Network Variation Maps
KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge of diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in terms of network variation maps (such as nt06210) consisting of network elements (such as N00014). The notation of network variation maps is as follows.
| Network element | Coloring |
| Reference network | Green |
| Variant network containing Human gene variant Pathogen gene/protein Environmental factor |
Red Purple Blue |
| Drug-target relation | Navy |
Gain-of-function variant indicated by ↗
| Edge | Interaction/reaction |
| → | Activation |
| ⊣ | Inhibition |
| ＝ | Complex formation |
| ⌿ | Missing interaction or reaction |
| ⇒ | Expression |
| ⫤ | Repression |
| — | Substrate binding to enzyme or transporter |
| → | Enzymatic reaction or transport process |
| ⇉ | Enzyme-enzyme relation of successive reactions |
Pathway view
Carbohydrate metabolism
Lipid/glycolipid metabolism
Nucleotide metabolism
Amino acid metabolism
Glycan/glycoprotein metabolism
Cofactor/vitamin metabolism
Replication, repair and transcription
- 06509
- DNA replication
- 06510
- Telomere length regulation
- 06504
- Base excision repair
- 06502
- Nucleotide excision repair
- 06503
- Mismatch repair
- 06506
- Double-strand break repair
- 06508
- Interstrand crosslink repair
- 06547
- Spliceosome
- 06523
- Epigenetic regulation by Polycomb complexes
Signal transduction
- 06526
- MAPK signaling
- 06530
- PI3K signaling
- 06505
- WNT signaling
- 06511
- NOTCH signaling
- 06501
- HH signaling
- 06507
- TGFB signaling
- 06518
- JAK-STAT signaling
- 06516
- TNF signaling
- 06528
- Calcium signaling
- 06522
- mTOR signaling
- 06542
- HIF signaling
- 06543
- NRG-ERBB signaling
- 06544
- Neuroactive ligand signaling
Cellular processes
- 06546
- IgSF CAM signaling
- 06548
- Integrin signaling
- 06549
- Cadherin signaling New!
- 06512
- Chromosome cohesion and segregation
- 06515
- Regulation of kinetochore-microtubule interactions
- 06534
- Unfolded protein response
- 06532
- Autophagy
- 06536
- Mitophagy
- 06535
- Efferocytosis
- 06550
- Lysosome biogenesis New!
- 06551
- Lysosome New!
- 06524
- Apoptosis
- 06525
- Ferroptosis
- 06527
- Necroptosis
- 06529
- Thermogenesis
- 06539
- Cytoskeleton in muscle cells
- 06541
- Cytoskeleton in neurons
- 06545
- Cornified envelope formation
- 06552
- Integrated stress response (ISR) signaling pathway New!
Immune system
- 06513
- Complement cascade
- 06514
- Coagulation cascade
- 06517
- TLR signaling
- 06521
- NLR signaling
- 06519
- RLR signaling
- 06520
- CGAS-STING signaling
- 06537
- TCR/BCR signaling
- 06533
- Chemokine signaling
Endocrine system
Disease view
Cancer (See Color codes of cancer types)
- 06260
- Colorectal cancer
- 06261
- Gastric cancer
- 06262
- Pancreatic cancer
- 06263
- Hepatocellular carcinoma
- 06264
- Renal cell carcinoma
- 06265
- Bladder cancer
- 06266
- Non-small cell lung cancer
- 06267
- Small cell lung cancer
- 06268
- Melanoma
- 06269
- Basal cell carcinoma
- 06270
- Breast cancer
- 06271
- Endometrial cancer
- 06272
- Prostate cancer
- 06273
- Glioma
- 06274
- Thyroid cancer
- 06275
- Acute myeloid leukemia
- 06276
- Chronic myeloid leukemia
Cancer signaling
- 06210
- ERK signaling
- 06214
- PI3K signaling
- 06213
- Other RAS signaling
- 06211
- Other MAPK signaling
- 06215
- WNT signaling
- 06216
- NOTCH signaling
- 06217
- HH signaling
- 06218
- TGFB signaling
- 06219
- JAK-STAT signaling
- 06220
- Calcium signaling
- 06234
- cAMP signaling
- 06222
- IFN signaling
- 06223
- TNF signaling
- 06224
- CXCR signaling
- 06225
- HIF-1 signaling
- 06226
- KEAP1-NRF2 signaling
- 06227
- Nuclear receptor signaling
- 06229
- MHC presentation
- 06230
- Cell cycle
- 06231
- Apoptosis
- 06232
- Telomerase activity
- 06240
- Transcription
- 06250
- DNA adduct formation
- 06251
- CYP-mediated ROS formation
- 06252
- Mitochondrial ROS formation
- 06253
- Antioxidant system
Neurodegenerative disease
- 06460
- Alzheimer disease
- 06463
- Parkinson disease
- 06464
- Amyotrophic lateral sclerosis
- 06461
- Huntington disease
- 06462
- Spinocerebellar ataxia
- 06465
- Prion disease
- 06466
- Pathways of neurodegeneration
Endocrine and metabolic disease
- 06360
- Cushing syndrome
- [hsa04934]
Viral infection (*oncovirus)
- 06160*
- Human T-cell leukemia virus 1
- 06161
- Human immunodeficiency virus 1
- 06162*
- Hepatitis B virus
- 06163*
- Hepatitis C virus
- 06171
- SARS coronavirus 2
- 06170
- Influenza A virus
- 06169
- Measles virus
- 06168
- Herpes simplex virus 1
- 06167
- Human cytomegalovirus
- 06164*
- Kaposi sarcoma herpesvirus
- 06165*
- Epstein-Barr virus
- 06166*
- Human papillomavirus
Bacterial infection
- 06180
- Pathogenic Escherichia coli
- 06181
- Salmonella
- 06182
- Shigella
- 06183
- Yersinia
Last updated: July 22, 2026