KEGG   ORTHOLOGY: K08291
Entry
K08291                      KO                                     

Symbol
GRK4_5_6
Name
G protein-coupled receptor kinase [EC:2.7.11.16]
Pathway
map04062  Chemokine signaling pathway
map04144  Endocytosis
map04341  Hedgehog signaling pathway - fly
map05032  Morphine addiction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04341 Hedgehog signaling pathway - fly
    K08291  GRK4_5_6; G protein-coupled receptor kinase
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K08291  GRK4_5_6; G protein-coupled receptor kinase
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K08291  GRK4_5_6; G protein-coupled receptor kinase
 09160 Human Diseases
  09165 Substance dependence
   05032 Morphine addiction
    K08291  GRK4_5_6; G protein-coupled receptor kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08291  GRK4_5_6; G protein-coupled receptor kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.16  G-protein-coupled receptor kinase
     K08291  GRK4_5_6; G protein-coupled receptor kinase
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  GRK family [OT]
   K08291  GRK4_5_6; G protein-coupled receptor kinase
Other DBs
GO: 0004703
Genes
HSA: 2868(GRK4) 2869(GRK5) 2870(GRK6)
PTR: 461082(GRK4) 466217(GRK5) 471760(GRK6)
PPS: 100972068(GRK6) 100972921(GRK4) 100975050(GRK5)
GGO: 101125204(GRK6) 101142802(GRK5) 101148767(GRK4)
PON: 100171722(GRK5) 100433745(GRK6) 100442141(GRK4)
NLE: 100592067(GRK6) 100593251(GRK5) 100595255(GRK4)
MCC: 100427251(GRK5) 700000(GRK6) 720047(GRK4)
MCF: 102115240(GRK4) 102128844(GRK6) 102132362(GRK5)
CSAB: 103216606(GRK5) 103245054(GRK6) 103246447(GRK4)
CATY: 105577971(GRK5) 105581727(GRK6) 105585464(GRK4)
PANU: 101000030(GRK6) 101001106(GRK4) 101025057(GRK5)
RRO: 104672234(GRK5) 104678955(GRK4) 104680460(GRK6)
RBB: 108513853(GRK5) 108522739(GRK4) 108544772(GRK6)
TFN: 117065331(GRK6) 117065894(GRK5) 117085065(GRK4)
PTEH: 111521617(GRK6) 111539096(GRK4) 111550779(GRK5)
CJC: 100400573(GRK5) 100403264(GRK6) 100403887(GRK4)
SBQ: 101030769(GRK6) 101037649(GRK5) 101054298(GRK4)
MMUR: 105856035(GRK4) 105857047(GRK5) 105883855(GRK6)
MMU: 14772(Grk4) 14773(Grk5) 26385(Grk6)
MCAL: 110285684(Grk5) 110294130(Grk4) 110307882(Grk6)
MPAH: 110326741(Grk5) 110330568(Grk4) 110333637(Grk6)
RNO: 59075(Grk5) 59076(Grk6) 59077(Grk4)
MCOC: 116070002(Grk4) 116082800(Grk6) 116104072(Grk5)
MUN: 110549769(Grk6) 110552404(Grk4) 110566290(Grk5)
CGE: 100767022(Grk4) 100771151(Grk5) 103161260(Grk6)
PLEU: 114686123(Grk5) 114689175(Grk6) 114694079(Grk4)
NGI: 103729285(Grk5) 103732366(Grk6) 103741150(Grk4)
HGL: 101718249(Grk6) 101718850(Grk5) 101720649(Grk4) 101720846
CPOC: 100718627(Grk4) 100719009(Grk5) 100735666(Grk6)
CCAN: 109676704 109685731(Grk4) 109685760(Grk6) 109700825(Grk5)
