KEGG image  Pharmacogenomic Biomarkers

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Companion diagnostics

Drug KEGG ATC Product Target Variant Biomarker Network
Rituximab D02994 L01XC02 Rituxan CD20 CD20 positive
Ofatumumab D09314 L01XC10 Arzerra CD20 CD20 positive
Obinutuzumab D09321 L01XC15 Gazyva CD20 CD20 positive
Ibritumomab tiuxetan D04489 V10XX02 Zevalin CD20 CD20 positive
Inotuzumab ozogamicin D08933 L01XC26 Besponsa CD22 CD22 positive
Gemtuzumab ozogamicin D03259 L01XC05 Mylotarg CD33 CD33 positive
Brentuximab vedotin D09587 L01XC12 Adcetris CD30 CD30 positive
Trastuzumab D03257 L01XC03 Herceptin HER2 2064v1
2064v3
HER2 overexpression/amplification N10009
Trastuzumab emtansine D09980 L01XC14 Kadcyla HER2 2064v1
2064v3
HER2 overexpression/amplification N10009
Pertuzumab D05446 L01XC13 Perjeta HER2 2064v1
2064v3
HER2 overexpression/amplification N10009
Neratinib D10898 L01XE45 Nerlynx EGFR
HER2
HER4
2064v1
2064v3
HER2 overexpression/amplification N10009
Lapatinib D04024 L01XE07 Tykerb EGFR
HER2
2064v1 HER2 overexpression
ESR1, PGR positive
HLA-DQA1*0201 or HLA-DRB1*0701 allele carrier
N10009
Cetuximab D03455 L01XC06 Erbitux EGFR EGFR expression, KRAS wild type
Panitumumab D05350 L01XC08 Vectibix EGFR EGFR expression, KRAS wild type
Gefitinib D01977 L01XE02 Iressa EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation N10005
Erlotinib D04023 L01XE03 Tarceva EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation N10005
Afatinib D09733 L01XE13 Giotrif EGFR 1956v2 EGFR exon 19 deletion or exon 21 L858R mutation N10005
Osimertinib D10766 L01XE35 Tagrisso EGFR 1956v3 EGFR T790M mutation N10006
Nivolumab D10316 L01XC17 Opdivo PD1 PDL1 positive
BRAF V600
microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR)
Pembrolizumab D10574 L01XC18 Keytruda PD1 PDL1 positive
microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR)
Cemiplimab D11108 Libtayo PD1 PDL1 positive
Durvalumab D10808 L01XC28 Imfinzi PDL1 PDL1 positive
Avelumab D10817 L01XC31 Bavencio PDL1 PDL1 positive
Atezolizumab D10773 L01XC32 Tecentriq PDL1 PDL1 positive
Dinutuximab D10559 L01XC16 Unituxin GD2 MYCN amplification
Busulfan D00248 L01AB01 Myleran Philadelphia chromosome (BCR-ABL fusion gene) negative
Blinatumomab D09325 L01XC19 Blincyto CD19 Philadelphia chromosome (BCR-ABL fusion gene) negative
Mogamulizumab D09761 L01XC25 Poteligeo CCR4 CCR4 positive
Imatinib D01441 L01XE01 Gleevec BCR-ABL
FIP1L1-PDGFRA
KIT
PDGFR
25v1 Philadelphia chromosome (BCR-ABL fusion gene)
FIP1L1-PDGFRA fusion gene
KIT mutation D816V negative
PDGFR rearrangement
N10001
Dasatinib D06414 L01XE06 Sprycel BCR-ABL 25v2 Philadelphia chromosome, BCR-ABL T315I mutation N10002
Nilotinib D06413 L01XE08 Tasigna BCR-ABL 25v2
