KEGG   ORTHOLOGY: K18366Help
Entry
K18366                      KO                                     

Name
bphJ, xylQ, nahO, tesF
Definition
acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87]
Pathway
ko00362  Benzoate degradation
ko00620  Pyruvate metabolism
ko00621  Dioxin degradation
ko00622  Xylene degradation
ko00650  Butanoate metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00620 Pyruvate metabolism
    K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
   00650 Butanoate metabolism
    K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00362 Benzoate degradation
    K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
   00622 Xylene degradation
    K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
   00621 Dioxin degradation
    K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.2  Acting on the aldehyde or oxo group of donors
   1.2.1  With NAD+ or NADP+ as acceptor
    1.2.1.10  acetaldehyde dehydrogenase (acetylating)
     K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
    1.2.1.87  propanal dehydrogenase (CoA-propanoylating)
     K18366  bphJ, xylQ, nahO, tesF; acetaldehyde/propanal dehydrogenase
BRITE hierarchy
Other DBs
RN: R00228 R01172 R09097
COG: COG4569
GO: 0008774
Genes
PSD: DSC_09370
RGL: CS053_01765
RBD: ALSL_0878 ALSL_1081
VAF: D1115_22445
PRE: PCA10_13830
PPI: ND085(nahO)
PPUT: L483_14060
PPUN: PP4_27270(mhpF)
PVR: PverR02_11590 PverR02_14705
PSC: A458_06515
PPUU: PputUW4_01661(mhpF)
PKC: PKB_4238(nahO)
PSET: THL1_1434
PSIL: PMA3_11730
AVN: Avin_30580(lapF)
AVL: AvCA_30580(lapF)
AVD: AvCA6_30580(lapF)
SPL: Spea_2117
SHL: Shal_2089
SWD: Swoo_1391
PHA: PSHAa2142(mhpF)
PTN: PTRA_a2595(bphJ)
PNG: PNIG_a2789(bphJ)
MARJ: MARI_05450(bphJ)
SALH: HMF8227_02731(bphJ)
CYQ: Q91_0509(nahO) Q91_1490
AEH: Mlg_2461
TBN: TBH_C0929
GPB: HDN1F_27080(aphF)
RPI: Rpic_4618
REH: H16_B0596(h16_B0596)
RME: Rmet_1320(mhpF)
CTI: RALTA_B0400(mhpF)
BCJ: BCAM1614(mhpF)
BCEO: I35_5474(mhpF)
BMEC: WJ16_26795
BXE: Bxe_C1188(bphJ)
BXB: DR64_8617
BFN: OI25_4590
RFR: Rfer_0455
PNA: Pnap_4143
AJS: Ajs_0223
VEI: Veis_2782
CTES: O987_07735
HPSE: HPF_01855(bphJ)
LCH: Lcho_3341
AZO: azo1856(lapF) azo1973(mhpF) azo2432(nahO)
ARC: ABLL_2443
SHZ: shn_33315
CID: P73_1381
SGI: SGRAN_1580(mhpF)
SJP: SJA_C1-11900(mhpF)
SINB: SIDU_08315
SFLA: SPHFLASMR4Y_02367(bphJ)
TXI: TH3_21413
HTL: HPTL_0048
KZO: NCTC404_01742(bphJ)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Horinouchi M, Hayashi T, Koshino H, Kurita T, Kudo T
  Title
Identification of 9,17-dioxo-1,2,3,4,10,19-hexanorandrostan-5-oic acid, 4-hydroxy-2-oxohexanoic acid, and 2-hydroxyhexa-2,4-dienoic acid and related enzymes involved in testosterone degradation in Comamonas testosteroni TA441.
  Journal
Appl Environ Microbiol 71:5275-81 (2005)
DOI:10.1128/AEM.71.9.5275-5281.2005
  Sequence

