KEGG   ORTHOLOGY: K08846
Entry
K08846                      KO                                     
Symbol
RIPK2
Name
receptor-interacting serine/threonine-protein kinase 2 [EC:2.7.11.1]
Pathway
map04621  NOD-like receptor signaling pathway
map04722  Neurotrophin signaling pathway
map05131  Shigellosis
map05132  Salmonella infection
map05152  Tuberculosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05131 Shigellosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
   05152 Tuberculosis
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  RIPK family [OT]
   K08846  RIPK2; receptor-interacting serine/threonine-protein kinase 2
Genes
HSA: 8767(RIPK2)
PTR: 464277(RIPK2)
PPS: 100986683(RIPK2)
GGO: 101124865(RIPK2)
PON: 100448203(RIPK2)
PPYG: 129042388(RIPK2)
NLE: 100584725(RIPK2)
HMH: 116813394(RIPK2)
SSYN: 129486587(RIPK2)
MCC: 695567(RIPK2)
MCF: 102141511(RIPK2)
MTHB: 126960539
MNI: 105497286(RIPK2)
CSAB: 103237096(RIPK2)
CATY: 105572870(RIPK2)
PANU: 101006774(RIPK2)
TGE: 112630634(RIPK2)
MLEU: 105541531(RIPK2)
RRO: 104654652(RIPK2)
RBB: 108526904(RIPK2)
TFN: 117079637(RIPK2)
PTEH: 111549683(RIPK2)
CANG: 105508241(RIPK2)
CJC: 100404956(RIPK2)
SBQ: 101030587(RIPK2)
CIMI: 108310867(RIPK2)
ANAN: 105725875(RIPK2)
CSYR: 103262889(RIPK2)
MMUR: 105860682(RIPK2)
LCAT: 123645000(RIPK2)
PCOQ: 105809800(RIPK2)
OGA: 100954549(RIPK2)
MMU: 192656(Ripk2)
MCAL: 110292783(Ripk2)
MPAH: 110338775(Ripk2)
RNO: 362491(Ripk2)
MCOC: 116088041(Ripk2)
ANU: 117698793(Ripk2)
MUN: 110545065(Ripk2)
CGE: 100751944(Ripk2)
MAUA: 101824238(Ripk2)
PROB: 127232481(Ripk2)
PLEU: 114694604(Ripk2)
MORG: 121452007(Ripk2)
MFOT: 126515611
AAMP: 119826831(Ripk2)
NGI: 103729531(Ripk2)
HGL: 101709696(Ripk2)
CPOC: 100716133(Ripk2)
CCAN: 109690126(Ripk2)
DORD: 105982876(Ripk2)
DSP: 122102463(Ripk2)
PLOP: 125360718(Ripk2)
NCAR: 124985002
MMMA: 107142305(Ripk2)
OCU: 100351901
OPI: 101519724(RIPK2)
TUP: 102473610(RIPK2)
GVR: 103603842(RIPK2)
CFA: 477936(RIPK2)
CLUD: 112650841(RIPK2)
VVP: 112930867(RIPK2)
VLG: 121499089(RIPK2)
NPO: 129495745(RIPK2)
AML: 100480506(RIPK2)
UMR: 103661470(RIPK2)
UAH: 113252964(RIPK2)
UAR: 123797904(RIPK2)
ELK: 111146577
LLV: 125098185
MPUF: 101685462(RIPK2)
MNP: 132014142(RIPK2) 132026122
MLK: 131814629 131826627(RIPK2)
NVS: 122904462(RIPK2)
ORO: 101374574(RIPK2)
EJU: 114216066(RIPK2)
ZCA: 113909698(RIPK2)
MLX: 118014994(RIPK2)
NSU: 110578687(RIPK2)
LWW: 102746338(RIPK2)
FCA: 101086783(RIPK2)
PYU: 121042668(RIPK2)
PCOO: 112859385(RIPK2)
PBG: 122495568(RIPK2)
PVIV: 125156513(RIPK2)
LRUF: 124519021
PTG: 102957311(RIPK2)
PPAD: 109269456(RIPK2)
PUC: 125924562
AJU: 106984785
HHV: 120237347(RIPK2)
BTA: 534407(RIPK2)
BOM: 102269037(RIPK2)
BIU: 109568588(RIPK2)
BBUB: 102407215(RIPK2)
BBIS: 105004581(RIPK2)
CHX: 102169397(RIPK2)
OAS: 101115883(RIPK2)
BTAX: 128059425(RIPK2)
ODA: 120878516(RIPK2)
CCAD: 122451134(RIPK2)
MBEZ: 129559967(RIPK2)
