| Entry |
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| Name |
all-trans-retinol dehydrogenase (NAD+);
retinol (vitamin A1) dehydrogenase;
MDR;
microsomal retinol dehydrogenase;
retinol dehydrogenase (misleading);
retinal reductase (ambiguous);
retinene reductase;
epidermal retinol dehydrogenase 2;
SDR16C5 (gene name);
RDH16 (gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
all-trans retinol:NAD+ oxidoreductase
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| Reaction(IUBMB) |
all-trans-retinol---[cellular-retinol-binding-protein] + NAD+ = all-trans-retinal---[cellular-retinol-binding-protein] + NADH + H+
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| Reaction(KEGG) |
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| Substrate |
all-trans-retinol---[cellular-retinol-binding-protein];
NAD+ [CPD: C00003]
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| Product |
all-trans-retinal---[cellular-retinol-binding-protein];
NADH [CPD: C00004];
H+ [CPD: C00080]
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| Comment |
The enzyme recognizes all-trans-retinol and all-trans-retinal as substrates and exhibits a strong preference for NAD+/NADH as cofactors. Recognizes the substrate both in free form and when bound to cellular-retinol-binding-protein (CRBP1), but has higher affinity for the bound form [2]. No activity with 11-cis-retinol or 11-cis-retinal (cf. EC 1.1.1.315, 11-cis retinol dehydrogenase). Also active with 3alpha-hydroxysteroids [2].
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| History |
EC 1.1.1.105 created 1972, modified 2011
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| Pathway |
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| Orthology |
| K13369 | 17beta-estradiol 17-dehydrogenase / all-trans-retinol dehydrogenase (NAD+) / 3alpha(17beta)-hydroxysteroid dehydrogenase (NAD+) |
| K15734 | all-trans-retinol dehydrogenase (NAD+) |
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| Genes |
» show all
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| Reference |
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| Authors |
Koen AL, Shaw CR. |
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| Title |
Retinol and alcohol dehydrogenases in retina and liver. |
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| Journal |
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| Reference |
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| Authors |
Gough WH, VanOoteghem S, Sint T, Kedishvili NY |
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| Title |
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids. |
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| Journal |
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| Reference |
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| Authors |
Matsuzaka Y, Okamoto K, Tsuji H, Mabuchi T, Ozawa A, Tamiya G, Inoko H |
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| Title |
Identification of the hRDH-E2 gene, a novel member of the SDR family, and its increased expression in psoriatic lesion. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Lee SA, Belyaeva OV, Kedishvili NY |
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| Title |
Biochemical characterization of human epidermal retinol dehydrogenase 2. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.105 |
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