OCU: 100351551(GRK4) 100357639(GRK6) 103351438(GRK5)
OPI: 101521205(GRK4) 101521481(GRK6) 101524148(GRK5)
TUP: 102474598(GRK6) 102480420(GRK4) 102485965(GRK5)
CFA: 100684653(GRK6) 479075(GRK4) 486915(GRK5)
VVP: 112916590(GRK5) 112920421(GRK4) 112925482(GRK6)
VLG: 121481324(GRK5) 121488264(GRK6) 121488859(GRK4)
AML: 100466557(GRK4) 100478616(GRK6) 100480732(GRK5)
UMR: 103657694(GRK5) 103664442(GRK6) 103676663(GRK4)
UAH: 113245697(GRK4) 113251993(GRK5) 113264153(GRK6)
ORO: 101366445(GRK4) 101377206(GRK6) 101385208(GRK5)
ELK: 111140814 111144787 111148957
MPUF: 101683582(GRK6) 101687496(GRK4) 101691123(GRK5)
EJU: 114198003(GRK4) 114208727(GRK6) 114223030(GRK5)
MLX: 118010768(GRK4) 118017323(GRK6) 118027000(GRK5)
FCA: 101086226(GRK4) 101087379(GRK6) 101089047(GRK5)
PYU: 121011732(GRK6) 121037297(GRK5) 121039056(GRK4)
PBG: 122479111(GRK4) 122489701(GRK6) 122493309(GRK5)
PTG: 102955344(GRK4) 102962153(GRK5) 102968971(GRK6)
PPAD: 109267583(GRK6) 109269752(GRK4) 109272977(GRK5)
AJU: 106969373(GRK5) 106975413(GRK6) 106978855(GRK4)
HHV: 120231805(GRK4) 120235181(GRK5) 120236759(GRK6)
BTA: 281801(GRK5) 512489(GRK4) 521413(GRK6)
BOM: 102271649(GRK6) 102272970(GRK5) 102283303(GRK4)
BIU: 109553055(GRK5) 109560743(GRK4) 109561904(GRK6)
BBUB: 102389056(GRK5) 102389526(GRK4) 102412507(GRK6)
CHX: 102183500(GRK4) 102186301(GRK6) 102190578(GRK5)
OAS: 101107019(GRK6) 101107151(GRK5) 101120060 101122439(GRK4)
ODA: 120861817(GRK4) 120863852(GRK6) 120873864(GRK5)
CCAD: 122428099(GRK4) 122440033(GRK6) 122445871(GRK5)
SSC: 100152937(GRK5) 100519668(GRK4) 110259389(GRK6)
CFR: 102518408(GRK5) 102522133(GRK4) 102524130(GRK6)
CBAI: 105062033(GRK6) 105072344(GRK4) 105080777(GRK5)
CDK: 105099593(GRK6) 105103924(GRK4) 105104188(GRK5)
BACU: 103005786(GRK5) 103011898(GRK4) 103017883(GRK6)
LVE: 103071087(GRK5) 103082340(GRK6)
OOR: 101275494(GRK5) 101276909(GRK6) 101288363(GRK4)
DLE: 111169865(GRK6) 111172254(GRK5)
PCAD: 102979868 102988242(GRK4) 102988311(GRK6)
PSIU: 116741728(GRK5) 116750668(GRK6)
ECB: 100053624(GRK4) 100065919(GRK5) 100068570(GRK6)
EPZ: 103539972(GRK6) 103554506(GRK5) 103558677(GRK4)
EAI: 106825835(GRK4) 106827137(GRK6) 106836364(GRK5)
MYB: 102246592(GRK5) 102255277(GRK6) 102260906(GRK4)
MYD: 102754944 102757801(GRK6) 102758601(GRK5) 102762532(GRK4)
MMYO: 118659264(GRK6) 118665906(GRK4) 118669688(GRK5)
MLF: 102418826(GRK4) 102423126(GRK6) 102428002(GRK5)
MNA: 107524071(GRK4) 107529777(GRK6) 107532096(GRK5)
PKL: 118707183(GRK4) 118710674(GRK6) 118719538(GRK5)
HAI: 109382992(GRK5) 109389794(GRK6) 109390911(GRK4)
DRO: 112300283(GRK5) 112316718(GRK4) 112320363(GRK6)
SHON: 118987574(GRK4) 118996302(GRK5) 118999751(GRK6)
AJM: 119035145(GRK6) 119035473(GRK4) 119051889(GRK5)
PDIC: 114489914(GRK4) 114496447(GRK5) 114509375(GRK6)
