921 Oxytocin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04926 Relaxin signaling pathway
    K08041  ADCY1; adenylate cyclase 1
   04935 Growth hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04918 Thyroid hormone synthesis
    K08041  ADCY1; adenylate cyclase 1
   04928 Parathyroid hormone synthesis, secretion and action
    K08041  ADCY1; adenylate cyclase 1
   04916 Melanogenesis
    K08041  ADCY1; adenylate cyclase 1
   04925 Aldosterone synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
   04927 Cortisol synthesis and secretion
    K08041  ADCY1; adenylate cyclase 1
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08041  ADCY1; adenylate cyclase 1
   04270 Vascular smooth muscle contraction
    K08041  ADCY1; adenylate cyclase 1
  09154 Digestive system
   04970 Salivary secretion
    K08041  ADCY1; adenylate cyclase 1
   04971 Gastric acid secretion
    K08041  ADCY1; adenylate cyclase 1
   04972 Pancreatic secretion
    K08041  ADCY1; adenylate cyclase 1
   04976 Bile secretion
    K08041  ADCY1; adenylate cyclase 1
  09156 Nervous system
   04724 Glutamatergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04727 GABAergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04725 Cholinergic synapse
    K08041  ADCY1; adenylate cyclase 1
   04720 Long-term potentiation
    K08041  ADCY1; adenylate cyclase 1
   04723 Retrograde endocannabinoid signaling
    K08041  ADCY1; adenylate cyclase 1
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08041  ADCY1; adenylate cyclase 1
  09149 Aging
   04211 Longevity regulating pathway
    K08041  ADCY1; adenylate cyclase 1
   04213 Longevity regulating pathway - multiple species
    K08041  ADCY1; adenylate cyclase 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K08041  ADCY1; adenylate cyclase 1
   04714 Thermogenesis
    K08041  ADCY1; adenylate cyclase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08041  ADCY1; adenylate cyclase 1
  09165 Substance dependence
   05032 Morphine addiction
    K08041  ADCY1; adenylate cyclase 1
  09166 Cardiovascular disease
   05414 Dilated cardiomyopathy
    K08041  ADCY1; adenylate cyclase 1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K08041  ADCY1; adenylate cyclase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K08041  ADCY1; adenylate cyclase 1
   05163 Human cytomegalovirus infection
    K08041  ADCY1; adenylate cyclase 1
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K08041  ADCY1; adenylate cyclase 1
   05142 Chagas disease
    K08041  ADCY1; adenylate cyclase 1
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K08041  ADCY1; adenylate cyclase 1
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08041  ADCY1; adenylate cyclase 1
Other DBs
RN: R00089 R00434
GO: 0008294
Genes
HSA: 107(ADCY1)
PTR: 463392(ADCY1)
PPS: 100984585(ADCY1)
GGO: 101125943(ADCY1)
PON: 100449504(ADCY1)
NLE: 100595636(ADCY1)
MCC: 697230(ADCY1)
MCF: 102147015(ADCY1)
CSAB: 103226115(ADCY1)
RRO: 104671165(ADCY1)
RBB: 108534793(ADCY1)
CJC: 100394265(ADCY1)
SBQ: 101027981(ADCY1)
MMU: 432530(Adcy1)
MCAL: 110305998(Adcy1)
MPAH: 110330584(Adcy1)
RNO: 305509(Adcy1)
MUN: 110555169(Adcy1)
CGE: 100764561(Adcy1)
NGI: 103741433(Adcy1)
HGL: 101711366(Adcy1)
CCAN: 109694874(Adcy1)
TUP: 102468873(ADCY1)
CFA: 607357(ADCY1)
VVP: 112911455(ADCY1)
