EC                Enzyme                                 

NADP-retinol dehydrogenase;
all-trans retinal reductase (ambiguous);
all-trans-retinol dehydrogenase;
NADP(H)-dependent retinol dehydrogenase/reductase;
retinol dehydrogenase 12;
retinol dehydrogenase 14;
retinol dehydrogenase [NADP+];
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
retinol:NADP+ oxidoreductase
retinol + NADP+ = retinal + NADPH + H+ [RN:R08379]
retinol [CPD:C00473];
NADP+ [CPD:C00006]
retinal [CPD:C00376];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Greater catalytic efficiency in the reductive direction. This observation, and the enzyme's localization at the entrance to the mitochondrial matrix, suggest that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinal produced from dietary beta-carotene by EC (beta-carotene 15,15'-dioxygenase) [2]. Km-values for NADP+ and NADPH are at least 800-fold lower than those for NAD+ and NADH [1,4]. This enzyme differs from EC, retinol dehydrogenase, which prefers NAD+ and NADH.
EC created 2009
K11146  short-chain dehydrogenase/reductase 3
K11152  retinol dehydrogenase 11
K11153  retinol dehydrogenase 12
K11161  retinol dehydrogenase 13
HSA: 112724(RDH13) 145226(RDH12) 51109(RDH11) 9249(DHRS3)
PTR: 100615509(RDH12) 452986(RDH11) 456293(RDH13) 737006(DHRS3)
PPS: 100971367(DHRS3) 100975938(RDH11) 100976717(RDH12) 100995016(RDH13)
GGO: 101133959(RDH12) 101134301(RDH11) 101136764(DHRS3)
PON: 100173396(RDH11) 100443109(RDH13) 100444779(RDH12) 100446028(DHRS3)
NLE: 100590397(RDH11) 100592081(RDH12) 100595824(RDH13) 100599507(DHRS3) 115833951
MCC: 106996362(RDH13) 711195(RDH11) 711438(RDH12) 715548(DHRS3) 722798
MCF: 101865597(RDH12) 101866088(RDH11) 102118061(RDH13) 102142015(DHRS3)
CSAB: 103225584(DHRS3) 103229214(RDH11) 103229215(RDH12) 103235287(RDH13)
RRO: 104664937(RDH12) 104664944(RDH11) 104668927(DHRS3) 104674753(RDH13)
RBB: 108533721(RDH11) 108533722(RDH12) 108539385(DHRS3) 108542524(RDH13)
CJC: 100386416(DHRS3) 100403102(RDH12) 100406713(RDH13) 103787305(RDH11)
SBQ: 101033448(RDH12) 101039627(DHRS3) 101045253(RDH13) 104649866(RDH11)
MMU: 108841(Rdh13) 17252(Rdh11) 20148(Dhrs3) 77974(Rdh12)
MCAL: 110292172(Dhrs3) 110297351(Rdh13) 110307013(Rdh11) 110307230(Rdh12)
MPAH: 110323041(Dhrs3) 110324273(Rdh11) 110324761(Rdh12) 110336860(Rdh13)
RNO: 313689(Dhrs3) 314264(Rdh12) 361504(Rdh13) 362757(Rdh11)
MUN: 110539426(Dhrs3) 110540988(Rdh13) 110557055(Rdh11) 110563447 110563448
CGE: 100756186(Dhrs3) 100759393(Rdh13) 100759583(Rdh12) 100759877(Rdh11)
NGI: 103744827(Rdh13) 103747479(Dhrs3) 103749297(Rdh11) 103749298(Rdh12)
HGL: 101707915(Dhrs3) 101715642(Rdh12) 101716026(Rdh13) 101716314(Rdh11)
CCAN: 109683963(Dhrs3) 109694521(Rdh11) 109694522(Rdh12) 109696274(Rdh13)
OCU: 100337836(RDH12) 100344639(RDH13) 100348969 100353716(RDH11) 103352513(DHRS3)
TUP: 102494216(RDH13) 102498009(RDH11) 102498963(RDH12) 102502620(DHRS3)
CFA: 480366(RDH11) 487436(DHRS3) 490744(RDH12) 611373(RDH13)
VVP: 112909346(RDH13) 112927128(RDH12) 112927195(RDH11) 112929696(DHRS3)
AML: 100468936(RDH12) 100469186(RDH11) 100470711(RDH13) 100481198(DHRS3)
UMR: 103666638(DHRS3) 103671847(RDH12) 103671858(RDH11) 103680271(RDH13)