SSC: 100518835(RIPK2)
CFR: 102507090(RIPK2)
CBAI: 105064730(RIPK2)
CDK: 105087544(RIPK2)
VPC: 102529559(RIPK2)
BACU: 103016338(RIPK2)
BMUS: 118883502(RIPK2)
LVE: 103089725(RIPK2)
OOR: 101273094(RIPK2)
DLE: 111180441(RIPK2)
PCAD: 102989713(RIPK2)
PSIU: 116742527(RIPK2)
NASI: 112406863(RIPK2)
ECB: 100051086(RIPK2)
EPZ: 103564122(RIPK2)
EAI: 106838970(RIPK2)
MYB: 102240596(RIPK2)
MYD: 102771269(RIPK2)
MMYO: 118670470(RIPK2)
MLF: 102434661(RIPK2)
MDT: 132220040(RIPK2)
PKL: 118718487(RIPK2)
EFUS: 103301859(RIPK2)
MNA: 107526473(RIPK2)
DRO: 112310313(RIPK2)
SHON: 118989283(RIPK2)
AJM: 119047894(RIPK2)
PDIC: 114502006(RIPK2)
PHAS: 123820979(RIPK2)
MMF: 118631733(RIPK2)
PPAM: 129088416(RIPK2)
HAI: 109387588(RIPK2)
RFQ: 117024046 117034136(RIPK2)
PALE: 102897241(RIPK2)
PGIG: 120614242(RIPK2)
PVP: 105304146(RIPK2)
RAY: 107507555(RIPK2)
MJV: 108395321(RIPK2)
TOD: 119239952(RIPK2)
SARA: 101548727(RIPK2)
SETR: 126020842(RIPK2)
LAV: 100663221(RIPK2)
TMU: 101347391
ETF: 101659564(RIPK2)
DNM: 101422988(RIPK2)
MDO: 100029371(RIPK2)
GAS: 123254942(RIPK2)
SHR: 100920956(RIPK2)
AFZ: 127544264
PCW: 110196727(RIPK2)
TVP: 118834441(RIPK2)
OAA: 100074957(RIPK2) 103166279
GGA: 415708(RIPK3) 420215(RIPK2)
PCOC: 116227588(RIPK2)
MGP: 100541245(RIPK2)
CJO: 107310368(RIPK2)
TPAI: 128090777(RIPK2)
LMUT: 125690619(RIPK2) 125699214
NMEL: 110394065(RIPK2) 110404370
APLA: 101797616 101801807(RIPK2)
ACYG: 106030539(RIPK2) 106043112
CATA: 118246392 118247865(RIPK2)
AFUL: 116486248(RIPK2) 116494199
TGU: 100223072(RIPK2) 115496886
LSR: 110477423(RIPK2)
SCAN: 103813399(RIPK2) 103816814
PMOA: 120495773(RIPK2) 120508095
OTC: 121333980 121340149(RIPK2)
PRUF: 121349010 121351936(RIPK2)
GFR: 102039354 102039478(RIPK2)
FAB: 101810818 101819872(RIPK2)
OMA: 130249264(RIPK2) 130258053
PHI: 102101204(RIPK2) 102105196
PMAJ: 107200811(RIPK2) 107209761
CCAE: 111924776(RIPK2) 111934565
CCW: 104687489 104692763(RIPK2)
CBRC: 103613441(RIPK2) 103620177
ETL: 114061736(RIPK2) 114071257
ZAB: 102061284 102063107(RIPK2)
ZLE: 135444610(RIPK2) 135452977
ACHL: 103807619 103809312(RIPK2)
SVG: 106849860(RIPK2) 106855833
MMEA: 130572716 130576428(RIPK2)
HRT: 120755475(RIPK2) 120757555
SATI: 136366618 136369973(RIPK2)
FPG: 101916675(RIPK2) 101922525
FCH: 102049954(RIPK2) 102054177
CCRI: 104158863(RIPK2) 104161923
NNT: 104401235 104404382
SHAB: 115610198(RIPK2) 115619627
ACUN: 113476158(RIPK2) 113484502
TALA: 104361359(RIPK2) 104367582
ACHC: 115340281(RIPK2) 115346445
HALD: 104312500 104320409(RIPK2)
HLE: 104828369(RIPK2) 104842357
AGEN: 126040706 126046588
GCL: 127013250 127021294
CSTI: 104556619 104560879(RIPK2)
LDI: 104340976 104343361
MNB: 103769879
DPUB: 104297204(RIPK2) 104299028
AVIT: 104277715 104279135
BRHI: 104490207(RIPK2) 104496480
EGZ: 104125840(RIPK2) 104130220
NNI: 104016365 104016403(RIPK2)
PCRI: 104028352 104035174(RIPK2)
PCAO: 104051864
PADL: 103914195 103917314(RIPK2)
