KEGG ORTHOLOGY: K21283

ORTHOLOGY: K21283

Entry

K21283                      KO

Symbol

BMP2

Name

bone morphogenetic protein 2

Pathway

map04060

Cytokine-cytokine receptor interaction

map04350

TGF-beta signaling pathway

map04390

Hippo signaling pathway

map05200

Pathways in cancer

map05217

Basal cell carcinoma

Disease

H00482

Brachydactyly

H02481

Syndromic disorder with short stature

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04350 TGF-beta signaling pathway
    K21283  BMP2; bone morphogenetic protein 2
   04390 Hippo signaling pathway
    K21283  BMP2; bone morphogenetic protein 2
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K21283  BMP2; bone morphogenetic protein 2
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K21283  BMP2; bone morphogenetic protein 2
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K21283  BMP2; bone morphogenetic protein 2
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K21283  BMP2; bone morphogenetic protein 2
   00536 Glycosaminoglycan binding proteins
    K21283  BMP2; bone morphogenetic protein 2
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K21283  BMP2; bone morphogenetic protein 2
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K21283  BMP2; bone morphogenetic protein 2

Other DBs

GO:

0070700

Genes

HSA:

650(BMP2)

PTR:	458090(BMP2)

PPS:	100967346(BMP2)

GGO:	101149410(BMP2)

PON:	100460853(BMP2)

PPYG:

129021963(BMP2)

NLE:	100586297(BMP2)

HMH:	116461210(BMP2)

SSYN:

129474640(BMP2)

MCC:	718330(BMP2)

MCF:	102145501(BMP2)

MTHB:

126964143

MNI:	105481543(BMP2)

CSAB:

103246725(BMP2)

CATY:

105582098(BMP2)

PANU:

101025190(BMP2)

TGE:	112633180(BMP2)

MLEU:

105552761(BMP2)

RRO:	104681477(BMP2)

RBB:	108525104 108533001(BMP2)

TFN:	117068478(BMP2)

PTEH:

111546455(BMP2)

CANG:

105511004(BMP2)

CJC:	100408260(BMP2)

SBQ:	101050026(BMP2)

CIMI:

108300970(BMP2)

ANAN:

105719363(BMP2)

CSYR:

103269536(BMP2)

MMUR:

105866089(BMP2)

LCAT:

123622305(BMP2)

PCOQ:

105806184(BMP2)

OGA:	100952817(BMP2)

MMU:	12156(Bmp2)

MCAL:

110289488(Bmp2)

MPAH:

110318284(Bmp2)

RNO:	29373(Bmp2)

MCOC:

116090993(Bmp2)

ANU:	117704668(Bmp2)

MUN:	110557991(Bmp2)

CGE:	100752564(Bmp2)

MAUA:

101833665(Bmp2)

PROB:

127221395(Bmp2)

PLEU:

114699539(Bmp2)

MORG:

121460473(Bmp2)

MFOT:

126496732

AAMP:

119814518(Bmp2)

NGI:	103725543(Bmp2)

HGL:	101723419(Bmp2)

CPOC:

100732974(Bmp2)

CCAN:

109677386(Bmp2)

DORD:

105981433(Bmp2)

DSP:	122120543(Bmp2)

PLOP:

125353272(Bmp2)

NCAR:

124978309

MMMA:

107145218(Bmp2)

OCU:	100009349(BMP2)

OPI:	101523631(BMP2)

TUP:	102469552(BMP2)

GVR:	103609832(BMP2)

CFA:	477162(BMP2)

CLUD:

112673617(BMP2)

VVP:	112930056(BMP2)

VLG:	121478407(BMP2)

NPO:	129497445(BMP2)

AML:	100465860(BMP2)

UMR:	103674423(BMP2)

UAH:	113258350(BMP2)

UAR:	123799694(BMP2)

ELK:

111141639

LLV:

125109434

MPUF:

101677371(BMP2)

MNP:	132008118 132021736(BMP2)

MLK:	131808045(BMP2)

NVS:	122916253(BMP2)

ORO:	101367237(BMP2)

EJU:	114216361(BMP2)

ZCA:	113938590(BMP2)

MLX:	118011254(BMP2)

NSU:	110579363(BMP2)

LWW:	102731853(BMP2)

FCA:	100301987(BMP2)

PYU:	121012472(BMP2)

PCOO:

112869247(BMP2)

PBG:	122496555(BMP2)

PVIV:

125162550(BMP2)

LRUF:

124504345

PTG:	102961685(BMP2)

PPAD:

109274726(BMP2)

PUC:

125936806

AJU:

106976426

HHV:	120226397(BMP2)

BTA:	615037(BMP2)

BOM:	102268860(BMP2)

BIU:	109567176(BMP2)

BBUB:

102408388(BMP2)

BBIS:

104986042(BMP2)

CHX:	100860831(BMP2)

OAS:	101117688(BMP2)

BTAX:

128058649(BMP2)

ODA:	120868917(BMP2)

CCAD:

122448237(BMP2)

MBEZ:

129560159(BMP2)

SSC:	100157103(BMP2)

CFR:	102514653(BMP2)

CBAI:

105083060(BMP2)

CDK:	105101322(BMP2)

VPC:	102528775(BMP2)

BACU:

103004284(BMP2)

BMUS:

118881854(BMP2)

LVE:	103070700(BMP2)

OOR:	101269813(BMP2)

DLE:	111165639(BMP2)

PCAD:

102978631(BMP2)

PSIU:

116740858(BMP2)

NASI:

112412519(BMP2)

ECB:	100051701(BMP2)

EPZ:	103563779(BMP2)

EAI:	106823202(BMP2)

MYB:	102241256(BMP2)

MYD:	102768711(BMP2)

MMYO:

118662859(BMP2)

MLF:	102427988(BMP2)

MDT:	132239366(BMP2)

PKL:	118707552(BMP2)

EFUS:

103285662(BMP2)