MMF: 118632060(GRK5) 118638950(GRK4) 118643634(GRK6)
RFQ: 117016850(GRK6) 117022130(GRK4) 117035983(GRK5)
PALE: 102877766(GRK5) 102881935(GRK6) 102893603(GRK4)
PGIG: 120582884(GRK4) 120608879(GRK5) 120616568(GRK6)
RAY: 107509758(GRK5) 107517532(GRK6) 107517995(GRK4)
MJV: 108396051(GRK5) 108406370(GRK6)
TOD: 119233347(GRK5) 119236985(GRK6) 119261280(GRK4)
LAV: 100659746 100663377(GRK5) 100663381(GRK6) 100670615(GRK4)
TMU: 101341711 101350552 101361031
MDO: 100021366(GRK4) 100026232(GRK5) 100031943(GRK6)
GAS: 123235485(GRK6) 123238190(GRK5) 123253030(GRK4)
SHR: 100915281(GRK5) 100921906(GRK6) 100931079(GRK4)
PCW: 110209572(GRK5) 110212220(GRK4) 110216761(GRK6)
OAA: 100074050(GRK4) 100084269(GRK5) 100084380(GRK6)
GGA: 416361(GRK6) 422879(GRK4) 423929(GRK5)
PCOC: 116225760(GRK4) 116231578(GRK5) 116232064(GRK6)
MGP: 100539666 100540688 100550765(GRK6)
CJO: 107314005(GRK4) 107316182(GRK5) 107320438(GRK6)
NMEL: 110398045(GRK4) 110399963(GRK5) 110405115(GRK6)
APLA: 101794252(GRK5) 101797744 101798639(GRK6) 101798987(GRK4)
ACYG: 106034651(GRK4) 106042780(GRK6) 106045200(GRK5)
TGU: 100227306(GRK5) 100229994(GRK6) 100232432(GRK4)
LSR: 110469989(GRK5) 110470777(GRK6) 110481866(GRK4)
SCAN: 103814115(GRK5) 103817367(GRK6) 103823915(GRK4)
PMOA: 120498597(GRK6) 120502190(GRK5) 120509382(GRK4)
OTC: 121332424(GRK6) 121335097(GRK4) 121341858(GRK5)
PRUF: 121350222(GRK5) 121361349(GRK6) 121365873(GRK4)
GFR: 102035414(GRK5) 102036653(GRK4) 102041334(GRK6)
FAB: 101807573(GRK4) 101814948(GRK5) 101818256(GRK6)
PHI: 102106169(GRK5) 102110063(GRK4) 102110395(GRK6)
PMAJ: 107202831(GRK4) 107206946(GRK5) 107210768(GRK6)
CCAE: 111928238(GRK4) 111930967(GRK5) 111935451(GRK6)
CCW: 104689515(GRK6) 104690771(GRK4) 104694850(GRK5)
ETL: 114060962(GRK5) 114061206(GRK4) 114066262(GRK6) 114066479
FPG: 101911963(GRK6) 101912780(GRK4) 101916330(GRK5) 101919471
FCH: 102046997 102048279(GRK4) 102049406(GRK6) 102050182(GRK5)
CLV: 102084153(GRK6) 102084308 102091969(GRK4) 102093957(GRK5)
EGZ: 104128614(GRK5) 104130186(GRK4) 104135895(GRK6)
NNI: 104016063 104018057(GRK4) 104018951(GRK6) 104022391(GRK5)
ACUN: 113479265(GRK4) 113481464(GRK5) 113485270(GRK6)
PADL: 103912228(GRK6) 103918548(GRK5) 103920932(GRK4)
AAM: 106489500(GRK5) 106489905(GRK6) 106498749(GRK4)
AROW: 112964781(GRK6) 112965452(LSM1) 112965530(GRK4) 112974152
NPD: 112943038(GRK4) 112954314(GRK6) 112957179(GRK5)
DNE: 112988000(GRK5) 112990756(GRK4) 112991594 112996962(GRK6)
ASN: 102381837(GRK4) 102383862 102387634(GRK6) 102388176(GRK5)
AMJ: 102557717(GRK5) 102569938(GRK6) 102572009(GRK4) 102573177
CPOO: 109310248(GRK6) 109317420 109322299(GRK4) 109324155(GRK5)
GGN: 109287664(GRK5) 109289813(GRK6) 109295546 109304040(GRK4)
PSS: 102451200(GRK4) 102451544 102461436(GRK5)
