KEGG   DRUG: RivoceranibHelp
Entry
D11288                      Drug                                   

Name
Rivoceranib (USAN/INN);
Apatinib
Formula
C24H23N5O
Exact mass
397.1903
Mol weight
397.4723
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Remark
Chemical structure group: DG02966
Efficacy
Antineoplastic, Receptor tyrosine kinase inhibitor
Target
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
  Pathway
hsa04010  MAPK signaling pathway
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
Interaction
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   VEGFR family
    VEGFR2 (KDR)
     D11288  Rivoceranib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 811803-05-1
PubChem: 384585266
ChEMBL: CHEMBL3186534
KCF data Show

ATOM        30
            1   C8y C    15.4700  -18.3400
            2   C8x C    14.2100  -19.0400
            3   C8x C    13.0200  -18.2700
            4   C8y C    13.0200  -16.9400
            5   C8x C    14.2100  -16.2400
            6   C8x C    15.4700  -16.9400
            7   N1b N    11.8300  -16.1700
            8   C5a C    10.5700  -16.8700
            9   O5a O    10.5700  -18.2700
            10  C8y C     9.3800  -16.1700
            11  C8y C     8.1900  -16.8700
            12  N5x N     7.0000  -16.1700
            13  C8x C     7.0000  -14.7700
            14  C8x C     8.1900  -14.0700
            15  C8x C     9.3800  -14.7700
            16  N1b N     8.1900  -18.2700
            17  C1b C     6.9776  -18.9700
            18  C8y C     5.7821  -18.2796
            19  C8x C     5.7820  -16.8703
            20  C8x C     4.5696  -16.1703
            21  N5x N     3.3572  -16.8703
            22  C8x C     3.3572  -18.2797
            23  C8x C     4.5696  -18.9796
            24  C1z C    16.6757  -19.0514
            25  C1x C    16.6901  -20.4397
            26  C1x C    18.0149  -20.8550
            27  C1x C    18.8193  -19.7234
            28  C1x C    17.9916  -18.6087
            29  C3b C    16.6766  -17.6500
            30  N3a N    16.6766  -16.2500
BOND        33
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    8  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15   14  15 2
            16   10  15 1
            17   11  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   20  21 2
            23   21  22 1
            24   22  23 2
            25   18  23 1
            26    1  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   24  28 1
            32   24  29 1
            33   29  30 3

» Japanese version   » Back

DBGET integrated database retrieval system