KEGG   ORTHOLOGY: K10534
Entry
K10534                      KO                                     

Name
NR
Definition
nitrate reductase (NAD(P)H) [EC:1.7.1.1 1.7.1.2 1.7.1.3]
Pathway
ko00910  Nitrogen metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
Module
M00531  Assimilatory nitrate reduction, nitrate => ammonia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09102 Energy metabolism
   00910 Nitrogen metabolism
    K10534  NR; nitrate reductase (NAD(P)H)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.7  Acting on other nitrogenous compounds as donors
   1.7.1  With NAD+ or NADP+ as acceptor
    1.7.1.1  nitrate reductase (NADH)
     K10534  NR; nitrate reductase (NAD(P)H)
    1.7.1.2  nitrate reductase [NAD(P)H]
     K10534  NR; nitrate reductase (NAD(P)H)
    1.7.1.3  nitrate reductase (NADPH)
     K10534  NR; nitrate reductase (NAD(P)H)
Other DBs
RN: R00794 R00796
GO: 0009703 0050463 0050464
Genes
ATH: AT1G37130(NIA2) AT1G77760(NIA1)
ALY: 9325221 9329985
CRB: 17895831 17897387
CSAT: 104702559 104713453 104742100 104743831 104751674 104757885 104777515
EUS: EUTSA_v10003628mg EUTSA_v10018092mg
BRP: 103830551 103832206 103853097
BNA: 106353470 106354597 106368948 106397776 106400358 106411852 111210558
BOE: 106300064 106300202 106327343
RSZ: 108814131 108817773 108827738 108832026
THJ: 104813138 104813644 104817024
CPAP: 110815200
CIT: 102610866
TCC: 18592259
EGR: 104450466
LJA: Lj0g3v0006719.1(Lj0g3v0006719.1)
ADU: 107460801
AIP: 107606095
FVE: 101295234
RCN: 112176179
PPER: 18790070
PMUM: 103332932
PAVI: 110753196
CSV: 101216001(NR1) 101219000(NR2) 101219242(NR3)
RCU: 8274143
JCU: 105638879
HBR: 110647032
MESC: 110608013
VVI: 100264320
SLY: 100736473(NR)
SPEN: 107004448
SOT: 102577728(NR3)
CANN: 107867964
NTA: 107785409(NIA2) 107820848 107823732(NIA1)
NTO: 104097998
NAU: 109206453
INI: 109176053
CCAV: 112504364
BVG: 104887841
SOE: 110786500
DOSA: Os02t0770800-01(Os02g0770800) Os08t0468100-01(Os08g0468100) Os08t0468700-00(Os08g0468700)
ATS: 109742560(LOC109742560) 109757553(LOC109757553) 109768384(LOC109768384)
PDA: 103710540
EGU: 105035363
DCT: 110097032
PEQ: 110019783
ATR: 18423189
CRE: CHLREDRAFT_184661(NIT1)
VCN: VOLCADRAFT_76569(nitA)
MNG: MNEG_1964
MIS: MICPUN_113975(nia)
NCR: NCU05298(nit-3)
NTE: NEUTE1DRAFT80350(NEUTE1DRAFT_80350)
MGR: MGG_06062
MAW: MAC_08624
BFU: BCIN_07g01270(BcniaD)
MBE: MBM_01744
ANG: ANI_1_2088064(An07g08910) ANI_1_2090064(An07g08920) ANI_1_802074(An08g05610)
PBL: PAAG_03766 PAAG_12411(PAAG_07727)
PTE: PTT_08192
SMIN: v1.2.036677.t1(symbB.v1.2.036677.t1) v1.2.039611.t1(symbB.v1.2.039611.t1)
 » show all
Reference
PMID:8355655
  Authors
Okamoto PM, Marzluf GA
  Title
Nitrate reductase of Neurospora crassa: the functional role of individual amino acids in the heme domain as examined by site-directed mutagenesis.
  Journal
Mol Gen Genet 240:221-30 (1993)
DOI:10.1007/BF00277060

