KEGG   NETWORK: N00020
Entry
N00020                      Network                                
Name
Amplified FGFR to RAS-ERK signaling pathway
Definition
FGFR* -> GRB2 -> SOS -> RAS -> RAF -> MEK -> ERK
  Expanded
(2260v1,2263v1) -> 2885 -> (6654,6655) -> (3265,3845,4893) -> (369,673,5894) -> (5604,5605) -> (5594,5595)
Class
nt06261 Gastric cancer
nt06270 Breast cancer
nt06210 ERK signaling (cancer)
Type
Variant
Pathway
hsa05224  Breast cancer
hsa05226  Gastric cancer
Disease
H00031  Breast cancer
H00018  Gastric cancer
Gene
2260  FGFR1; fibroblast growth factor receptor 1
2263  FGFR2; fibroblast growth factor receptor 2
2885  GRB2; growth factor receptor bound protein 2
6654  SOS1; SOS Ras/Rac guanine nucleotide exchange factor 1
6655  SOS2; SOS Ras/Rho guanine nucleotide exchange factor 2
3265  HRAS; HRas proto-oncogene, GTPase
3845  KRAS; KRAS proto-oncogene, GTPase
4893  NRAS; NRAS proto-oncogene, GTPase
369  ARAF; A-Raf proto-oncogene, serine/threonine kinase
673  BRAF; B-Raf proto-oncogene, serine/threonine kinase
5894  RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604  MAP2K1; mitogen-activated protein kinase kinase 1
5605  MAP2K2; mitogen-activated protein kinase kinase 2
5594  MAPK1; mitogen-activated protein kinase 1
5595  MAPK3; mitogen-activated protein kinase 3
Variant
2260v1 (FGFR*)  FGFR1 amplification
2263v1 (FGFR*)  FGFR2 amplification
Reference
PMID:24649067
  Authors
Zhang MH, Man HT, Zhao XD, Dong N, Ma SL
  Title
Estrogen receptor-positive breast cancer molecular signatures and therapeutic potentials (Review).
  Journal
Biomed Rep 2:41-52 (2014)
DOI:10.3892/br.2013.187
Reference
PMID:20179196
  Authors
Turner N, Pearson A, Sharpe R, Lambros M, Geyer F, Lopez-Garcia MA, Natrajan R, Marchio C, Iorns E, Mackay A, Gillett C, Grigoriadis A, Tutt A, Reis-Filho JS, Ashworth A
  Title
FGFR1 amplification drives endocrine therapy resistance and is a therapeutic target in breast cancer.
  Journal
Cancer Res 70:2085-94 (2010)
DOI:10.1158/0008-5472.CAN-09-3746
Reference
PMID:23696246
  Authors
Katoh M, Nakagama H
  Title
FGF receptors: cancer biology and therapeutics.
  Journal
Med Res Rev 34:280-300 (2014)
DOI:10.1002/med.21288
Reference
PMID:19387476
  Authors
Katoh M
  Title
FGFR2 abnormalities underlie a spectrum of bone, skin, and cancer pathologies.
  Journal
J Invest Dermatol 129:1861-7 (2009)
DOI:10.1038/jid.2009.97
Reference
PMID:20836672
  Authors
Katoh M
  Title
Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics.
  Journal
Expert Rev Anticancer Ther 10:1375-9 (2010)
DOI:10.1586/era.10.128

  All links  
Pathway (2)   
   KEGG PATHWAY (2)   
Network (2)   
   KEGG VARIANT (2)   
Gene (15)   
   KEGG GENES (15)   
Literature (5)   
   PubMed (5)   
All databases (24)   

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