KEGG   ENZYME: 1.2.1.87Help
Entry
EC 1.2.1.87                 Enzyme                                 

Name
propanal dehydrogenase (CoA-propanoylating);
BphJ
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
propanal:NAD+ oxidoreductase (CoA-propanoylating)
Reaction(IUBMB)
propanal + CoA + NAD+ = propanoyl-CoA + NADH + H+ [RN:R09097]
Reaction(KEGG)
R09097;
(other) R01172
Show
Substrate
propanal [CPD:C00479];
CoA [CPD:C00010];
NAD+ [CPD:C00003]
Product
propanoyl-CoA [CPD:C00100];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme forms a bifunctional complex with EC 4.1.3.43, 4-hydroxy-2-oxohexanoate aldolase, with a tight channel connecting the two subunits [1,2,3]. Also acts, more slowly, on glycolaldehyde and butanal. In Pseudomonas species the enzyme forms a bifunctional complex with EC 4.1.3.39, 4-hydroxy-2-oxovalerate aldolase. The enzymes from the bacteria Burkholderia xenovorans and Thermus thermophilus also perform the reaction of EC 1.2.1.10, acetaldehyde dehydrogenase (acetylating). NADP+ can replace NAD+ with a much slower rate [3].
History
EC 1.2.1.87 created 2013
Pathway
ec00622  Xylene degradation
ec00640  Propanoate metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K13922  propionaldehyde dehydrogenase
K18366  acetaldehyde/propanal dehydrogenase
Genes
ECG: E2348C_2143(pduP)
ECW: EcE24377A_2292(pduP)
ECC: c4534
ECV: APECO1_2291(eutE)
ECQ: ECED1_3458
EUM: ECUMN_2347
ECZ: ECS88_4675
ELN: NRG857_10215
ELF: LF82_343
EFE: EFER_2021
STY: STY2256(pduP)
STT: t0823(pduP)
STM: STM2051(pduP)
SEO: STM14_2540(pduP)
SEY: SL1344_2027(pduP)
SEJ: STMUK_2081(pduP)
SEB: STM474_2136(pduP)
SEF: UMN798_2216(pduP)
SENR: STMDT2_20241(pduP)
SEND: DT104_21081(pduP)
SENI: CY43_11070
SPT: SPA0820(pduP)
SEK: SSPA0767
SEI: SPC_1663(pduP)
SEC: SCH_2059(pduP)
SHB: SU5_02645
SENS: Q786_10125
SED: SeD_A2387
SEG: SG2080(pduP)
SEL: SPUL_0849(pduP)
SEGA: SPUCDC_0849(pduP)
SET: SEN2049(pduP)
SENA: AU38_10340
SENO: AU37_10350
SENV: AU39_10350
SENQ: AU40_11595
SENL: IY59_10635
SEEP: I137_03830
SENE: IA1_10235
SSN: SSON_2071(pduP)
KPN: KPN_03216(pduP)
KPU: KP1_4485(pduP)
KPP: A79E_0893
KPE: KPK_0899(pduP)
KPR: KPR_1818(pduP)
KPJ: N559_1023
KPX: PMK1_00697(adhE_2)
KPNU: LI86_05055
KPNK: BN49_0892(pduP)
KVA: Kvar_0854
KOX: KOX_01510
KOE: A225_4767
KLW: DA718_05410(pduP)
CKO: CKO_00785
CRO: ROD_21371(pduP)
CAMA: F384_10465
REE: electrica_01995(adhE_2)
METY: MRY16398_18470(pduP)
AHN: NCTC12129_00739(eutE)
YEN: YE2741(pduP)
YEY: Y11_16281
YEW: CH47_2090
YET: CH48_3140
YEE: YE5303_31741(pduP)
YAL: AT01_4022
YFR: AW19_708
YIN: CH53_3356
YKR: CH54_954
PEC: W5S_4254
SOD: Sant_2129(eutE)
PSD: DSC_09370
PPI: ND085(nahO)
PPUT: L483_14060
PPUN: PP4_27270(mhpF)
PPUU: PputUW4_01661(mhpF)
PKC: PKB_4238(nahO)
PSET: THL1_1434
PSIL: PMA3_11730
AVN: Avin_30580(lapF)
AVL: AvCA_30580(lapF)
AVD: AvCA6_30580(lapF)
SPL: Spea_2117
SHL: Shal_2089
SWD: Swoo_1391
PHA: PSHAa2142(mhpF)
PTN: PTRA_a2595(bphJ)
PNG: PNIG_a2789(bphJ)
MARJ: MARI_05450(bphJ)
SALH: HMF8227_02731(bphJ)
CYQ: Q91_0509(nahO) Q91_1490
AEH: Mlg_2461
TAU: Tola_1697
TBN: TBH_C0929
GPB: HDN1F_27080(aphF)
RPI: Rpic_4618
REH: H16_B0596(h16_B0596)
RME: Rmet_1320(mhpF)
CTI: RALTA_B0400(mhpF)
BCJ: BCAM1614(mhpF)
BCEO: I35_5474(mhpF)
BMEC: WJ16_26795
BXE: Bxe_C1188(bphJ)
BXB: DR64_8617
BFN: OI25_4590
RFR: Rfer_0455
PNA: Pnap_4143
AJS: Ajs_0223
VEI: Veis_2782
CTES: O987_07735
HPSE: HPF_01855(bphJ)
LCH: Lcho_3341
AZO: azo1856(lapF) azo1973(mhpF) azo2432(nahO)
ARC: ABLL_2443
SHZ: shn_33315