MNA:	107536373(BMP2)

DRO:	112304048(BMP2)

SHON:

118990873(BMP2)

AJM:	119051190(BMP2)

PDIC:

114506674(BMP2)

PHAS:

123815283(BMP2)

MMF:	118618684(BMP2)

PPAM:

129070533(BMP2)

HAI:	109383815(BMP2)

RFQ:	117016157(BMP2)

PALE:

102886941(BMP2)

PGIG:

120603409(BMP2)

PVP:	105298720(BMP2)

RAY:	107511521(BMP2)

MJV:	108403876(BMP2)

TOD:	119232694(BMP2)

SARA:

101548404(BMP2)

SETR:

126017375(BMP2)

LAV:	100654878(BMP2)

TMU:	101351517 105756867

ETF:	101648616(BMP2)

DNM:	101423691(BMP2)

MDO:	100031674(BMP2)

GAS:	123234308 123234746(BMP2)

SHR:	100935094(BMP2)

AFZ:

127548505

PCW:	110207865(BMP2) 110215386

TVP:	118829548 118844876(BMP2)

OAA:	100084030(BMP2) 100084266 114810112

GGA:	112532694 378779(BMP2) 395622(ADMP)

PCOC:

116231818(BMP2) 116236101 116238163

MGP:	100549917(BMP2) 104911967

CJO:	107310979(BMP2) 107315785 107325334

TPAI:

128075477(BMP2) 128077695

LMUT:

125684943 125689721(BMP2) 125693593

NMEL:

110389029 110396085(BMP2) 110400626

APLA:

101796903 106016176(BMP2) 106017909

ACYG:

106036603(BMP2) 106045698

CATA:

118246999 118251105(BMP2) 118259003

AFUL:

116487650(BMP2) 116491316 116499204

TGU:	100217480 100218108(BMP2) 100226673

LSR:	110469508 110475579 110475851(BMP2)

SCAN:

103819311(BMP2) 103821883 108961668

PMOA:

120496382 120502032 120506049(BMP2)

OTC:	121341712 121342635(BMP2)

PRUF:

121350125 121357049(BMP2)

GFR:	102033365 102034024 102037777(BMP2)

FAB:	101811098 101816355(BMP2) 101817809

OMA:	130251489(BMP2) 130254817 130264371

PHI:	102101225(BMP2) 102111754 102113643

PMAJ:

107201669(BMP2) 107206564 107215618

CCAE:

111926633(BMP2) 111931148 111940378

CCW:	104691561(BMP2) 104696917 109145925

CBRC:

103620612 103623019(BMP2) 108444666

ETL:	114055874 114065073(BMP2) 114070573

ZAB:	102062522(BMP2) 106630734

ZLE:	135446180(BMP2) 135449603 135458875

ACHL:

103807234(BMP2) 103810317

SVG:	106852581 106857981 106865179(BMP2)

MMEA:

130576385 130579832 130583388(BMP2)

HRT:	120750973(BMP2) 120755816 120763448

SATI:

136359685(BMP2) 136371836

FPG:	101920616 101922026(BMP2) 106112594

FCH:	102048793(BMP2) 102050671 106631726

CCRI:

104161018 104167555

NNT:	104403325 104405183(BMP2)

SHAB:

115608774 115609844(BMP2) 115618139

ACUN:

113477994(BMP2) 113481610

TALA:

104360661 104366608(BMP2) 116964224

ACHC:

115344649(BMP2) 115348327 115349216

HALD:

104320973 104322454(BMP2)

HLE:	104829341 104836449(BMP2) 104839877

AGEN:

126038797 126041854 126042950

GCL:	127014417 127017907 127025643

CSTI:

104551024 104552255(BMP2)

LDI:	104347181(BMP2) 104354202

MNB:	103768326(BMP2) 103782019

DPUB:

104297779 104305986(BMP2) 104308579

AVIT:

104268673 104277986(BMP2)

BRHI:

104495773(BMP2) 104500291

EGZ:	104128703(BMP2) 104129039

NNI:	104019616 104022480(BMP2)

PCRI:

104027180(BMP2) 104034312

PCAO:

104046116 104047620(BMP2)

PADL:

103913163(BMP2) 103913979

AFOR:

103897080 103897828 103901640(BMP2)

FGA:	104070873 104079232 104080408(BMP2)

GSTE:

104257000 104259056

CLV:	102083678(BMP2) 102098143 106146130

MUI:	104545809(BMP2) 104547370

PGUU:

104460633(BMP2)

PLET:

104619902 104620148

EHS:	104504901 104507578 104514575

CMAC:

104473434 104475783(BMP2)

CUCA:

104055437(BMP2) 104062070 104067961

TEO:	104374331 104377831(BMP2)

BREG:

104630703 104637942(BMP2)

OHA:	104330458 104330727(BMP2)

ACAR:

104526766 104527934 104530595(BMP2)

CPEA:

104391131 104391966 104397208(BMP2)

CVF:	104282498 104287383(BMP2) 104289801

RTD:	128900642 128907138(BMP2) 128911355

AAM:	106490352(BMP2) 106497809 106498530

AROW:

112965313(BMP2) 112967619 112971439

NPD:	112943958 112958058 112958934(BMP2)

TGT:	104571579 104573611

DNE:	112980106(BMP2) 112986252 112989065

SCAM:

104140872 104143486(BMP2)

ASN:	102368464 102378152 102378655(BMP2) 102380095

AMJ:	102564323(BMP2) 102574161(ADMP) 102575698

CPOO:

109319038(BMP2) 109320565 109323853

GGN:	109287147 109295037 109296705(BMP2)

PSS:	102445218 102453078 102455280(BMP2)

CMY:	102932771 102937339 102939464(BMP2)

CCAY:

125627346 125633370(BMP2) 125639796

DCC:	119848458 119853830(BMP2) 119858997

CPIC:

101933479(BMP2) 101935968 103306317

TST:	117870603 117880562 117889054

CABI:

116816947 116824056(BMP2) 116825838

MRV:	120391725 120400009(BMP2) 120409511

ACS:	100560955(bmp2) 103279318

ASAO:

132780268 132781428(BMP2) 132781464

PVT:	110072653 110078983(BMP2) 110088535

SUND:

121917554 121917608 121919380(BMP2) 121936500

PBI:	103059412(BMP2) 103064164

PMUR:

107285368(BMP2) 107299617

CTIG:

120299534 120312041 120315300(BMP2)

TSR:	106540084 106550496(BMP2)

PGUT:

117670569 117674357(BMP2) 117677687

APRI:

131188423 131197342(BMP2)

PTEX:

113442688(BMP2)

NSS:	113412734(BMP2)

VKO:	123018689 123030433(BMP2)

PMUA:

114588566 114593655(BMP2) 114603316

PRAF:

128405906 128410049(BMP2)

ZVI:	118082499(BMP2) 118085958 118086063

HCG:	128339230(BMP2) 128343787

GJA:	107105603 107118716 107123913(BMP2)

STOW:

125434709(BMP2)

EMC:	129330259 129341054(BMP2)

XLA:	100036830(admp2.L) 108713078(admp.L) 378780(bmp2.S) 397873(bmp2.L) 398053(admp.S)

XTR:	100494614(admp2) 548717(bmp2) 733983(admp)

NPR:	108795406(BMP2) 108796465 108802433

RTEM:

120909121 120924945 120938036(BMP2)

BBUF:

120991637 120998902(BMP2)

BGAR:

122928621 122934895(BMP2)

MUO:	115464625(BMP2) 115471272 115480954

GSH:	117358091(BMP2) 117359747 117365483

DRE:	100329171(bmp16) 140619(admp) 30631(bmp2a) 30632(bmp2b)

SRX:	107709563 107725066 107737893 107740845 107742710 107750936 107754609 107756668

SANH:

107653903 107656957 107663136 107678728 107685371 107687929 107692530 107696672 107697100

SGH:	107552681 107552890 107566293 107575557 107577119 107580644 107593250 107594089(bmp2) 107596296

CCAR:

109048667 109069296 109072918 109075712 109082902 109085882 109109281 109113648

CAUA:

113045265 113056454 113060810 113061888 113071787 113077235 113078692 113092587 113110345 113117755 113118705 113120546

CGIB:

127933127 127934692 127938505 127950863 127976669 127977836 127983456 128023911 128025634

PTET:

122323144(bmp16) 122324335(bmp2b) 122333398 122334366(bmp2a) 122335673

LROH:

127152488(admp) 127173897 127180224(bmp2a) 127180594(bmp16) 127182504(bmp2b)

OMC:	131523390(bmp2a) 131523920(bmp16) 131527766(bmp2b) 131550779 131550827(admp)

PPRM:

120460008(bmp16) 120460158(bmp2b) 120460862 120464126(bmp2a) 120466737

RKG:	130070009(bmp16) 130071356 130075788(bmp2a) 130103229(bmp2b) 130105612(admp)

MAMB:

125251577 125254347(bmp16) 125255729 125269304(bmp2a) 125278460(bmp2b)

CIDE:

127494143 127498097 127499700 127502873 127523605

CERY:

137003663(admp) 137006346(bmp2a) 137007532 137018560(bmp2b) 137022535(bmp16)

MASI:

127409684 127410723 127415671 127417445 127423306 127441446 127442759 127455227 127456380

TROS:

130554812(admp) 130560256(bmp2a) 130562873(bmp16) 130566405(bmp2b)

TDW:	130417446(admp) 130434939(bmp2b) 130435847(bmp16) 130437378(bmp2a) 130439438

MANU:

129417932(bmp2a) 129419187(bmp16) 129421127 129429892(bmp2b) 129441411(admp)

IPU:	108258023(bmp2b) 108264167(bmp16) 108270435(bmp2a) 108280256(admp) 128634538

IFU:	128601464(bmp2b) 128606346(bmp16) 128613037(bmp2a) 128617322 128624263(admp)

PHYP:

113524890 113527300 113533204 113538939 113545171

SMEO:

124376521(bmp2b) 124388798 124390595(bmp2a) 124395979(bmp16) 124402754

TFD:	113644575(bmp2b) 113645282 113649645(bmp16) 113650676 113659797(bmp2a)

TVC:	132843286(bmp2b) 132851754(bmp16) 132852340(bmp2a) 132857979 132862727(admp)

TRN:	134302751(admp) 134320074(bmp2b) 134323099(bmp16) 134324937(bmp2a)

AMEX:

103021856(bmp2a) 103028976(bmp2b) 103029324(bmp16) 103039137

CMAO:

118797369 118808781 118815566(bmp2b) 118818353(bmp16) 118823997(bmp2a)

EEE:	113572660 113574269 113577430 113581931 113591123

CHAR:

105893904 105909432(bmp2a) 105910662(bmp2b) 105911162(bmp16) 122130805

TRU:	101063690 101065146(bmp2) 101069608 101074463

TFS:	130516597(bmp2b) 130529486 130535024(bmp16) 130539223(admp)

TNG:	GSTEN00007099G001 GSTEN00014809G001 GSTEN00020275G001

LCO:	104920857(bmp2) 104928596 104931444 104936815

NCC:	104947649(bmp2) 104950308 104959047 104963088

TBEN:

117470349(bmp16) 117484615 117498361(bmp2b) 117500078(admp)

CGOB:

115003426(bmp2) 115017332 115022925 115024794

PGEO:

117439958(bmp2b) 117457884(bmp16) 117461798(admp) 117465107

GACU:

117532373 117542219(admp) 117552291(bmp16) 117554167(bmp2b)

EMAC:

134866037(admp) 134871144 134876504(bmp2b) 134880675(bmp16)

