KEGG DISEASE: Esophageal cancer

DISEASE: Esophageal cancer

Entry

H00017                      Disease

Name

Esophageal cancer

Description

Esophageal cancer represents the 9th leading cancer in the world and is associated with a 5-year survival rate under 25%. The two main forms are squamous-cell carcinoma (ESCC) and adenocarcinoma (EAC). ESCC is the most frequent histological subtype in esophageal cancer, although the incidence of EAC is increasing faster than any other malignancy in the western world. Whereas ESCC can be attributed to alcohol and tobacco consumption, the most important risk factor for the development of EAC is duodenal-gastric-esophageal reflux. In the process of tumorigenesis at the cellular level, multiple genetic alterations are involved, including mutation of the p53 gene, amplification of cyclin D1 gene, among others.

Category

Cancer

Brite

Human diseases in ICD-11 classification [BR:br08403]
02 Neoplasms
  Malignant neoplasms, except primary neoplasms of lymphoid, haematopoietic, central nervous system or related tissues
   Malignant neoplasms, stated or presumed to be primary, of specified sites, except of lymphoid, haematopoietic, central nervous system or related tissues
    Malignant neoplasms of digestive organs
     2B70  Malignant neoplasms of oesophagus
      H00017  Esophageal cancer

Pathway

hsa04110

Cell cycle

hsa04218

Cellular senescence

Gene

EGFR (overexpression) [HSA:1956] [KO:K04361]
PTGS2 (overexpression) [HSA:5743] [KO:K11987]
NOS2 (increased expression) [HSA:4843] [KO:K13241]
FAS (increased expression) [HSA:355] [KO:K04390]
CCND1 (amplification) [HSA:595] [KO:K04503]
TP53 [HSA:7157] [KO:K04451]
CDKN2A [HSA:1029] [KO:K06621]
RB1 [HSA:5925] [KO:K06618]
APC [HSA:324] [KO:K02085]
DCC [HSA:1630] [KO:K06765]
LZTS1 [HSA:11178] [KO:K26460]
RNF6 [HSA:6049] [KO:K22753]
TGFBR2 [HSA:7048] [KO:K04388]
WWOX [HSA:51741] [KO:K19329]

Drug

Capecitabine [DR:D01223]
Floxuridine [DR:D04197]
Nivolumab [DR:D10316]
Pembrolizumab [DR:D10574] (PD-L1 expressed)
Tislelizumab [DR:D11487]
Porfimer sodium [DR:D03327]

Other DBs

ICD-11:

ICD-10:

MeSH:

OMIM:

Reference

PMID:15622457 (EGFR, TP53, PTGS2, NOS2, CCND1, CDKN2A, RB1)

Authors

Kuwano H, Kato H, Miyazaki T, Fukuchi M, Masuda N, Nakajima M, Fukai Y, Sohda M, Kimura H, Faried A.

Title

Genetic alterations in esophageal cancer.

Journal

Surg Today 35:7-18 (2005)
DOI:10.1007/s00595-004-2885-3

Reference

PMID:12951586 (APC, CDKN2A, NOS2, RB1, PTGS2, TP53, RB1, EGFR, FAS)

Authors

Wild CP, Hardie LJ.

Title

Reflux, Barrett's oesophagus and adenocarcinoma: burning questions.

Journal

Nat Rev Cancer 3:676-84 (2003)
DOI:10.1038/nrc1166

Reference

PMID:15914317 (CCND1, TP53, RB1, CDKN2A, APC, WWOX, FAS)

Authors

McCabe ML, Dlamini Z.

Title

The molecular mechanisms of oesophageal cancer.

Journal

Int Immunopharmacol 5:1113-30 (2005)
DOI:10.1016/j.intimp.2004.11.017

Reference

PMID:8187090 (DCC)

Authors

Miyake S, Nagai K, Yoshino K, Oto M, Endo M, Yuasa Y

Title

Point mutations and allelic deletion of tumor suppressor gene DCC in human esophageal squamous cell carcinomas and their relation to metastasis.

Journal

Cancer Res 54:3007-10 (1994)

Reference

PMID:11504921 (LZTS1)

Authors

Ishii H, Vecchione A, Murakumo Y, Baldassarre G, Numata S, Trapasso F, Alder H, Baffa R, Croce CM

Title

FEZ1/LZTS1 gene at 8p22 suppresses cancer cell growth and regulates mitosis.

Journal

Proc Natl Acad Sci U S A 98:10374-9 (2001)
DOI:10.1073/pnas.181222898

Reference

PMID:12154016 (RNF6)

Authors

Lo HS, Hu N, Gere S, Lu N, Su H, Goldstein AM, Taylor PR, Lee MP

Title

Identification of somatic mutations of the RNF6 gene in human esophageal squamous cell carcinoma.

Journal

Cancer Res 62:4191-3 (2002)

Reference

PMID:10789724 (TGFBR2)

Authors

Tanaka S, Mori M, Mafune K, Ohno S, Sugimachi K

Title

A dominant negative mutation of transforming growth factor-beta receptor type II gene in microsatellite stable oesophageal carcinoma.

Journal

Br J Cancer 82:1557-60 (2000)
DOI:10.1054/bjoc.1999.1178

Reference

PMID:11956080 (WWOX)

Authors

Kuroki T, Trapasso F, Shiraishi T, Alder H, Mimori K, Mori M, Croce CM

Title

Genetic alterations of the tumor suppressor gene WWOX in esophageal squamous cell carcinoma.

Journal

Cancer Res 62:2258-60 (2002)

» Japanese version

All links

Disease (1)   
   OMIM (1)   
Drug (16)   
   KEGG DRUG (16)   
Gene (28)   
   KEGG ORTHOLOGY (14)   
   KEGG GENES (14)   
Literature (8)   
   PubMed (8)   
All databases (53)   

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