KEGG   ENZYME: 1.1.1.355Help
Entry
EC 1.1.1.355                Enzyme                                 

Name
2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
kanamycin A:NADP+ oxidoreductase
Reaction(IUBMB)
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN:R10417]
Reaction(KEGG)
Substrate
kanamycin A [CPD:C01822];
NADP+ [CPD:C00006]
Product
2'-dehydrokanamycin A [CPD:C20509];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
History
EC 1.1.1.355 created 2013
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20152  2'-dehydrokanamycin reductase
Reference
1  [PMID:22374809]
  Authors
Sucipto H, Kudo F, Eguchi T
  Title
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
  Journal
Angew Chem Int Ed Engl 51:3428-31 (2012)
DOI:10.1002/anie.201108122
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.355
IUBMB Enzyme Nomenclature: 1.1.1.355
ExPASy - ENZYME nomenclature database: 1.1.1.355
BRENDA, the Enzyme Database: 1.1.1.355

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