KEGG   DRUG: LenvatinibHelp
Entry
D09919                      Drug                                   

Name
Lenvatinib (USAN/INN)
Formula
C21H19ClN4O4
Exact mass
426.1095
Mol weight
426.853
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Metabolizing enzyme substrate
 DG01633  CYP3A substrate
Transporter substrate
 DG01665  ABCB1 (P-GP) substrate
Remark
ATC code: L01XE29
Chemical structure group: DG01362
Product (DG01362): D09920<JP/US>
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
FGFR [HSA:2260 2263 2261 2264] [KO:K04362 K05093 K05094 K05095]
RET [HSA:5979] [KO:K05126]
  Pathway
hsa04010  MAPK signaling pathway
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer
hsa05216  Thyroid cancer
Metabolism
Enzyme: CYP3A [HSA:1576 1577 1551]
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE29 Lenvatinib
      D09919  Lenvatinib (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   FGFR family
    FGFR
     D09919  Lenvatinib (USAN/INN)
   VEGFR family
    VEGFR1 (FLT1)
     D09919  Lenvatinib (USAN/INN)
    VEGFR2 (KDR)
     D09919  Lenvatinib (USAN/INN)
    VEGFR3 (FLT4)
     D09919  Lenvatinib (USAN/INN)
   RET family
    RET
     D09919  Lenvatinib (USAN/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D09919
BRITE hierarchy
Other DBs
CAS: 417716-92-8
PubChem: 135626656
ChEBI: 85994
ChEMBL: CHEMBL1289601
PDB-CCD: LEV[PDBj]
LigandBox: D09919
KCF data Show

ATOM        30
            1   C8y C     8.9600  -18.7600
            2   C8y C     8.9600  -20.1600
            3   C8x C    10.1724  -20.8600
            4   C8y C    11.3849  -20.1600
            5   C8y C    11.3849  -18.7600
            6   C8x C    10.1724  -18.0600
            7   C8y C    12.5973  -20.8600
            8   C8x C    13.8097  -20.1600
            9   C8x C    13.8097  -18.7600
            10  N5x N    12.5973  -18.0600
            11  O2a O    12.5973  -22.2600
            12  C8y C    13.8118  -22.9612
            13  C8x C    13.8117  -24.3598
            14  C8y C    15.0242  -25.0599
            15  C8y C    16.2366  -24.3599
            16  C8x C    16.2366  -22.9612
            17  C8x C    15.0242  -22.2612
            18  O2a O     7.7476  -18.0600
            19  C5a C     7.7476  -20.8600
            20  N1a N     6.5521  -20.1696
            21  O5a O     7.7475  -22.2598
            22  X   Cl   15.0241  -26.4598
            23  N1b N    17.4516  -25.0614
            24  C5a C    18.6483  -24.3703
            25  N1b N    19.8350  -25.0555
            26  O5a O    18.6485  -22.9603
            27  C1a C     6.5521  -18.7504
            28  C1y C    21.0267  -24.3674
            29  C1x C    22.4267  -24.3674
            30  C1x C    21.7267  -23.1549
BOND        33
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20    1  18 1
            21    2  19 1
            22   19  20 1
            23   19  21 2
            24   14  22 1
            25   15  23 1
            26   23  24 1
            27   24  25 1
            28   24  26 2
            29   18  27 1
            30   25  28 1
            31   28  29 1
            32   28  30 1
            33   30  29 1

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