CMY: 102936492(GRK4) 102943434(GRK5) 102944452(GRK6) 102948318
CPIC: 101931530(GRK5) 101936310(LSM1) 101938937(GRK4) 101944859(GRK6)
TST: 117873014 117878096(GRK4) 117879774(GRK5) 117881831(GRK6)
CABI: 116821421 116825070(GRK5) 116825225(GRK4) 116833307(GRK6)
MRV: 120370306(GRK6) 120399467 120405942(GRK4) 120409578(GRK5)
ACS: 100554970 100564440(grk6) 100568068(grk5)
PVT: 110075170 110075316(GRK5) 110077405(GRK6)
SUND: 121922400(GRK6) 121926079(GRK5) 121933491
PBI: 103055580 103064613 103065042(GRK6)
PMUR: 107288606(GRK5) 107291402(GRK6) 107295358
TSR: 106540873(GRK6) 106547508
PGUT: 117677009 117678758(GRK5) 117679819(GRK6)
VKO: 123027071 123028251(GRK5) 123033978(GRK6)
PMUA: 114585237 114591452(GRK6) 114597434(GRK5)
ZVI: 118080514(GRK6) 118096617(GRK5) 118096815
GJA: 107106728(GRK5) 107108166 107111541(GRK6)
XLA: 108696022(grk5.L) 108697324(grk5.S) 108711651(grk5l.L) 108712671(grk5l.S) 446831(grk4.L) 447337(grk6.S) 474158(grk4.S) 733256(grk6.L)
XTR: 100379796(grk6) 100497344 448587(grk4) 550070(grk5)
NPR: 108783744(GRK6) 108785832(GRK4) 108795411 108802218(GRK5)
DRE: 560761(grk4) 560806(grk5) 561288(grk6) 567452(grk5l)
SRX: 107707119 107723186 107725141 107733280 107751883 107756834 107758889
SANH: 107665967 107691567 107692618 107692774(grk6) 107697331 107702864 107704119
SGH: 107548280 107548972 107557931 107561710 107565039 107568601 107587195
CCAR: 109045840 109066536 109075598 109089862 109091197 109092812
CAUA: 113038360(grk6) 113044338 113051313 113070699 113089020 113102524 113107344 113110158
IPU: 108265152 108277214(Grk5) 108278711(grk6)
PHYP: 113541572(grk6) 113544728 113546069
AMEX: 103027282(grk6) 103033196 103046047
EEE: 113571255(grk6) 113584115 113591386
TRU: 101070620 101072843 101074586(grk6) 101074960(grk4) 115246487
TNG: GSTEN00014578G001 GSTEN00022638G001 GSTEN00025391G001
LCO: 104918943(grk6) 104921947(grk4) 104930665 104934131
NCC: 104946107(grk4) 104953072 104963411
CGOB: 115013191 115016729 115018681(grk6) 115020893
ELY: 117246244(grk6) 117252435(grk5l) 117255160(grk4) 117269370(grk5)
PLEP: 121941873(grk4) 121944300(grk5l) 121952115(grk6) 121960128
SLUC: 116039552(grk4) 116041785(grk5) 116055945(grk6) 116057255(grk5l)
ECRA: 117953498(grk4) 117955479(grk6) 117959151(grk5)
PFLV: 114566729(grk6) 114566958(grk4) 114570552
GAT: 120822226(grk6) 120824978(grk4) 120830739(grk5l) 120831790
PPUG: 119215627(grk6) 119217487(grk4) 119225099(grk5l) 119226379(grk5)
MSAM: 119891474(grk5l) 119895353(grk6) 119899651(grk4) 119914502(grk5)
CUD: 121508850(grk4) 121509659(grk5l) 121518443(grk6) 121525085
MZE: 101467438 101468334 101472775 101486524(grk6)
ONL: 100689749 100692015(grk6) 100696126 100703321
OAU: 116317448 116323757(grk5l) 116328486(grk6) 116331581(grk4)
OLA: 101160171 101162460 101166613(grk6) 101173769(grk4)
