KEGG   ORTHOLOGY: K20152
Entry
K20152            Tight     KO                                     
Symbol
kanK, kacC
Name
2'-dehydrokanamycin reductase [EC:1.1.1.355]
Pathway
map00524  Neomycin, kanamycin and gentamicin biosynthesis
map01110  Biosynthesis of secondary metabolites
Reaction
R10417  kanamycin-A:NADP+ oxidoreductase
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00524 Neomycin, kanamycin and gentamicin biosynthesis
    K20152  kanK, kacC; 2'-dehydrokanamycin reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.355  2'-dehydrokanamycin reductase
     K20152  kanK, kacC; 2'-dehydrokanamycin reductase
Other DBs
COG: COG0451
Genes
AG: BAD20766(kanK)
Reference
PMID:15303497
  Authors
Yanai K, Murakami T
  Title
The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus.
  Journal
J Antibiot (Tokyo) 57:351-4 (2004)
DOI:10.7164/antibiotics.57.351
  Sequence
[ag:BAD20766]
Reference
PMID:22374809
  Authors
Sucipto H, Kudo F, Eguchi T
  Title
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
  Journal
Angew Chem Int Ed Engl 51:3428-31 (2012)
DOI:10.1002/anie.201108122

  All links  
Ontology (3)   
   KEGG BRITE (2)   
   COG (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (3)   
   KEGG ENZYME (1)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (1)   
   KEGG GENES (1)   
Literature (2)   
   PubMed (2)   
All databases (13)   

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