KEGG   ORTHOLOGY: K13242
Entry
K13242                      KO                                     
Symbol
NOS3
Name
nitric-oxide synthase, endothelial [EC:1.14.13.39]
Pathway
map00220  Arginine biosynthesis
map00330  Arginine and proline metabolism
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
map04020  Calcium signaling pathway
map04022  cGMP-PKG signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04151  PI3K-Akt signaling pathway
map04370  VEGF signaling pathway
map04371  Apelin signaling pathway
map04611  Platelet activation
map04915  Estrogen signaling pathway
map04921  Oxytocin signaling pathway
map04926  Relaxin signaling pathway
map04931  Insulin resistance
map04933  AGE-RAGE signaling pathway in diabetic complications
map05415  Diabetic cardiomyopathy
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Reaction
R00111  N-(omega)-hydroxyarginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
R00557  L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming)
R00558  L-arginine,NADPH:oxygen oxidoreductase (N-(omega)-hydroxyarginine-forming)
Disease
H01529  Avascular necrosis of femoral head
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00220 Arginine biosynthesis
    K13242  NOS3; nitric-oxide synthase, endothelial
   00330 Arginine and proline metabolism
    K13242  NOS3; nitric-oxide synthase, endothelial
 09130 Environmental Information Processing
  09132 Signal transduction
   04370 VEGF signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04371 Apelin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04066 HIF-1 signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04020 Calcium signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04071 Sphingolipid signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04022 cGMP-PKG signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04151 PI3K-Akt signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K13242  NOS3; nitric-oxide synthase, endothelial
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04921 Oxytocin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
   04926 Relaxin signaling pathway
    K13242  NOS3; nitric-oxide synthase, endothelial
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05418 Fluid shear stress and atherosclerosis
    K13242  NOS3; nitric-oxide synthase, endothelial
   05415 Diabetic cardiomyopathy
    K13242  NOS3; nitric-oxide synthase, endothelial
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K13242  NOS3; nitric-oxide synthase, endothelial
   04933 AGE-RAGE signaling pathway in diabetic complications
    K13242  NOS3; nitric-oxide synthase, endothelial
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.39  nitric-oxide synthase (NADPH)
     K13242  NOS3; nitric-oxide synthase, endothelial
Other DBs
GO: 0004517
Genes
HSA: 4846(NOS3)
PTR: 463893(NOS3)
PPS: 100974638(NOS3)
GGO: 101128007(NOS3)
PON: 100447953(NOS3)
PPYG: 129040236(NOS3)
NLE: 100592456(NOS3)
HMH: 116814534(NOS3)
SSYN: 129485205(NOS3)
MCC: 714231(NOS3)
MCF: 102143504(NOS3)
MTHB: 126951570
MNI: 105474900(NOS3)
CSAB: 103227233(NOS3)
CATY: 105584734(NOS3)
PANU: 101024888(NOS3)
TGE: 112620359(NOS3)
MLEU: 105542707(NOS3)
RRO: 104675393(NOS3)
RBB: 108532525(NOS3)
TFN: 117072600(NOS3)
PTEH: 111551457(NOS3)
CANG: 105511327(NOS3)
CJC: 100405019(NOS3)
SBQ: 101034220(NOS3)
CIMI: 108297770(NOS3)
ANAN: 105710740(NOS3)
CSYR: 103275280(NOS3)
MMUR: 105883168(NOS3)
LCAT: 123647518(NOS3)
PCOQ: 105824632(NOS3)
OGA: 100956703(NOS3)
MMU: 18127(Nos3)
MCAL: 110293897(Nos3)
MPAH: 110315110(Nos3)
RNO: 24600(Nos3)
MCOC: 116097543(Nos3)
ANU: 117720753(Nos3)
MUN: 110562552(Nos3)
CGE: 100769961(Nos3)
MAUA: 101838293(Nos3)
PROB: 127235683(Nos3)
PLEU: 114700088(Nos3)
MORG: 121439958(Nos3)
MFOT: 126489431
AAMP: 119807052(Nos3)
NGI: 103745303(Nos3)
HGL: 101711110(Nos3)
CPOC: 100135577(Nos3)
CCAN: 109694442(Nos3)
DORD: 105993873(Nos3)
DSP: 122105913(Nos3)
PLOP: 125347314(Nos3)
NCAR: 124990691
MMMA: 107148937(Nos3)
OCU: 100009498(NOS3) 127493711
OPI: 101520691(NOS3)
TUP: 102495986(NOS3)
GVR: 103585106(NOS3)
CFA: 403784(NOS3)
CLUD: 112663787(NOS3)
VVP: 112916218(NOS3)
