KEGG   ENZYME: 1.1.1.105Help
Entry
EC 1.1.1.105                Enzyme                                 

Name
all-trans-retinol dehydrogenase (NAD+);
retinol (vitamin A1) dehydrogenase;
MDR;
microsomal retinol dehydrogenase;
retinol dehydrogenase (misleading);
retinal reductase (ambiguous);
retinene reductase;
epidermal retinol dehydrogenase 2;
SDR16C5 (gene name);
RDH16 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
all-trans retinol:NAD+ oxidoreductase
Reaction(IUBMB)
all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+
Reaction(KEGG)
(other) R02124
Show
Substrate
all-trans-retinol---[cellular-retinol-binding-protein];
NAD+ [CPD:C00003]
Product
all-trans-retinal---[cellular-retinol-binding-protein];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].
History
EC 1.1.1.105 created 1972, modified 2011
Pathway
ec00830  Retinol metabolism
ec01100  Metabolic pathways
Orthology
K13369  17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+)
K15734  all-trans-retinol dehydrogenase (NAD+)
Genes
HSA: 195814(SDR16C5) 8630(HSD17B6)
PTR: 472773(SDR16C5)
PPS: 100993740(SDR16C5) 100996145(HSD17B6)
GGO: 101152181(SDR16C5) 101153072(HSD17B6)
PON: 100450496(SDR16C5) 100458219(HSD17B6)
NLE: 100600756(SDR16C5) 100606923(HSD17B6)
MCC: 696397(SDR16C5) 713549(HSD17B6)
MCF: 101926544(HSD17B6) 101926736(SDR16C5)
CSAB: 103236829(SDR16C5) 103238543(HSD17B6)
RRO: 104661773 104673659(HSD17B6)
RBB: 108516069(HSD17B6) 108538388
CJC: 100387390(HSD17B6) 100392998(SDR16C5)
SBQ: 101038570 101054253(HSD17B6)
MMU: 242285(Sdr16c5) 27400(Hsd17b6)
RNO: 100362350 286964(Hsd17b6) 297805(Sdr16c5)
CGE: 100760372(Sdr16c5) 100762147(Hsd17b6)
NGI: 103730224(Hsd17b6) 103734179(Sdr16c5)
HGL: 101699287(Hsd17b6) 101723971(Sdr16c5)
CCAN: 109686095 109702463(Sdr16c5)
OCU: 100357209
TUP: 102485005(HSD17B6) 102489556(SDR16C5)
CFA: 477888(SDR16C5) 481118(HSD17B6)
AML: 100464987(SDR16C5) 100474694(HSD17B6)
UMR: 103656323(HSD17B6) 103677445(SDR16C5)
ORO: 101368715(HSD17B6) 101381803(SDR16C5)
FCA: 101082207(SDR16C5) 101088341(HSD17B6)
PTG: 102959434(SDR16C5) 102971783(HSD17B6)
AJU: 106982532(SDR16C5) 106986922(HSD17B6)
BTA: 526726(SDR16C5) 533086(HSD17B6)
BOM: 102278015(SDR16C5) 102283510(HSD17B6)
BIU: 109559345 109568694(SDR16C5)
PHD: 102332625(HSD17B6) 102338064(SDR16C5)
CHX: 102185066(HSD17B6) 102186703(SDR16C5)
OAS: 100302354(SDR16C5) 101105400(HSD17B6)
SSC: 100157319(SDR16C5) 100620470
CFR: 102508382 102517328(SDR16C5)
BACU: 103000587(SDR16C5) 103008169(HSD17B6)
LVE: 103076064(HSD17B6) 103076578(SDR16C5)
OOR: 101278484(HSD17B6) 101278906 101289971(SDR16C5)
EPZ: 103545357 103552507(SDR16C5) 103565330(HSD17B6)
EAI: 106832977(HSD17B6) 106841659
MYB: 102260999(SDR16C5)