54658v1
Philadelphia chromosome (BCR-ABL fusion gene)
UGT1A1*28 allele homozygotes
N10002
Bosutinib D09728 L01XE14 Bosulif BCR-ABL 25v2 Philadelphia chromosome (BCR-ABL fusion gene) N10002
Ponatinib D09951 L01XE24 Iclusig BCR-ABL 25v2 Philadelphia chromosome, BCR-ABL T315I mutation N10002
Crizotinib D09731 L01XE16 Xalkori EML4-ALK
ROS1
238v1
6098v1
EML4-ALK fusion gene
ROS1 fusion gene
N10003
Ceritinib D10551 L01XE28 Zykadia EML4-ALK 238v2 ALK gene rearrangement N10004
Alectinib D10450 L01XE36 Alecensa EML4-ALK 238v2 ALK gene rearrangement N10004
Brigatinib D10866 L01XE43 Alunbrig EML4-ALK 238v2 ALK gene rearrangement N10004
Everolimus D02714 L01XE10
L04AA18
Afinitor
Zortress
MTOR ESR1 positive
HER2 negative
Palbociclib D10372 L01XE33 Ibrance CDK4/6 ESR1 positive
HER2 negative
Ribociclib D10979 L01XE42 Kisqali CDK4/6 ESR1 positive
HER2 negative
Abemaciclib D10688 Verzenio CDK4/6 ESR1 positive
HER2 negative
Vemurafenib D09996 L01XE15 Zelboraf BRAF 673v1 BRAF V600E mutation
NRAS mutation
N10007
Dabrafenib D10104 L01XE23 Tafinlar BRAF 673v1 BRAF V600E mutation
G6PD deficient
N10007
Encorafenib D11053 Braftovi BRAF 673v1 BRAF V600E/K mutation N10007
Trametinib D10176 L01XE25 Mekinist MEK 673v1 BRAF V600E/K mutation N10008
Cobimetinib D10615 L01XE38 Cotellic MEK 673v1 BRAF V600E/K mutation N10008
Binimetinib D10604 L01XE41 Mektovi MEK 673v1 BRAF V600E/K mutation N10008
Ibrutinib D10223 L01XE27 Imbruvica BTK Chromosome 17p deletion
Chromosome 11q deletion
Midostaurin D05029 L01XE39 Rydapt FLT3 (CD135) 2322v1
2322v2
FLT3 mutation
Tretinoin D00094 L01XX14 Vesanoid* PML-RARA 5371v1 PML-RARA translocation
Arsenic trioxide D02106 L01XX27 Trisenox PML-RARA 5371v1 PML-RARA translocation
Denileukin diftitox D03682 L01XX29 Ontak IL2RA (CD25) CD25 positive
Omacetaxine D08956 L01XX40 Synribo CCND1 Philadelphia chromosome (BCR-ABL fusion gene) negative
Venetoclax D10679 L01XX52 Venclexta BCL2 Chromosome 17p deletion
Olaparib D09730 L01XX46 Lynparza PARP1 BRCA1,2 mutation
HER2 negative
Niraparib D10140 L01XX54 Zejula PARP1 BRCA1,2 mutation or wild type
Rucaparib D10079 L01XX55 Rubraca PARP1 BRCA1,2 mutation
Enasidenib D11044 L01XX59 Idhifa IDH2 3418v1 IDH2 mutation
Tamoxifen D00966 L02BA01 Nolvadex* NR3A (ESR) ESR1, PGR positive
Factor V Leiden negative
Prothrombin mutation negative
Fulvestrant D01161 L02BA03 Faslodex NR3A (ESR) ESR1, PGR positive
HER2 negative
Anastrozole D00960 L02BG03 Arimidex CYP19A1 (ARO) ESR1, PGR positive
Letrozole D00964 L02BG04 Femara CYP19A1 (ARO) ESR1, PGR positive
Exemestane D00963 L02BG06 Aromasin CYP19A1 (ARO) ESR1, PGR positive
Eteplirsen D09900 M09AX06 Exondys 51 DMD DMD mutation (exon 51 skipping)
Ivacaftor D09916 R07AX02 Kalydeco CFTR (ABCC7) CFTR mutation (G551D, etc.)