ORO: 101365883(RDH11) 101366366(RDH12) 101370738(DHRS3) 101383491(RDH13)
FCA: 101080307(DHRS3) 101093062(RDH13) 101093193(RDH11) 101093615(RDH12)
PTG: 102958225(RDH12) 102958792(RDH11) 102961855(RDH13) 102970609(DHRS3)
PPAD: 109259903(RDH13) 109268278(RDH12) 109268280(RDH11) 109274137(DHRS3)
AJU: 106971557(RDH11) 106971559(RDH12) 106980937(RDH13) 106988168(DHRS3)
BTA: 281482(DHRS3) 369021(RDH12) 505995(RDH11) 508082(RDH13)
BOM: 102265772(DHRS3) 102270792(RDH13) 102270801(RDH11) 102271090(RDH12)
BIU: 109564569(RDH12) 109565274(RDH11) 109570447(DHRS3) 109572930(RDH13)
BBUB: 102404826(DHRS3) 102405382(RDH12) 102405721(RDH11) 102411635(RDH13)
CHX: 102171883(RDH11) 102173010(RDH12) 102179583(DHRS3) 102181531(RDH13)
OAS: 101109288(DHRS3) 101115127(RDH11) 101115797(RDH12) 101122882 114108681(RDH13)
SSC: 100153020(RDH12) 100154684(RDH11) 100514967(DHRS3) 110261049(RDH13)
CFR: 102511414(RDH13) 102516964(RDH12) 102517215(RDH11) 102524578(DHRS3)
CDK: 105086164(RDH12) 105086165(RDH11) 105098733(RDH13) 105107044(DHRS3)
BACU: 103008561(RDH11) 103009435(RDH12) 103011644(RDH13) 103018059(DHRS3)
LVE: 103082238(DHRS3) 103085939(RDH13) 103090972(RDH12) 103091250(RDH11)
OOR: 101277554(RDH13) 101283025(RDH11) 101283442(RDH12) 101290385(DHRS3)
DLE: 111173039(RDH11) 111173259(RDH12) 111181006(RDH13) 111187101(DHRS3)
PCAD: 102978048(RDH12) 102978320(RDH11) 102982136(DHRS3) 102987556 114484116
ECB: 100055280(RDH13) 100055537(DHRS3) 100063295(RDH11) 100063369(RDH12)
EPZ: 103541138(RDH11) 103541139(RDH12) 103552172(DHRS3) 103554723(RDH13)
EAI: 106836659(DHRS3) 106840917(RDH13) 106844772(RDH12) 106844775
MYB: 102246028(RDH13) 102248154(DHRS3) 102260151(RDH11) 102260844(RDH12)
MYD: 102756510(RDH13) 102762827(DHRS3) 102764631(RDH12) 102765110(RDH11)
MNA: 107531562(DHRS3) 107541313(RDH13) 107545709(RDH11) 107545710(RDH12)
HAI: 109373731(RDH13) 109381266(DHRS3) 109382035(RDH11) 109382038(RDH12)
DRO: 112299121(DHRS3) 112311390(RDH12) 112311797(RDH11) 112314049(RDH13)
PALE: 102880345(DHRS3) 102886009(RDH11) 102886424(RDH12) 102890503(RDH13)
RAY: 107503265(RDH11) 107503281(RDH12) 107513138(DHRS3) 107515444(RDH13)
MJV: 108396332(RDH13) 108402930(DHRS3) 108410077(RDH11) 108410078(RDH12)
LAV: 100656973(DHRS3) 100659620(RDH12) 100664643(RDH11) 100668990(RDH13)
MDO: 100010099(DHRS3) 100028370(RDH11) 100028379(RDH12)
PCW: 110198918(DHRS3) 110220123(RDH13) 110220578(RDH12) 110220629(RDH11)
GGA: 419480(DHRS3) 423274(RDH12)
MGP: 100540846 100541886(DHRS3)
CJO: 107314931 107323359(DHRS3)
NMEL: 110401302 110408680(DHRS3)
APLA: 101792259(DHRS3) 101793409
ACYG: 106031772 106040190(DHRS3)
TGU: 100221618(DHRS3) 100226769
LSR: 110473996 110476789(DHRS3)
SCAN: 103820840(DHRS3) 103826955
GFR: 102032402(DHRS3) 102032925(RDH12)
FAB: 101814379(DHRS3) 101816060(RDH12)
PHI: 102106104(RDH12) 102110985(DHRS3)
PMAJ: 107205238 107213682(DHRS3)
CCAE: 111930091 111938724(DHRS3)
CCW: 104688342 104693251(DHRS3)
ETL: 114062535 114065123(DHRS3)
FPG: 101916630(RDH12) 101921484(DHRS3)
FCH: 102055890 102058887(DHRS3)
EGZ: 104122065 104133092(DHRS3)
NNI: 104009010(DHRS3) 104020414
ACUN: 113480412 113487888(DHRS3)
PADL: 103914367 103917993(DHRS3)
AAM: 106482457(DHRS3) 106483104(RDH12)
ASN: 102370531(DHRS3) 102373718