AFOR: 103895748(RIPK2) 103896832
FGA: 104070825(RIPK2) 104079004
GSTE: 104253189 104259807(RIPK2)
CLV: 102083897(RIPK2) 102087693
MUI: 104535310 104539630(RIPK2) 104545071
PGUU: 104470802 104471636
PLET: 104620539(RIPK2) 104621495
EHS: 104510095(RIPK2) 104510842
CMAC: 104475306 104486708(RIPK2)
CUCA: 104055928
TEO: 104376228
BREG: 104640084(RIPK2) 104644152
OHA: 104335244 104337551(RIPK2)
ACAR: 104520456(RIPK2) 104531910
CPEA: 104394790 104396565(RIPK2)
CVF: 104287734 104292469(RIPK2)
RTD: 128905642(RIPK2) 128909377
AAM: 106483330 106496319(RIPK2)
AROW: 112961084 112964082(RIPK2)
NPD: 112950571 112960327(RIPK2)
TGT: 104568340(RIPK2) 104575537
DNE: 112982958(RIPK2) 112984287
SCAM: 104143941(RIPK2) 104146298
ASN: 102374298 102380156(RIPK2)
AMJ: 102565156 102572630(RIPK2)
CPOO: 109320195(RIPK2)
GGN: 109305018(RIPK2)
PSS: 102461132(RIPK2)
CMY: 102940358(RIPK2) 102941377
CCAY: 125620784 125632634(RIPK2)
DCC: 119841007 119852259(RIPK2)
CPIC: 101944477(RIPK2) 101946154
TST: 117873640(RIPK2) 117886605
CABI: 116817534 116829434(RIPK2)
MRV: 120384459 120399286(RIPK2)
ACS: 100557554(ripk2) 103279342
ASAO: 132774966(RIPK2) 132783158
PVT: 110085504 110090233(RIPK2)
SUND: 121914514 121928539(RIPK2)
PBI: 103051915 103067943(RIPK2)
PMUR: 107285743(RIPK2) 107295258
CTIG: 120309463(RIPK2) 120312719
TSR: 106541579 106545514(RIPK2)
PGUT: 117668484(RIPK2) 117670372
APRI: 131184378 131194474(RIPK2)
PTEX: 113439927(RIPK2) 113445136
NSS: 113426019 113428568(RIPK2)
VKO: 123020585(RIPK2) 123025465
PMUA: 114600449(RIPK2) 114601914
PRAF: 128417268(RIPK2) 128419129
ZVI: 118087093 118089949(RIPK2)
HCG: 128323550(RIPK2) 128334139
GJA: 107111703 107121846(RIPK2) 107126194
STOW: 125439533(RIPK2) 125443257
EMC: 129333328(RIPK2) 129344328
XLA: 108695377(ripk2.S) 108719325(ripk2.L)
XTR: 100496958(ripk2)
NPR: 108795169 108804489(RIPK2)
RTEM: 120941273(RIPK2)
BBUF: 121001280(RIPK2)
BGAR: 122938946(RIPK2)
MUO: 115478731(RIPK2)
GSH: 117355651(RIPK2)
DRE: 373874(ripk2)
SRX: 107715521 107722215 107750646 107754657
SANH: 107674432 107681812 107700600 107701343
SGH: 107568621 107593863
CCAR: 109053530 109057485 109085372(ripk2)
CAUA: 113038373 113046020 113049481
CGIB: 127939462 127950817 128021969
PTET: 122360624(ripk2)
LROH: 127181464(ripk2)
OMC: 131521218(ripk2)
PPRM: 120471438(ripk2)
RKG: 130097217(ripk2)
MAMB: 125251519
CIDE: 127497953
CERY: 137002755
MASI: 127440378 127442259
TROS: 130554266(ripk2)
TDW: 130417280(ripk2)
MANU: 129442634
IPU: 108267689 108271158(si:dkey-181f22.4)
IFU: 128609699(ripk2)
PHYP: 113536411 113540487(ripk2)
SMEO: 124387093(ripk2)
TFD: 113644082
TVC: 132848276(ripk2)
TRN: 134312123
AMEX: 103022466(ripk2)
CMAO: 118826197
EEE: 113570106(ripk2) 113586917
CHAR: 105889504(ripk2)
TRU: 101073996(ripk2)
TFS: 130538819
TNG: GSTEN00014972G001
LCO: 104920921(ripk2)
NCC: 104949100(ripk2)
TBEN: 117488828(ripk2)
CGOB: 115022478(ripk2)
PGEO: 117462151(ripk2)
GACU: 117545636(ripk2)
