| Entry |
|
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| Name |
Clomipramine (INN);
Anafranil (TN) |
|---|
| Formula |
C19H23ClN2
|
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| Exact mass |
314.155
|
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| Mol weight |
314.8523
|
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| Structure |
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| Simcomp |
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| Class |
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG01728 Tricyclic antidepressant
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG01639 CYP2C19 substrate
DG01644 CYP2D6 substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
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| Remark |
| Product (DG00929): | D00811<JP/US> |
|
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| Efficacy |
Antidepressant, Serotonin-noradrenaline reuptake inhibitor (SNRI) |
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| Target |
|
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]; CYP1A2 [HSA: 1544], CYP3A4 [HSA: 1576], CYP2C19 [HSA: 1557]
|
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| Interaction |
|
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| Structure map |
| map07234 | Neurotransmitter transporter inhibitors |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AA Non-selective monoamine reuptake inhibitors
N06AA04 Clomipramine
D07727 Clomipramine (INN)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00929 Clomipramine
D07727 Clomipramine
DG01728 Tricyclic antidepressant
DG00929 Clomipramine
D07727 Clomipramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00929 Clomipramine
D07727 Clomipramine
DG01639 CYP2C19 substrate
DG00929 Clomipramine
D07727 Clomipramine
DG01644 CYP2D6 substrate
DG00929 Clomipramine
D07727 Clomipramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00929 Clomipramine
D07727 Clomipramine
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC6
SLC6A2 (NAT1)
D07727 Clomipramine (INN)
SLC6A4 (HTT)
D07727 Clomipramine (INN)
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D07727
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01730 Non-selective monoamine reuptake inhibitor
DG00929 Clomipramine
DG01728 Tricyclic antidepressant
DG00929 Clomipramine
Metabolizing enzyme substrate
DG01892 CYP1A2 substrate
DG00929 Clomipramine
DG01639 CYP2C19 substrate
DG00929 Clomipramine
DG01644 CYP2D6 substrate
DG00929 Clomipramine
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00929 Clomipramine
|
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| Other DBs |
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| KCF data |
ATOM 22
1 C1x C 23.3100 -21.2100
2 C8y C 22.4700 -20.0900
3 C8y C 22.7500 -18.6900
4 N1y N 24.0800 -18.1300
5 C1x C 24.7100 -21.2100
6 C8y C 25.2700 -18.7600
7 C8y C 25.6200 -20.1600
8 C8x C 21.7700 -17.7800
9 C8y C 20.4400 -18.1300
10 C8x C 20.0900 -19.5300
11 C8x C 21.0700 -20.4400
12 C8x C 26.9500 -20.5800
13 C8x C 28.0000 -19.6700
14 C8x C 27.7200 -18.2700
15 C8x C 26.3200 -17.8500
16 X Cl 19.3900 -17.1500
17 C1b C 24.0800 -16.7300
18 C1b C 25.2700 -16.1000
19 C1b C 26.4600 -16.8000
20 N1c N 27.7200 -16.1000
21 C1a C 28.9100 -16.8700
22 C1a C 27.7200 -14.7000
BOND 24
1 3 4 1
2 1 5 1
3 4 6 1
4 2 3 1
5 5 7 1
6 1 2 1
7 6 7 1
8 3 8 2
9 8 9 1
10 9 10 2
11 10 11 1
12 2 11 2
13 7 12 2
14 12 13 1
15 13 14 2
16 14 15 1
17 6 15 2
18 9 16 1
19 4 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 20 22 1
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