KEGG   DRUG: Brinzolamide and timolol maleateHelp
Entry
D10512            Mixture   Drug                                   

Name
Brinzolamide and timolol maleate;
Azorga (TN)
Component
Brinzolamide [DR:D00652], Timolol maleate [DR:D00603]
Remark
Therapeutic category: 1319
ATC code: S01EC54 S01ED51
Product: D10512<JP>
Efficacy
Antiglaucoma
Comment
Carbonic anhydrase inhibitor / bete-adrenergic receptor antagonist combination
Brinzolamide is metabolized by CYP3A4 with some contribution from CYP2A6, CYP2B6, CYP2C8 and CYP2C9.
Timolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]; CYP2A6 [HSA:1548], CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC54 Brinzolamide, combinations
      D10512  Brinzolamide and timolol maleate <JP>
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D10512  Brinzolamide and timolol maleate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D10512  Brinzolamide and timolol maleate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10512
BRITE hierarchy
Other DBs
PubChem: 172232605

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