KEGG   ENZYME: 1.1.1.300Help
Entry
EC 1.1.1.300                Enzyme                                 

Name
NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
RDH11;
RDH12;
RDH13;
RDH14;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
RalR1;
PSDR1
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
retinol:NADP+ oxidoreductase
Reaction(IUBMB)
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
Reaction(KEGG)
Substrate
retinol [CPD:C00473];
NADP+ [CPD:C00006]
Product
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC 1.13.11.63 (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC 1.1.1.105, retinol dehydrogenase, which prefers NAD+ and NADH.
History
EC 1.1.1.300 created 2009
Orthology
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
Genes
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3) 115833951
MCC: 106996362(RDH13) 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13)
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
MCAL: 110292172(Dhrs3) 110297351(Rdh13) 110307013(Rdh11) 110307230(Rdh12)
MPAH: 110323041(Dhrs3) 110324273(Rdh11) 110324761(Rdh12) 110336860(Rdh13)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
MUN: 110539426(Dhrs3) 110540988(Rdh13) 110557055(Rdh11) 110563447 110563448
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3)
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
VVP: 112909346(RDH13) 112927128(RDH12) 112927195(RDH11) 112929696(DHRS3)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
PPAD: 109259903(RDH13) 109268278(RDH12) 109268280(RDH11) 109274137(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
BBUB: 102404826(DHRS3) 102405382(RDH12) 102405721(RDH11) 102411635(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882 114108681(RDH13)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
DLE: 111173039(RDH11) 111173259(RDH12) 111181006(RDH13) 111187101(DHRS3)
PCAD: 102978048(RDH12) 102978320(RDH11) 102982136(DHRS3) 102987556 114484116
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
MNA: 107531562(DHRS3) 107541313(RDH13) 107545709(RDH11) 107545710(RDH12)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
DRO: 112299121(DHRS3) 112311390(RDH12) 112311797(RDH11) 112314049(RDH13)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
RAY: 107503265(RDH11) 107503281(RDH12) 107513138(DHRS3) 107515444(RDH13)
MJV: 108396332(RDH13) 108402930(DHRS3) 108410077(RDH11) 108410078(RDH12)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
PCW: 110198918(DHRS3) 110220123(RDH13) 110220578(RDH12) 110220629(RDH11)
GGA: 419480(DHRS3) 423274(RDH12)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931 107323359(DHRS3)
NMEL: 110401302 110408680(DHRS3)
APLA: 101792259(DHRS3) 101793409
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769
LSR: 110473996 110476789(DHRS3)
SCAN: 103820840(DHRS3) 103826955
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
ETL: 114062535 114065123(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890 102058887(DHRS3)
EGZ: 104122065 104133092(DHRS3)
NNI: 104009010(DHRS3) 104020414
ACUN: 113480412 113487888(DHRS3)
PADL: 103914367 103917993(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
PSS: 102445977(DHRS3) 102446647
CMY: 102934533(RDH12) 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
PBI: 103054360(DHRS3) 103055029
PMUR: 107284674(DHRS3) 107285841
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13)
DRE: 100141353(si:dkey-94e7.2) 100150965(si:dkey-73n8.3) 407663(si:ch211-107o10.3) 436597(rdh12) 445083(dhrs3a) 450050(dhrs3b) 494176(rdh12l) 553712(zgc:112332) 561542(si:dkey-23o4.6) 751745(zgc:153441)
IPU: 100528113(rdh13) 108255144(dhrs3) 108257080 108263330(rdh11) 108268141 108270740(RDH12) 108275517(DHRS3) 108280225
LCM: 102347732(RDH13) 102349654 102353614(RDH12) 102354914 102361459(DHRS3)
DSI: Dsimw501_GD10497(Dsim_GD10497) Dsimw501_GD10498(Dsim_GD10498) Dsimw501_GD10499(Dsim_GD10499) Dsimw501_GD10500(Dsim_GD10500) Dsimw501_GD10501(Dsim_GD10501)
DPE: 6602084
ACEP: 105626379
CBR: CBG04620(Cbr-dhs-22) CBG24516(Cbr-dhs-24)
BMY: Bm1_34620
EGL: EGR_02372
PDAM: 113667168
CIT: 102619498
LJA: Lj1g3v0342000.1(Lj1g3v0342000.1) Lj2g3v1016620.1(Lj2g3v1016620.1) Lj4g3v3014530.1(Lj4g3v3014530.1)
PAVI: 110760997
VVI: 100261623
BVG: 104892580
SOE: 110796518
DOSA: Os09t0570300-01(Os09g0570300)
BDI: 100827273
ATS: 109772785(LOC109772785) 109772786(LOC109772786)
SBI: 8078000
SITA: 101786469
PIC: PICST_29666(RDH1)
MAJ: MAA_07435
CMT: CCM_01960
MBE: MBM_08426
ANG: ANI_1_1940074(An08g04690)
PTE: PTT_20036
ABP: AGABI1DRAFT59093(AGABI1DRAFT_59093) AGABI1DRAFT70956(AGABI1DRAFT_70956)
ABV: AGABI2DRAFT117623(AGABI2DRAFT_117623) AGABI2DRAFT186625(AGABI2DRAFT_186625) AGABI2DRAFT203820(AGABI2DRAFT_203820)
DFA: DFA_01654
SMIN: v1.2.009977.t1(symbB.v1.2.009977.t1) v1.2.033662.t1(symbB.v1.2.033662.t1)
CCX: COCOR_00754(yciK)
HOH: Hoch_2073
RPB: RPB_3188
RPC: RPC_2983
RPD: RPD_1039
MDI: METDI3947
MEX: Mext_3159
MCH: Mchl_3483
MPO: Mpop_3355
MOR: MOC_4304
META: Y590_15415
RVA: Rvan_0765
BMD: BMD_2832
BMEG: BG04_5337
MANA: MAMMFC1_03177(fabG_2)
MCHE: BB28_17475
MSTE: MSTE_03452
HAU: Haur_3830
ATM: ANT_25440
DGE: Dgeo_1140
DFC: DFI_07860
PBOR: BSF38_01904(rhlG)
GAU: GAU_2064
BVU: BVU_1966
SLI: Slin_0197
HSW: Hsw_2466
FLM: MY04_4115
IAL: IALB_0056
TAF: THA_705
NGA: Ngar_c13700(sdr2)
NVN: NVIE_020260(sdr-2)
NEV: NTE_00111
LOKI: Lokiarch_06920(rhlG_1)
 » show all
Taxonomy
Reference
1  [PMID:15865448]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
  Title
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
  Journal
Biochemistry 44:7035-47 (2005)
DOI:10.1021/bi050226k
  Sequence
[hsa:145226]
Reference
2  [PMID:18039331]
  Authors
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
  Title
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
  Journal
FEBS J 275:138-47 (2008)
DOI:10.1111/j.1742-4658.2007.06184.x
  Sequence
[hsa:112724]
Reference
3  [PMID:9705317]
  Authors
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
  Title
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
  Journal
J Biol Chem 273:21790-9 (1998)
DOI:10.1074/jbc.273.34.21790
  Sequence
[hsa:9249] [mmu:20148] [bta:281482]
Reference
4  [PMID:12036956]
  Authors
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
  Title
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
  Journal
J Biol Chem 277:28909-15 (2002)
DOI:10.1074/jbc.M202588200
  Sequence
[hsa:51109]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.300
IUBMB Enzyme Nomenclature: 1.1.1.300
ExPASy - ENZYME nomenclature database: 1.1.1.300
BRENDA, the Enzyme Database: 1.1.1.300

DBGET integrated database retrieval system