KEGG ORTHOLOGY: K16436

ORTHOLOGY: K16436

Entry

K16436                      KO

Symbol

evaB, megDII, angB, staI

Name

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase [EC:2.6.1.- 2.6.1.106]

Pathway

map00523

Polyketide sugar unit biosynthesis

map01055

Biosynthesis of vancomycin group antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

map01250

Biosynthesis of nucleotide sugars

Module

M00797

dTDP-D-desosamine biosynthesis

M00800

dTDP-L-megosamine biosynthesis

M00803

dTDP-D-angolosamine biosynthesis

Reaction

R06426

dTDP-3-amino-3,4,6-trideoxy-D-glucose:2-oxoglutarate aminotransferase

R06631

dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose:2-oxoglutarate aminotransferase

R08928

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   00523 Polyketide sugar unit biosynthesis
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
   01055 Biosynthesis of vancomycin group antibiotics
    K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase
Enzymes [BR:ko01000]
2. Transferases
  2.6  Transferring nitrogenous groups
   2.6.1  Transaminases
    2.6.1.106  dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose transaminase
     K16436  evaB, megDII, angB, staI; dTDP-3-amino-2,3,6-trideoxy-4-keto-D-glucose/dTDP-3-amino-3,4,6-trideoxy-alpha-D-glucose/dTDP-2,6-dideoxy-D-kanosamine transaminase

Genes

DTX:	ATSB10_36020

OME:	OLMES_5572

BOK:

DM82_922

BOC:

BG90_13

BUU:	WS70_10345

PTRP:

DCO17_01695

CSER:

CCO03_02175

HHF:	E2K99_02740

BGZ:	XH91_11590

BSEI:

BROS:

RPE:

GEM:

GUR:

GEO:

GBM:

GBN:	GEOBRER4_09100

GER:	KP004_03990

GSUB:

KP001_11415

GPL:	M1B72_16735

DMA:

DMR_07600

DCB:	C3Y92_16655

DBR:

Deba_0354

NBR:	O3I_007490

NIE:	KV110_35795

DPC:	A6048_11425

SGR:

SGR_631

SGRF:

SGFS_016280

SCYE:

R2B67_24630

SXI:	SXIM_35740

SAMB:

SAM23877_7111

SLE:	sle_09260(sle_09260)

SRN:	A4G23_02284(fdtB_3)

SCLF:

BB341_29650

SGM:	GCM10017557_01770

SCAD:

DN051_13785

SALF:

SMD44_08276

SFK:	KY5_0020c KY5_8143

SLK:	SLUN_13800

STIR:

DDW44_27825

SKA:	CP970_39865

SFIC:

EIZ62_03940 EIZ62_09600

SGAL:

SSPO:

SPAD:

SRIM:

SPHV:

SCIN:

STSU:

SCHA:

SCOE:

SFEU:

SLIA:

SFB:	CP974_12570

SMOB:

J7W19_00830

SPEU:

CGZ69_24380

SGJ:	IAG43_33085

SMAO:

SAOV:

SRUG:

SAKB:

STAA:

SNIG:

STUD:

SJN:	RI060_18320

SHAU:

K9S39_40580

SKG:	KJK29_16120

SFP:	QUY26_02165

SCHG:

NRO40_12725

STTN:

BSL84_24970

SPRF:

K4G22_02655 K4G22_25835

KAB:	B7C62_31175

CRY:	B7495_14410

ARUB:

J5A65_00470

NCA:

Noca_4220

TALX:

FOF52_07485 FOF52_14840

NDA:

Ndas_4709

NAL:

B005_1433

NGV:	CDO52_02790

NEC:	KGD82_07535

NAKE:

KGD83_01610

NCG:	KGD84_13445

STRR:

EKD16_15580(fdtB)

SNAH:

SAIU:

TCU:

ACTQ:

NOW:	GBF35_40090

NCX:	Nocox_25585(fdtB)

SVI:	Svir_29860

SACC:

EYD13_16495(fdtB)

AOI:

AORI_1500

AJA:	AJAP_32020(dnrJ)

AMYC:

CU254_17445

AMYB:

BKN51_41540

AMYY:

YIM_11615(fdtB1) YIM_22860(fdtB2)

AORI:

AROO:

ACYN:

ACOR:

PSEQ:

PECQ:

SESP:

BN6_58910(sam30)

SSYI:

EKG83_32250

KAL:	KALB_6580(acuN1)

KUT:	JJ691_101530 JJ691_70310

KPHY:

AOZ06_22490 AOZ06_23370

LED:	BBK82_43745

AHM:	TL08_05640

ACTI:

UA75_05680

ACAD:

UA74_05675

AHG:	AHOG_05440(fdtB1)

ACTA:

C1701_01555

ALO:

CRK56086

PMAD:

BAY61_07750

ACTU:

Actkin_00392(fdtB_1)

SAQ:

Sare_2337

MAU:	Micau_3988

MIL:

ML5_4433

MICB:

MicB006_4930

MCAB:

HXZ27_04125(evdS12)

MCRA:

ID554_11925 ID554_28075

VER:	HUT12_18910

MENO:

Jiend_53130

MCHL:

PVK74_00295

MCAY:

PVK37_23840

AMS:	AMIS_50590 AMIS_56730

AOU:	ACTOB_006482

PFLA:

Pflav_057110

PSUU:

Psuf_016700(gnnB) Psuf_058220

DAUR:

Daura_37950

NHY:	JQS43_06860

PVN:	A7sIIA15_06590

PLS:	VT03_24275(fdtB)

CCOS:

Pan44_47430(fdtB)

LKB:	LPTSP3_g21180

AG:	AAG13910(megDII) ABV49595(angB) BAC55216(staI)

» show all

Reference

PMID:24884615

Authors

Xu L, Huang H, Wei W, Zhong Y, Tang B, Yuan H, Zhu L, Huang W, Ge M, Yang S, Zheng H, Jiang W, Chen D, Zhao GP, Zhao W

Title

Complete genome sequence and comparative genomic analyses of the vancomycin-producing Amycolatopsis orientalis.

Journal

BMC Genomics 15:363 (2014)
DOI:10.1186/1471-2164-15-363

Sequence

[aoi:AORI_1500]

Reference

PMID:20418422

Authors

Useglio M, Peiru S, Rodriguez E, Labadie GR, Carney JR, Gramajo H

Title

TDP-L-megosamine biosynthesis pathway elucidation and megalomicin a production in Escherichia coli.

Journal

Appl Environ Microbiol 76:3869-77 (2010)
DOI:10.1128/AEM.03083-09

Sequence

[ag:AAG13910]

Reference

PMID:16514147

Authors

Rodriguez E, Peiru S, Carney JR, Gramajo H

Title

In vivo characterization of the dTDP-D-desosamine pathway of the megalomicin gene cluster from Micromonospora megalomicea.

Journal

Microbiology 152:667-73 (2006)
DOI:10.1099/mic.0.28680-0

Sequence

[ag:AAG13910]

Reference

PMID:18802638

Authors

Schell U, Haydock SF, Kaja AL, Carletti I, Lill RE, Read E, Sheehan LS, Low L, Fernandez MJ, Grolle F, McArthur HA, Sheridan RM, Leadlay PF, Wilkinson B, Gaisser S

Title

Engineered biosynthesis of hybrid macrolide polyketides containing D-angolosamine and D-mycaminose moieties.

Journal

Org Biomol Chem 6:3315-27 (2008)
DOI:10.1039/b807914e

Sequence

[ag:ABV49595]

Reference

PMID:12617516

Authors

Onaka H, Taniguchi S, Igarashi Y, Furumai T

Title

Cloning of the staurosporine biosynthetic gene cluster from Streptomyces sp. TP-A0274 and its heterologous expression in Streptomyces lividans.

Journal

J Antibiot (Tokyo) 55:1063-71 (2002)
DOI:10.7164/antibiotics.55.1063

Sequence

[ag:BAC55216]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (13)   
   KEGG PATHWAY (10)   
   KEGG MODULE (3)   
Chemical reaction (7)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
Gene (1584)   
   KEGG GENES (149)   
   KEGG MGENES (1403)   
   RefGene (31)   
   OC (1)   
Literature (5)   
   PubMed (5)   
All databases (1611)   

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