KEGG   DRUG: Dorzolamide hydrochlorideHelp
Entry
D00653                      Drug                                   

Name
Dorzolamide hydrochloride (JP17/USP);
Trusopt (TN)
Product
  Generic
Formula
C10H16N2O4S3. HCl
Exact mass
360.0039
Mol weight
360.901
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01534  Carbonic anhydrase inhibitor
Metabolizing enzyme substrate
 DG01642  CYP2C9 substrate
 DG01639  CYP2C19 substrate
 DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1319
ATC code: S01EC03
Chemical structure group: DG01135
Product (DG01135): D00653<JP/US>
Product (mixture): D08493<JP/US>
Efficacy
Antiglaucoma, Carbonic anhydrase inhibitor
  Disease
Open-angle glaucoma [DS:H00612]
Comment
Diuretic aciton
Target
  Pathway
hsa04964  Proximal tubule bicarbonate reclamation
Metabolism
Enzyme: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07054  Antiglaucoma agents
map07055  Sulfonamide derivatives - overview
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC03 Dorzolamide
      D00653  Dorzolamide hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Intraocular Pressure Lowering Agents
   Carbonic Anhydrase Inhibitors, Ophthalmic
    Dorzolamide
     D00653  Dorzolamide hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D00653  Dorzolamide hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Lyases (EC4)
   Aldehyde-lyases
    CA
     D00653  Dorzolamide hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00653  Dorzolamide hydrochloride
  D00653  Dorzolamide hydrochloride ophthalmic solution
BRITE hierarchy
Other DBs
CAS: 130693-82-2
PubChem: 7847719
ChEBI: 4703
ChEMBL: CHEMBL1201162
DrugBank: DB00869
LigandBox: D00653
NIKKAJI: J489.796J
KCF data Show

ATOM        20
            1   C8y C    19.3200  -14.9100
            2   C8y C    19.3200  -16.3100
            3   S2x S    20.5100  -14.2800
            4   S2x S    17.9900  -14.4900
            5   C1y C    20.5100  -17.0100
            6   C8x C    17.9900  -16.7300
            7   C1y C    21.7000  -14.9100
            8   O3c O    19.2500  -13.3700
            9   O3c O    21.6300  -13.4400
            10  C8y C    17.2200  -15.6100
            11  C1x C    21.7000  -16.3100
            12  N1b N    20.5100  -18.4100
            13  C1a C    22.8900  -14.2800
            14  S4a S    15.8200  -15.6100
            15  C1b C    21.7000  -19.0400
            16  N1a N    15.8200  -17.2200
            17  O3c O    15.8200  -14.2800
            18  O3c O    14.3500  -15.6100
            19  C1a C    21.7314  -20.4396
            20  X   Cl   23.7300  -17.6400
BOND        20
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     3   9 2
            9     4  10 1
            10    5  11 1
            11    5  12 1 #Down
            12    7  13 1 #Up
            13   10  14 1
            14   12  15 1
            15   14  16 1
            16   14  17 2
            17   14  18 2
            18    6  10 2
            19    7  11 1
            20   15  19 1

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