KEGG   ENZYME: 1.7.1.1
Entry
EC 1.7.1.1                  Enzyme                                 

Name
nitrate reductase (NADH);
assimilatory nitrate reductase (ambiguous);
NADH-nitrate reductase;
NADH-dependent nitrate reductase;
assimilatory NADH: nitrate reductase;
nitrate reductase (NADH2);
NADH2:nitrate oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
nitrite:NAD+ oxidoreductase
Reaction(IUBMB)
nitrite + NAD+ + H2O = nitrate + NADH + H+ [RN:R00794]
Reaction(KEGG)
R00794
Substrate
nitrite [CPD:C00088];
NAD+ [CPD:C00003];
H2O [CPD:C00001]
Product
nitrate [CPD:C00244];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
An iron-sulfur molybdenum flavoprotein.
History
EC 1.7.1.1 created 1961 as EC 1.6.6.1, transferred 2002 to EC 1.7.1.1
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10534  nitrate reductase (NAD(P)H)
Genes
ATH: AT1G37130(NIA2) AT1G77760(NIA1)
ALY: 9325221 9329985
CRB: 17895831 17897387
CSAT: 104702559 104713453 104742100 104743831 104751674 104757885 104777515
EUS: EUTSA_v10003628mg EUTSA_v10018092mg
BRP: 103830551 103832206 103853097
BNA: 106353470 106354597 106368948 106397776 106400358 106411852 111210558
BOE: 106300064 106300202 106327343
RSZ: 108814131 108817773 108827738 108832026
THJ: 104813138 104813644 104817024
CPAP: 110815200
CIT: 102610866
TCC: 18592259
EGR: 104450466
LJA: Lj0g3v0006719.1(Lj0g3v0006719.1)
ADU: 107460801
AIP: 107606095
FVE: 101295234
RCN: 112176179
PPER: 18790070
PMUM: 103332932
PAVI: 110753196
CSV: 101216001(NR1) 101219000(NR2) 101219242(NR3)
RCU: 8274143
JCU: 105638879
HBR: 110647032
MESC: 110608013
VVI: 100264320
SLY: 100736473(NR)
SPEN: 107004448
SOT: 102577728(NR3)
CANN: 107867964
NTA: 107785409(NIA2) 107820848 107823732(NIA1)
NTO: 104097998
NAU: 109206453
INI: 109176053
CCAV: 112504364
BVG: 104887841
SOE: 110786500
DOSA: Os02t0770800-01(Os02g0770800) Os08t0468100-01(Os08g0468100) Os08t0468700-00(Os08g0468700)
ATS: 109742560(LOC109742560) 109757553(LOC109757553) 109768384(LOC109768384)
PDA: 103710540
EGU: 105035363
DCT: 110097032
PEQ: 110019783
ATR: 18423189
CRE: CHLREDRAFT_184661(NIT1)
VCN: VOLCADRAFT_76569(nitA)
MNG: MNEG_1964
MIS: MICPUN_113975(nia)
NCR: NCU05298(nit-3)
NTE: NEUTE1DRAFT80350(NEUTE1DRAFT_80350)
MGR: MGG_06062
MAW: MAC_08624
BFU: BCIN_07g01270(BcniaD)
MBE: MBM_01744
ANG: ANI_1_2088064(An07g08910) ANI_1_2090064(An07g08920) ANI_1_802074(An08g05610)
PBL: PAAG_03766 PAAG_12411(PAAG_07727)
PTE: PTT_08192
SMIN: v1.2.036677.t1(symbB.v1.2.036677.t1) v1.2.039611.t1(symbB.v1.2.039611.t1)
 » show all
Reference
1  [PMID:13699254]
  Authors
FEWSON CA, NICHOLAS DJ.
  Title
Nitrate reductase from Pseudomonas aeruginosa.
  Journal
Biochim Biophys Acta 49:335-49 (1961)
DOI:10.1016/0006-3002(61)90133-0
Reference
2
  Authors
Nason, A.
  Title
Nitrate reductases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 587-607.
Reference
3  [PMID:14381380]
  Authors
NICHOLAS DJ, NASON A
  Title
Diphosphopyridine nucleotide-nitrate reductase from Escherichia coli.
  Journal
J Bacteriol 69:580-3 (1955)
DOI:10.1128/JB.69.5.580-583.1955
Reference
4
  Authors
Spencer, D.
  Title
A reduced diphosphopyridine-specific nitrate reductase from germinating wheat.
  Journal
Aust J Biol Sci 12:181-189 (1959)
Reference
5  [PMID:8534676]
  Authors
Berks BC, Ferguson SJ, Moir JW, Richardson DJ.
  Title
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.
  Journal
Biochim Biophys Acta 1232:97-173 (1995)
DOI:10.1016/0005-2728(95)00092-5
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.1
IUBMB Enzyme Nomenclature: 1.7.1.1
ExPASy - ENZYME nomenclature database: 1.7.1.1
UM-BBD (Biocatalysis/Biodegradation Database): 1.7.1.1
BRENDA, the Enzyme Database: 1.7.1.1
CAS: 9013-03-0