OML: 112139372(grk4) 112141415(grk6) 112148836(grk5l) 112162856
XMA: 102223822 102226135(grk6) 102233865 102237931(grk4)
XCO: 114144411(grk4) 114148995 114153297(grk6) 114154950
XHE: 116719701(grk4) 116724739 116728561(grk6) 116729515
PRET: 103464439(grk4) 103470661 103473195 103476239(grk6)
GAF: 122819251 122828716(grk5l) 122829219(grk4) 122845373(grk6)
CVG: 107092761 107093759(grk4) 107097517(grk6) 107102169
CTUL: 119784965(grk5l) 119790299(grk6) 119790902 119797993(grk4)
NFU: 107387089(grk6) 107393217(grk4) 107393676 107395648
KMR: 108236374(grk4) 108236562(grk5l) 108242174(grk6) 108245374
ALIM: 106514672(grk6) 106516718 106524349(grk4) 106532121
AOCE: 111567208(grk4) 111574425 111575037 111579089
CSEM: 103384199(grk4) 103389663 103395602(grk6) 103396909 103398033 103398938
POV: 109626034 109627610(grk4) 109641092 109642388(grk6)
SSEN: 122761348 122764743(grk5) 122769980(grk5l) 122770708(grk4) 122779532(grk6)
HHIP: 117762885(grk4) 117767301(grk5l) 117771903 117774383(grk6)
LCF: 108875671(grk4) 108878593 108885354(grk6) 108895494
SDU: 111217880(grk4) 111228851 111233077(grk6) 111239654
SLAL: 111644991 111659466 111664583(grk6) 111664624
XGL: 120800678(grk4) 120802985(grk6) 120805646(grk5l) 120806423(grk5)
HCQ: 109511636 109514519(grk6) 109525096 109527370
BPEC: 110156480(grk6) 110166672 110169810 110175665(grk4)
MALB: 109954945 109957868(grk4) 109968696(grk6) 109974760
SASA: 106562980 106568006 106568462 106580577 106585171 106592297 106603485
OTW: 112222429 112228545 112230874 112248791 112257901 112262620 121844691
OMY: 110509607 110516120 110518749 110522817 110525940 110533606 110536318 110537519
SALP: 111950365 111957863 111961796 111963860 111974314 111980885 112079466
SNH: 120021543 120025823 120030515 120044494(grk5l) 120057037(grk6) 120063387
ELS: 105011133(grk6) 105014098 105015238 105020825(grk4)
SFM: 108920065(grk6) 108923749 108925730(grk4) 108936160 108940333
PKI: 111847947 111853108(grk4) 111857546 111860778 111861162
AANG: 118206606(grk5l) 118212075 118228514 118231715 118235755(grk6)
LOC: 102684991(grk5) 102690196(grk6) 102696690 102696762(grk4)
PSPA: 121296931 121324752 121325075 121325156 121330478
ARUT: 117409448 117413199 117418215 117421430 117431448
LCM: 102345414(GRK5) 102358242 102359573(GRK6) 102364205(GRK4)
CMK: 103177327 103186330 103186576
RTP: 109917307 109933260 109936422(grk5)
BFO: 118414302
BBEL: 109475498
CIN: 100177731 100186924
SCLV: 120338834 120345691
SPU: 756375
APLC: 110988180
SKO: 100374101(GRK5)
DME: Dmel_CG17998(Gprk2)
DER: 6554722
DSE: 6612984
DSI: Dsimw501_GD21578(Dsim_GD21578)
DYA: Dyak_GE10942
DAN: 6500568
DSR: 110191388
DPO: Dpse_GA14759
DPE: 6598666
DMN: 108155750
DWI: 6649829
DGR: 6567694
DMO: Dmoj_GI22206
DAZ: 108608671
DNV: 108659601
DHE: 111597155
