KEGG ENZYME: 1.1.1.105

ENZYME: 1.1.1.105

Entry

EC 1.1.1.105                Enzyme

Name

all-trans-retinol dehydrogenase (NAD+);
retinol (vitamin A1) dehydrogenase;
MDR;
microsomal retinol dehydrogenase;
retinol dehydrogenase (misleading);
retinal reductase (ambiguous);
retinene reductase;
epidermal retinol dehydrogenase 2;
SDR16C5 (gene name);
RDH16 (gene name)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

all-trans retinol:NAD+ oxidoreductase

Reaction(IUBMB)

all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+

Reaction(KEGG)

(other) R02124

Substrate

all-trans-retinol---[cellular-retinol-binding-protein];
NAD+ [CPD:C00003]

Product

all-trans-retinal---[cellular-retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis-retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].

History

EC 1.1.1.105 created 1972, modified 2011

Pathway

ec00830

Retinol metabolism

ec01100

Metabolic pathways

Orthology

K13369

17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)

K15734

all-trans-retinol dehydrogenase (NAD+)

Genes

HSA:	195814(SDR16C5) 8630(HSD17B6)

PTR:	472773(SDR16C5)

PPS:	100993740(SDR16C5) 100996145(HSD17B6)

GGO:	101152181(SDR16C5) 101153072

PON:	100450496 100454653 100458219(HSD17B6)

PPYG:

129010009(HSD17B6) 129043059(SDR16C5)

NLE:	100600756(SDR16C5) 100606923

HMH:	116480891 116812631(SDR16C5)

SSYN:

129465575 129485805(SDR16C5)

MCC:	696397(SDR16C5) 713549(HSD17B6)

MCF:	101926544(HSD17B6) 101926736(SDR16C5)

MTHB:

126930391 126961730

MNI:	105474127(HSD17B6) 105482271(SDR16C5)

CSAB:

103236829(SDR16C5) 103238543(HSD17B6)

CATY:

105587281(HSD17B6) 105592158(SDR16C5)

PANU:

100998417(SDR16C5)

TGE:	112630256(SDR16C5) 112634424

MLEU:

105545551(HSD17B6) 105552066(SDR16C5)

RRO:	104661773(SDR16C5) 104673659(HSD17B6)

RBB:	108516069(HSD17B6) 108538388

TFN:	117078998(SDR16C5) 117089914(HSD17B6)

PTEH:

111524870(SDR16C5) 111541833(HSD17B6)

CANG:

105500532(HSD17B6) 105508672

CJC:	100387390(HSD17B6) 100392998(SDR16C5)

SBQ:	101038570 101054253(HSD17B6)

CIMI:

108306739(SDR16C5) 108309703(HSD17B6)

ANAN:

105715970(HSD17B6) 105724890(SDR16C5)

CSYR:

103261738 103275150(HSD17B6) 103275152

MMUR:

105865568 105876404(SDR16C5)

LCAT:

123639631 123639632(HSD17B6) 123644775(SDR16C5)

PCOQ:

105816028 105824070

OGA:	100945062(SDR16C5) 100947460

MMU:	242285(Sdr16c5) 27400(Hsd17b6)

MCAL:

110293742(Sdr16c5) 110303948

MPAH:

110326955(Hsd17b6) 110338936(Sdr16c5)

RNO:	134479803 286964(Hsd17b6) 297805(Sdr16c5)

MCOC:

116076149 116088118(Sdr16c5)

ANU:	117696662 117698699

MUN:	110562497(Sdr16c5)

CGE:	100760372 100762147

MAUA:

101823255

PROB:

127215652(Hsd17b6) 127231788

PLEU:

114686923 114710231

MORG:

121451913 121463305

MFOT:

126486605 126492032

AAMP:

119803641 119826780(Sdr16c5)

NGI:	103730224(Hsd17b6) 103734179(Sdr16c5)

HGL:	101699287(Hsd17b6) 101723971(Sdr16c5)

CPOC:

100717492 100717768 100718054 100734980(Sdr16c5)

CCAN:

109686095 109702463(Sdr16c5)

DORD:

105980444(Sdr16c5) 105986857(Hsd17b6)

DSP:	122121940(Sdr16c5) 122124416(Hsd17b6)

PLOP:

125360472(Sdr16c5) 125362512(Hsd17b6)

NCAR:

124988715

MMMA:

107142402

OCU:

100357209

TUP:	102485005(HSD17B6) 102489556(SDR16C5)

GVR:

103610706

CFA:	477888(SDR16C5) 481118(HSD17B6)

CLUD:

112678001(HSD17B6) 112678474(SDR16C5)

VVP:	112922366(HSD17B6) 112929554(SDR16C5)

VLG:	121491966(HSD17B6) 121499010(SDR16C5)

NPO:	129505279(SDR16C5) 129511964

AML:	100464987(SDR16C5) 100474694

UMR:	103656323(HSD17B6) 103677445(SDR16C5)

UAH:	113256406(HSD17B6) 113268084(SDR16C5)

UAR:	123786718(SDR16C5) 123787236(HSD17B6)

ELK:	111155447 111160200

LLV:	125098675 125106172

MPUF:

101672306(HSD17B6) 101677841(SDR16C5)

MNP:	132013115(SDR16C5) 132019817(HSD17B6)

MLK:	131826814(SDR16C5) 131838584(HSD17B6)

NVS:	122892252(HSD17B6) 122904582(SDR16C5)

ORO:	101368715(HSD17B6) 101381803(SDR16C5)

EJU:	114215053(HSD17B6) 114220874(SDR16C5)

ZCA:	113921488(HSD17B6) 113937633(SDR16C5)

MLX:	118008692 118014839(SDR16C5)

NSU:	110577830 110578646(SDR16C5)

LWW:	102743313(HSD17B6) 102748884(SDR16C5)

FCA:	101082207(SDR16C5) 101088341(HSD17B6)