AMJ: 102567292(RDH12) 102574201(DHRS3)
PSS: 102445977(DHRS3) 102446647
CMY: 102934533(RDH12) 102944040(DHRS3)
CPIC: 101941293(DHRS3) 101950060(RDH12)
PBI: 103054360(DHRS3) 103055029
PMUR: 107284674(DHRS3) 107285841
GJA: 107112214(RDH12) 107124081(DHRS3)
XLA: 108697667 444106(rdh13.L) 444269(dhrs3.L)
XTR: 493258(dhrs3) 496409(rdh13)
NPR: 108783931(DHRS3) 108788946(RDH13)
DRE: 100141353(si:dkey-94e7.2) 100150965(si:dkey-73n8.3) 407663(si:ch211-107o10.3) 436597(rdh12) 445083(dhrs3a) 450050(dhrs3b) 494176(rdh12l) 553712(zgc:112332) 561542(si:dkey-23o4.6) 751745(zgc:153441)
IPU: 100528113(rdh13) 108255144(dhrs3) 108257080 108263330(rdh11) 108268141 108270740(RDH12) 108275517(DHRS3) 108280225
KMR: 108228975 108230029 108230278(rdh12l) 108231475(dhrs3b) 108232585(rdh12) 108237226 108237291(si:ch211-107o10.3) 108243166(si:dkey-73n8.3) 108243167(zgc:112332)
LCM: 102347732(RDH13) 102349654 102353614(RDH12) 102354914 102361459(DHRS3)
DSI: Dsimw501_GD10497(Dsim_GD10497) Dsimw501_GD10498(Dsim_GD10498) Dsimw501_GD10499(Dsim_GD10499) Dsimw501_GD10500(Dsim_GD10500) Dsimw501_GD10501(Dsim_GD10501)
DPE: 6602084
ACEP: 105626379
CBR: CBG04620(Cbr-dhs-22) CBG24516(Cbr-dhs-24)
BMY: Bm1_34620
EGL: EGR_02372
PDAM: 113667168
ATH: AT1G64590
ALY: 9323935
CPAP: 110807030
TCC: 18597799
CAM: 101509179
LJA: Lj1g3v0342000.1(Lj1g3v0342000.1)
FVE: 101295243
RCN: 112193888
PMUM: 103339747
PAVI: 110760997
MCHA: 111014975
RCU: 8269384
JCU: 105636270
MESC: 110622567
POP: 7487251
PEU: 105122473
JRE: 109006782
SLY: 101258297
DCR: 108215406
DOSA: Os09t0570300-01(Os09g0570300)
BDI: 100827273
SITA: 101786469
PDA: 103710518
EGU: 105056971
DCT: 110107237
PEQ: 110022984
PIC: PICST_29666(RDH1)
MAJ: MAA_07435
CMT: CCM_01960
MBE: MBM_08426
ANG: ANI_1_1940074(An08g04690)
PTE: PTT_20036
DFA: DFA_01654
SMIN: v1.2.009977.t1(symbB.v1.2.009977.t1) v1.2.033662.t1(symbB.v1.2.033662.t1)
ALK: ALEK_2395
CCX: COCOR_00754(yciK)
HOH: Hoch_2073
RPB: RPB_3188
RPC: RPC_2983
RPD: RPD_1039
MEX: Mext_3159
MCH: Mchl_3483
MPO: Mpop_3355
MOR: MOC_4304
META: Y590_15415
RVA: Rvan_0765
BMD: BMD_2832
BMEG: BG04_5337
MANA: MAMMFC1_03177(fabG_2)
MMAG: MMAD_31940
MCHE: BB28_17475
MSTE: MSTE_03452
HAU: Haur_3830
ATM: ANT_25440
DGE: Dgeo_1140
DFC: DFI_07860
PBOR: BSF38_01904(rhlG)
GAU: GAU_2064
BVU: BVU_1966
SLI: Slin_0197
HSW: Hsw_2466
FLM: MY04_4115
IAL: IALB_0056
TAF: THA_705
NGA: Ngar_c13700(sdr2)
NVN: NVIE_020260(sdr-2)
NEV: NTE_00111
LOKI: Lokiarch_06920(rhlG_1)
 » show all
1  [PMID:15865448]
Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY
Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids.
Biochemistry 44:7035-47 (2005)
2  [PMID:18039331]
Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY
Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity.
FEBS J 275:138-47 (2008)
3  [PMID:9705317]
Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K
Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal.
J Biol Chem 273:21790-9 (1998)
[hsa:9249] [mmu:20148] [bta:281482]
4  [PMID:12036956]
Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS
Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1).
J Biol Chem 277:28909-15 (2002)
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