KEGG   MODULE: M00846
Entry
M00846            Pathway   Module                                 
Name
Siroheme biosynthesis, glutamyl-tRNA => siroheme
Definition
K02492 K01845 K01698 K01749 (K01719,K13542,K13543) (K02302,(K00589,K02303,K02496,K13542,K13543)+(K02304,(K24866+K03794)))
Diagram
M00846

Orthology
K02492  
glutamyl-tRNA reductase [EC:1.2.1.70] [RN:R04109]
K01845  
glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8] [RN:R02272]
K01698  
porphobilinogen synthase [EC:4.2.1.24] [RN:R00036]
K01749  
hydroxymethylbilane synthase [EC:2.5.1.61] [RN:R00084]
K01719,K13542,K13543  
uroporphyrinogen-III synthase [EC:4.2.1.75] [RN:R03165]
K02302,K00589,K02303,K02496,K13542,K13543  
uroporphyrin-III C-methyltransferase [EC:2.1.1.107] [RN:R03194]
K02302,K02304,K24866  
precorrin-2 dehydrogenase [EC:1.3.1.76] [RN:R03947]
K02302,K02304,K03794  
sirohydrochlorin ferrochelatase [EC:4.99.1.4] [RN:R02864]
Class
Pathway modules; Metabolism of cofactors and vitamins; Cofactor and vitamin metabolism
Pathway
map00860  Porphyrin metabolism
map01240  Biosynthesis of cofactors
map01100  Metabolic pathways
map01110  Biosynthesis of secondary metabolites
Reaction
R04109  
R02272  
R00036  
R00084  
R03165  
R03194  
R03947  
R02864  
Compound
C02987  L-Glutamyl-tRNA(Glu)
C03741  (S)-4-Amino-5-oxopentanoate
C00430  5-Aminolevulinate
C00931  Porphobilinogen
C01024  Hydroxymethylbilane
C01051  Uroporphyrinogen III
C02463  Precorrin 2
C05778  Sirohydrochlorin
C00748  Siroheme
Reference
PMID:12408752
  Authors
Raux E, Leech HK, Beck R, Schubert HL, Santander PJ, Roessner CA, Scott AI, Martens JH, Jahn D, Thermes C, Rambach A, Warren MJ
  Title
Identification and functional analysis of enzymes required for precorrin-2 dehydrogenation and metal ion insertion in the biosynthesis of sirohaem and cobalamin in Bacillus megaterium.
  Journal
Biochem J 370:505-16 (2003)
DOI:10.1042/BJ20021443

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (9)   
   KEGG COMPOUND (9)   
Chemical reaction (16)   
   KEGG ENZYME (8)   
   KEGG REACTION (8)   
Gene (14)   
   KEGG ORTHOLOGY (14)   
Literature (1)   
   PubMed (1)   
All databases (44)   

Download RDF
DBGET integrated database retrieval system