PYU:	121038246(SDR16C5) 121040906(HSD17B6)

PCOO:

112859527(SDR16C5) 112863243(HSD17B6)

PBG:	122473787(HSD17B6) 122495429(SDR16C5)

PVIV:

125156636(SDR16C5) 125170822(HSD17B6)

LRUF:

124502205 124507658

PTG:	102959434(SDR16C5) 102971783(HSD17B6)

PPAD:

109250295(SDR16C5) 109270351(HSD17B6)

PUC:	125920256 125924865

AJU:	106982532 106986922

HHV:	120222469(SDR16C5) 120224864(HSD17B6)

BTA:	526726(SDR16C5) 533086(HSD17B6)

BOM:	102278015(SDR16C5) 102283510(HSD17B6)

BIU:	109559345 109568694(SDR16C5)

BBUB:

102407967 123464947

BBIS:

104987881 104988095

CHX:	102185066 102186703

OAS:	100302354(SDR16C5) 101105400

BTAX:

128048794 128059508(SDR16C5)

ODA:	120857465 120878592(SDR16C5)

CCAD:

122427641 122451358

MBEZ:

129537008 129560344(SDR16C5)

SSC:	100157319(SDR16C5) 100620470

CFR:	102508382 102517328

CBAI:

105075641 105081478

CDK:	105096750 105097050

VPC:	102525284(SDR16C5) 102527912 102534817 107034922

BACU:

103000587(SDR16C5) 103008169(HSD17B6)

BMUS:

118883679 118902700

LVE:	103076064(HSD17B6) 103076578(SDR16C5)

OOR:	101278484(HSD17B6) 101278906(SDR16C5) 101289971

DLE:	111165821(SDR16C5) 111165839 111173857(HSD17B6)

PCAD:

102974623 102988625

PSIU:

116742177(SDR16C5) 116761374

NASI:

112393956(HSD17B6) 112398143(SDR16C5)

ECB:	100052840 100067801

EPZ:	103552507(SDR16C5) 103565330(HSD17B6)

EAI:	106832977(HSD17B6) 106841659

MYB:	102260999(SDR16C5)

MYD:	102753241(SDR16C5)

MMYO:

118670855(SDR16C5)

MLF:	102432383(SDR16C5)

MDT:	132220175(SDR16C5)

PKL:	118718279(SDR16C5)

EFUS:

103287623(SDR16C5)

MNA:	107533137(SDR16C5)

DRO:	112315502(SDR16C5)

SHON:

118974971(SDR16C5)

AJM:	119041336 119065586

PDIC:

114514795(SDR16C5)

PHAS:

123833379(SDR16C5)

MMF:

118623751

PPAM:

129084146

HAI:

109394445

RFQ:	117028833 117033801(SDR16C5)

PALE:

102881754(SDR16C5) 102883634(HSD17B6)

PGIG:

120604931 120607397

PVP:	105291407 105302561

RAY:	107521200(HSD17B6)

MJV:	108402619 108407808(SDR16C5)

TOD:

119242981

SETR:

126020452

LAV:	100653594(SDR16C5) 100657790

TMU:	101340363 101345897

DNM:	101433653(SDR16C5)

MDO:	100029976(SDR16C5)

GAS:

123231702

SHR:	100927996 100931687

AFZ:	127539058 127543850

PCW:	110211084 110221381(SDR16C5)

TVP:	118834148 118850303 118850652 118850653 118851548 118851597

OAA:	100083362(SDR16C5)

GGA:	421130(SDR16C5) 428538(ERD2L)

PCOC:

116242190 116242263

MGP:	100538468(SDR16C5) 100550995

CJO:	107310166 107310176

TPAI:

128090701(SDR16C5) 128090713

LMUT:

125691044 125691046

NMEL:

110393074 110395001

APLA:

101805250(SDR16C5)

ACYG:

106039064(SDR16C5)

CATA:

118251204

AFUL:

116486720

TGU:	100224990(SDR16C5) 100231724

LSR:	110484757 110484803

SCAN:

103812390(SDR16C5) 103812400

PMOA:

120499285 120499302

OTC:	121340184(SDR16C5) 121340263

PRUF:

121356837 121356882

GFR:	102033253(SDR16C5) 102033420

FAB:	101814462(SDR16C5) 101814732

OMA:	130249540 130249683(SDR16C5)

PHI:	102102919 102105535

PMAJ:

107201015 107214541

CCAE:

111924712(SDR16C5) 111924713

CCW:	104690373 104690375(SDR16C5)

CBRC:

103625506(SDR16C5) 103625507

ETL:	114060199(SDR16C5) 114060211

ZAB:	102072226 102072391

ZLE:	135443307 135444446(SDR16C5)

ACHL:

103809911 103810322(SDR16C5)

SVG:	106851222(SDR16C5) 106851264

MMEA:

130573842 130573844 130579987

HRT:	120755424 120756312

SATI:

136368893 136368902(SDR16C5) 136370226

FPG:	101912866 101913893

FCH:	102047754 102056451

CCRI:

104156479(SDR16C5) 104156505

NNT:	104400952(SDR16C5) 104411690

SHAB:

115607236 115609683(SDR16C5)

ACUN:

113476203

TALA:

104356492 104357915(SDR16C5)

ACHC:

115340575

HALD:

104312051(SDR16C5) 104316085

HLE:	104841337 104841359(SDR16C5)

AGEN:

126047293 126050508

GCL:	127013824 127013826

CSTI:

104559405 104563300(SDR16C5)

LDI:	104341591(SDR16C5) 104344761

MNB:	103774731(SDR16C5)

DPUB:

104303518(SDR16C5)

AVIT:

104274809 104281401(SDR16C5)

BRHI:

104495357(SDR16C5)

EGZ:	104127571(SDR16C5) 104127582

NNI:	104019745(SDR16C5) 104019746

PCRI:

104028914(SDR16C5) 104032495

PCAO:

104048640 104051433

PADL:

103923670 103923671

AFOR:

103907196(SDR16C5) 103907198

FGA:	104069915 104082129(SDR16C5)

GSTE:

104250585 104252580(SDR16C5)

CLV:

102083489

MUI:	104546021(SDR16C5) 104546022

PGUU:

104464090 104468667(SDR16C5)

PLET:

104616664 104627557(SDR16C5)

EHS:	104513055(SDR16C5)

CMAC:

104473107(SDR16C5) 104476462

CUCA:

104067677

TEO:	104369947 104371018(SDR16C5)

BREG:

104629486 104644074(SDR16C5)

OHA:

104332300

ACAR:

104529479

CPEA:

104395715 104395716

CVF:	104293285(SDR16C5) 104293286

RTD:	128905657 128905813(SDR16C5)

AAM:	106494376(SDR16C5) 106494442

AROW:

112962016 112978647 112978650

NPD:	112956391 112956588(SDR16C5) 112956597

TGT:	104574328(SDR16C5)

DNE:	112992579 112992581 112994731

SCAM:

104143182

ASN:	102370921 102371169 102379954 102380512 102385619

AMJ:	102563418 102563664 102567845 102577108(SDR16C5) 109285947

CPOO:

109315145 109324411 109324469

GGN:	109298733 109304761 109304769 109304780

PSS:	102444001 102447010(SDR16C5) 102454079

CMY:	102933472 102934983 102944543

CCAY:

125627856 125632471 125632473

DCC:	119845913(HSD17B6) 119851473 119852237

CPIC:

101934621(SDR16C5) 101952318 103306704

TST:	117871821 117873503 117888588(HSD17B6)

CABI:

116827724 116834637 116834650

MRV:	120391156 120398148 120398926

ACS:	100555957 100556351 100556742 100556847(sdr16c5) 100557132 100557327 100557526 100564174(hsd17b6) 103281170

ASAO:

132768358 132768360 132772817 132772818 132772819 132772823 132774854 132774855 132774856 132774857 132774858

PVT:	110071325 110089696 110089703 110089706 110091362

SUND:

121923187 121927547 121927548 121928351 121929128

PBI:	103063029(SDR16C5) 103063622

PMUR:

107284324(SDR16C5) 107293735

CTIG:

120302959 120311676(SDR16C5)

TSR:	106540515(SDR16C5) 106545328(HSD17B6)

PGUT:

117662721 117672813(SDR16C5)

APRI:

131192991 131193302(HSD17B6) 131194226(SDR16C5)

PTEX:

113440025(SDR16C5) 113445491 113445552

NSS:	113422732 113422749 113429894(SDR16C5)

VKO:	123020483 123020521

PMUA:

114592701 114592979 114592981 114600589(SDR16C5)

PRAF:

128405337 128405345 128405364 128405369 128405390 128417438(SDR16C5)

ZVI:	118077226(HSD17B6) 118090083(SDR16C5)

HCG:	128323664(SDR16C5) 128339160 128339162 128344041 128345225 128345226 128346238 128346556 128346634

GJA:	107113871 107113872 107113873 107113879 107120904(HSD17B6)

STOW:

125430225 125430298 125430340 125439184 125439447

EMC:	129328144 129333551 129333652 129334074 129346101 129346224

XLA:	444148(sdr16c5.L)

XTR:	100498221 448386(sdr16c5)

NPR:	108789963(SDR16C5)

RTEM:

120941013(SDR16C5)

BBUF:

121001619(SDR16C5)

BGAR:

122938145 122938225

MUO:	115477625(SDR16C5)

GSH:	117355509(SDR16C5) 117356363

DRE:	405814(sdr16c5a) 406799(sdr16c5b) 563950(si:dkey-221h15.4)

SRX:	107711413 107727604 107730129

SANH:

107660835 107676237 107698670(sdr16c5)

SGH:	107570430 107574325 107602180

CAUA:

113074269 113114822 113120431

CGIB:

127961375 127984303(si:dkey-221h15.4)

PTET:

122324484 122324982 122349324(sdr16c5b)

LROH:

127168919(sdr16c5b) 127176559(sdr16c5a) 127183231(si:dkey-221h15.4)

OMC:	131527357(si:dkey-221h15.4) 131544991(sdr16c5b)

PPRM:

120480132(sdr16c5b) 120482754(sdr16c5a) 120493886(si:dkey-221h15.4)

RKG:	130094508(sdr16c5a) 130103177(si:dkey-221h15.4) 130106279(sdr16c5b)

MAMB:

125250875(sdr16c5a) 125265869(sdr16c5b) 125278360(si:dkey-221h15.4)

CIDE:

127502309(si:dkey-221h15.4) 127502721 127515865

CERY:

137002887(sdr16c5a) 137019130(si:dkey-221h15.4) 137030126(sdr16c5b)

MASI:

127428026 127442808 127454229

TROS:

130554516(sdr16c5a) 130558485(sdr16c5b) 130565433(si:dkey-221h15.4)

TDW:	130417732(sdr16c5a) 130418377(sdr16c5b) 130434376(si:dkey-221h15.4)

MANU:

129429088(si:dkey-221h15.4) 129442524(sdr16c5a) 129452962(sdr16c5b)

IPU:	108268084(sdr16c5b) 108280727(sdr16c5a)

IFU:	128609886(sdr16c5b) 128623960(sdr16c5a)

PHYP:

113539777 113546342

SMEO:

124386956(sdr16c5b) 124403327(sdr16c5a)

TFD:	113650157(sdr16c5a) 113657443(sdr16c5b)

TVC:	132844278(sdr16c5a) 132848474(sdr16c5b)

TRN:	134302765(sdr16c5a) 134312241(sdr16c5b)

AMEX:

103044391(si:dkey-221h15.4) 103045570(sdr16c5b) 103046429(sdr16c5a)

CMAO:

118796934(sdr16c5a) 118815205(si:dkey-221h15.4) 118825648(sdr16c5b)

EEE:	113579307 113590025

CHAR:

105893819(sdr16c5a) 105901701(si:dkey-221h15.4) 116224441

TRU:	101062133(sdr16c5)

TFS:

130539306

TNG:	GSTEN00033658G001

LCO:	104939798(sdr16c5)

TBEN:

117473770 117478553

CGOB:

115022156(sdr16c5)

PGEO:

117449405 117461747

GACU:

117538588 117546361

EMAC:

134866314(sdr16c5a)

ELY:

117272043

EFO:

125902820

PLEP:

121951102

SLUC:

116040786 116040811

ECRA:

117954087 117954095

ESP:	116675471 116699139

PFLV:

114565360 114565674

GAT:

120816204

PPUG:

119209286

AFB:

129113653

CLUM:

117746267

PSWI:

130197865

MSAM:

119902539 119902660

SCHU:

122886657(sdr16c5a)

CUD:

121520026

ALAT:

119011288

MZE:	101474670(sdr16c5)

ONL:	100706426(sdr16c5)

OAU:

116334141

OLA:	101174946(sdr16c5)

OML:

112151014

CSAI:

133452296

XMA:	102229885(sdr16c5)

XCO:	114146916(sdr16c5)

XHE:	116721391(sdr16c5)

PRET:

103479220(sdr16c5)

PFOR:

103130805(sdr16c5)

PLAI:

106942986(sdr16c5)

PMEI:

106911742(sdr16c5)

GAF:

122840782

PPRL:

129361579

CVG:	107099250(sdr16c5)

CTUL:

119781487

GMU:

124870114

NFU:	107395036(sdr16c5)

KMR:

108249507

ALIM:

106510864(sdr16c5)

NWH:

119414862

AOCE:

111575778(sdr16c5)

MCEP:

125010370

CSEM:

103396624(sdr16c5)

POV:	109647912(sdr16c5)

SSEN:

122770626

HHIP:

117777780

HSP:

118117767

PPLT:

128453986

SMAU:

118310919(sdr16c5a)

LCF:	108895259 108896706 108896722

SDU:	111233932(sdr16c5)

SLAL:

111648402(sdr16c5)

XGL:

120798871

HCQ:	109524163(sdr16c5)

SSCV:

125984913

SBIA:

133510651(sdr16c5a)

PEE:

133411655

PTAO:

133488676

BPEC:

110175116(sdr16c5)

MALB:

109971387(sdr16c5)

BSPL:

114844042

SJO:

128369114

SASA:

106568881 106571445 106590215(sdr16c5) 106599159

STRU:

115156824 115169874 115174752 115195703(sdr16c5)

OTW:	112227030 112227894(sdr16c5b) 112250350(si:dkey-221h15.4) 112260378

OMY:	110489858(sdr16c5b) 110508828 110529649(si:dkey-221h15.4) 110530198

OGO:	123990793(si:dkey-221h15.4) 124010223 124039722(sdr16c5b) 124041951

ONE:	115103179 115107795 115130303(sdr16c5)

OKI:	109871755 109875284 109899417 109900782

OKE:	118372478(sdr16c5b) 118394575 118398615(si:dkey-221h15.4) 118402215

SALP:

111953449(sdr16c5) 111954526 111957130 111979024

SNH:	120020430 120024278(si:dkey-221h15.4) 120051101(sdr16c5b) 120055522

CCLU:

121535118 121552605(si:dkey-221h15.4) 121569387(sdr16c5b) 121580834(sdr16c5a)

ELS:	105008851 105028193(sdr16c5)

SFM:	108925177 108929620(sdr16c5) 108937716

PKI:	111847229(sdr16c5) 111852572 111854019

AANG:

118225930(sdr16c5b) 118229768(si:dkey-221h15.4) 118234138

LOC:	102691815(sdr16c5) 102698185

PSPA:

121313917(sdr16c5b) 121317492

ARUT:

117394815(sdr16c5b) 117403406 117410685

PSEX:

120530234(sdr16c5b)

CMK:	103177053(sdr16c5b)

RTP:

125487894

CPLA:

122549479(sdr16c5b)

HOC:	132814153(sdr16c5b)

LERI:

129696040 129696283

PMRN:

116942594(SDR16C5)

LRJ:	133349166(SDR16C5)

BFO:	118404158 118404160 118404373 118404535 118417376

BBEL:

109472987 109473050 109473120 109482029 109483156

CIN:

100185899

SCLV:

120346389

SPU:	115925479 576258 581999 584929

LPIC:

129256301 129261783 129262327

APLC:

110975292 110978714 110981684 110981685 110985069 110989492 110989493 110989497

ARUN:

117300611 117300679 117301065 117302628 117304598

AJC:	117100550 117103072 117117268

SKO:	100313719 100367370 100367677 100371162 100371317 100371328 100373839 100373993 100375555

DME:	Dmel_CG15629(CG15629) Dmel_CG9265(CG9265)

DER:	6543511 6548958

DSE:	6613379 6618227

DSI:	Dsimw501_GD21662(Dsim_GD21662) Dsimw501_GD23300(Dsim_GD23300)

DYA:	Dyak_GE13009 Dyak_GE18307

DAN:	6498298 6506830

DSR:	110179149 110187453

DPO:	4800909 4817365 4818198

DPE:	6589354 6593370 6598809

DMN:	108154198 108162810 108163769

DWI:	6643745 6643805

DGR:	6562764 6562885

DMO:	Dmoj_GI10765 Dmoj_GI11003 Dmoj_GI16082 Dmoj_GI17845

DAZ:	108609755 108611423 108611934 108619807

DNV:	108649546 108649690 115563336

DHE:	111591974 111595191 111601867

DVI:	6628411 6635728

CCAT:

101449443 101455622

BOD:	106614937 106623403

BDR:	105224204 105229342

RZE:	108362792 108365640

AOQ:	129246861 129248034

TDA:	119662016 119662764

MDE:	101891702 101900159 131806324

SCAC:

106081217 106095587

LCQ:	111676864 111688606

LSQ:	119603153 119610133

GFS:	119633176 119633210

ECOE:

129948889 129950100

CLON:

129608352 129615281

HIS:	119646848 119660231

AGA:	1271983 1273476 1277830 1279655

ACOZ:

120952876 120955980 120958576

AARA:

120897962 120900946 120901973

AMER:

121596515 121597203

ASTE:

118511022 118513729

AFUN:

125762115 125766169

AMOU:

128301290 128304449

AALI:

118458393 118461742

AAG:	5566918 5567861 5569925 5573100 5574879

AALB:

109415689 109416528 109421982 109421983 109428798

ASUA:

134206078 134212766 134212809 134228177

CQU:	CpipJ_CPIJ003837 CpipJ_CPIJ011768 CpipJ_CPIJ018974 CpipJ_CPIJ019362

CPII:

120415478 120421420 120423210 120425339

CNS:	116340685 116341163

BCOO:

119072679 119072681

AME:	100576773 409260 411340 552689 552746

ACER:

107993079 107995023 107995102 107995130 107995788

ALAB:

122713514 122717850 122717864 122717865 122718300

ADR:	102674092 102675817 102675951 102677182

AFLR:

100865255 100866597 100868525 100868644

BIM:	100740757 100740999 100744378 100745985 100747729

BBIF:

117207176 117211347 117212590 117212605

BVK:	117234052 117237379 117242232 117242235

BVAN:

117154908 117160953 117161388 117161443

BTER:

100642695 100645094 100645459 100652085 100652203

BAFF:

126917147 126917267 126917268 126920216

BPYO:

122571034 122572408 122572452 122572453

BPAS:

132906293 132906739 132906896 132907469

FVI:	122529532 122529533 122537711

CCAL:

108622824 108622835 108625536 108625537 108625601

OBB:	114872450 114872451 114878577 114878578

OLG:	117601902 117602209 117602210

MGEN:

117225255 117225455

NMEA:

116434987 116434991 116435155

CGIG:

122404550 122404551 122404992

SOC:	105196948 105199875 105199876 105199948 105199949 105200084 105203799 105204747 105205311 105205874 113002670 113003951 113006089

MPHA:

105830228 105832401 105832560 105832561 105832631 105834011 105835775 105837148 114254760

AEC:	105143793 105146841 105146848 105146876 105147280 105151697 105153175 105153854

ACEP:

105620170 105623670 105623671 105623693 105623936 105624389 105625104 105625156

PBAR:

105424352 105424665 105429593 105429594 105429595 105431294 105431295

VEM:	105559201 105560103 105560104 105560179 105564781 105565916 105565917 105567041 105567043

HST:	105184749 105184773 105185315 105186440 105189955 105189957 105189959 105191247

DQU:	106743574 106747611 106747612 106747797 106750429 106750648 106750652

CFO:	105248667 105251488 105251489 105253640 105256276 105256565 105259009 105259010 112639353 112639883

FEX:	115235875 115238060 115238095

LHU:	105667938 105668045 105669155 105670704 105676089 105676093 105676200 105676204 105677723 105679939 105679940

PGC:	109851918 109857519 109857523 109857529 109864019 109864020 109864083 109864171

OBO:	105278205 105278223 105280225 105286228 105286229 105286827

PCF:	106785459 106785609 106785636 106787008 106791176 106793019

PFUC:

122513676 122513730 122515237 122519645 122526525

VPS:	122631722 122633167 122633791 122633792 122635908

VCRB:

124427020 124429184 124429185 124429187 124429188 124431692

VVE:	124948733 124952199 124953256 124953289 124953541 124953546 124955191 124955399

NVI:	100115486 100117288 100122971 100122990

CSOL:

105360774 105360990 105361917 105361918

TPRE:

106658724 106659031

LHT:	122510383 122510385

LBD:	127291387 127291393

MDL:	103575214 103575215 103575272

CGLO:

123261801 123261811

FAS:	105265216 105266664

DAM:	107041981 107042806

AGIF:

122850822 122851792 122851798 122853694 122854369

CINS:

118065029 118065056

VCAN:

122407486 122407783

CCIN:

107270295 107273274

DSM:	124412917 124413691

NPT:	124224885 124224886

NFB:	124187799 124187800

NLO:	107221754 107221765

NVG:	124310335 124310336

AROA:

105687598 105687599

TCA:	658820 660376 660853 661003

DPA:	109544357 109544358 109544611 109544632

SOY:	115879170 115879215

AGRG:

126737764 126737766 126737874

ATD:	109595916 109599978 109600115 109609095 109609195

CSET:

123316798 123317041

AGB:	108913949 108913953

LDC:	111517381 111517384

DVV:	126881248 126886618

NVL:	108556621 108557786 108558764

APLN:

108732576

PPYR:

116178869 116179024 116179299 116179565 116180947 116181132

OTU:	111426122 111426123 111426545

BMOR:

101739531 101739674 101739814 101745050 101745197 733110

BMAN:

114244035 114247443 114247464 114251575 114251586

MSEX:

115440204 115440222 115448528

DPL:	KGM_200410 KGM_215703 KGM_215711

BANY:

112045232 112045351 112055852

MJU:	123873771 123874084 123877382

NIQ:	126770350 126771952 126771956

VCD:	124532269 124536645 124537092

MCIX:

123660333 123660339 123670372

PMAC:

106714151 106720934 106720958

PPOT:

106099366 106110871 106110917

PXU:	106124821 106126840 106126893

PRAP:

110998193 110999193 111000984

PBX:	123712613 123713230 123714083

PNAP:

125059969 125060995 125063333

ZCE:	119829616 119838849 119839889 119840045

CCRC:

123695443 123697733 123698050

LSIN:

126968729 126977502 126977506

AAGE:

121730296 121730626 121730630 121735198 121735417

HAW:	110372917 110372919 110372931 110375388 110377521 110382232

HZE:	124631745 124638713 124638764

TNL:	113496357 113501657 113501760 113501859 113506809 113506824 113507735 113507744

SLIU:

111353515 111353985 111354128

OFU:	114360122 114360123

ATRA:

106129792 106129834 106129838 106133527 106134275 106134312 132902566

GMW:	113513526 113515999 113516197 113517960 113518190 113519159

PXY:	105380049 105380050 105390208 105390210 105390212 105395139

PGW:	126373578 126373583

LGLY:

125225286 125225450 125225494 125225754 125225818 125225819 125230945 125231134

CFEL:

113375495 113377291

CCRN:

123292795 123299584 123299775 123300679

API:	100160730 100162762 100169469 100169629 100571730 100573512

DNX:	107166861 107166862 107166864 107168849 107169423

AGS:	114124129 114130246 114130248 114132337

RMD:	113548825 113552930 113553673 113553798 113554535

ACOO:

126833599

DVT:	126899615 126900767 126908386

BTAB:

109030070 109035415

DCI:	103504833 103523327

CLEC:

106660795

NLU:

111058478

HVI:

124367823

MQU:	128982440 128982966 128994998 128995816 128999275

PHU:	Phum_PHUM376560 Phum_PHUM376670 Phum_PHUM399690 Phum_PHUM616080 Phum_PHUM616090 Phum_PHUM617650

FOC:

113215532

TPAL:

117641196 117647436

ZNE:	110836285 110836291

CSEC:

111871510

SGRE:

126304725

BROR:

134529426 134529428 134532667 134541021

IEL:

124163293

FCD:	110843603 110844605 110847635 110852390

DPX:	DAPPUDRAFT_231613 DAPPUDRAFT_302163 DAPPUDRAFT_328312 DAPPUDRAFT_328313

DMK:	116928353 116932344 116932345 123475601

DPZ:	124348462 124348463 124351151

PVM:	113805906 113807126 113807853 113817581

PJA:	122242321 122249883 122251590 122259862

PCHN:

125027371 125032955 125038549

PMOO:

119595873 119597933

HAME:

121856527 121872278 121872279 121872281

PCLA:

123754463 123754464 123759999

CQD:	128687109 128687120

PTRU:

123513716 123513717 123513718 123513719 123519930

ESN:	126999540 126999541 126999542 126999543

MNZ:	135217037 135221601 135221851 135225460

HAZT:

108665621 108681314

EAF:	111710115 111710158 111712555

LSM:

121114399

TCF:

131892634

PPOI:

119102475 119102476 119103291

DSV:	119450347 119460661 119464839

RMP:	119170494 119170559 119179486

VDE:

111245087

VJA:

111266766

TUT:	107363341 107365987 107366541 107371655

DPTE:

113792533 113793937 113796975

DFR:	124494997 124497082

CSCU:

111624556 111624557 111631647 111631654 111631655 111640586 111640588

CVS:	136974067 136974074 136974075 136974113 136974525 136974526

PTEP:

107437685 107438429 107438430 107442888 107447068 107455476

ABRU:

129960005 129962090 129971347 129972465 129981840

UDV:	129216174 129222710 129229939 129231500 129232577 129233051 129233181 129233807

SDM:	118180419 118186327 118188956 118191893 118198813

LPOL:

106458619 106475751

PMEO:

129589333 129590250 129590314 129593310

CEL:	CELE_T02E1.5(dhs-3) CELE_T11F9.11(dhs-19)

CBR:	CBG_04146(Cbr-dhs-3) CBG_23222(Cbr-dhs-19)

CRQ:	GCK72_000959 GCK72_016772

NAI:	NECAME_00963 NECAME_04279

LOA:	LOAG_08821

TSP:

Tsp_09971

HRO:	HELRODRAFT_175156 HELRODRAFT_87424 HELRODRAFT_87513 HELRODRAFT_94681

LGI:	LOTGIDRAFT_141736 LOTGIDRAFT_167880 LOTGIDRAFT_180616

PVUL:

126810546 126815651 126815956 126828346

PCAN:

112562173 112562174 112563790 112563794 112563795

BGT:	106069124 106073075

GAE:	121377269 121377350 121377522 121390291

HRF:	124117470 124139466 124139467 124149281

HRJ:	124269994 124269995 124278165 124280962 124289002

CRG:	105330579 105342862 105343217

CANU:

128157474 128162079 128166733

CVN:	111111885 111114174 111114621 111138494

OED:	125646022 125683831

MYI:	110444247 110450919 110451842 110458121 110466177

PMAX:

117316201 117316477 117316732 117316733 117316734 117318303

MCAF:

127719989 127723615

MMER:

123531644 123531645 123532231 123540291 123541558

RPHI:

132712986 132715842 132719757 132734128 132736821 132737641 132737771 132738844 132742335 132746089 132746090

DPOL:

127847065 127847066 127855977 127857797

MAEA:

128205523 128206346 128206551 128208576 128236155 128236793 128237301 128244468 128244563

OBI:	106873408 106880148 106882308 106884518

OSN:	115209397 115210961 115223626

LJP:	135463803 135463814 135463889 135465853

LAK:	106152058 106152060 106156307

SMM:	Smp_000190

OVI:	T265_01173

EGL:

EGR_00981

LLON:

135495808 135495920 135503194

NVE:	5496865 5501904 5511431 5513270

EPA:	110234337 110239584

ATEN:

116294925 116297633 116298163

ADF:	107335705 107343261 107343262 107348377 107355192

AMIL:

114947336 114947337 114947338 114954791 114968934 114968936

PDAM:

113678700 113681812

SPIS:

111328039 111340058 111345038

DGT:	114518366 114527558 114527573 114528488

XEN:	124443815 124448707 124456309

HMG:	100200144 100200877 101235992

HSY:	130647105 130647106 130655463

RES:	135688453 135689361 135689780

TAD:	TRIADDRAFT_22801 TRIADDRAFT_26937 TRIADDRAFT_33710 TRIADDRAFT_62171

AQU:	100633883 100636579 100641367

PAN:	PODANSg10047 PODANSg1399

TTT:	THITE_2123415

MTM:	MYCTH_2305985

CTHR:

CTHT_0039790 CTHT_0053510

MGR:	MGG_01604 MGG_06556

TMN:	UCRPA7_5953

FGR:	FGSG_00488 FGSG_11300

FPU:	FPSE_01353 FPSE_08419

FVR:	FVEG_00946 FVEG_01703 FVEG_11846 FVEG_13958

FOX:	FOXG_00568 FOXG_02853 FOXG_13412

NHE:	NECHADRAFT_16878 NECHADRAFT_34821 NECHADRAFT_39692 NECHADRAFT_54364 NECHADRAFT_64661 NECHADRAFT_90141 NECHADRAFT_94746

FFC:	NCS54_00102100 NCS54_00335600

TRE:	TRIREDRAFT_54991 TRIREDRAFT_59196

TRR:	M419DRAFT_4616 M419DRAFT_75180

MAW:	19248101(J3458_003054) 19249280(J3458_015149) 19252766(J3458_006976)

MAJ:	MAA_04221 MAA_06096 MAA_08286

MBRN:

26247488(RED2_1)

PCHM:

VFPPC_00380 VFPPC_02214

CMT:	CCM_06296 CCM_08001 CCM_09226

AMUS:

LMH87_007914 LMH87_010686

PLJ:	28882177(PLICBS_001773) 28882571(PLICBS_001414) 28887207(PLICBS_002476) 28892510(PLICBS_006459) 28892846(PLICBS_009013)

PTKZ:

JDV02_001386 JDV02_005563

VAL:	VDBG_04606

VDA:	VDAG_04156 VDAG_05468

CFJ:	CFIO01_01367 CFIO01_11524

CLUP:

CLUP02_05654

SAPO:

SAPIO_CDS6324

ELA:	UCREL1_8150

PFY:	PFICI_00826 PFICI_12724 PFICI_13345

SSL:	SS1G_09883

MBE:

MBM_05882

PSCO:

LY89DRAFT_443778

NFI:	NFIA_002720

ANG:	An14g01270

TRG:	TRUGW13939_02961

PNO:	SNOG_01230 SNOG_07623

PTE:

PTT_12628

BZE:	COCCADRAFT_112963 COCCADRAFT_41870 COCCADRAFT_98235

BSC:	COCSADRAFT_33143 COCSADRAFT_39728 COCSADRAFT_41309

BOR:	COCMIDRAFT_109230 COCMIDRAFT_110176 COCMIDRAFT_1974 COCMIDRAFT_96648

AALT:

CC77DRAFT_1025878 CC77DRAFT_938955 CC77DRAFT_941885

ZTR:	MYCGRDRAFT_106942

PFJ:	MYCFIDRAFT_211250

CNE:

CNH02090

CNB:

CNBL2080

CNG:	CNAG_08027

CGI:	CGB_L2480C

CDEU:

CNBG_4311

CDEP:

91089848(L203_105639)

KMG:	30162394(I203_100941)

KNE:	92179397(IAR55_002138)

TASA:

A1Q1_05574

UMA:	UMAG_03126 UMAG_03229 UMAG_05936

PFP:	PFL1_05491

MSYM:

MSY001_2273

NCE:	NCER_100361

VNX:	VNE69_07233

MBR:	MONBRDRAFT_32991

SRE:	PTSG_10313

ACAN:

ACA1_098130

TET:	TTHERM_001015921 TTHERM_00649500

PTM:	GSPATT00012196001 GSPATT00015614001 GSPATT00029821001 GSPATT00030258001

NGD:	NGA_2097300

PIF:	PITG_05888 PITG_17768

PSOJ:

PHYSODRAFT_337099 PHYSODRAFT_563134 PHYSODRAFT_563395

SPAR:

SPRG_09787 SPRG_12595

EHX:	EMIHUDRAFT_434961

PSHI:

SAMEA2665130_1592(fabG_2)

FAU:	Fraau_1601

VSH:	BSZ05_23705

ADI:

B5T_04430

AXE:

P40_21605

APAC:

S7S_18390

DDZ:	DSYM_19180

BMED:

GYM46_01270

ROH:	FIU89_04815(sadH)

PARU:

CYR75_05220

DAL:	Dalk_0382 Dalk_4703

DWD:	DSCW_16050 DSCW_55530

DALK:

DSCA_16220

ADE:

Adeh_2306

ACP:	A2cp1_1643

ANK:	AnaeK_1565

VIN:	AKJ08_3285

PCAY:

FRD00_06175

BSTO:

C0V70_14125

EUZ:	DVS28_a0436

MKU:	I2456_00770

MPAG:

C0J29_00535

MGOR:

H0P51_00710

MSPG:

F6B93_14140

MKY:	IWGMT90018_01500

ASD:	AS9A_3226 AS9A_3935

CVT:	B843_08905

CSPH:

CSPHI_03695

CPEG:

CPELA_00035(fabG1)

CGK:	CGERO_00035(fabG1)

CPSO:

CPPEL_00035(fabG1)

NFA:

NFA_34340

NFR:	ERS450000_00613(budC_2)

NCY:	NOCYR_2366

NBR:	O3I_027165

NNO:	NONO_c32670

NSL:	BOX37_11170

NSR:	NS506_05187

NTP:	CRH09_16885

NOZ:	DMB37_06215

NOD:	FOH10_11920

NAH:	F5544_27040

NAD:	NCTC11293_04557(budC_3)

