Network Variation Maps

KEGG NETWORK represents a renewed attempt by KEGG to capture knowledge of diseases and drugs in terms of perturbed molecular networks (see Background of KEGG DISEASE). It accumulates variations of molecular interaction/reaction networks in terms of network variation maps (such as nt06210) consisting of network elements (such as N00014). The notation of network variation maps is as follows.
Network element Coloring
Reference network Green
Variant network containing
   Human gene variant
   Pathogen gene/protein
   Environmental factor

Red
Purple
Blue
Drug-target relation Navy
Edge   Interaction/reaction
→   Activation
Inhibition
Complex formation
Missing interaction or reaction
Expression
Repression
Substrate binding to enzyme or transporter
Enzymatic reaction or transport process
Enzyme-enzyme relation of successive reactions


Cancers (See Color codes of cancer types)

Signaling networks

Cancers in pathway maps

Neurodegenerative diseases

Signaling networks

Diseases in pathway maps

Endocrine and metabolic diseases

Signaling networks

Diseases in pathway maps

Congenital disorders of metabolism

Carbohydrate metabolism

Lipid/glycolipid metabolism

Nucleotide metabolism

Amino acid metabolism

Glycan/glycoprotein metabolism

Cofactor/vitamin metabolism

Viral and bacterial infections

Signaling networks

Viral infections in pathway maps (*oncovirus)

06160*
HTLV-1
06161
HIV-1
06162*
HBV
06163*
HCV
06171
SARS-CoV-2
06170
IAV
06169
MV
06168
HSV-1
06167
HCMV
06164*
KSHV
06165*
EBV
06166*
HPV

Last updated: August 18, 2022