Network Variation Maps
KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge of diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in terms of network variation maps (such as nt06210) consisting of network elements (such as N00014). The notation of network variation maps is as follows.
| Network element | Coloring |
| Reference network | Green |
| Variant network containing Human gene variant Pathogen gene/protein Environmental factor |
Red Purple Blue |
| Drug-target relation | Navy |
Gain-of-function variant indicated by ↗
| Edge | Interaction/reaction |
| → | Activation |
| ⊣ | Inhibition |
| ＝ | Complex formation |
| ⌿ | Missing interaction or reaction |
| ⇒ | Expression |
| ⫤ | Repression |
| — | Substrate binding to enzyme or transporter |
| → | Enzymatic reaction or transport process |
| ⇉ | Enzyme-enzyme relation of successive reactions |
Last updated: June 18, 2025