KEGG   ENZYME: 1.7.1.2
Entry
EC 1.7.1.2                  Enzyme                                 

Name
nitrate reductase [NAD(P)H];
assimilatory nitrate reductase ( ambiguous);
assimilatory NAD(P)H-nitrate reductase;
NAD(P)H bispecific nitrate reductase;
nitrate reductase (reduced nicotinamide adenine dinucleotide (phosphate));
nitrate reductase NAD(P)H;
NAD(P)H-nitrate reductase;
nitrate reductase [NAD(P)H2];
NAD(P)H2:nitrate oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
nitrite:NAD(P)+ oxidoreductase
Reaction(IUBMB)
nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+ [RN:R00794 R00796]
Reaction(KEGG)
R00794 R00796
Substrate
nitrite [CPD:C00088];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
nitrate [CPD:C00244];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
An iron-sulfur molybdenum flavoprotein.
History
EC 1.7.1.2 created 1961 as EC 1.6.6.2, transferred 2002 to EC 1.7.1.2
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10534  nitrate reductase (NAD(P)H)
Genes
ATH: AT1G37130(NIA2) AT1G77760(NIA1)
ALY: 9325221 9329985
CRB: 17895831 17897387
CSAT: 104702559 104713453 104742100 104743831 104751674 104757885 104777515
EUS: EUTSA_v10003628mg EUTSA_v10018092mg
BRP: 103830551 103832206 103853097
BNA: 106353470 106354597 106368948 106397776 106400358 106411852 111210558
BOE: 106300064 106300202 106327343
RSZ: 108814131 108817773 108827738 108832026
THJ: 104813138 104813644 104817024
CPAP: 110815200
CIT: 102610866
TCC: 18592259
EGR: 104450466
LJA: Lj0g3v0006719.1(Lj0g3v0006719.1)
ADU: 107460801
AIP: 107606095
FVE: 101295234
RCN: 112176179
PPER: 18790070
PMUM: 103332932
PAVI: 110753196
CSV: 101216001(NR1) 101219000(NR2) 101219242(NR3)
RCU: 8274143
JCU: 105638879
HBR: 110647032
MESC: 110608013
VVI: 100264320
SLY: 100736473(NR)
SPEN: 107004448
SOT: 102577728(NR3)
CANN: 107867964
NTA: 107785409(NIA2) 107820848 107823732(NIA1)
NTO: 104097998
NAU: 109206453
INI: 109176053
CCAV: 112504364
BVG: 104887841
SOE: 110786500
DOSA: Os02t0770800-01(Os02g0770800) Os08t0468100-01(Os08g0468100) Os08t0468700-00(Os08g0468700)
ATS: 109742560(LOC109742560) 109757553(LOC109757553) 109768384(LOC109768384)
PDA: 103710540
EGU: 105035363
DCT: 110097032
PEQ: 110019783
ATR: 18423189
CRE: CHLREDRAFT_184661(NIT1)
VCN: VOLCADRAFT_76569(nitA)
MNG: MNEG_1964
MIS: MICPUN_113975(nia)
NCR: NCU05298(nit-3)
NTE: NEUTE1DRAFT80350(NEUTE1DRAFT_80350)
MGR: MGG_06062
MAW: MAC_08624
BFU: BCIN_07g01270(BcniaD)
MBE: MBM_01744
ANG: ANI_1_2088064(An07g08910) ANI_1_2090064(An07g08920) ANI_1_802074(An08g05610)
PBL: PAAG_03766 PAAG_12411(PAAG_07727)
PTE: PTT_08192
SMIN: v1.2.036677.t1(symbB.v1.2.036677.t1) v1.2.039611.t1(symbB.v1.2.039611.t1)
 » show all
Reference
1
  Authors
Nason, A.
  Title
Nitrate reductases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 587-607.
Reference
2  [PMID:5864033]
  Authors
Paneque A, Del Campo FF, Ramirez JM, Losada M.
  Title
Flavin nucleotide nitrate reductase from spinach.
  Journal
Biochim Biophys Acta 109:79-85 (1965)
DOI:10.1016/0926-6585(65)90092-0
Reference
3  [PMID:11289301]
  Authors
Campbell WH.
  Title
Structure and function of eukaryotic NAD(P)H:nitrate reductase.
  Journal
Cell Mol Life Sci 58:194-204 (2001)
DOI:10.1007/PL00000847
Reference
4  [PMID:8534676]
  Authors
Berks BC, Ferguson SJ, Moir JW, Richardson DJ.
  Title
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.
  Journal
Biochim Biophys Acta 1232:97-173 (1995)
DOI:10.1016/0005-2728(95)00092-5
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.2
IUBMB Enzyme Nomenclature: 1.7.1.2
ExPASy - ENZYME nomenclature database: 1.7.1.2
BRENDA, the Enzyme Database: 1.7.1.2
CAS: 9029-27-0