EMAC: 134865454(ripk2)
ELY: 117272546
EFO: 125901687
PLEP: 121951391
SLUC: 116046139
ECRA: 117954221
ESP: 116699318
PFLV: 114565798(ripk2)
GAT: 120815847
PPUG: 119209529(ripk2)
AFB: 129089176
CLUM: 117745930
PSWI: 130197885
MSAM: 119902315
SCHU: 122886258(ripk2)
CUD: 121520054
ALAT: 119010724
MZE: 101478382(ripk2)
ONL: 100704387(ripk2)
OAU: 116320422(ripk2)
OLA: 101161336(ripk2)
OML: 112147518
CSAI: 133453032
XMA: 102234179(ripk2)
XCO: 114146519(ripk2)
XHE: 116721580(ripk2)
PRET: 103479078(ripk2)
PFOR: 103139959(ripk2)
PLAI: 106961897(ripk2)
PMEI: 106920595(ripk2)
GAF: 122840600
PPRL: 129361810
CVG: 107096457(ripk2)
CTUL: 119796370(ripk2)
GMU: 124870240
NFU: 107396213(ripk2)
KMR: 108238203
ALIM: 106530176(ripk2)
NWH: 119414525
AOCE: 111581478(ripk2)
MCEP: 125010143
CSEM: 103396134(ripk2)
POV: 109639366(ripk2)
SSEN: 122774301
HHIP: 117778891
HSP: 118117808
PPLT: 128454700
SMAU: 118310960(ripk2)
LCF: 108883753
SDU: 111228763(ripk2)
SLAL: 111661295(ripk2)
XGL: 120799207
HCQ: 109520486(ripk2)
SSCV: 125985164
SBIA: 133511377
PEE: 133411262
PTAO: 133489540
BPEC: 110173454(ripk2)
MALB: 109951958(ripk2)
BSPL: 114845064
SJO: 128368809
SASA: 106562048 106568754 106587145 106598827
STRU: 115156667 115170051
OTW: 112227135 112249052 112260196 112263564
OMY: 110506391 110508995 110526239 110530062
OGO: 124010027 124042075
ONE: 115103310 115114150
OKI: 109872027 109875399
OKE: 118394444 118401722
SALP: 111956958 111969277 111973687 111978984
SNH: 120020573 120025385 120025388 120046062(si:dkey-181f22.4) 120056262
CCLU: 121534977 121580702
ELS: 105017200 105030385(ripk2)
SFM: 108937842 108938332(ripk2)
PKI: 111846146
AANG: 118225470(ripk2)
LOC: 102695929(ripk2)
PSPA: 121296577(si:dkey-181f22.4) 121312705 121314155 121325584
ARUT: 117399479 117424414(si:dkey-181f22.4) 117425474 117435339
PSEX: 120530115(ripk2)
LCM: 102348796 102354731(RIPK2)
CMK: 103184934(ripk2) 103185913(si:dkey-181f22.4) 103185937
RTP: 109911129
CPLA: 122549011
HOC: 132815016(ripk2)
LERI: 129696135(ripk2) 129705150
PMRN: 116944190(RIPK2)
LRJ: 133350895
BFO: 118408279 118408549 118408554 118408562 118408570 118408571
BBEL: 109471764 109473874 109480245
CIN: 100181177
LAK: 106162229
 » show all
Reference
PMID:21123652
  Authors
Tigno-Aranjuez JT, Asara JM, Abbott DW
  Title
Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.
  Journal
Genes Dev 24:2666-77 (2010)
DOI:10.1101/gad.1964410
Reference
PMID:9642260
  Authors
McCarthy JV, Ni J, Dixit VM
  Title
RIP2 is a novel NF-kappaB-activating and cell death-inducing kinase.
  Journal
J Biol Chem 273:16968-75 (1998)
DOI:10.1074/jbc.273.27.16968
  Sequence
[hsa:8767]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (790)   
   KEGG GENES (569)   
   KEGG MGENES (104)   
   RefGene (109)   
   OC (8)   
Literature (2)   
   PubMed (2)   
All databases (806)   

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