VLG: 121489275(NOS3)
NPO: 129515953(NOS3)
AML: 100483990(NOS3)
UMR: 103660958(NOS3)
UAH: 113241474(NOS3)
UAR: 123788781(NOS3)
ELK: 111154402
LLV: 125081326
MPUF: 101673532(NOS3)
MNP: 132015570(NOS3)
MLK: 131829935(NOS3)
NVS: 122905198(NOS3)
ORO: 101382350(NOS3)
EJU: 114198019(NOS3)
ZCA: 113911718(NOS3)
MLX: 118026800(NOS3)
NSU: 110582947(NOS3)
LWW: 102740880 102741156
FCA: 101096463(NOS3)
PYU: 121022952(NOS3)
PCOO: 112866504(NOS3)
PBG: 122488527(NOS3)
PVIV: 125154173(NOS3)
LRUF: 124524465
PTG: 102967516(NOS3)
PPAD: 109252365(NOS3)
PUC: 125930302
AJU: 106969560
HHV: 120230927(NOS3)
BTA: 287024(NOS3)
BOM: 102267556(NOS3)
BIU: 109557793(NOS3)
BBUB: 102408451(NOS3)
BBIS: 105001191(NOS3)
CHX: 102185338(NOS3)
OAS: 443077(NOS3)
BTAX: 128046225(NOS3)
ODA: 120877875(NOS3)
MBEZ: 129552779(NOS3)
SSC: 397557(NOS3)
CFR: 102524296(NOS3)
CBAI: 105067010(NOS3)
CDK: 105105831(NOS3)
VPC: 102536194(NOS3)
BACU: 103017861(NOS3)
BMUS: 118901142(NOS3)
LVE: 103087259(NOS3)
OOR: 101280520(NOS3)
DLE: 111176849(NOS3)
PCAD: 102985806(NOS3)
PSIU: 116759107(NOS3)
NASI: 112405905(NOS3)
ECB: 100063339(NOS3)
EPZ: 103540937(NOS3)
EAI: 106823361(NOS3)
MYB: 102256555(NOS3)
MYD: 102764374(NOS3)
MMYO: 118679429(NOS3)
MLF: 102436714(NOS3)
MDT: 132242619(NOS3)
PKL: 118704763(NOS3)
EFUS: 103301781(NOS3)
MNA: 107524933(NOS3)
DRO: 112308288(NOS3)
SHON: 118975507(NOS3)
AJM: 119039263(NOS3)
PDIC: 114508069(NOS3)
PHAS: 123817951(NOS3)
MMF: 118620067(NOS3)
PPAM: 129086753(NOS3)
HAI: 109389680(NOS3)
RFQ: 117018217(NOS3)
PALE: 102879945(NOS3)
PGIG: 120601518(NOS3)
PVP: 105303769(NOS3)
RAY: 107520319(NOS3)
MJV: 108391841(NOS3)
TOD: 119251590(NOS3)
SARA: 101547011(NOS3)
SETR: 126021768(NOS3)
LAV: 100668912(NOS3)
TMU: 101356953
ETF: 101644765(NOS3)
DNM: 101433723(NOS3)
MDO: 100018035(NOS3)
GAS: 123250621(NOS3)
SHR: 100913437(NOS3)
AFZ: 127564122
PCW: 110201937(NOS3)
TVP: 118852152(NOS3)
OAA: 100091599(NOS3)
GGA: 107057170
PCOC: 116242834(NOS3)
MGP: 100545552
CJO: 107308662(NOS3)
TPAI: 128085808(NOS3)
LMUT: 125696090(NOS3)
ACYG: 125180896(NOS3)
CATA: 118251735(NOS3)
AFUL: 116486135(NOS3)
TGU: 115493592(NOS3)
LSR: 110475121(NOS3)
PMOA: 120510540(NOS3)
OTC: 121334878(NOS3)
PRUF: 121356981(NOS3)
OMA: 130249115(NOS3)
PHI: 102112141(NOS3)
ETL: 114068013(NOS3)
ZLE: 135443479(NOS3)
SVG: 106861781(NOS3)
MMEA: 130574590(NOS3)
SATI: 136375600(NOS3)
FPG: 101918492(NOS3)
FCH: 102057360(NOS3)
SHAB: 115610765(NOS3)
HLE: 104829386(NOS3)
AGEN: 126037657
DPUB: 104298517(NOS3)
AROW: 112963744(NOS3)
NPD: 112958193
DNE: 112978916
ASN: 102381196(NOS3)
AMJ: 102575253(NOS3)
CMY: 102942806(NOS3)
CCAY: 125632956(NOS3)
DCC: 119851036(NOS3)
CPIC: 101952927(NOS3)
TST: 117871954(NOS3)
CABI: 116834210
MRV: 120397587(NOS3)
ACS: 100557597(nos3)
ASAO: 132779125(NOS3)
PVT: 110082598(NOS3)
SUND: 121934954(NOS3)
PBI: 103065136
CTIG: 120320267(NOS3)
TSR: 106544793(NOS3)
PGUT: 117669221(NOS3)
APRI: 131196506(NOS3)
VKO: 123019550(NOS3)
PMUA: 114607850(NOS3)
PRAF: 128423990(NOS3)
ZVI: 118092264(NOS3)
HCG: 128329346(NOS3)
GJA: 107118610(NOS3)
STOW: 125441159(NOS3)
EMC: 129337473(NOS3)
XLA: 108704634(nos3.L)
XTR: 100486016(nos3)
NPR: 108803428
RTEM: 120941752(NOS3)
BBUF: 121000747(NOS3)
BGAR: 122938595 122938785
MUO: 115465186(NOS3)
GSH: 117354473(NOS3)
LOC: 102697373
PSPA: 121312985 121314660
ARUT: 117400058
PSEX: 120515929
LERI: 129694458
OTA: OT_ostta17g00030
 » show all
Reference
PMID:1378832
  Authors
Janssens SP, Shimouchi A, Quertermous T, Bloch DB, Bloch KD
  Title
Cloning and expression of a cDNA encoding human endothelium-derived relaxing factor/nitric oxide synthase.
  Journal
J Biol Chem 267:14519-22 (1992)
  Sequence
[hsa:4846]

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Ontology (3)   
   KEGG BRITE (2)   
   GO (1)   
Pathway (40)   
   KEGG PATHWAY (40)   
Disease (2)   
   KEGG DISEASE (2)   
Drug (2)   
   KEGG DRUG (2)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (491)   
   KEGG GENES (227)   
   KEGG MGENES (118)   
   RefGene (142)   
   OC (4)   
Literature (1)   
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All databases (547)   

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