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Functional Hierarchies

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KEGG BRITE is a collection of hierarchical classification systems capturing functional hierarchies of various biological objects, especially those represented as KEGG objects. They are represented as BRITE hierarchy files, also called hierarchical text (htext) files, supplemented with BRITE table files using html tables. BRITE hierarchy files may contain tab-delimited attributes that are added manually or computationally. BRITE table files focus more on such multi-column attributes rather than hierarchy relationships. In contrast to KEGG PATHWAY, which is limited to molecular interactions and reactions, KEGG BRITE incorporates many different types of relationships including: KEGG BRITE is the reference database for brite mapping in KEGG Mapper.

Brite Identifiers

Each brite hierarchy/table is identified by the combination of 2-4 letter prefix code and 5 digit number (see KEGG Identifier). The prefix has the following meaning:
br
non-gene/protein reference hierarchy or table
jp
non-gene/protein reference hierarchy or table in Japanese
ko
gene/protein reference hiearchy for KO expansion
<org>
organism-specific hierarchy generated by converting KOs to gene identifiers

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Pathway and Brite

1. Genes and Proteins

1.1 Orthologs and modules (K/M nubmers)
1.2 Protein families: metabolism (K numbers)
1.3 Protein families: genetic information processing (K numbers)
1.4 Protein families: signaling and cellular processes (K numbers)
1.5 RNA family (K numbers)
1.6 Sequence data collection: antimicrobial resistance
1.7 Sequence data collection: nomenclature
1.8 Annotation guide
1.9 Signature KOs and modules

2. Compounds and Reactions

2.1 Compounds (C numbers)
2.2 Reactions (R/RC numbers)

3. Drugs

3.1 Drug classifications (D numbers)
3.2 Drug information (D numbers)
3.3 Other related information (E/C numbers)

4. Diseases

4.1 Human diseases (H numbers)
4.2 Disease genes and markers

5. Organisms and Cells

5.1 Organisms
5.2 Cells, tissues, and organs

Binary Relationships

The following binary relation files may be used in the KEGG Mapper tool Join Brite to computationally extend the Brite hierarchy file.
K number to:    COG    GO    TC    CAZy
D number to:    Target    Enzyme    Transporter   
H number to:    Human gene    Pathogen genome   
KEGG organism code to:    Keywords   

Codes and Abbreviations


Last updated: April 1, 2020
KEGG GenomeNet Kanehisa Laboratories