Lumacaftor and ivacaftor D10685 R07AX30 Orkambi CFTR mutation (F508del)
Tezacaftor and ivacaftor D11042 Cymdeko CFTR mutation (F508del)

Polymorphisms and germline mutations

Drug KEGG ATC Variant Biomarker Network
Omeprazole D00455
D05259
A02BC01 1557v1 CYP2C19 poor metabolizer
Pantoprazole D02593 A02BC02 1557v1 CYP2C19 poor metabolizer
Lansoprazole D00355 A02BC03 1557v1 CYP2C19 intermediate or poor metabolizer
Rabeprazole D00724 A02BC04 1557v1 CYP2C19 poor metabolizer
Esomeprazole D01984
D04056
D10120
A02BC05 1557v1 CYP2C19 poor metabolizer
Dexlansoprazole D08903 A02BC06 1557v1 CYP2C19 poor metabolizer
Metoclopramide D05008 A03FA01 CYB5R1-4 deficient
G6PD deficient
Palonosetron D05343 A04AA05 1565v1 CYP2D6 poor metabolizer
Dronabinol D00306 A04AD10 1559v1 CYP2C9 poor metabolizer
Cholic acid D10699 A05AA03 AKR1D1,HSD3B7,CYP27A1,AMACR,CYP7A1 deficient
Sulfasalazine D00448 A07EC01 G6PD deficient
Glibenclamide (Glyburide) D00336 A10BB01 G6PD deficient
Chlorpropamide D00271 A10BB02 G6PD deficient
Glipizide D00335 A10BB07 G6PD deficient
Glimepiride D00593 A10BB12 G6PD deficient
Carglumic acid D07130 A16AA05 NAGS deficient
Velaglucerase alfa D09029 A16AB10 GBA deficient
Elosulfase D10333 A16AB12 GALNS deficient
Cerliponase alfa D10813 A16AB17 TPP1 deficient
Sodium phenylbutyrate D05868 A16AX03 CPS,OTC,NAGS /ASS,ASL /ARG deficient
Sodium phenylacetate and sodium benzoate D10205 CPS,OTC,NAGS /ASS,ASL /ARG deficient
Eliglustat D09893 A16AX10 CYP2D6 ultrarapid, intermediate or poor metabolizer
Warfarin D00564 B01AA03 79001v1
1559v1
VKORC1 rs9923231 allele carrier
CYP2C9 intermediate or poor metabolizer
PROS deficient
PROC deficient
Clopidogrel D00769 B01AC04 1557v1 CYP2C19 intermediate or poor metabolizers
Prasugrel D05597 B01AC22 1557v1
1559v1
1577v1
CYP2C19 poor metabolizer
CYP2C9 variant allele carrier
CYP3A5 variant allele carrier
CYP2B6 variant allele carrier
Ticagrelor D09017 B01AC24 1557v1 CYP2C19 poor metabolizer
Eltrombopag D03978 B02BX05 Factor V Leiden carrier
SERPINC1 deficient
Quinidine D00642
D02272
C01BA01 1565v1 CYP2D6 poor metabolizer
Propafenone D00640 C01BC03 1565v1 CYP2D6 poor metabolizer
Isosorbide Dinitrate D00516 C01DA08 CYB5R1-4 deficiency
Isosorbide Mononitrate D00630 C01DA14 CYB5R1-4 deficiency
Hydralazine and isosorbide D10209 9v1
10v1
NAT1,2 slow acetylator
Propranolol D00483 C07AA05 1565v1 CYP2D6 poor metabolizer
Metoprolol D00601
D00635
C07AB02 1565v1 CYP2D6 poor metabolizer
Carvedilol D00255
D03415
C07AG02 1565v1 CYP2D6 poor metabolizer
Pravastatin D00893 C10AA03 LDLR mutation heterozygotes and homozygotes
Atorvastatin D00887
D02258
C10AA05 LDLR deficient
Rosuvastatin D01915 C10AA07 LDLR deficient
Mipomersen D08946 C10AX11 LDLR mutation heterozygotes and homozygotes
Lomitapide D09638 C10AX12 LDLR mutation homozygotes
Evolocumab D10557 C10AX13 LDLR mutation heterozygotes and homozygotes
Alirocumab D10335 C10AX14 LDLR mutation heterozygotes
Terbinafine D02219 D01AE15
D01BA02
1565v1 CYP2D6 poor metabolizer
Mafenide D01166 D06BA03 G6PD deficient
Dapsone D00592 D10AX05
J04BA02
G6PD deficient
