KEGG ORTHOLOGY: K09097

ORTHOLOGY: K09097

Entry

K09097                      KO

Symbol

ARNT

Name

aryl hydrocarbon receptor nuclear translocator

Pathway

map04066

HIF-1 signaling pathway

map04148

Efferocytosis

map04934

Cushing syndrome

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05208

Chemical carcinogenesis - reactive oxygen species

map05211

Renal cell carcinoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04066 HIF-1 signaling pathway
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
09140 Cellular Processes
  09141 Transport and catabolism
   04148 Efferocytosis
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
   05207 Chemical carcinogenesis - receptor activation
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
   05208 Chemical carcinogenesis - reactive oxygen species
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
  09162 Cancer: specific types
   05211 Renal cell carcinoma
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator
Transcription factors [BR:ko03000]
Eukaryotic type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    K09097  ARNT; aryl hydrocarbon receptor nuclear translocator

Other DBs

GO:

0017162

Genes

HSA:

405(ARNT)

PTR:	457279(ARNT)

PPS:	100973177(ARNT)

GGO:	101144887(ARNT)

PON:	100172172(ARNT)

PPYG:

129029730(ARNT)

NLE:	100579793(ARNT)

HMH:	116469474(ARNT)

SSYN:

134734246(ARNT)

MCC:	715971(ARNT)

MCF:	102118770(ARNT)

MTHB:

126931516

MNI:	105498242(ARNT)

CSAB:

103247208(ARNT)

CATY:

105590203(ARNT)

PANU:

101022512(ARNT)

TGE:	112620303(ARNT)

MLEU:

105534792(ARNT)

RRO:	104681067(ARNT)

RBB:	108533260(ARNT)

TFN:	117075081(ARNT)

PTEH:

111543620(ARNT)

CANG:

105508846(ARNT)

CJC:	100410534(ARNT)

SBQ:	101038733(ARNT)

CIMI:

108316464(ARNT)

ANAN:

105724218(ARNT)

CSYR:

103251386(ARNT)

MMUR:

105873069(ARNT)

LCAT:

123633914(ARNT)

PCOQ:

105821763(ARNT)

OGA:	100941626(ARNT)

MMU:	11863(Arnt)

MCAL:

110290783(Arnt)

MPAH:

110319819(Arnt)

RNO:	25242(Arnt)

MCOC:

116093411(Arnt)

ANU:	117707489(Arnt)

ASYL:

127682986(Arnt)

MUN:	110541000(Arnt)

CGE:	100752106(Arnt)

MAUA:

101843258(Arnt)

PROB:

127232980(Arnt)

PLEU:

114682408(Arnt)

MORG:

121437877 121450566

MFOT:

126489970

AAMP:

119801327(Arnt)

NGI:	103729101(Arnt)

HGL:	101717560(Arnt)

CPOC:

100379223(Arnt)

CCAN:

109681203(Arnt)

DORD:

105984727(Arnt)

DSP:	122109758(Arnt)

DMER:

138821503 138827485

PLOP:

125360055(Arnt)

NCAR:

124977856

MMMA:

107156832(Arnt)

ITI:	101968151(Arnt)

OCU:	100008996(ARNT)

OPI:	101532703(ARNT)

TUP:	102503401(ARNT)

GVR:	103600278(ARNT)

CFA:	119863992(ARNT)

CLUD:

112663994(ARNT)

VVP:	112907783(ARNT)

VLG:	121490824(ARNT)

NPO:	129501302(ARNT)

AML:	100482504(ARNT)

UMR:	103667537(ARNT)

UAH:	113246207(ARNT)

UAR:	123787736(ARNT)

ELK:

111161943

LLV:

125096874

MPUF:

101677663(ARNT)

MNP:	132001449(ARNT)

MLK:	131810360(ARNT)

NVS:	122900431(ARNT)

ORO:	101371497(ARNT)

EJU:	114197246(ARNT)

ZCA:	113915092(ARNT)

