KEGG   DRUG: Modafinil
Entry
D01832                      Drug                                   

Name
Modafinil (JAN/USP/INN);
Provigil (TN)
Product
  Generic
MODAFINIL (A-S Medication Solutions), MODAFINIL (A-S Medication Solutions), MODAFINIL (A-S Medication Solutions), MODAFINIL (Actavis Pharma), MODAFINIL (Alembic Pharmaceuticals), MODAFINIL (Alembic Pharmaceuticals Limited), MODAFINIL (American Health Packaging), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Apotex Corp.), MODAFINIL (Aurobindo Pharma Limited), MODAFINIL (AvKARE), MODAFINIL (AvPAK), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (CIMA LABS), MODAFINIL (Cadila Healthcare Limited), MODAFINIL (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MODAFINIL (Major Pharmaceuticals), MODAFINIL (Major Pharmaceuticals), MODAFINIL (Mylan Pharmaceuticals), MODAFINIL (NuCare Pharmaceuticals), MODAFINIL (OrchidPharma), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Proficient Rx LP), MODAFINIL (Proficient Rx LP), MODAFINIL (Quality Care Products), MODAFINIL (Rising Health), MODAFINIL (Viona Pharmaceuticals)
Formula
C15H15NO2S
Exact mass
273.0823
Mol weight
273.3501
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01971  Agents for narcolepsy
Metabolizing enzyme substrate
 DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
 DG02891  CYP2B6 inducer
 DG01635  CYP3A4 inducer
Remark
Therapeutic category: 1179
ATC code: N06BA07
Product: D01832<JP/US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Comment
Treatment of narcolepsy and hypersomnia
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
CYP induction: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP3A4 [HSA:1576]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA07 Modafinil
      D01832  Modafinil (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Wakefulness Promoting Agents
   Modafinil
    D01832  Modafinil (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01832  Modafinil (JAN/USP/INN)
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01832
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01832
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01832
Other DBs
CAS: 68693-11-8
PubChem: 7848894
ChEBI: 31859
ChEMBL: CHEMBL1373
DrugBank: DB00745
LigandBox: D01832
NIKKAJI: J33.118J
KCF data

ATOM        19
            1   C8x C    21.4292  -18.4524
            2   C8x C    21.4292  -19.8539
            3   C8x C    22.6459  -20.5546
            4   C8x C    23.8554  -19.8539
            5   C8y C    23.8554  -18.4524
            6   C8x C    22.6459  -17.7516
            7   C1c C    25.0604  -17.7516
            8   C8y C    26.2708  -18.4524
            9   C8x C    26.2691  -19.8510
            10  C8x C    27.4794  -20.5517
            11  C8x C    28.6914  -19.8539
            12  C8x C    28.6931  -18.4552
            13  C8x C    27.4828  -17.7545
            14  S4a S    25.0590  -16.3501
            15  C1b C    26.2721  -15.6482
            16  O3c O    23.8447  -15.6505
            17  C5a C    26.2708  -14.2467
            18  N1a N    27.4839  -13.5447
            19  O5a O    25.0563  -13.5471
BOND        20
            1     4   5 1
            2     5   6 2
            3     6   1 1
            4     8   9 2
            5     9  10 1
            6    10  11 2
            7    11  12 1
            8    12  13 2
            9    13   8 1
            10    7  14 1
            11    5   7 1
            12   14  15 1
            13    1   2 2
            14   14  16 2
            15    7   8 1
            16   15  17 1
            17    2   3 1
            18   17  18 1
            19    3   4 2
            20   17  19 2

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   KEGG BRITE (6)   
Disease (1)   
   KEGG DISEASE (1)   
Drug (9)   
   KEGG DGROUP (6)   
   CHEMBL (1)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (9)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   MASSBANK (4)   
   NIKKAJI (1)   
All databases (25)   

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