KEGG   DRUG: Brinzolamide and timolol maleate
Entry
D10512            Mixture   Drug                                   
Name
Brinzolamide and timolol maleate;
Azorga (TN)
Component
Brinzolamide [DR:D00652], Timolol maleate [DR:D00603]
Class
Ophthalmic agent
 DG03201  Intraocular pressure lowering agent
  DG03030  Combination of carbonic anhydrase inhibitor and beta blocker
Metabolizing enzyme substrate
 DG01638  CYP2A6 substrate
 DG02919  CYP2B6 substrate
 DG02918  CYP2C8 substrate
 DG01642  CYP2C9 substrate
 DG01644  CYP2D6 substrate
 DG01633  CYP3A/CYP3A4 substrate
  DG02913  CYP3A4 substrate
Remark
Therapeutic category: 1319
ATC code: S01EC54 S01ED51
Product: D10512<JP>
Efficacy
Antiglaucoma
Comment
Carbonic anhydrase inhibitor / bete-adrenergic receptor antagonist combination
Brinzolamide is metabolized by CYP3A4 with some contribution from CYP2A6, CYP2B6, CYP2C8 and CYP2C9.
Timolol is primarily metabolized by CYP2D6.
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]; CYP2A6 [HSA:1548], CYP2B6 [HSA:1555], CYP2C8 [HSA:1558], CYP2C9 [HSA:1559]
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EC Carbonic anhydrase inhibitors
     S01EC54 Brinzolamide, combinations
      D10512  Brinzolamide and timolol maleate <JP>
    S01ED Beta blocking agents
     S01ED51 Timolol, combinations
      D10512  Brinzolamide and timolol maleate <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D10512  Brinzolamide and timolol maleate
Drug groups [BR:br08330]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   DG03030  Combination of carbonic anhydrase inhibitor and beta blocker
    D10512  Brinzolamide and timolol maleate
 Metabolizing enzyme substrate
  DG01638  CYP2A6 substrate
   D10512  Brinzolamide and timolol maleate
  DG02919  CYP2B6 substrate
   D10512  Brinzolamide and timolol maleate
  DG02918  CYP2C8 substrate
   D10512  Brinzolamide and timolol maleate
  DG01642  CYP2C9 substrate
   D10512  Brinzolamide and timolol maleate
  DG01644  CYP2D6 substrate
   D10512  Brinzolamide and timolol maleate
  DG01633  CYP3A/CYP3A4 substrate
   DG02913  CYP3A4 substrate
    D10512  Brinzolamide and timolol maleate
Drug classes [BR:br08332]
 Ophthalmic agent
  DG03201  Intraocular pressure lowering agent
   D10512  Brinzolamide and timolol maleate
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D10512
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D10512
Other DBs
PubChem: 172232605

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