RPC: RPC_1174
RCP: RCAP_rcc02201(adhE)
CID: P73_1381
RSU: NHU_00544(adhE)
SGI: SGRAN_1580(mhpF)
SJP: SJA_C1-11900(mhpF)
SINB: SIDU_08315
SFLA: SPHFLASMR4Y_02367(bphJ)
RRU: Rru_A0914
RRF: F11_04715
TXI: TH3_21413
HTL: HPTL_0048
BSE: Bsel_3117
LMO: lmo1165
LMOC: LMOSLCC5850_1154(pduP)
LMOE: BN418_1367
LMOB: BN419_1365
LMOD: LMON_1158
LMOW: AX10_14330
LMOQ: LM6179_1472(eutE)
LMR: LMR479A_1186(eutE)
LMOM: IJ09_04510
LMF: LMOf2365_1173(pduP)
LMOG: BN389_11840(eutE)
LMP: MUO_06020
LMOL: LMOL312_1152(pduP)
LMOX: AX24_03195
LMQ: LMM7_1171(pduP)
LML: lmo4a_1148(pduP)
LMS: LMLG_1099
LMW: LMOSLCC2755_1157(pduP)
LMX: LMOSLCC2372_1160(pduP)
LMZ: LMOSLCC2482_1204(pduP)
LMON: LMOSLCC2376_1116(pduP)
LMOS: LMOSLCC7179_1132(pduP)
LMOY: LMOSLCC2479_1161(pduP)
LMOT: LMOSLCC2540_1143(pduP)
LMOA: LMOATCC19117_1165(pduP)
LMOK: CQ02_05990
LIN: lin1129
LWE: lwe1123(pduP)
LSG: lse_1043(pduP)
LIV: LIV_1097
KZO: NCTC404_01742(bphJ)
LBR: LVIS_1603
LRE: Lreu_1735
LRF: LAR_1623
PCE: PECL_1370(pduP)
CBK: CLL_A1748
CBT: CLH_1846
CSB: CLSA_c22740(eutE) CLSA_c33640(ald)
CSQ: CSCA_5280
RUM: CK1_20690
ROB: CK5_18240
CPY: Cphy_1178
EHL: EHLA_3029
CST: CLOST_0674(eutE)
ELM: ELI_4072
AWO: Awo_c25770(pduP)
OVA: OBV_17600
THX: Thet_0994
TOC: Toce_0560
TSH: Tsac_0219
VDN: NCTC11831_01740(sucD)
PUF: UFO1_1126
PFT: JBW_03293
PAC: PPA1741
PAW: PAZ_c18150(eutE)
PACC: PAC1_08955
PACH: PAGK_1670
CACN: RN83_09030
CGRN: 4412665_00729(sucD_1)
PFR: PFREUD_09130(pduP)
PFRE: RM25_1259
ACIJ: JS278_01049(adhE)
BIP: Bint_1611
TLI: Tlie_0209
SBR: SY1_15720
 » show all
Taxonomy
Reference
1  [PMID:19476337]
  Authors
Baker P, Pan D, Carere J, Rossi A, Wang W, Seah SY
  Title
Characterization of an aldolase-dehydrogenase complex that exhibits substrate channeling in the polychlorinated biphenyls degradation pathway.
  Journal
Biochemistry 48:6551-8 (2009)
DOI:10.1021/bi9006644
  Sequence
[bxe:Bxe_C1188]
Reference
2  [PMID:21838275]
  Authors
Carere J, Baker P, Seah SY
  Title
Investigating the molecular determinants for substrate channeling in BphI-BphJ, an aldolase-dehydrogenase complex from the polychlorinated biphenyls degradation  pathway.
  Journal
Biochemistry 50:8407-16 (2011)
DOI:10.1021/bi200960j
  Sequence
[bxe:Bxe_C1188]
Reference
3  [PMID:22316175]
  Authors
Baker P, Hillis C, Carere J, Seah SY
  Title
Protein-protein interactions and substrate channeling in orthologous and chimeric aldolase-dehydrogenase complexes.
  Journal
Biochemistry 51:1942-52 (2012)
DOI:10.1021/bi201832a
  Sequence
[ttj:TTHB247]
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.87
IUBMB Enzyme Nomenclature: 1.2.1.87
ExPASy - ENZYME nomenclature database: 1.2.1.87
BRENDA, the Enzyme Database: 1.2.1.87

KEGG   REACTION: R09097Help
Entry
R09097                      Reaction                               

Name
propanal:NAD+ oxidoreductase (CoA-propanoylating)
Definition
Propanal + NAD+ + CoA <=> Propanoyl-CoA + NADH + H+
Equation
Reaction class
RC00001  C00003_C00004
RC00004  C00010_C00100
RC00184  C00100_C00479
Enzyme
Pathway
rn00622  Xylene degradation
rn00640  Propanoate metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01220  Degradation of aromatic compounds
Module
M00569  Catechol meta-cleavage, catechol => acetyl-CoA / 4-methylcatechol => propanoyl-CoA
Orthology
K13922  propionaldehyde dehydrogenase [EC:1.2.1.87]
K18366  acetaldehyde/propanal dehydrogenase [EC:1.2.1.10 1.2.1.87]
Other DBs
RHEA: 36030

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