MLX:	118000312(ARNT)

NSU:	110578596(ARNT)

LWW:	102731426(ARNT)

FCA:	101093627(ARNT)

PYU:	121021044(ARNT)

PCOO:

112872033(ARNT)

PBG:	122481132(ARNT)

PVIV:

125159460(ARNT)

LRUF:

124516159

LGF:	123598661(ARNT)

AJU:

106979844

PTG:	102969285(ARNT)

PPAD:

109257022(ARNT)

PUC:

125912122

PLEZ:

122228681(ARNT)

HHV:	120241247(ARNT)

BTA:	281010(ARNT)

BOM:	102287994(ARNT)

BIU:	109555321(ARNT)

BBUB:

102407029(ARNT)

BBIS:

104987656(ARNT)

CHX:	102183027(ARNT)

OAS:	443285(ARNT)

BTAX:

128045491(ARNT)

CSUM:

138073777(ARNT)

ODA:	120855911(ARNT)

CCAD:

122434357(ARNT)

MREE:

136145946(ARNT)

OVR:	110149625(ARNT)

MBEZ:

129540298(ARNT)

SSC:	396653(ARNT)

CFR:	102511573(ARNT)

CBAI:

105071739(ARNT)

CDK:	105103194(ARNT)

VPC:	102545427(ARNT)

BACU:

103008733(ARNT)

BMUS:

118899159(ARNT)

LVE:	103075373(ARNT)

OOR:	101270436(ARNT)

LALB:

132514395(ARNT)

GMF:	115846986(ARNT)

DLE:	111169763(ARNT)

PCAD:

102980846(ARNT)

PSIU:

116750338(ARNT)

PPHC:

136128860(ARNT)

NASI:

112411615(ARNT)

ECB:	100059178(ARNT)

EPZ:	103547639(ARNT)

EAI:	106846532(ARNT)

MYB:	102258023(ARNT)

MYD:	102771771(ARNT)

MMYO:

118672743(ARNT)

MLF:	102440721(ARNT)

MDT:	132220678(ARNT)

MYUM:

138996245(ARNT)

PKL:	118727470(ARNT)

EFUS:

103299034(ARNT)

MNA:	107539126(ARNT)

DRO:	112313526(ARNT)

AJM:	119034693(ARNT)

PDIC:

114488743(ARNT)

PHAS:

123804442(ARNT)

MMF:	118637089(ARNT)

PPAM:

129076824(ARNT) 129076825

HAI:	109372278(ARNT)

RFQ:	117014588(ARNT)

PALE:

102885691(ARNT)

PGIG:

120585209(ARNT)

PVP:	105303857(ARNT)

RAY:	107498988(ARNT)

MJV:	108408262(ARNT)

TOD:	119237264(ARNT)

SARA:

101553552(ARNT)

SFUM:

130036792(ARNT)

SETR:

125997471(ARNT)

LAV:	100673667(ARNT)

TMU:

101340519

ETF:	101657179(ARNT)

DNM:	101428022(ARNT)

MDO:	100017492(ARNT)

GAS:	123246755(ARNT)

SHR:	100917700(ARNT)

AFZ:

127559101

PCW:	110220577(ARNT)

TVP:	118858512(ARNT)

PBRV:

138162688(ARNT)

MLAO:

141488580(ARNT)

OAA:	100088277(ARNT)

TACU:

119947062(ARNT)

GGA:	374026(ARNT)

PCOC:

116238443(ARNT)

MGP:	100542194(ARNT)

CJO:	107324542(ARNT)

TPAI:

128071923(ARNT)

LMUT:

125685747(ARNT)

NMEL:

110387840(ARNT)

APLA:

101793121(ARNT)

ACYG:

106049269(ARNT)

CATA:

118260434(ARNT)

AFUL:

116499612(ARNT)

TGU:	100227939(ARNT)

LSR:	110476822(ARNT)

SCAN:

103823947(ARNT)

PMOA:

120502593(ARNT)

