| Entry |
|
|---|
| Name |
Amosulalol hydrochloride (JP18);
Lowgan (TN) |
|---|
| Formula |
C18H24N2O5S. HCl
|
|---|
| Exact mass |
416.1173
|
|---|
| Mol weight |
416.9195
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
|
|---|
| Remark |
| Therapeutic category: | 2149 |
| Product (DG01302): | D01469<JP> |
|
|---|
| Efficacy |
Antihypertansive, alpha1/beta-Adrenergic receptor antagonist |
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07214 | beta-Adrenergic receptor agonists/antagonists |
| map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
|---|
| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01469 Amosulalol hydrochloride (JP18)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
D01469 Amosulalol hydrochloride
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
D01469 Amosulalol hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01469 Amosulalol hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01469 Amosulalol hydrochloride (JP18) <JP>
ADRB1
D01469 Amosulalol hydrochloride (JP18) <JP>
ADRB2
D01469 Amosulalol hydrochloride (JP18) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01469 Amosulalol hydrochloride
D01469 Amosulalol hydrochloride tablets
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
DG03231 Antihypertensive
DG03180 alpha1 and beta-Adrenergic receptor antagonist
DG01302 Amosulalol
|
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| Other DBs |
|
|---|
| KCF data |
ATOM 27
1 C8y C 8.8900 -28.7000
2 C8x C 8.8900 -30.1000
3 C8x C 10.1024 -30.8000
4 C8y C 11.3149 -30.1000
5 C8x C 11.3149 -28.7000
6 C8y C 10.1024 -28.0000
7 C1a C 7.6776 -28.0000
8 S4a S 10.1024 -26.6002
9 N1a N 10.1024 -25.2002
10 O3c O 8.6800 -26.6002
11 O3c O 11.4800 -26.6002
12 C1c C 12.5460 -30.8110
13 C1b C 13.7512 -30.1153
14 O1a O 12.5457 -32.1999
15 N1b N 14.9335 -30.7981
16 C1b C 16.1275 -30.1088
17 C1b C 17.3154 -30.7948
18 O2a O 18.5065 -30.1071
19 C8y C 19.6959 -30.7939
20 C8y C 19.6959 -32.1998
21 C8x C 20.9084 -32.8998
22 C8x C 22.1208 -32.1998
23 C8x C 22.1208 -30.7939
24 C8x C 20.9084 -30.0939
25 O2a O 18.4641 -32.9112
26 C1a C 17.2588 -32.2154
27 X Cl 24.6400 -31.5000
BOND 27
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 1 7 1
8 6 8 1
9 8 9 1
10 8 10 2
11 8 11 2
12 4 12 1
13 12 13 1
14 12 14 1
15 13 15 1
16 15 16 1
17 16 17 1
18 17 18 1
19 18 19 1
20 19 20 2
21 20 21 1
22 21 22 2
23 22 23 1
24 23 24 2
25 19 24 1
26 20 25 1
27 25 26 1
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