Rx-to-OTC Switch List in Japan Rx-to-OTC Switch List in Japan| Approved | KEGG | Ingredient |
| 1983 | D04269 | Soysterol |
| D01612 | Sodium picosulfate | |
| 1984 | D08751 | Semi-alkaline proteinase |
| 1985 | D01585 | Exalamide |
| D01506 | Dimemorfan phosphate | |
| D00141 | Indometacin | |
| D00126 | Ibuprofen | |
| 1986 | D04267 | Polyenephosphatidyl choline |
| 1987 | D04825 | Sodium polyethylenesulfonate |
| D01451 | Scopolamine butylbromide | |
| D01778 | Bromhexine hydrochloride | |
| D02266 | Cetraxate hydrochloride | |
| D02535 | Timepidium bromide | |
| D01364 | Ciclopirox olamine | |
| D00882 | Miconazole nitrate | |
| 1988 | D01143 | Isothipendyl hydrochloride |
| D01529 | Gefarnate | |
| D00881 | Econazole nitrate | |
| D06393 | Carbocysteine | |
| 1989 | D01882 | Hepronicate |
| D00729 | Loperamide hydrochloride | |
| 1990 | D01065 | Ubidecarenone |
| D01619 | Hydrocortisone butyrate | |
| D01324 | Mequitazine | |
| D01191 | Bisoxatin acetate | |
| D01122 | Ibuprofen piconol | |
| 1991 | D01384 | Tolciclate |
| D01823 | Ufenamate | |
| D01106 | Eprazinone hydrochloride | |
| D00890 | Tioconazole | |
| 1992 | D03246 | Mecobalamin |
| D03301 | Prednisolone valerate acetate | |
| D01598 | Calcium L-Aspartate | |
| 1993 | D00886 | Sulconazole nitrate |
| D01775 | Bifonazole | |
| D00885 | Oxiconazole nitrate | |
| 1994 | D00127 | Piroxicam |
| D00132 | Ketoprofen | |
| 1995 | D01152 | Oxethazaine |
| D01500 | Trimebutine maleate | |
| D01675 | Felbinac | |
| D05276 | Pirenzepine hydrochloride hydrate | |
| 1997 | D00526 | Sodium cromoglicate |
| D00295 | Cimetidine | |
| D00318 | Famotidine | |
| D00673 | Ranitidine hydrochloride | |
| 1998 | D01956 | Sofalcone |
| 1999 | D00418 | Minoxidil |
| 2000 | D01827 | Teprenone |
| 2001 | D03365 | Nicotine |
| 2002 | D01720 | Amorolfine hydrochloride |
| D01093 | Butenafine hydrochloride | |
| D01620 | Neticonazole hydrochloride | |
| D01578 | Pranoprofen | |
| D02219 | Terbinafine hydrochloride | |
| 2005 | D01467 | Roxatidine acetate hydrochloride |
| D00440 | Nizatidine | |
| D01332 | Ketotifen fumarate | |
| 2006 | D00659 | Azelastine hydrochloride |
| D02300 | Adenosine triphosphate disodium hydrate | |
| D01875 | Tiquizium bromide | |
| D01092 | Lanoconazole | |
| D00983 | Triamcinolone acetonide | |
| 2007 | D00222 | Aciclovir |
| D01479 | Ambroxol hydrochloride | |
| D01136 | Tranexamic acid | |
| 2008 | D01480 | Isoconazole nitrate |
| D02249 | Emedastine difumarate | |
| D00718 | Flavoxate hydrochloride | |
| 2009 | D00904 | Diclofenac sodium |
| D06298 | Vidarabine | |
| 2010 | D01709 | Loxoprofen sodium hydrate |
| D01713 | Epinastine hydrochloride | |
| D01306 | Troxipide | |
| D00689 | Beclometasone dipropionate | |
| 2011 | D00282 | Clotrimazole |
| D01022 | Oxymetazoline hydrochloride | |
| D03233 | Acitazanolast hydrate | |
| D01088 | Pemirolast potassium | |
| 2012 | D00671 | Fexofenadine hydrochloride |
| D01892 | Icosapent ethyl | |
| D00664 | Cetirizine hydrochloride | |
| 2013 | D02027 | Tranilast |
| D01478 | Ebastine | |
| 2014 | D01513 | Alminoprofen |
| D10748 | Chaste berry extract | |
| 2015 | D00943 | Sodium fluoride |
| 2017 | D00364 | Loratadine |
| D01654 | Bepotastine besylate | |
| 2018 | D00324 | Flunisolide |
| 2019 | D01708 | Fluticasone propionate |
| 2020 | D03354 | Hyaluronate sodium |
| D08738 | Rosskastanien extract | |
| D01357 | Betamethasone valerate | |
| 2021 | D01007 | Propiverine hydrochloride |
| D00118 | Naproxen | |
| D02729 | Itopride hydrochloride | |
| 2022 | D07709 | Polyvinyl alcohol and iodine |
| D03306 | Calcium polycarbophil | |
| 2023 | D00885 | Oxiconazole nitrate |
| D10252 | Fexofenadine hydrochloride and pseudoephedrine hydrochloride | |
| 2024 | D00330 | Flurbiprofen |
| 2025 | D03325 | Mometasone furoate hydrate |
| D00969 | Meloxicam | |
| D00724 | Rabeprazole sodium |