Entry
Symbol
ribBA
Name
3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:
4.1.99.12 3.5.4.25 ]
Pathway
map01110 Biosynthesis of secondary metabolites
Module
M00125 Riboflavin biosynthesis, plants and bacteria, GTP => riboflavin/FMN/FAD
M00840 Tetrahydrofolate biosynthesis, mediated by ribA and trpF, GTP => THF
Reaction
R00425 GTP 7,8-8,9-dihydrolase (diphosphate-forming)
R07281 D-ribulose 5-phosphate formate-lyase (L-3,4-dihydroxybutan-2-one 4-phosphate-forming)
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00740 Riboflavin metabolism
K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
00790 Folate biosynthesis
K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
Enzymes [BR:ko01000 ]
3. Hydrolases
3.5 Acting on carbon-nitrogen bonds, other than peptide bonds
3.5.4 In cyclic amidines
3.5.4.25 GTP cyclohydrolase II
K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
4. Lyases
4.1 Carbon-carbon lyases
4.1.99 Other carbon-carbon lyases
4.1.99.12 3,4-dihydroxy-2-butanone-4-phosphate synthase
K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II
BRITE hierarchy
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Genes
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Taxonomy UniProt
Reference
Authors
Herz S, Eberhardt S, Bacher A
Title
Biosynthesis of riboflavin in plants. The ribA gene of Arabidopsis thaliana specifies a bifunctional GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase.
Journal
Sequence
Reference
Authors
Vitreschak AG, Rodionov DA, Mironov AA, Gelfand MS.
Title
Regulation of riboflavin biosynthesis and transport genes in bacteria by transcriptional and translational attenuation.
Journal