DVI: 6631057
CCAT: 101452366
BOD: 106621557
MDE: 101901760
SCAC: 106092777
LCQ: 111682859
AGA: AgaP_AGAP004117
ACOZ: 120961119
AARA: 120908350
AAG: 5567507
AALB: 109403598 109414765
CPII: 120425983
AME: 410632
ACER: 107997984
BIM: 100741600
BBIF: 117208080
BVK: 117240269
BVAN: 117164518
BTER: 100642779
BPYO: 122575605
CCAL: 108630771
OBB: 114876758
MGEN: 117219628
NMEA: 116424018
CGIG: 122405451
SOC: 105199349
MPHA: 105829530
AEC: 105146542
ACEP: 105624805
PBAR: 105433159
VEM: 105564122
HST: 105184862
DQU: 106749793
CFO: 105252842
FEX: 115239879
LHU: 105672492
PGC: 109860236
OBO: 105275024
PCF: 106788165
PFUC: 122526475
VPS: 122632506
NVI: 100122766
CSOL: 105363233
TPRE: 106660598
MDL: 103578293
CGLO: 123271771
FAS: 105267940
DAM: 107043961
AGIF: 122860994
CCIN: 107263158
TCA: 656376
DPA: 109545471
ATD: 109594515
AGB: 108906035
LDC: 111517172
NVL: 108560187
APLN: 108745270
PPYR: 116176350
OTU: 111427048
BMOR: 101747093
BMAN: 114241498
MSEX: 115447089
BANY: 112044013
PPOT: 106105858
PXU: 106116076
PRAP: 110998692
ZCE: 119837743
HAW: 110377080
TNL: 113495152
PXY: 105387737 105394381 105396592
API: 100165035
DNX: 107168275
AGS: 114127518
RMD: 113555217
BTAB: 109038990
DCI: 103515681
CLEC: 106662266
HHAL: 106684277
NLU: 111045485
PHU: Phum_PHUM066650
FOC: 113202394
ZNE: 110837064
CSEC: 111873812
FCD: 110858013
DPX: DAPPUDRAFT_127071(Grk1)
DMK: 116926511
PVM: 113817454
PJA: 122253585
HAME: 121869335
HAZT: 108670457 108671622
EAF: 111704102
ISC: IscW_ISCW004541
DSV: 119461403
RSAN: 119379036
RMP: 119175982
VDE: 111252092
VJA: 111268895 111271941
TUT: 107369896
DPTE: 113795012
CSCU: 111612737
PTEP: 107452617
SDM: 118187228
CEL: CELE_F19C6.1(grk-1)
CBR: CBG_01947(Cbr-grk-1)
LOA: LOAG_09581 LOAG_13169
NAI: NECAME_08066
HRO: HELRODRAFT_100074
LGI: LOTGIDRAFT_117728
PCAN: 112564568
BGT: 106074042
GAE: 121384544
CRG: 105324517
MYI: 110451725
PMAX: 117339870
OBI: 106876126
OSN: 115215078
LAK: 106178688
SMM: Smp_123640
SHX: MS3_0013452
OVI: T265_00665
EGL: EGR_02568
NVE: 5519770
EPA: 110245004
ATEN: 116288429
ADF: 107338742
AMIL: 114958128
PDAM: 113682745
SPIS: 111331987
DGT: 114515746
HMG: 100197054
TAD: TRIADDRAFT_28308
AQU: 100637826
 » show all
Reference
PMID:8626439
  Authors
Premont RT, Macrae AD, Stoffel RH, Chung N, Pitcher JA, Ambrose C, Inglese J, MacDonald ME, Lefkowitz RJ
  Title
Characterization of the G protein-coupled receptor kinase GRK4. Identification of four splice variants.
  Journal
J Biol Chem 271:6403-10 (1996)
DOI:10.1074/jbc.271.11.6403
  Sequence
[hsa:2868]
Reference
  Authors
Vroon A, Heijnen CJ, Kavelaars A
  Title
GRKs and arrestins: regulators of migration and inflammation.
  Journal
J Leukoc Biol 80:1214-21 (2006)
DOI:10.1189/jlb.0606373

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