KEGG   MODULE: M00802
Entry
M00802            Pathway   Module                                 

Name
dTDP-D-forosamine biosynthesis
Definition
K16435 K13327 K13328 K13329 K13330
Diagram
M00802

Orthology
K16435  
spnO; dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase [EC:4.2.1.159] [RN:R05518]
K13327  
spnN; dTDP-3,4-didehydro-2,6-dideoxy-alpha-D-glucose 3-reductase [EC:1.1.1.384] [RN:R05526]
K13328  
spnQ; dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase [EC:4.2.1.164] [RN:R08930]
K13329  
spnR; dTDP-4-dehydro-2,3,6-trideoxy-D-glucose 4-aminotransferase [EC:2.6.1.110] [RN:R08931]
K13330  
spnS; dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose N,N-dimethyltransferase [EC:2.1.1.324] [RN:R08932]
Class
Pathway modules; Biosynthesis of terpenoids and polyketides; Polyketide sugar unit biosynthesis
Pathway
map00523  Polyketide sugar unit biosynthesis
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
Compound
C11907  dTDP-4-oxo-6-deoxy-D-glucose
C06620  dTDP-3,4-dioxo-2,6-dideoxy-D-glucose
C11922  dTDP-4-oxo-2,6-dideoxy-D-glucose
C18032  dTDP-4-oxo-2,3,6-trideoxy-D-glucose
C18033  dTDP-4-amino-2,3,4,6-tetradeoxy-D-glucose
C18034  dTDP-D-forosamine
RModule
RM035  Transamination and N,N-dimethylation in polyketide biosynthesis
RM038  Deoxygenation (dehydration and reduction) in deoxysugar biosynthesis
Reference
  Authors
Waldron C, Matsushima P, Rosteck PR Jr, Broughton MC, Turner J, Madduri K, Crawford KP, Merlo DJ, Baltz RH
  Title
Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa.
  Journal
Chem Biol 8:487-99 (2001)
DOI:10.1016/S1074-5521(01)00029-1

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