KEGG   ENZYME: 1.1.1.339Help
Entry
EC 1.1.1.339                Enzyme                                 

Name
dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+);
tll (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
dTDP-6-deoxy-beta-L-talose:NAD+ 4-oxidoreductase
Reaction(IUBMB)
dTDP-6-deoxy-beta-L-talose + NAD+ = dTDP-4-dehydro-beta-L-rhamnose + NADH + H+ [RN:R10190]
Reaction(KEGG)
Substrate
dTDP-6-deoxy-beta-L-talose [CPD:C03187];
NAD+ [CPD:C00003]
Product
dTDP-4-dehydro-beta-L-rhamnose [CPD:C00688];
NADH [CPD:C00004];
H+ [CPD:C00080]
Comment
The enzyme has been characterized from the bacterium Aggregatibacter actinomycetemcomitans, in which it participates in the biosynthesis of the serotype c-specific polysaccharide antigen. Shows no activity with NADP+.
History
EC 1.1.1.339 created 2012
Pathway
ec00523  Polyketide sugar unit biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K19180  dTDP-6-deoxy-L-talose 4-dehydrogenase (NAD+)
Genes
AAT: D11S_1703
PPW: PputW619_3715
PFE: PSF113_1542
PMAN: OU5_5130
PCG: AXG94_23275
PBC: CD58_08165
PSV: PVLB_17310
PCH: EY04_07630
PCZ: PCL1606_44840
PCP: JM49_22240
PSES: PSCI_3460
PSEM: TO66_08035
PSOS: POS17_1647
MEJ: Q7A_2390
DSU: Dsui_0069
PCA: Pcar_1128
PPD: Ppro_3346
DAS: Daes_3275
PPRF: DPRO_2618
DOL: Dole_1963
AVI: Avi_0633
NHA: Nham_2771
SPSE: SULPSESMR1_00522(tll)
SLU: KE3_0783
LRM: LRC_00960
BFI: CIY_27860
DHD: Dhaf_4463
ELM: ELI_3844
MTS: MTES_0570
NML: Namu_4188
BAD: BAD_1506
BBP: BBPR_0064
BBRJ: B7017_2005
BPSP: AH67_07595
BPSC: BBPC_1646
BSCA: BBSC_2386
EPO: Epro_1247
FAE: FAES_5465
MLA: Mlab_1426
 » show all
Taxonomy
Reference
1  [PMID:10702238]
  Authors
Nakano Y, Suzuki N, Yoshida Y, Nezu T, Yamashita Y, Koga T
  Title
Thymidine diphosphate-6-deoxy-L-lyxo-4-hexulose reductase synthesizing dTDP-6-deoxy-L-talose from Actinobacillus actinomycetemcomitans.
  Journal
J Biol Chem 275:6806-12 (2000)
DOI:10.1074/jbc.275.10.6806
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.339
IUBMB Enzyme Nomenclature: 1.1.1.339
ExPASy - ENZYME nomenclature database: 1.1.1.339
BRENDA, the Enzyme Database: 1.1.1.339

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