OTC:	121335609(ARNT)

PRUF:

121353487(ARNT)

ATRC:

139585070(ARNT)

GFR:	102031860(ARNT)

OMA:	130263394(ARNT)

PHI:	102101745(ARNT)

PMAJ:

107214656(ARNT)

CCAE:

111939474(ARNT)

CBRC:

103619601(ARNT)

ACOE:

138098584(ARNT)

ETL:	114071956(ARNT)

ZAB:	102061304(ARNT)

ZLE:	135457671(ARNT)

SVG:	106862350(ARNT)

MMEA:

130586599(ARNT)

HRT:	120764210(ARNT)

SATI:

136372935(ARNT)

CCIC:

134055357(ARNT)

FPG:	101911894(ARNT)

FCH:	102055383(ARNT)

CCRI:

104167843(ARNT)

NNT:	104406603(ARNT)

SHAB:

115602628(ARNT)

ACUN:

113488716(ARNT)

TALA:

104361268 122152392

ACHC:

115345537(ARNT)

HALD:

104315794

HLE:	104830530(ARNT)

AGEN:

126040212

HHAR:

128146010(ARNT)

GCL:

127027053

CSTI:

104563342(ARNT)

LDI:	104352007(ARNT)

MNB:	103775646(ARNT)

PPUS:

135192675(ARNT)

EGZ:	104129701(ARNT)

NNI:	104014431(ARNT)

PCRI:

104027098(ARNT)

PCAO:

104053396(ARNT)

PADL:

103919478(ARNT)

AFOR:

103900500(ARNT)

FGA:	104073392(ARNT)

GSTE:

104256869(ARNT)

CBOY:

140644292(ARNT)

CLV:	102096216(ARNT)

CNIC:

136000135(ARNT)

MUI:

104534856

PGUU:

104468538(ARNT)

PLET:

104622627(ARNT)

EHS:	104513416(ARNT)

CMAC:

104484161(ARNT)

CUCA:

104066020(ARNT)

TEO:	104380666(ARNT)

BREG:

104636045(ARNT)

OHA:	104330236(ARNT)

ACAR:

104524722(ARNT)

CPEA:

104385232(ARNT)

CVF:	104285438(ARNT)

RTD:	128900885(ARNT)

CRID:

134525983(ARNT)

AAM:	106495415(ARNT)

AROW:

112972477(ARNT)

NPD:	112952958(ARNT)

TGT:	104573261(ARNT)

DNE:	112990035(ARNT)

SCAM:

104139542(ARNT)

ASN:	102382787(ARNT)

AMJ:	102575411(ARNT)

CPOO:

109324825(ARNT)

GGN:	109305218(ARNT)

PSS:	102446386(ARNT)

CMY:	102948385(ARNT)

CCAY:

125625609(ARNT)

DCC:	119847689(ARNT)

CPIC:

101931479(ARNT)

TST:	117869483(ARNT)

CABI:

116817625(ARNT)

MRV:	120390077(ARNT)

ACS:	100565607(arnt)

ASAO:

132764181(ARNT)

PVT:	110081480(ARNT)

SUND:

121916247(ARNT)

PBI:	103053367(ARNT)

PMUR:

107292913(ARNT)

CTIG:

120317054(ARNT)

TSR:	106546303(ARNT)

PGUT:

117670135(ARNT)

PCAE:

139322441(ARNT)

APRI:

131186538(ARNT)

PTEX:

113449242(ARNT)

NSS:

113430974

VKO:	123032929(ARNT)

PMUA:

114586114(ARNT)

PRAF:

128403735(ARNT)

ZVI:	118075794(ARNT)

HCG:	128337337(ARNT)

GJA:	107121566(ARNT)

STOW:

125440963(ARNT)

EMC:	129342354(ARNT)

XLA:	398241(arnt.L) 399025(arnt.S)

XTR:	100144695(arnt)

NPR:	108789811(ARNT)

RTEM:

120920690(ARNT)

ACAT:

141116866(ARNT)

BBUF:

120982477(ARNT)

BGAR:

122923213(ARNT)

DTC:	141083044(ARNT)

PWL:	138268663(ARNT)

MUO:	115458067(ARNT)

GSH:	117349982(ARNT)

DRE:	493634(arnt)

SRX:	107713900 107726231

SANH:

107688995 107689175

SGH:	107558626 107559034

CCAR:

109087689(arnt) 109111104

CAUA:

113059701 113060051 113116566

CGIB:

127975435 128030914

PTET:

122360215(arnt)

LROH:

127178017(arnt)

GRF:	141342079(arnt)

OMC:	131521716(arnt)

PPRM:

120485502(arnt)

RKG:	130090528(arnt)

MAMB:

125243044(arnt)

CIDE:

127497910

CERY:

137030160(arnt)

MASI:

127452621 127454380

TROS:

130557541(arnt)

TDW:	130432715(arnt)

MANU:

129449071(arnt)

PDAB:

135720925(arnt)

IPU:	108264157(arnt)

IFU:	128601226(arnt)

PHYP:

113533924

SMEO:

124384064(arnt)

TFD:	113659051(arnt)

TVC:	132846382(arnt)

CGAR:

128520126(arnt)

NGRA:

132886435(arnt)

TRN:	134310882(arnt)

AMEX:

103047410(arnt)

CMAO:

118820268(arnt)

EEE:

113573097

CHAR:

105912992(arnt)

SPIL:

134082410(arnt)

TRU:

101073418

TFS:	130532923(arnt)

TNG:	GSTEN00015369G001

LCO:

104920544

NCC:	104944902 104944904

TBEN:

117480564

CGOB:

115021084

PGEO:

117460485(arnt)

GACU:

117540989(arnt)

EMAC:

134862054(arnt)

ELY:	117266257(arnt)

EFO:	125893371(arnt)

PLEP:

121945380(arnt)

SLUC:

116049590(arnt)

ECRA:

117946706(arnt)

ESP:

116691349

PFLV:

114557034

GAT:	120810232(arnt)

PPUG:

119197549(arnt)

AFB:	129109093(arnt)

CLUM:

117745054(arnt)

PSWI:

130212891(arnt)

CANA:

137781151(arnt)

CVE:	137890939(arnt)

MSAM:

119897548(arnt)

SCHU:

122882322(arnt)

CUD:	121514230(arnt)

SPUL:

138583663(arnt)

LMIX:

132983875(arnt)

ALAT:

119006567

ASTR:

137601290(arnt)

MZE:

101465807

ONL:

100708914

OAU:	116321109(arnt)

OLA:	101160689(arnt)

OML:	112143497(arnt)

CSAI:

133432911(arnt)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122830573(arnt)

PPRL:

129371137(arnt)

CVG:

107088815

CTUL:

119783000

GMU:	124865833(arnt)

NFU:

107379579

KMR:

108241135

ALIM:

106515088

NWH:	119410007(arnt)

AOCE:

111576792(arnt)

EJA:	138194169(arnt)

BFRE:

138619416(arnt)

MCEP:

125016230(arnT)

CSEM:

POV:

SSEN:

SSOE:

HHIP:

HSP:	118113309(arnt)

PPLT:

128449020(arnt)

SMAU:

118316401(arnt)

LCF:

108885906

SDU:

111230171

SLAL:

111652194

XGL:	120784270(arnt)

HCQ:	109522788(arnt)

SSCV:

125975663(arnt)

SBIA:

133500859(arnt)

PEE:	133401339(arnt)

PTAO:

133479443(arnt)

BPEC:

110163199

ENY:	140373578(arnt)

MALB:

109970213(arnt)

BSPL:

114843536(arnt)

SJO:	128367115(arnt)

SSCO:

133983811(arnt)

GMH:

115553933

SASA:

106605812

STRU:

