KEGG   DRUG: Modafinil
Entry
D01832                      Drug                                   
Name
Modafinil (JAN/USP/INN);
Provigil (TN)
Product
PROVIGIL (Cephalon)
  Generic
MODAFINIL (Alembic Pharmaceuticals Limited), MODAFINIL (Alembic Pharmaceuticals), MODAFINIL (American Health Packaging), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Aphena Pharma Solutions - Tennessee), MODAFINIL (Apotex Corp.), MODAFINIL (Aurobindo Pharma Limited), MODAFINIL (AvPAK), MODAFINIL (Bionpharma), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (Bryant Ranch Prepack), MODAFINIL (CIMA LABS), MODAFINIL (Golden State Medical Supply), MODAFINIL (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), MODAFINIL (Major Pharmaceuticals), MODAFINIL (NuCare Pharmaceuticals), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Preferred Pharmaceuticals), MODAFINIL (Proficient Rx LP), MODAFINIL (Proficient Rx LP), MODAFINIL (Proficient Rx LP), MODAFINIL (Rising Pharma Holdings), MODAFINIL (Viona Pharmaceuticals), MODAFINIL (Zydus Lifesciences Limited)
Formula
C15H15NO2S
Exact mass
273.0824
Mol weight
273.35
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01971  Agents for narcolepsy
Metabolizing enzyme substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Metabolizing enzyme inhibitor
 DG01643  CYP2C9 inhibitor
 DG01933  CYP2C19 inhibitor
Metabolizing enzyme inducer
 DG01637  CYP1A2 inducer
 DG02891  CYP2B6 inducer
 DG02853  CYP3A/CYP3A4 inducer
  DG01635  CYP3A4 inducer
Remark
Therapeutic category: 1179
ATC code: N06BA07
Product: D01832<JP/US>
Efficacy
Stimulant (central)
  Disease
Narcolepsy [DS:H01293]
Comment
Treatment of narcolepsy and hypersomnia
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
CYP inhibition: CYP2C9 [HSA:1559], CYP2C19 [HSA:1557]
CYP induction: CYP1A2 [HSA:1544], CYP2B6 [HSA:1555], CYP3A4 [HSA:1576]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA07 Modafinil
      D01832  Modafinil (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  Wakefulness Promoting Agents
   Modafinil
    D01832  Modafinil (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D01832  Modafinil (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01971  Agents for narcolepsy
   D01832  Modafinil
 Metabolizing enzyme substrate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D01832  Modafinil
 Metabolizing enzyme inhibitor
  DG01643  CYP2C9 inhibitor
   D01832  Modafinil
  DG01933  CYP2C19 inhibitor
   D01832  Modafinil
 Metabolizing enzyme inducer
  DG01637  CYP1A2 inducer
   D01832  Modafinil
  DG02891  CYP2B6 inducer
   D01832  Modafinil
  DG02853  CYP3A/CYP3A4 inducer
   DG01635  CYP3A4 inducer
    D01832  Modafinil
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D01832
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D01832
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D01832
Narcotics and psychotropics in Japan [br08308.html]
 Psychotropics by Cabinet order Article 3 (78 substances)
  D01832
Other DBs
CAS: 68693-11-8
PubChem: 7848894
ChEBI: 31859
LigandBox: D01832
NIKKAJI: J33.118J
KCF data

ATOM        19
            1   C8x C    21.4292  -18.4524
            2   C8x C    21.4292  -19.8539
            3   C8x C    22.6459  -20.5546
            4   C8x C    23.8554  -19.8539
            5   C8y C    23.8554  -18.4524
            6   C8x C    22.6459  -17.7516
            7   C1c C    25.0604  -17.7516
            8   C8y C    26.2708  -18.4524
            9   C8x C    26.2691  -19.8510
            10  C8x C    27.4794  -20.5517
            11  C8x C    28.6914  -19.8539
            12  C8x C    28.6931  -18.4552
            13  C8x C    27.4828  -17.7545
            14  S4a S    25.0590  -16.3501
            15  C1b C    26.2721  -15.6482
            16  O3c O    23.8447  -15.6505
            17  C5a C    26.2708  -14.2467
            18  N1a N    27.4839  -13.5447
            19  O5a O    25.0563  -13.5471
BOND        20
            1     4   5 1
            2     5   6 2
            3     6   1 1
            4     8   9 2
            5     9  10 1
            6    10  11 2
            7    11  12 1
            8    12  13 2
            9    13   8 1
            10    7  14 1
            11    5   7 1
            12   14  15 1
            13    1   2 2
            14   14  16 2
            15    7   8 1
            16   15  17 1
            17    2   3 1
            18   17  18 1
            19    3   4 2
            20   17  19 2

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Drug (2)   
   LigandBox (1)   
   SIDER (1)   
Chemical substance (9)   
   PubChem (1)   
   ChEBI (1)   
   HMDB (1)   
   HSDB (1)   
   MASSBANK (4)   
   NIKKAJI (1)   
All databases (11)   

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