KEGG ENZYME: 1.1.1.355

ENZYME: 1.1.1.355

Entry

EC 1.1.1.355                Enzyme

Name

2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

kanamycin A:NADP+ oxidoreductase

Reaction(IUBMB)

kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN:R10417]

Reaction(KEGG)

R10417

Substrate

kanamycin A [CPD:C01822];
NADP+ [CPD:C00006]

Product

2'-dehydrokanamycin A [CPD:C20509];
NADPH [CPD:C00005];
H+ [CPD:C00080]

Comment

Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.

History

EC 1.1.1.355 created 2013

Pathway

ec00524

Neomycin, kanamycin and gentamicin biosynthesis

ec01110

Biosynthesis of secondary metabolites

Orthology

K20152

2'-dehydrokanamycin reductase

Reference

1 [PMID:22374809]

Authors

Sucipto H, Kudo F, Eguchi T

Title

The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.

Journal

Angew Chem Int Ed Engl 51:3428-31 (2012)
DOI:10.1002/anie.201108122

Sequence

[ag:BAD20766]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.355

IUBMB Enzyme Nomenclature:

1.1.1.355

ExPASy - ENZYME nomenclature database:

1.1.1.355

BRENDA, the Enzyme Database:

1.1.1.355

DBGET integrated database retrieval system