NWL:	NWFMUON74_41750

NIE:	KV110_26545

NTC:	KHQ06_21560

NHU:	H0264_20325

NYA:	LTV02_13905

NGP:	LTT66_26525

NSPU:

IFM12276_21830

NYU:	D7D52_08480

ROP:

ROP_35410

ROA:	Pd630_LPD00060

RTM:	G4H71_21655

DTM:	BJL86_2081

CBQ:	AL705_00780 AL705_05025

LXY:	O159_28020

LSE:	F1C12_16305

LEIZ:

IT072_18450

MWA:	E4K62_10585

MCAW:

F6J84_06240

MLZ:	F6J85_10345

MVD:	AWU67_15750

AGY:	ATC03_18540

AGM:	DCE93_13715

AGF:	ET445_04870

AARC:

G127AT_06965

CART:

PA27867_3337

CRY:	B7495_16220

AMIN:

AUMI_114330

AUM:	AURMO_01689

AUW:	AURUGA1_01569(fabG_2)

AUT:	AINA4_14850

MYL:	C3E77_10340

SALC:

C2138_01095

SALA:

ESZ53_07895

SALD:

FVA74_12510

HUW:	FPZ11_11405

LYD:	D7I47_10555

LTR:	EVS81_14275

LDN:	H9L06_03310

MANT:

BHD05_00765

SUBT:

KPL76_12010

ART:

Arth_2505

ARM:

ART_2310

ARL:	AFL94_09440

ARE:	AL755_05865

AAQ:	AOC05_09420

ARW:	MB46_14410

ARY:	ATC04_08760

ARU:	ASPU41_18380

ARTP:

E5206_10025

AAI:	AARI_18030

GCR:	GcLGCM259_1565

GLU:	F0M17_09055

GPR:	JQN66_09365

GMI:	NMP99_09305

GMY:

XH9_16700

GNC:	QQS42_09055

RSA:	RSal33209_0715

MLU:	Mlut_09850

MICK:

B1A86_00004865

MYU:	M8233_04590

SATK:

SA2016_3466

CCYC:

SCMU_35280

NAE:	BHE16_09855

PAEY:

KUF55_10190

BRX:	BH708_01045

BRZ:	CFK38_06335

KSE:	Ksed_21900

SANW:

G7063_08985

PSEI:

GCE65_09315

ORZ:	FNH13_14975

BLY:	A2T55_03945

BLIN:

BLSMQ_0754

BRI:	FDF13_07180

BLUT:

EW640_13185

MIK:	FOE78_16755

TDF:	H9L22_05385

NAK:	EH165_04945

MCU:	HMPREF0573_11007

TBW:	NCTC13354_00741(fabG_1)

ACTO:

C3V41_02025

FSL:	EJO69_10350

FLH:	EJ997_12110

WIK:	H8R18_00365

BGX:	ESN35_07800

BLEM:

BL8807_07290

BEU:	BE0216_04235

RXY:

Rxyl_2457

SDYN:

Mal52_55240(sadH)

GMS:	SOIL9_41700

STA:	STHERM_c14070

STQ:	Spith_1544

SLR:	L21SP2_0042

BHC:	JFL75_06695

LBI:	LEPBI_I3274

LBF:

LBF_3161

SGN:

SGRA_4013

SCN:	Solca_0757

FLI:	Fleli_1101

PACT:

CA264_09235

RSR:	T7867_18200

FCO:	FCOL_12430

FCV:	AWN65_08410

FOE:	JJC03_10305

LAN:	Lacal_2549

LACI:

CW733_07835

POB:	LPB03_05700

POA:	CW731_12340

PPEC:

H9W90_04045

TMAR:

MARIT_1274

SALT:

AO058_16765

SMIS:

LDL76_00220

AFLA:

FHG64_03170

ANP:	FK178_02555

OCI:	FEZ18_07050

HWS:	RNZ46_06950

RAN:	Riean_1035

RAI:

RA0C_1296

RAR:

RIA_1196

RAG:

B739_0856

RAE:

G148_0579

RAT:

M949_1320

CTAK:

4412677_00576(acr1)

CSAL:

NBC122_02675(acr1)

CSUP:

MTP09_05190

CHRC:

QGN23_05040

CMAQ:

H0S70_02140

CCAS:

EIB73_00965

CANT:

NCTC13489_00252(acr1) NCTC13489_01308(fabG_1)

KDA:	EIB71_00545

KHI:	EG338_08870

KBE:	J4771_03730

KFA:	Q73A0000_06485

KAQ:	L0B70_10170

CFAE:

LL667_10915

CNR:	EB819_02865

» show all

Reference

1 [PMID:5972368]

Authors

Koen AL, Shaw CR.

Title

Retinol and alcohol dehydrogenases in retina and liver.

Journal

Biochim Biophys Acta 128:48-54 (1966)
DOI:10.1016/0926-6593(66)90140-8

Reference

2 [PMID:9677409]

Authors

Gough WH, VanOoteghem S, Sint T, Kedishvili NY

Title

cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.

Journal

J Biol Chem 273:19778-85 (1998)
DOI:10.1074/jbc.273.31.19778

Reference

3 [PMID:12372410]

Authors

Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H

Title

Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.

Journal

Biochem Biophys Res Commun 297:1171-80 (2002)
DOI:10.1016/S0006-291X(02)02344-6

Sequence

[hsa:195814]

Reference

4 [PMID:18926804]

Authors

Lee SA, Belyaeva OV, Kedishvili NY

Title

Biochemical characterization of human epidermal retinol dehydrogenase 2.

Journal

Chem Biol Interact 178:182-7 (2009)
DOI:10.1016/j.cbi.2008.09.019

Sequence

[hsa:195814]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.105

IUBMB Enzyme Nomenclature:

1.1.1.105

ExPASy - ENZYME nomenclature database:

1.1.1.105

BRENDA, the Enzyme Database:

1.1.1.105

CAS:

9033-53-8

DBGET integrated database retrieval system