KEGG   ENZYME: 1.7.1.3
Entry
EC 1.7.1.3                  Enzyme                                 

Name
nitrate reductase (NADPH);
assimilatory nitrate reductase (ambiguous);
assimilatory reduced nicotinamide adenine dinucleotide phosphate-nitrate reductase;
NADPH-nitrate reductase;
assimilatory NADPH-nitrate reductase;
triphosphopyridine nucleotide-nitrate reductase;
NADPH:nitrate reductase;
nitrate reductase (NADPH2);
NADPH2:nitrate oxidoreductase
Class
Oxidoreductases;
Acting on other nitrogenous compounds as donors;
With NAD+ or NADP+ as acceptor
Sysname
nitrite:NADP+ oxidoreductase
Reaction(IUBMB)
nitrite + NADP+ + H2O = nitrate + NADPH + H+ [RN:R00796]
Reaction(KEGG)
R00796
Substrate
nitrite [CPD:C00088];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
nitrate [CPD:C00244];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
An iron-sulfur molybdenum flavoprotein.
History
EC 1.7.1.3 created 1961 as EC 1.6.6.3, transferred 2002 to EC 1.7.1.3
Pathway
ec00910  Nitrogen metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K10534  nitrate reductase (NAD(P)H)
Genes
ATH: AT1G37130(NIA2) AT1G77760(NIA1)
ALY: 9325221 9329985
CRB: 17895831 17897387
CSAT: 104702559 104713453 104742100 104743831 104751674 104757885 104777515
EUS: EUTSA_v10003628mg EUTSA_v10018092mg
BRP: 103830551 103832206 103853097
BNA: 106353470 106354597 106368948 106397776 106400358 106411852 111210558
BOE: 106300064 106300202 106327343
RSZ: 108814131 108817773 108827738 108832026
THJ: 104813138 104813644 104817024
CPAP: 110815200
CIT: 102610866
TCC: 18592259
EGR: 104450466
LJA: Lj0g3v0006719.1(Lj0g3v0006719.1)
ADU: 107460801
AIP: 107606095
FVE: 101295234
RCN: 112176179
PPER: 18790070
PMUM: 103332932
PAVI: 110753196
CSV: 101216001(NR1) 101219000(NR2) 101219242(NR3)
RCU: 8274143
JCU: 105638879
HBR: 110647032
MESC: 110608013
VVI: 100264320
SLY: 100736473(NR)
SPEN: 107004448
SOT: 102577728(NR3)
CANN: 107867964
NTA: 107785409(NIA2) 107820848 107823732(NIA1)
NTO: 104097998
NAU: 109206453
INI: 109176053
CCAV: 112504364
BVG: 104887841
SOE: 110786500
DOSA: Os02t0770800-01(Os02g0770800) Os08t0468100-01(Os08g0468100) Os08t0468700-00(Os08g0468700)
ATS: 109742560(LOC109742560) 109757553(LOC109757553) 109768384(LOC109768384)
PDA: 103710540
EGU: 105035363
DCT: 110097032
PEQ: 110019783
ATR: 18423189
CRE: CHLREDRAFT_184661(NIT1)
VCN: VOLCADRAFT_76569(nitA)
MNG: MNEG_1964
MIS: MICPUN_113975(nia)
NCR: NCU05298(nit-3)
NTE: NEUTE1DRAFT80350(NEUTE1DRAFT_80350)
MGR: MGG_06062
MAW: MAC_08624
BFU: BCIN_07g01270(BcniaD)
MBE: MBM_01744
ANG: ANI_1_2088064(An07g08910) ANI_1_2090064(An07g08920) ANI_1_802074(An08g05610)
PBL: PAAG_03766 PAAG_12411(PAAG_07727)
PTE: PTT_08192
SMIN: v1.2.036677.t1(symbB.v1.2.036677.t1) v1.2.039611.t1(symbB.v1.2.039611.t1)
 » show all
Reference
1
  Authors
Nason, A.
  Title
Nitrate reductases.
  Journal
In: Boyer, P.D., Lardy, H. and Myrback, K. (Eds.), The Enzymes, 2nd ed., vol. 7, Academic Press, New York, 1963, p. 587-607.
Reference
2  [PMID:13061490]
  Authors
NASON A, EVANS HJ.
  Title
Triphosphopyridine nucleotide-nitrate reductase in Neurospora.
  Journal
J Biol Chem 202:655-73 (1953)
Reference
3  [PMID:13152110]
  Authors
NICHOLAS DJ, NASON A.
  Title
Molybdenum and nitrate reductase. II. Molybdenum as a constituent of nitrate reductase.
  Journal
J Biol Chem 207:353-60 (1954)
Reference
4
  Authors
Taniguchi, H., Mitsui, H., Nakamura, K. and Egami, F.
  Title
Ann Acad Sci Fenn Ser A II 60:200 (1955)
Reference
5  [PMID:8534676]
  Authors
Berks BC, Ferguson SJ, Moir JW, Richardson DJ.
  Title
Enzymes and associated electron transport systems that catalyse the respiratory reduction of nitrogen oxides and oxyanions.
  Journal
Biochim Biophys Acta 1232:97-173 (1995)
DOI:10.1016/0005-2728(95)00092-5
Other DBs
ExplorEnz - The Enzyme Database: 1.7.1.3
IUBMB Enzyme Nomenclature: 1.7.1.3
ExPASy - ENZYME nomenclature database: 1.7.1.3
BRENDA, the Enzyme Database: 1.7.1.3
CAS: 9029-28-1