AML: 100472777(ADCY1)
UAH: 113257705(ADCY1)
ORO: 101379158(ADCY1)
ELK: 111157054
FCA: 101101375(ADCY1)
PTG: 102961712(ADCY1)
PPAD: 109267948(ADCY1)
AJU: 106968223(ADCY1)
BTA: 281601(ADCY1)
BOM: 102267116(ADCY1)
BIU: 109557525(ADCY1)
BBUB: 102415323(ADCY1)
CHX: 102180724(ADCY1)
OAS: 101117327(ADCY1)
SSC: 100624934(ADCY1)
CFR: 102517882(ADCY1)
CDK: 105095715(ADCY1)
BACU: 102998650(ADCY1)
LVE: 103081539(ADCY1)
OOR: 101278368(ADCY1)
DLE: 111184534(ADCY1)
PCAD: 102981199(ADCY1)
ECB: 100065563(ADCY1)
EPZ: 103550430(ADCY1)
EAI: 106822932(ADCY1)
MYB: 102257679(ADCY1)
MYD: 102759978(ADCY1)
MNA: 107526004(ADCY1)
HAI: 109373011(ADCY1)
DRO: 112306844(ADCY1)
PALE: 102887497(ADCY1)
RAY: 107512406(ADCY1)
MJV: 108403511(ADCY1)
LAV: 100671072(ADCY1)
TMU: 101354868
MDO: 100030463(ADCY1)
SHR: 100922193(ADCY1)
PCW: 110197533(ADCY1)
OAA: 103168601(ADCY1)
GGA: 420788(ADCY1)
CJO: 107309766(ADCY1)
NMEL: 110390836(ADCY1)
APLA: 101804073(ADCY1)
ACYG: 106046455(ADCY1)
TGU: 100226080(ADCY1)
LSR: 110477391(ADCY1)
SCAN: 103819377(ADCY1)
GFR: 102040399(ADCY1)
FAB: 101807752(ADCY1)
PHI: 102110269(ADCY1)
PMAJ: 107201036(ADCY1)
CCAE: 111923918(ADCY1)
CCW: 104689252(ADCY1)
ETL: 114068677(ADCY1)
FPG: 101914769(ADCY1)
FCH: 102056699(ADCY1)
CLV: 102094612(ADCY1)
EGZ: 104125965(ADCY1)
NNI: 104015394(ADCY1)
ACUN: 113477314(ADCY1)
PADL: 103916246(ADCY1)
AAM: 106492856(ADCY1)
ASN: 102372645(ADCY1)
AMJ: 102573818(ADCY1)
PSS: 102445759(ADCY1)
CMY: 102939135(ADCY1)
CPIC: 101935286(ADCY1)
ACS: 100564004(adcy1)
PVT: 110091617(ADCY1)
PBI: 103068192
PMUR: 107287848(ADCY1)
TSR: 106543976(ADCY1)
PMUA: 114607043(ADCY1)
GJA: 107119176(ADCY1)
XLA: 108695214 108705348(adcy1.S) 108718988(adcy1.L)
XTR: 100492373(adcy1)
NPR: 108796974(ADCY1)
DRE: 557026(adcy1a) 569499(adcy1b)
IPU: 108257925 108267157(adcy1)
PHYP: 113545185 113547307(adcy1)
TRU: 101074661(adcy1)
NCC: 104962323
POV: 109637504(adcy1) 109643317
BPEC: 110159474(adcy1) 110172262
CMK: 103187011(adcy1)
RTP: 109910491
DME: Dmel_CG9533(rut)
DER: 6550736
DSE: 6619554
DSI: Dsimw501_GD15838(Dsim_rut)
DSR: 110182103
DPE: 6598394
DMN: 108161375
DWI: 6653130
DAZ: 108618185
DNV: 108656529
DHE: 111600202
DVI: 6631926
MDE: 101890662
LCQ: 111684525
AAG: 5571379
AALB: 109401880
TCA: 661438(rut)
DPA: 109546607
NVL: 108566779
BMOR: 101741402
BMAN: 114248717
PMAC: 106720337
PRAP: 110991594
HAW: 110369899
TNL: 113501500
PXY: 105380532
API: 100164676
DNX: 107168960
AGS: 114126041
RMD: 113559605
BTAB: 109030117
CLEC: 106662482
ZNE: 110826860
FCD: 110861546
DPX: DAPPUDRAFT_48469(Adcy2)
PVM: 113821369
TUT: 107360550
DPTE: 113792109
CSCU: 111626639
PTEP: 107453371
PCAN: 112564559
MYI: 110465124
OBI: 106868905
LAK: 106159379
 » show all
Reference
PMID:9662407
  Authors
Abdel-Majid RM, Leong WL, Schalkwyk LC, Smallman DS, Wong ST, Storm DR, Fine A, Dobson MJ, Guernsey DL, Neumann PE
  Title
Loss of adenylyl cyclase I activity disrupts patterning of mouse somatosensory cortex.
  Journal
Nat Genet 19:289-91 (1998)
DOI:10.1038/980
  Sequence
[mmu:432530]
Reference
PMID:8314585
  Authors
Villacres EC, Xia Z, Bookbinder LH, Edelhoff S, Disteche CM, Storm DR
  Title
Cloning, chromosomal mapping, and expression of human fetal brain type I adenylyl cyclase.
  Journal
Genomics 16:473-8 (1993)
DOI:10.1006/geno.1993.1213
  Sequence
[hsa:107]

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