KEGG DISEASE: Small cell lung cancer

DISEASE: Small cell lung cancer

Entry

H00013                      Disease

Name

Small cell lung cancer

Description

Lung cancer is a leading cause of cancer death among men and women in industrialized countries. Small cell lung carcinoma (SCLC) is a highly aggressive neoplasm, which accounts for approximately 25% of all lung cancer cases. Molecular mechanisms altered in SCLC include induced expression of oncogene, MYC, and loss of tumorsuppressor genes, such as p53, PTEN, RB, and FHIT. The overexpression of MYC proteins in SCLC is largely a result of gene amplification. Such overexpression leads to more rapid proliferation and loss of terminal differentiation. Mutation or deletion of p53 or PTEN can lead to more rapid proliferation and reduced apoptosis. The retinoblastoma gene RB1 encodes a nuclear phosphoprotein that helps to regulate cell-cycle progression. The fragile histidine triad gene FHIT encodes the enzyme diadenosine triphosphate hydrolase, which is thought to have an indirect role in proapoptosis and cell-cycle control.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of middle ear, respiratory or intrathoracic organs
     2C25  Malignant neoplasms of bronchus or lung
      H00013  Small cell lung cancer
Pathway-based classification of diseases [BR:br08402]
Signal transduction
  nt06526  MAPK signaling
   H00013  Small cell lung cancer
Cellular processes
  nt06512  Chromosome cohesion and segregation
   H00013  Small cell lung cancer
  nt06524  Apoptosis
   H00013  Small cell lung cancer
Tumor markers [br08442.html]
H00013
Cancer-associated carbohydrates [br08441.html]
H00013

Disease
pathway

hsa05222

Small cell lung cancer

Pathway

hsa04210

Apoptosis

Network

nt06267 Small cell lung cancer
nt06512 Chromosome cohesion and segregation
nt06524 Apoptosis

Gene

MYC (amplification) [HSA:4609] [KO:K04377]
BCL2 (overexpression) [HSA:596] [KO:K02161]
FHIT [HSA:2272] [KO:K01522]
TP53 [HSA:7157] [KO:K04451]
RB1 [HSA:5925] [KO:K06618]
PTEN [HSA:5728] [KO:K01110]
PPP2R1B [HSA:5519] [KO:K03456]

Drug

Methotrexate sodium [DR:D02115]
Etoposide [DR:D00125]
Etoposide phosphate [DR:D04107]
Topotecan hydrochloride [DR:D02168]
Nivolumab [DR:D10316]
Durvalumab [DR:D10808]
Atezolizumab [DR:D10773]
Tarlatamab [DR:D12234]
Lurbinectedin [DR:D11644]
Trilaciclib dihydrochloride [DR:D11987]

Other DBs

ICD-11:

2C25.1

MeSH:

D055752

Reference

PMID:12741677

Authors

Yokota J, Nishioka M, Tani M, Kohno T.

Title

Genetic alterations responsible for metastatic phenotypes of lung cancer cells.

Journal

Clin Exp Metastasis 20:189-93 (2003)
DOI:10.1023/a:1022978932215

Reference

PMID:12711111

Authors

Sanchez-Cespedes M.

Title

Dissecting the genetic alterations involved in lung carcinogenesis.

Journal

Lung Cancer 40:111-21 (2003)
DOI:10.1016/S0169-5002(03)00033-3

Reference

PMID:12407699

Authors

Mitsuuchi Y, Testa JR.

Title

Cytogenetics and molecular genetics of lung cancer.

Journal

Am J Med Genet 115:183-8 (2002)
DOI:10.1002/ajmg.10692

Reference

PMID:16112428

Authors

Panani AD, Roussos C.

Title

Cytogenetic and molecular aspects of lung cancer.

Journal

Cancer Lett 239:1-9 (2006)
DOI:10.1016/j.canlet.2005.06.030

Reference

PMID:2983887 (MYC amplification)

Authors

Saksela K, Bergh J, Lehto VP, Nilsson K, Alitalo K

Title

Amplification of the c-myc oncogene in a subpopulation of human small cell lung cancer.

Journal

Cancer Res 45:1823-7 (1985)

Reference

PMID:17426248 (BCL2 overexpression)

Authors

Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D

Title

Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Journal

Mol Cancer Res 5:331-9 (2007)
DOI:10.1158/1541-7786.MCR-06-0367

Reference

PMID:8620533 (FHIT)

Authors

Sozzi G, Veronese ML, Negrini M, Baffa R, Cotticelli MG, Inoue H, Tornielli S, Pilotti S, De Gregorio L, Pastorino U, Pierotti MA, Ohta M, Huebner K, Croce CM

Title

The FHIT gene 3p14.2 is abnormal in lung cancer.

Journal

Cell 85:17-26 (1996)
DOI:10.1016/s0092-8674(00)81078-8

Reference

PMID:2554494 (TP53)

Authors

Takahashi T, Nau MM, Chiba I, Birrer MJ, Rosenberg RK, Vinocour M, Levitt M, Pass H, Gazdar AF, Minna JD

Title

p53: a frequent target for genetic abnormalities in lung cancer.

Journal

Science 246:491-4 (1989)
DOI:10.1126/science.2554494

Reference

PMID:2594029 (RB1)

Authors

Yandell DW, Campbell TA, Dayton SH, Petersen R, Walton D, Little JB, McConkie-Rosell A, Buckley EG, Dryja TP

Title

Oncogenic point mutations in the human retinoblastoma gene: their application to genetic counseling.

Journal

N Engl J Med 321:1689-95 (1989)
DOI:10.1056/NEJM198912213212501

Reference

PMID:9696041 (PTEN)

Authors

Yokomizo A, Tindall DJ, Drabkin H, Gemmill R, Franklin W, Yang P, Sugio K, Smith DI, Liu W

Title

PTEN/MMAC1 mutations identified in small cell, but not in non-small cell lung cancers.

Journal

Oncogene 17:475-9 (1998)
DOI:10.1038/sj.onc.1201956

Reference

PMID:9765152 (PPP2R1B)

Authors

Wang SS, Esplin ED, Li JL, Huang L, Gazdar A, Minna J, Evans GA

Title

Alterations of the PPP2R1B gene in human lung and colon cancer.

Journal

Science 282:284-7 (1998)
DOI:10.1126/science.282.5387.284

» Japanese version

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