115176537 115176554

OTW:	112236966 112242416

OMY:	100136759(arnt) 110501040

OGO:	123998193 124005250

ONE:	115126058 115127972

OKI:	109884521 116376542

OKE:	118378879 118378880

OMM:	135520689(arnt) 135521813

OCLA:

139388394 139421120

SALP:

112075351

SNH:	120039498 120039502

CCLU:

ELS:

OEP:

SFM:

PKI:

AANG:

118225484(arnt)

AROT:

135233309(arnt)

CCOG:

133126820(arnt)

LOC:

PSPA:

ARUT:

PSEX:

LCM:	102355678(ARNT)

RTP:

CPLA:

HOC:

LERI:

HAKA:

PMRN:

LRJ:

CIN:	778541(arnt)

SCLV:

120331479 120331480 120337228 120340363

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AJC:

PFLL:

DME:	Dmel_CG11987(tgo)

DER:

6552456

DSE:

6607165

DSI:	Dsimw501_GD20825(Dsim_GD20825)

DYA:	Dyak_GE24803

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI10175

DNV:

108658971

DHE:

111604921

DVI:	6632456(tgo)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:	119679857 119685195

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135949394(tgo)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ014773

CPII:

120421141

CBRI:

134829306

CNS:	116340471 116340864

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108722240(tgo)

PBAR:

105430879

VEM:

105559437

COBS:

139112204(Tgo)

TLN:	139820381(Tgo)

HST:

DQU:

CFO:

FEX:

PMEC:

138944128(Tgo)

LHU:	105670481(tgo)

PGC:

109851639

OBO:	105277018 105280925

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

CTYP:

141529576(Tgo)

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:	124214028(tgo)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138140399(tgo)

DPA:

109541020

ESIM:

136417333(tgo)

EFOR:

136350434(tgo)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:	108557683 108557760 108558760

DCOR:

135796851(tgo)

APLN:

108740910

PPYR:

116165486

OTU:	111414171 111428635

BMOR:

BMAN:

MSEX:

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137926551(tgo)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:	110375112(tgo)

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141437933 141438118 141438144

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:	111050820 120349608

HVI:

124354891

MQU:

128997671

PHU:	Phum_PHUM505970

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138692575(tgo)

SGRE:

126273196

BROR:

134540263

IEL:

124166063

HAMR:

139694591(tgo)

FCD:

110858606

DPX:	DAPPUDRAFT_309730

DMK:

116919161

DPZ:

124343175

AFRA:

136031127

PVM:	113830391(tgo)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128693905(tgo)

PTRU:

123503838

ESN:

127006664

MNZ:

135206206

MRJ:	136834355(tgo)

PORN:

139753431(tgo)

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:	136970806(tgo)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

CEL:	CELE_C25A1.11(aha-1)

CBR:	CBG_12219(Cbr-aha-1)

CRQ:	GCK72_002318

NAI:	NECAME_01427

BMY:	BM_BM2359(Bm2359)

LOA:	LOAG_08661

TSP:

Tsp_10414

HRO:	HELRODRAFT_110615

LGI:	LOTGIDRAFT_179263

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111130408 111130916

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_123420

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_14211

AQU:

100635962

» show all

Reference

PMID:9159130

Authors

Kallio PJ, Pongratz I, Gradin K, McGuire J, Poellinger L

Title

Activation of hypoxia-inducible factor 1alpha: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor.

Journal

Proc Natl Acad Sci U S A 94:5667-72 (1997)
DOI:10.1073/pnas.94.11.5667

Reference

PMID:1852076

Authors

Hoffman EC, Reyes H, Chu FF, Sander F, Conley LH, Brooks BA, Hankinson O

Title

Cloning of a factor required for activity of the Ah (dioxin) receptor.

Journal

Science 252:954-8 (1991)
DOI:10.1126/science.1852076

Sequence

[hsa:405]

All links

Ontology (1)   
   GO (1)   
Gene (886)   
   MGENES (175)   
   RefGene (707)   
   OC (4)   
All databases (887)   

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