ELY:	117247730 117260320(bmp16) 117270466(bmp2b) 117271446(admp)

EFO:	125880751 125888337(bmp16) 125897187(bmp2b) 125902521

PLEP:

121943754(bmp16) 121950954 121955429(bmp2b) 121958473

SLUC:

116041940(bmp2b) 116045259 116046871 116047725(bmp16)

ECRA:

117936760 117942173(bmp16) 117954482(admp) 117961092(bmp2b)

ESP:	116684384 116685679 116699500 116706254(bmp2)

PFLV:

114547607 114552582 114565836 114572770(bmp2)

GAT:	120808490(bmp2b) 120816213 120819618 120826401(bmp16)

PPUG:

119194536(bmp2b) 119209707 119213302 119217593(bmp16)

AFB:	129089292(admp) 129090265(bmp16) 129091700 129106916(bmp2b)

CLUM:

117727327(bmp2b) 117741881(bmp16) 117746747(admp) 117748801

PSWI:

130191533(admp) 130202603(bmp2b) 130204138 130210613(bmp16)

MSAM:

119883176(bmp16) 119903030 119908523(bmp2b) 119916133

SCHU:

122863602(bmp2b) 122867609 122879642(bmp16) 122887446

CUD:	121515919(bmp16) 121519738 121521734(bmp2b) 121528676

ALAT:

119009700 119011305 119012936(bmp16) 119013049(bmp2b)

MZE:	101466492(bmp2) 101466778 101467600 101470930

ONL:	100693128 100694608 100706900(bmp2) 100711855

OAU:	116310360(bmp16) 116313457 116330316 116332299(bmp2b)

OLA:	100125471(bmp2) 101163346 101170375

OML:	112141371 112147395(admp) 112149994(bmp16) 112157608(bmp2b)

CSAI:

133418351(bmp2b) 133419105 133441771(bmp16) 133452188(admp)

XMA:	102223402 102224497(bmp2) 102230387

XCO:	114133430 114147081 114158609(bmp2)

XHE:	116708083 116726834 116733616(bmp2)

PRET:

103457871(bmp2) 103474638 103479773 103482029

PFOR:

103136288 103144839 103146058 103148044(bmp2)

PLAI:

106936146 106939157 106946449(bmp2)

PMEI:

106914767 106920166 106926788(bmp2)

GAF:	122825009(bmp2b) 122833260(bmp16) 122841088

PPRL:

129369019(bmp2b) 129369960(bmp16) 129377585 129378091(admp)

CVG:	107085933 107096868 107097808(bmp2)

CTUL:

119784161(bmp2b) 119785221 119797332(bmp16)

GMU:	124870642 124875580 124881554(bmp2b) 124884668(bmp16)

NFU:	107378114(bmp2) 107380286 107383582 107387546

KMR:	108231728(bmp2b) 108232862 108240827(bmp16) 108250775

ALIM:

106516871 106518550(bmp2) 106526097 106527856

NWH:	119411253(bmp16) 119418474(bmp2b) 119429488

AOCE:

111569676(bmp2) 111570811 111572058 111575499

MCEP:

124999546(bmp2b) 125010208 125013998(bmp16) 125022791

CSEM:

103378059 103381057(bmp2) 103382170 103396478

POV:	109626981 109629970 109632388(bmp2) 109637197

SSEN:

122759640 122761212 122773977(bmp16) 122781489 122783746(bmp2b)

HHIP:

117752834 117758548(bmp2b) 117772981(bmp16) 117778230(admp)

HSP:	118099031(bmp2b) 118106647(bmp16) 118118153

PPLT:

128439898(bmp16) 128454710(admp) 128460286(bmp2b)

SMAU:

118287544 118290183(bmp2b) 118299644(bmp16) 118310301

LCF:	108884186 108889169 108896937(bmp2b) 108900833

SDU:	111219654 111231201 111238756(bmp2) 111238903

SLAL:

111646099 111648691 111656008 111669160 111672564(bmp2)

XGL:	120788680(bmp2b) 120791503(bmp16) 120794488 120799374

HCQ:	109507202(bmp2) 109507321 109508410 109526430

SSCV:

125972416 125985206 125990545 125991030

SBIA:

133495910 133496836(bmp2b) 133505262(bmp16) 133511203(admp)

PEE:	133395196 133404985(bmp16) 133411601(admp) 133417263(bmp2b)

PTAO:

133468262(bmp2b) 133469337 133482637(bmp16) 133489317(admp)

BPEC:

110159789 110163564 110164114 110168257(bmp2)

MALB:

109951486 109955403 109962214(bmp2) 109974322

BSPL:

114845015(admp) 114846039 114849955(bmp2b) 114867783(bmp16)

SJO:	128360795(bmp16) 128369154(admp) 128376725(bmp2b) 128381721

SASA:

100380549(bmp2) 106569623 106571739 106579050 106612383

STRU:

115156427 115162980 115163233 115173509 115174481 115205939

OTW:	112217819 112223287 112244718 112250571(bmp2b) 112261158 112266665

OMY:	110491444 110503302 110507419(bmp16) 110522446 110529145 110529872

OGO:	123990997(bmp2b) 123993072 123995697 124006312 124009453 124047572

ONE:	115106162 115114036 115137089 115139218 115141457

OKI:	109865195 109866516 109900316 109905415 109909593

OKE:	118369272 118376183 118385993 118385997 118398406 118401650(admp)

SALP:

111949878 111954622 111960597 111978438 112070739 112071072

SNH:	120018407(bmp16) 120019105(bmp2b) 120024472 120028985 120055399

CCLU:

121534458 121549246 121552647 121560373 121568238 121581373 121582107

ELS:	105012052 105017519(bmp2) 105022886 109615754

SFM:	108918880 108929372(bmp2) 108932103 108937129

PKI:	111837303(bmp2) 111844909 111847594 111848437 111857901 111860359

AANG:

118208857(bmp16) 118212320(bmp2a) 118221525 118225371(admp) 118229327(bmp2b)

LOC:	102682751(bmp2) 102688763 102689112 102690765

PSPA:

121300525 121301175 121303903 121305005 121315932 121317055 121326255

ARUT:

117395390 117401277 117402384 117410840(bmp2a) 117415773 117417752 117966292

PSEX:

120516503(bmp2a) 120519125 120538679(bmp16)

LCM:	102351081 102358352 102361854 102364340(BMP2)

CMK:	103186457(bmp2a)

RTP:	109915138 109933449

CPLA:

122541707 122553081 122565284

HOC:	132819883 132829225(admp)

LERI:

129699289(bmp2a)

PMRN:

103091781 103091843

LRJ:	133341296 133342428

BFO:

118411660

BBEL:

109472830 109478266

SCLV:

120326309 120341667

SPU:	100889251 100891353 373196(BMP2/4) 373488

LPIC:

129264991 129272602 129281348

APLC:

110973657 110978423

ARUN:

117294797 117303940

AJC:

117111673

SKO:	100303514(bmp2/4) 100303522(admp) 100313546(Admp2) 100313762

ACER:

CFO:

TPRE:

LHT:

LBD:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

SOY:

AGRG:

CSET:

AGB:	108906407 108909139

DVV:	114338522 126879190

OTU:

CFEL:

CCRN:

DNX:

HHAL:

CSEC:

IEL:

DMK:

DPZ:

PJA:	122243612 122249607

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128696341 128700651

PTRU:

123505119 123505374

ESN:	126981356 127001845

MNZ:	135197761 135223774

HAZT:

108664624

PPOI:

119111802

DSV:	119437212 119457506

RSAN:

119374021 119391718 119404841

RMP:	119160925 119166933 119181471

VDE:	111250784 111254481

VJA:	111261769 111261900

TUT:

DPTE:

CSCU:

CVS:

PTEP:

ABRU:

UDV:	129225616 129226990 129229883

SDM:	118187433 118204153

LPOL:

106459331 106460744 106478149 111088017

PMEO:

129582160

NAI:	NECAME_17080

BMY:	BM_BM2914(Bma-dbl-1)

HRO:	HELRODRAFT_154960

LGI:	LOTGIDRAFT_205842

PVUL:

126811430 126816196 126816225 126820981

PCAN:

112569894

BGT:

106066197

GAE:

121370342

HRJ:	124266275 124275421

CRG:	105333366 117684260

CANU:

128178035

CVN:

111130759

OED:

125651838

MYI:	110459184 110466127 110466608

PMAX:

117323562 117325038 117325787

MCAF:

127698968

MMER:

123525172 123531445

RPHI:

132715091 132723754

MAEA:

128207171 128214531 128219738 128220490

OBI:	106874725 106876368 106877247

OSN:	115227489 115231476 118761052

LJP:

135482260

LLON:

135486882

NVE:	5510773 5519265

EPA:

110243875

ATEN:

116302105

ADF:	107334071(AdiBmp2/4) 107337024

AMIL:

114950990 114957817 114975799

PDAM:

113669028 113669029 113669300 113676885 113683424

SPIS:

111323223 111324109 111328800

DGT:

114532337

XEN:

124437008

HSY:

130657444

RES:	135685150 135692607

TAD:	TRIADDRAFT_57057

» show all

Reference

PMID:3201241

Authors

Wozney JM, Rosen V, Celeste AJ, Mitsock LM, Whitters MJ, Kriz RW, Hewick RM, Wang EA

Title

Novel regulators of bone formation: molecular clones and activities.

Journal

Science 242:1528-34 (1988)
DOI:10.1126/science.3201241

Sequence

[hsa:650]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (10)   
   KEGG PATHWAY (10)   
Disease (2)   
   KEGG DISEASE (2)   
Gene (1734)   
   KEGG GENES (1201)   
   KEGG MGENES (215)   
   RefGene (312)   
   OC (6)   
Literature (1)   
   PubMed (1)   
All databases (1751)   

Download RDF

ORTHOLOGY: K04662

Entry

K04662                      KO

Symbol

BMP4

Name

bone morphogenetic protein 4

Pathway

map04013

MAPK signaling pathway - fly

map04060

Cytokine-cytokine receptor interaction

map04341

Hedgehog signaling pathway - fly

map04350

TGF-beta signaling pathway

map04390

Hippo signaling pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04919

Thyroid hormone signaling pathway

map05200

Pathways in cancer

map05217

Basal cell carcinoma

map05418

Fluid shear stress and atherosclerosis

Disease

H00516

Cleft lip and/or cleft palate

H02170

Microphthalmia, syndromic

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04341 Hedgehog signaling pathway - fly
    K04662  BMP4; bone morphogenetic protein 4
   04350 TGF-beta signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
   04390 Hippo signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K04662  BMP4; bone morphogenetic protein 4
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K04662  BMP4; bone morphogenetic protein 4
09150 Organismal Systems
  09152 Endocrine system
   04919 Thyroid hormone signaling pathway
    K04662  BMP4; bone morphogenetic protein 4
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K04662  BMP4; bone morphogenetic protein 4
  09162 Cancer: specific types
   05217 Basal cell carcinoma
    K04662  BMP4; bone morphogenetic protein 4
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K04662  BMP4; bone morphogenetic protein 4
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K04662  BMP4; bone morphogenetic protein 4
   00536 Glycosaminoglycan binding proteins
    K04662  BMP4; bone morphogenetic protein 4
Cytokines and neuropeptides [BR:ko04052]
Cytokines
  Transforming growth factors (RSTK binding)
   K04662  BMP4; bone morphogenetic protein 4
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K04662  BMP4; bone morphogenetic protein 4

Other DBs

GO:

0070700

Genes

HSA:

652(BMP4)

PTR:	107968170(BMP4)

PPS:	100987443(BMP4)

GGO:	101126138(BMP4)