KEGG   REACTION: R00794
Entry
R00794                      Reaction                               

Name
nitrite:NAD+ oxidoreductase;
NADH:nitrate oxidoreductase
Definition
Nitrite + NAD+ + H2O <=> Nitrate + NADH + H+
Equation
Comment
NADP+ (ec 1.7.1.2, see R00796)
Reaction class
RC00001  C00003_C00004
RC02812  C00088_C00244
Enzyme
1.7.1.1         1.7.1.2
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00531  Assimilatory nitrate reduction, nitrate => ammonia
Orthology
K10534  nitrate reductase (NAD(P)H) [EC:1.7.1.1 1.7.1.2 1.7.1.3]
Other DBs
RHEA: 17916

KEGG   REACTION: R00796
Entry
R00796                      Reaction                               

Name
nitrite:NADP+ oxidoreductase;
NADPH:nitrate oxidoreductase
Definition
Nitrite + NADP+ + H2O <=> Nitrate + NADPH + H+
Equation
Comment
NAD+ (ec 1.7.1.2, see R00794)
Reaction class
RC00001  C00005_C00006
RC02812  C00088_C00244
Enzyme
1.7.1.2         1.7.1.3
Pathway
rn00910  Nitrogen metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
Module
M00531  Assimilatory nitrate reduction, nitrate => ammonia
Orthology
K10534  nitrate reductase (NAD(P)H) [EC:1.7.1.1 1.7.1.2 1.7.1.3]
Other DBs
RHEA: 19064

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