Network Variation Maps
KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge of diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in terms of network variation maps (such as nt06210) consisting of network elements (such as N00014). The notation of network variation maps is as follows.
Network element | Coloring |
Reference network | Green |
Variant network containing Human gene variant Pathogen gene/protein Environmental factor |
Red Purple Blue |
Drug-target relation | Navy |
Edge | Interaction/reaction |
→ | Activation |
⊣ | Inhibition |
= | Complex formation |
⌿ | Missing interaction or reaction |
↗ | Gain of function |
⇒ | Expression |
⫤ | Repression |
— | Substrate binding to enzyme or transporter |
→ | Enzymatic reaction or transport process |
⇉ | Enzyme-enzyme relation of successive reactions |
Last updated: November 27, 2024