PON:	100449444(BMP4)

PPYG:

129012077(BMP4)

NLE:	100586277(BMP4)

HMH:	116485021(BMP4)

SSYN:

129487872(BMP4)

MCC:	694618(BMP4)

MCF:	102132568(BMP4)

MTHB:

126959339

MNI:	105481800(BMP4)

CSAB:

103229007(BMP4)

CATY:

105586635(BMP4)

PANU:

100137596(BMP4)

TGE:	112629358(BMP4)

MLEU:

105553593(BMP4)

RRO:	104669157(BMP4)

RBB:

108513693

TFN:	117069628(BMP4)

PTEH:

111555060(BMP4)

CANG:

105525983(BMP4)

CJC:	100398270(BMP4)

SBQ:	101038031(BMP4)

CIMI:

108289624(BMP4)

ANAN:

105716410(BMP4)

CSYR:

103251761(BMP4)

MMUR:

105867695(BMP4)

LCAT:

123649038(BMP4)

PCOQ:

105825859(BMP4)

OGA:	100961860(BMP4)

MMU:	12159(Bmp4)

MCAL:

110309274(Bmp4)

MPAH:

110325391(Bmp4)

RNO:	25296(Bmp4)

MCOC:

116084889(Bmp4)

ANU:	117706351(Bmp4)

MUN:	110550958(Bmp4)

CGE:	100754303(Bmp4)

MAUA:

101828063(Bmp4)

PROB:

127216408(Bmp4)

PLEU:

114696047(Bmp4)

MORG:

121434984(Bmp4)

MFOT:

126513813

AAMP:

119800048(Bmp4)

NGI:	103739231(Bmp4)

HGL:	101711207(Bmp4)

CPOC:

100733516(Bmp4)

CCAN:

109701382(Bmp4)

DORD:

105982610(Bmp4)

DSP:	122110043(Bmp4)

PLOP:

125363324(Bmp4)

NCAR:

124976922

MMMA:

107138284(Bmp4)

OCU:	100009569(BMP4)

OPI:	101531889(BMP4)

TUP:	102497487(BMP4)

GVR:	103588444(BMP4)

CFA:	490695(BMP4)

CLUD:

112657550(BMP4)

VVP:	112921419(BMP4)

VLG:	121493806(BMP4)

NPO:	129496358(BMP4)

AML:	100477715(BMP4)

UMR:	103672975(BMP4)

UAH:	113242361(BMP4)

UAR:	123800688(BMP4)

ELK:

111162047

LLV:

125105283

MPUF:

101670047(BMP4)

MNP:	131999957(BMP4)

MLK:	131836584(BMP4)

NVS:	122893660(BMP4)

ORO:	101380696(BMP4)

EJU:	114204559(BMP4)

ZCA:	113910450(BMP4)

MLX:	118002167(BMP4)

NSU:	110590602(BMP4)

LWW:	102740547(BMP4)

FCA:	101100311(BMP4)

PYU:	121031781(BMP4)

PCOO:

112855771(BMP4)

PBG:	122469107(BMP4)

PVIV:

125168872(BMP4)

LRUF:

124512337

PTG:	102950088(BMP4)

PPAD:

109268456(BMP4)

PUC:

125909500

AJU:

106983046

HHV:	120237282(BMP4)

BTA:	407216(BMP4)

BOM:	102266106(BMP4)

BIU:	109565174(BMP4)

BBUB:

102398788(BMP4)

BBIS:

104994225(BMP4)

CHX:	100860789(BMP4)

OAS:	443502(BMP4)

BTAX:

128054087(BMP4)

ODA:	120852924(BMP4)

CCAD:

122443659(BMP4)

MBEZ:

129563172(BMP4)

SSC:	100113425(BMP4)

CFR:	102509507(BMP4)

CBAI:

105074585(BMP4)

CDK:	105091431(BMP4)

VPC:	102531340(BMP4) 102544403

BACU:

103010740(BMP4)

BMUS:

118891260(BMP4)

LVE:	103072786(BMP4)

OOR:	101278431(BMP4)

DLE:	111173145(BMP4)

PCAD:

102981535(BMP4)

PSIU:

116749741(BMP4)

NASI:

112392905(BMP4)

ECB:	100034048(BMP4)

EPZ:	103558707(BMP4)

EAI:	106846123(BMP4)

MYB:	102262406(BMP4)

MYD:	102769625(BMP4) 102770741

MMYO:

118655552(BMP4)

MLF:	102436795(BMP4)

MDT:	132234482(BMP4)

PKL:	118718012(BMP4)

EFUS:

103283730(BMP4)

MNA:	107525879(BMP4)

DRO:	112311413(BMP4)

SHON:

118992410(BMP4)

AJM:	119057110(BMP4)

PDIC:

114491821(BMP4)

PHAS:

123808240(BMP4)

MMF:	118618825 118633302(BMP4)

PPAM:

129066024(BMP4)

HAI:	109384420(BMP4)

RFQ:	117024157(BMP4)

PALE:

102881920(BMP4)

PGIG:

120604412(BMP4)

PVP:	105309232(BMP4)

RAY:	107509544(BMP4)

MJV:	108407678(BMP4)

TOD:	119239102(BMP4)

SARA:

101540080(BMP4)

SETR:

125999250(BMP4)

LAV:	100654115(BMP4)

TMU:

101356019

ETF:	101653730(BMP4)

DNM:	101420561(BMP4)

MDO:	100010652(BMP4)

GAS:	123235751(BMP4)

SHR:	100916609(BMP4)

AFZ:

127549714

PCW:	110199877(BMP4)

TVP:	118840791(BMP4)

OAA:	100089255(BMP4)

GGA:	396165(BMP4)

PCOC:

116234629(BMP4)

MGP:	100544182(BMP4)

CJO:	107315532(BMP4)

TPAI:

128087220(BMP4)

LMUT:

125695096(BMP4)

NMEL:

110401682(BMP4)

APLA:

101803077(BMP4)

ACYG:

136791007(BMP4)

CATA:

118250336(BMP4)

AFUL:

116490007(BMP4)

TGU:	100221891(BMP4)

LSR:	110474762(BMP4)

SCAN:

103826326(BMP4)

PMOA:

120503839(BMP4)

OTC:	121340676(BMP4)

PRUF:

121354039(BMP4)

GFR:	102044724(BMP4)

FAB:	101816834(BMP4)

OMA:	130254291(BMP4)

PHI:	102110411(BMP4)

PMAJ:

107205267(BMP4)

CCAE:

111929526(BMP4)

CCW:	104687658(BMP4)

CBRC:

103618849(BMP4)

ETL:	114067429(BMP4)

ZAB:	102075485(BMP4)

ZLE:	135448438(BMP4)

ACHL:

103798768(BMP4)

SVG:	106850263(BMP4)

MMEA:

130582325(BMP4)

HRT:	120754053(BMP4)

SATI:

136362743(BMP4)

FPG:	101923141(BMP4)

FCH:	102047171(BMP4)

CCRI:

104168548(BMP4)

SHAB:

115607389(BMP4)

TALA:

116965637(BMP4)

ACHC:

115338579(BMP4)

HLE:	104839481(BMP4)

AGEN:

126050616

GCL:

127016740

LDI:	104341680(BMP4)

DPUB:

104299364(BMP4)

AVIT:

104271994(BMP4)

BRHI:

104491584(BMP4)

EGZ:	104122989(BMP4)

NNI:	104019440(BMP4)

PCRI:

104026570(BMP4)

PADL:

103915984(BMP4)

AFOR:

103907630(BMP4)

FGA:

104077613

CLV:	102098788(BMP4)

MUI:	104541294(BMP4)

PGUU:

104464124(BMP4)

PLET:

104618873(BMP4)

EHS:	104509313(BMP4)

CMAC:

104481164

CUCA:

104057425(BMP4)

TEO:	104379624(BMP4)

BREG:

104642562

OHA:	104333959(BMP4)

ACAR:

104527952(BMP4)

CPEA:

104387678(BMP4)

CVF:	104294310(BMP4)

RTD:	128908746(BMP4)

AAM:	106494596(BMP4)

AROW:

112961235(BMP4)

NPD:	112957780(BMP4)

TGT:	104568228(BMP4)

DNE:	112988547(BMP4)

SCAM:

104141415(BMP4)

ASN:	102371622(BMP4)

AMJ:	102573848(BMP4)

CPOO:

109324597(BMP4)

GGN:	109287494(BMP4)

PSS:	102459846(BMP4)

CMY:	102932745(BMP4)

CCAY:

125638901(BMP4)

DCC:	119857204(BMP4)

CPIC:

101949490(BMP4)

TST:	117877057(BMP4)

CABI:

116819607(BMP4)

MRV:	120405267(BMP4)

ACS:	100567033(bmp4)

ASAO:

132760954(BMP4) 132780062

PVT:	110089746(BMP4)

SUND:

121920015(BMP4)

PBI:	103054912(BMP4)

PMUR:

107293299(BMP4)

CTIG:

120297875(BMP4)

TSR:	106539867(BMP4)

PGUT:

117675078(BMP4)

APRI:

131191966(BMP4) 131204359

PTEX:

113435122(BMP4) 113446077

NSS:	113413743(BMP4) 113426422

VKO:

123025775

PMUA:

114594877(BMP4)

PRAF:

128413754(BMP4) 128418286

ZVI:	118077290(BMP4)

HCG:	128333393 128339914(BMP4)

GJA:	107118494(BMP4)

STOW:

125425547(BMP4) 125434890

EMC:	129324388(BMP4) 129343674

XLA:	397874(bmp4.L) 399322(bmp4.S)

XTR:	549788(bmp4)

NPR:	108788625(BMP4)

RTEM:

120921208(BMP4)

BBUF:

120981976(BMP4)

BGAR:

122921246(BMP4)

MUO:	115477941(BMP4)

GSH:	117364205(BMP4)

DRE:	30612(bmp4)

SRX:	107723271 107752724

SANH:

107701526 107702232

SGH:	107565000 107565007 107577028

CCAR:

109051714 109086016

CAUA:

113060420 113116948

CGIB:

127975813 128031385

PTET:

122361543(bmp4)

LROH:

127179236(bmp4)

OMC:	131523788(bmp4)

PPRM:

120479086(bmp4)

RKG:	130076709(bmp4)

MAMB:

125268289(bmp4)

CIDE:

127498054

CERY:

137006351(bmp4)

MASI:

127410972 127455377

TROS:

130560822(bmp4)

TDW:	130436744(bmp4)

MANU:

129417753(bmp4)

IPU:

108270422

IFU:	128613048(bmp4)

PHYP:

113538966(bmp4)

SMEO:

124390596(bmp4)

TFD:	113659289(bmp4)

TVC:	132852387(bmp4)

TRN:	134324912(bmp4)

AMEX:

103024384(bmp4)

CMAO:

118823939(bmp4)

EEE:	113572633(bmp4)

CHAR:

105896020(bmp4)

TRU:	101061931(bmp4)

TFS:	130540295(bmp4)

TNG:	GSTEN00031991G001

LCO:	104922404(bmp4)

NCC:	104964390(bmp4)

TBEN:

117479100(bmp4)

CGOB:

115027803(bmp4)

PGEO:

117467331(bmp4)

GACU:

117549316(bmp4)

EMAC:

134880952(bmp4)

ELY:	117266620(bmp4)

EFO:	125901407(bmp4)

PLEP:

121954057(bmp4)

SLUC:

116057644(bmp4)

ECRA:

117936136(bmp4)

ESP:	116669659(bmp4)

PFLV:

114546704(bmp4)

GAT:	120833309(bmp4)

PPUG:

119228075(bmp4)

AFB:	129103245(bmp4)

CLUM:

117751459(bmp4)

PSWI:

130201919(bmp4)

MSAM:

119910406(bmp4)

SCHU:

122861887(bmp4)

CUD:	121526798(bmp4)

ALAT:

119005123(bmp4)

MZE:	101478902(bmp4)

ONL:	100693424(bmp4)

OAU:	116326100(bmp4)

OLA:	100049354(bmp4)

OML:	112149693(bmp4)

CSAI:

133462262(bmp4)

XMA:	102236800(bmp4)

XCO:	114134479(bmp4)

XHE:	116709359(bmp4)

PRET:

103458754(bmp4)

PFOR:

103154912(bmp4)

PLAI:

106953912(bmp4)

PMEI:

106906536(bmp4)

GAF:	122845608(bmp4)

PPRL:

129365485(bmp4)

CVG:	107096913(bmp4)

CTUL:

119775042(bmp4)

GMU:	124855391(bmp4)

NFU:	107392164(bmp4)

KMR:	108232299(bmp4)

ALIM:

106518439(bmp4)

NWH:	119427409(bmp4)

AOCE:

111573266(bmp4)

MCEP:

125024060(bmp4)

CSEM:

103378831(bmp4)

POV:	109646622(bmp4)

SSEN:

122783422(bmp4)

HHIP:

117756327(bmp4)

HSP:	118117006(bmp4)

PPLT:

128451535(bmp4)

SMAU:

118286620(bmp4)

LCF:

108875064

SDU:	111225424(bmp4)

SLAL:

111651019(bmp4)

XGL:	120795913(bmp4)

HCQ:	109509080 109517481(bmp4)

SSCV:

125980814

SBIA:

133513462(bmp4)

PEE:	133412948(bmp4)

PTAO:

133488099(bmp4)

BPEC:

110153633(bmp4)

MALB:

109968000(bmp4)

BSPL:

114849003(bmp4)

SJO:	128375465(bmp4)

SASA:

100194815(bmp4) 106611121

STRU:

115162164 115172445

OTW:	112256771 112261632(bmp4)

OMY:	110497765(bmp4) 110505700 118936649

OGO:	124001729 124046584

ONE:	115138632 115146089

OKI:	109894393 109904173

OKE:	118362655 118368167(bmp4)

SALP:

111963403 111968588

SNH:	120023676 120060389

CCLU:

121539447 121544776

ELS:	105015523(bmp4)

SFM:	108919383 108924036

PKI:	111859967(bmp4)

AANG:

118219736(bmp4)

LOC:	102684136(bmp4)

PSPA:

121324802 121330351

ARUT:

117395489 117421860

PSEX:

120518861(bmp4)

LCM:	102365184(BMP4)

CMK:	103175246(bmp4)

RTP:	109911221(bmp4) 109915190

CPLA:

122542790 122553612(bmp4)

HOC:	132818298(bmp4) 132836734

LERI:

129700174(bmp4)

PMRN:

103091842

LRJ:

133347370

BFO:

118427296

BBEL:

109477517 109482544 109488141

LPIC:

129264992

ARUN:

117294632

DME:	Dmel_CG9885(dpp)

DER:

6542079

DSE:

6613103

DSI:	Dsimw501_GD23157(Dsim_dpp)

DYA:	Dyak_GE18157(Dyak_dpp)

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15572

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:	119662278 119687217

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AMOU:

AALI:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ004806

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:	105672334(dpp)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

TCA:	654513(Dpp)

DPA:

109534820

ATD:	109598554 109606765

LDC:	111506036 111506625

NVL:	108557335 108557337

APLN:

108736677

PPYR:

116168588

OTU:

111417459

BMOR:

100270781(Dpp)

BMAN:

114248672

MSEX:

115440434

DPL:	KGM_214072

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119834728 119834729

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PGW:

LGLY:

API:	100163532 100168426 100168935 100572599

DNX:	107163146 107164798 107168331

AGS:	114122517 114123096 114128049 114129981

RMD:	113548569 113553177 113556510 113557330 113558507

ACOO:

126835553 126836191

DVT:	126895949 126896804

BTAB:

DCI:

CLEC:

NLU:

HVI:

PHU:	Phum_PHUM346320

FOC:

TPAL:

ZNE:

SGRE:

BROR:

IEL:

FCD:

DPX:	DAPPUDRAFT_347232(DPP)

DMK:	116924596 123473760

DPZ:

MNZ:

HAZT:

LSM:

TCF:

PPOI:

RSAN:

CSCU:

CVS:	136980674 136985827

PTEP:

ABRU:

SDM:

LPOL:

CEL:	CELE_T25F10.2(dbl-1)

CBR:	CBG_19011(Cbr-dbl-1)

CRQ:	GCK72_017989

LOA:	LOAG_01966

HRF:

HRJ:

CRG:

CANU:

DPOL:

OSN:

LJP:	135466599 135471731

LAK:

106163298

LLON:

135485615

» show all

Reference

PMID:24362451

Authors

Tanaka K, Kaji H, Yamaguchi T, Kanazawa I, Canaff L, Hendy GN, Sugimoto T

Title

Involvement of the osteoinductive factors, Tmem119 and BMP-2, and the ER stress response PERK-eIF2alpha-ATF4 pathway in the commitment of myoblastic into osteoblastic cells.

Journal

Calcif Tissue Int 94:454-64 (2014)
DOI:10.1007/s00223-013-9828-1

Reference

PMID:17301089

Authors

Hens JR, Dann P, Zhang JP, Harris S, Robinson GW, Wysolmerski J

Title

BMP4 and PTHrP interact to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.

Journal

Development 134:1221-30 (2007)
DOI:10.1242/dev.000182

Sequence

[mmu:12159]

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Disease (2)   
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Gene (1039)   
   KEGG GENES (639)   
   KEGG MGENES (135)   
   RefGene (263)   
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