KEGG   DRUG: Phenobarbital sodium
Entry
D00701                      Drug                                   
Name
Phenobarbital sodium (JAN/USP/INN);
Luminal sodium (TN)
Product
SEZABY (Sun Pharmaceutical Industries)
Formula
C12H11N2O3. Na
Exact mass
254.0667
Mol weight
254.22
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG03199  Antiepileptic agent
  DG01904  Barbiturate antiepileptic
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
 DG02891  CYP2B6 inducer
 DG02886  CYP2C9 inducer
 DG02853  CYP3A/CYP3A4 inducer
Remark
Therapeutic category: 1125 1139
ATC code: N03AA02
Chemical structure group: DG00845
Product (DG00845): D00506<JP> D00701<JP/US>
Efficacy
Antianxiety, Anticonvulsant, Sedative-hypnotic
  Disease
Anxiety-tension states [DS:H01662]
Hyperthyroidism [DS:H01645]
Insomnia [DS:H01609]
Comment
Barbiturates
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
CYP induction: CYP3A [HSA:1576 1577 1551]; CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP2C9 [HSA:1559]
Structure map
map07032  Hypnotics
map07033  Anticonvulsants
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AA Barbiturates and derivatives
     N03AA02 Phenobarbital
      D00701  Phenobarbital sodium (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Barbituates
    Phenobarbital
     D00701  Phenobarbital sodium (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1125  Barbiturates and thiobarbiturates
     D00701  Phenobarbital sodium (JAN/USP/INN)
   113  Antiepileptics
    1139  Others
     D00701  Phenobarbital sodium (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   DG00845  Phenobarbital
    D00701  Phenobarbital sodium
  DG03199  Antiepileptic agent
   DG01904  Barbiturate antiepileptic
    DG00845  Phenobarbital
     D00701  Phenobarbital sodium
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00845  Phenobarbital
    D00701  Phenobarbital sodium
  DG02891  CYP2B6 inducer
   DG00845  Phenobarbital
    D00701  Phenobarbital sodium
  DG02886  CYP2C9 inducer
   DG00845  Phenobarbital
    D00701  Phenobarbital sodium
  DG02853  CYP3A/CYP3A4 inducer
   DG00845  Phenobarbital
    D00701  Phenobarbital sodium
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00701  Phenobarbital sodium
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00701  Phenobarbital sodium (JAN/USP/INN) <JP/US>
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00701
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   DG00845  Phenobarbital
  DG03199  Antiepileptic agent
   DG01904  Barbiturate antiepileptic
    DG00845  Phenobarbital
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   DG00845  Phenobarbital
  DG02891  CYP2B6 inducer
   DG00845  Phenobarbital
  DG02886  CYP2C9 inducer
   DG00845  Phenobarbital
  DG02853  CYP3A/CYP3A4 inducer
   DG00845  Phenobarbital
Other DBs
CAS: 57-30-7
PubChem: 7847766
ChEBI: 8070
LigandBox: D00701
NIKKAJI: J246.884K
KCF data

ATOM        18
            1   C1z C    25.6023  -19.5651
            2   C8y C    26.8072  -18.8573
            3   C5x C    25.6023  -20.9690
            4   C5x C    24.3621  -18.8807
            5   C1b C    26.8014  -20.2611
            6   C8x C    28.0180  -19.5417
            7   C8x C    26.7897  -17.4536
            8   N1x N    24.3621  -21.6709
            9   O5x O    26.7955  -21.6709
            10  N2x N    23.1573  -19.5651
            11  O5x O    24.3621  -17.4653
            12  C1a C    28.2053  -20.2611
            13  C8x C    29.2230  -18.8340
            14  C8x C    27.9946  -16.7457
            15  C2y C    23.1573  -20.9690
            16  C8x C    29.2113  -17.4359
            17  O1a O    21.9465  -21.6650 #-
            18  Z   Na   20.0103  -19.7054 #+
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     1   5 1
            5     2   6 2
            6     2   7 1
            7     3   8 1
            8     3   9 2
            9     4  10 1
            10    4  11 2
            11    5  12 1
            12    6  13 1
            13    7  14 2
            14    8  15 1
            15   13  16 2
            16   15  17 1
            17   10  15 2
            18   14  16 1

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Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (3)   
   PubChem (1)   
   ChEBI (1)   
   NIKKAJI (1)   
All databases (5)   

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