KEGG   ORTHOLOGY: K12902
Entry
K12902            Tight     KO                                     
Symbol
fom3
Name
phosphonoacetaldehyde methylase [EC:2.1.1.308]
Pathway
map00998  Biosynthesis of various antibiotics
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Module
M00903  Fosfomycin biosynthesis, phosphoenolpyruvate => fosfomycin
Reaction
R08862  methylcobalamin:2-hydroxyethylphosphonate C-methyltransferase
R12497  S-adenosyl-L-methionine:cytidine 5'-{[hydroxy(2-hydroxyethyl)phosphonoyl]phosphate} C-methyltransferase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00998 Biosynthesis of various antibiotics
    K12902  fom3; phosphonoacetaldehyde methylase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.308  cytidylyl-2-hydroxyethylphosphonate methyltransferase
     K12902  fom3; phosphonoacetaldehyde methylase
Genes
AG: ACG70826(fom3) BAA32490(fom3)
Reference
PMID:7789803
  Authors
Hidaka T, Hidaka M, Kuzuyama T, Seto H
  Title
Sequence of a P-methyltransferase-encoding gene isolated from a bialaphos-producing Streptomyces hygroscopicus.
  Journal
Gene 158:149-50 (1995)
DOI:10.1016/0378-1119(95)00101-B
  Sequence
[ag:BAA32490]
Reference
PMID:19489722
  Authors
Metcalf WW, van der Donk WA
  Title
Biosynthesis of phosphonic and phosphinic acid natural products.
  Journal
Annu Rev Biochem 78:65-94 (2009)
DOI:10.1146/annurev.biochem.78.091707.100215
Reference
PMID:17220970
  Authors
Woodyer RD, Li G, Zhao H, van der Donk WA
  Title
New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin.
  Journal
Chem Commun (Camb) 359-61 (2007)
DOI:10.1039/b614678c
  Sequence
[ag:ACG70826]

  All links  
Ontology (2)   
   KEGG BRITE (2)   
Pathway (7)   
   KEGG PATHWAY (6)   
   KEGG MODULE (1)   
Chemical reaction (5)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (2)   
Gene (2)   
   KEGG GENES (2)   
Literature (3)   
   PubMed (3)   
All databases (19)   

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