KEGG   ENZYME: 1.1.1.353Help
Entry
EC 1.1.1.353                Enzyme                                 

Name
versiconal hemiacetal acetate reductase;
VHA reductase;
VHA reductase I;
VHA reductase II;
vrdA (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
versiconol-acetate:NADP+ oxidoreductase
Reaction(IUBMB)
(1) versicolorone + NADP+ = 1'-hydroxyversicolorone + NADPH + H+ [RN:R09756];
(2) versiconol acetate + NADP+ = versiconal hemiacetal acetate + NADPH + H+ [RN:R10399];
(3) versiconol + NADP+ = versiconal + NADPH + H+ [RN:R10400]
Reaction(KEGG)
Substrate
versicolorone [CPD:C20504];
NADP+ [CPD:C00006];
versiconol acetate [CPD:C20506];
versiconol [CPD:C20508]
Product
1'-hydroxyversicolorone [CPD:C20503];
NADPH [CPD:C00005];
H+ [CPD:C00080];
versiconal hemiacetal acetate [CPD:C20505];
versiconal [CPD:C20507]
Comment
Isolated from the mold Aspergillus parasiticus. Involved in a metabolic grid that leads to aflatoxin biosynthesis.
History
EC 1.1.1.353 created 2013
Pathway
ec00254  Aflatoxin biosynthesis
ec01110  Biosynthesis of secondary metabolites
ec01130  Biosynthesis of antibiotics
Orthology
K17647  versiconal hemiacetal acetate reductase
Genes
AOR: AO090120000002
AFV: AFLA_090030
Taxonomy
Reference
1  [PMID:16349333]
  Authors
Matsushima K, Ando Y, Hamasaki T, Yabe K
  Title
Purification and characterization of two versiconal hemiacetal acetate reductases involved in aflatoxin biosynthesis.
  Journal
Appl Environ Microbiol 60:2561-7 (1994)
  Sequence
Reference
2  [PMID:19211038]
  Authors
Shima Y, Shiina M, Shinozawa T, Ito Y, Nakajima H, Adachi Y, Yabe K
  Title
Participation in aflatoxin biosynthesis by a reductase enzyme encoded by vrdA gene outside the aflatoxin gene cluster.
  Journal
Fungal Genet Biol 46:221-31 (2009)
DOI:10.1016/j.fgb.2008.12.005
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.353
IUBMB Enzyme Nomenclature: 1.1.1.353
ExPASy - ENZYME nomenclature database: 1.1.1.353
BRENDA, the Enzyme Database: 1.1.1.353

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