Flibanserin D02577 G02CX02 1559v1
1557v1
1565v1
CYP2C9 poor metabolizer
CYP2C19 poor metabolizer
CYP2D6 poor metabolizer
Drospirenone and ethinylestradiol D09741 G03AA12 1557v1 CYP2C19 intermediate metabolizer
Tolterodine D01148 G04BD07 1565v1 CYP2D6 poor metabolizer
Darifenacin D01699 G04BD10 1565v1 CYP2D6 poor metabolizer
Fesoterodine D08923 G04BD11 1565v1 CYP2D6 poor metabolizer
Parathyroid hormone D05364 H05AA03 CASR positive
Sulfamethoxazole and trimethoprim D00285 J01EE01 G6PD deficient
Nalidixic acid D00183 J01MB02 G6PD deficient
Nitrofurantoin D00439 J01XE01 G6PD deficient
Voriconazole D00578 J02AC03 1557v1 CYP2C19 intermediate or poor metabolizer
Rifampin, isoniazid, and pyrazinamide D10210 9v1
10v1
NAT1,2 slow acetylator
Telaprevir D09012 J05AE11 IL28B SNP rs12979860
Boceprevir D08876 J05AE12 IL28B SNP rs12979860
Simeprevir D10469 J05AE14 IL28B SNP rs12979860
Efavirenz D00896 J05AG03 CYP2B6
Abacavir D00891 J05AF06 HLA-B*5701
Daclatasvir D10105 J05AP07 IL28B SNP rs12979860
Elbasvir and Grazoprevir D10778 J05AP54 IL28B allele carrier
Dolutegravir D10113 J05AX12 54658v1 UGT1A1 poor metabolizer
Sofosbuvir D10366 J05AX15 IL28B SNP rs12979860
Dasabuvir, Ombitasvir, Paritaprevir, and Ritonavir D10582 J05AX66 IL28B SNP rs12979860
Mercaptopurine D00161 L01BB02 7172v1 TPMT polymorphism
Thioguanine D06109 L01BB03 7172v1 TPMT polymorphism
Fluorouracil D00584 L01BC02 DPD deficient
Capecitabine D01223 L01BC06 DPD deficient
Cisplatin D00275 L01XA01 7172v1 TPMT polymorphism
Lapatinib D04024 L01XE07 HLA-DQA1*0201
HLA-DRB1*0701
Nilotinib D06413 L01XE08 54658v1 UGT1A1 poor metabolizer
Pazopanib D05380 L01XE11 54658v1 UGT1A1 poor metabolizer
Irinotecan D01061 L01XX19 54658v1 UGT1A1 poor metabolizer
Belinostat D08870 L01XX49 54658v1 UGT1A1 poor metabolizer
Peginterferon alfa-2b D02748 L03AB10 IL28B SNP rs12979860
Mycophenolic acid D00752
D05095
D05096
L04AA06 HGPRT deficient
Belimumab D03068 L04AA26 ANA positive
Azathioprine D00238 L04AX01 7172v1 TPMT polymorphism
Lenalidomide D04687 L04AX04 Chromosome 5q deletion
Piroxicam D00127 M01AC01 1559v1 CYP2C9 poor metabolizer
Celecoxib D00567 L01XX33
M01AH01
1559v1 CYP2C9 polymorphism
Flurbiprofen D00330
D02290
M01AE09
M02AA19
R02AX01
S01BC04
1559v1 CYP2C9 polymorphism
Succinylcholine D00766 M03AB01 BCHE deficient
Carisoprodol D00768 M03BA02 1557v1 CYP2C19 polymorphism
Lesinurad D09921 M04AB05 1559v1 CYP2C9 poor metabolizer
Pegloticase D09316 M04AX02 G6PD deficient
Sevoflurane D00547 N01AB08 RYR1 positive
Prilocaine and lidocaine D02740 N01BB52
N01BB54
CYBR1-4 deficient
G6PD deficient
Tramadol D01355 N02AX02 1565v1 CYP2D6 poor metabolizer
Tramadol and acetaminophen D09999 N02AX52 1565v1 CYP2D6 poor metabolizer
Phenytoin D00512
D02103
N03AB02 HLA-B*1502
Carbamazepine D00252 N03AF01 HLA-B*1502
HLA-A*3101
Oxcarbazepine D00533 N03AF02 HLA-B*1502
Valproic acid D00399
D00304
D00710
N03AG01 POLG deficient
CPS,OTC,NAGS /ASS,ASL /ARG deficiency
Lacosamide D07299 N03AX18 1557v1 CYP2C19 poor metabolizer
Brivaracetam D08879 N03AX23 1557v1 CYP2C19 poor metabolizer