MYD: 102753241(SDR16C5)
HAI: 109394445
RSS: 109434273(SDR16C5) 109452917
PALE: 102881754(SDR16C5) 102883634(HSD17B6)
LAV: 100653594(SDR16C5) 100657790
MDO: 100029976(SDR16C5)
OAA: 100083362(SDR16C5)
GGA: 421130(SDR16C5)
MGP: 100538468(SDR16C5)
APLA: 101805250(SDR16C5)
ACYG: 106039064(SDR16C5)
TGU: 100224990(SDR16C5) 100230309
GFR: 102033253(SDR16C5) 102033420
FAB: 101814462(SDR16C5) 101814732
CCW: 104690373 104690375(SDR16C5)
CLV: 102083489
EGZ: 104127571(SDR16C5) 104127582
AAM: 106494376(SDR16C5) 106494442
CPIC: 101934621(SDR16C5) 101952318
PBI: 103063029(SDR16C5) 103063622
XLA: 398882(rdh16.L) 444148(sdr16c5.L)
XTR: 100135184(rdh16) 448386(sdr16c5)
NPR: 108789963(SDR16C5)
DRE: 405814(sdr16c5a) 406799(sdr16c5b) 563950(si:dkey-221h15.4)
SANH: 107660835 107676237 107698670(sdr16c5)
CCAR: 109054380
IPU: 108268084(sdr16c5) 108280727
TRU: 101062133(sdr16c5)
LCO: 104939798(sdr16c5) 109140817
NCC: 104945091
MZE: 101474670(sdr16c5)
OLA: 101174946(sdr16c5)
XMA: 102229885(sdr16c5)
PRET: 103479220(sdr16c5)
NFU: 107395036(sdr16c5)
CSEM: 103396624(sdr16c5)
HCQ: 109524163(sdr16c5)
BPEC: 110175116(sdr16c5)
ELS: 105008851 105028193(sdr16c5)
CMK: 103177053(sdr16c5)
CIN: 100185899
SPU: 581999
DME: Dmel_CG15629(CG15629) Dmel_CG9265
DSI: Dsimw501_GD21662(Dsim_GD21662) Dsimw501_GD23300(Dsim_GD23300)
CEL: CELE_T02E1.5(dhs-3) CELE_T11F9.11(dhs-19)
CBR: CBG04146(Cbr-dhs-3) CBG23222(Cbr-dhs-19)
SHX: MS3_07779
HMG: 100200144
SMIN: v1.2.025487.t1(symbB.v1.2.025487.t1)
DAL: Dalk_4703
BLIN: BLSMQ_0754
 » show all
Taxonomy
Reference
1  [PMID:5972368]
  Authors
Koen AL, Shaw CR.
  Title
Retinol and alcohol dehydrogenases in retina and liver.
  Journal
Biochim Biophys Acta 128:48-54 (1966)
Reference
2  [PMID:9677409]
  Authors
Gough WH, VanOoteghem S, Sint T, Kedishvili NY
  Title
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids.
  Journal
J Biol Chem 273:19778-85 (1998)
DOI:10.1074/jbc.273.31.19778
Reference
3  [PMID:12372410]
  Authors
Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H
  Title
Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion.
  Journal
Biochem Biophys Res Commun 297:1171-80 (2002)
DOI:10.1016/S0006-291X(02)02344-6
  Sequence
[hsa:195814]
Reference
4  [PMID:18926804]
  Authors
Lee SA, Belyaeva OV, Kedishvili NY
  Title
Biochemical characterization of human epidermal retinol dehydrogenase 2.
  Journal
Chem Biol Interact 178:182-7 (2009)
DOI:10.1016/j.cbi.2008.09.019
  Sequence
[hsa:195814]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.105
IUBMB Enzyme Nomenclature: 1.1.1.105
ExPASy - ENZYME nomenclature database: 1.1.1.105
BRENDA, the Enzyme Database: 1.1.1.105
CAS: 9033-53-8

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