Perphenazine D00503 N05AB03 1565v1 CYP2D6 poor metabolizer
Thioridazine D00798 N05AC02 1565v1 CYP2D6 poor metabolizer
Pimozide D00560 N05AG02 1565v1 CYP2D6 poor metabolizer
Clozapine D00283 N05AH02 1565v1 CYP2D6 poor metabolizer
Risperidone D00426 N05AX08 1565v1 CYP2D6 poor metabolizer
Aripiprazole D01164
D10364
N05AX12 1565v1 CYP2D6 poor metabolizer
Brexpiprazole D10309 N05AX13 1565v1 CYP2D6 poor metabolizer
Iloperidone D02666 N05AX14 1565v1 CYP2D6 poor metabolizer
Diazepam D00293 N05BA01 1557v1 CYP2C19 polymorphism
Clobazam D01253 N05BA09 1557v1 CYP2C19 polymorphism
Desipramine D00812 N06AA01 1565v1 CYP2D6 poor metabolizer
Imipramine D00815 N06AA02 1565v1 CYP2D6 poor metabolizer
Clomipramine D00811 N06AA04 1565v1 CYP2D6 poor metabolizer
Amitriptyline D00809 N06AA09 1565v1 CYP2D6 poor metabolizer
Trimipramine D02408 N06AA06 1565v1 CYP2D6 poor metabolizer
Nortriptyline D00816 N06AA10 1565v1 CYP2D6 poor metabolizer
Protriptyline D00484 N06AA11 1565v1 CYP2D6 poor metabolizer
Doxepin D00814 N06AA12 1557v1
1565v1
CYP2C19 poor metabolizer
CYP2D6 polymorphism
Fluoxetine D00823 N06AB03 1565v1 CYP2D6 poor metabolizer
Citalopram D00822 N06AB04 1557v1
1565v1
CYP2C19 poor metabolizer
CYP2D6 polymorphism
Paroxetine D02260
D05374
D05375
N06AB05 1565v1 CYP2D6 poor metabolizer
Fluvoxamine D00824 N06AB08 1565v1 CYP2D6 poor metabolizer
Escitalopram D02567 N06AB10 1557v1
1565v1
CYP2C19 poor metabolizer
CYP2D6 poor metabolizer
Nefazodone D00819 N06AX06 1565v1 CYP2D6 poor metabolizer
Venlafaxine D00821 N06AX16 1565v1 CYP2D6 poor metabolizer
Duloxetine D01179 N06AX21 1565v1 CYP2D6 poor metabolizer
Vortioxetine D10185 N06AX26 1565v1 CYP2D6 poor metabolizer
Chlordiazepoxide and amitriptyline D10207 N06CA01 1565v1 CYP2D6 poor metabolizer
Modafinil D01832 N06BA07 1565v1 CYP2D6 poor metabolizer
Atomoxetine D02574 N06BA09 1565v1 CYP2D6 poor metabolizer
Galantamine D02173 N06DA04 1565v1 CYP2D6 poor metabolizer
Cevimeline D00661 N07AX03 1565v1 CYP2D6 poor metabolizer
Lofexidine D04765 N07BC04 1565v1 CYP2D6 poor metabolizer
Tetrabenazine D08575 N07XX06 1565v1 CYP2D6 poor metabolizer
Dextromethorphan and quinidine D10208 N07XX59 1565v1 CYP2D6 poor metabolizer
Deutetrabenazine D10701 1565v1 CYP2D6 poor metabolizer
Valbenazine D10999 1565v1 CYP2D6 poor metabolizer
Chloroquine D02125 P01BA01 G6PD deficient
Primaquine D02126 P01BA03 G6PD deficient
Quinine sulfate D02262 P01BC01
1565v1
G6PD deficient
CYP2D6 poor metabolizer
Indacaterol D09319 R03AC18 54658v1 UGT1A1 poor metabolizer
Arformoterol D02981 54658v1
1565v1
UGT1A1 poor metabolizer
CYP2D6 intermediate or poor metabolizer
Codeine D03580 R05DA04 1565v1 CYP2D6 poor metabolizer
Sodium nitrite D05865 V03AB08 G6PD deficient
Methylene blue D02312 V03AB17 G6PD deficient
Succimer D00572 G6PD deficient
Rasburicase D05704 V03AF07 G6PD deficient
CYB5R1-4 deficiency

Pathogen genes

Drug KEGG ATC Efficacy Biomarker
Maraviroc D06670 J05AX09 Antiviral CCR5-tropic HIV-1

According to the Pharmacogenomic biomarkers in drug labels

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Last updated: October 18, 2018