KEGG   ENZYME: 1.1.1.355Help
Entry
EC 1.1.1.355                Enzyme                                 

Name
2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
kanamycin A:NADP+ oxidoreductase
Reaction(IUBMB)
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN:R10417]
Reaction(KEGG)
Substrate
kanamycin A [CPD:C01822];
NADP+ [CPD:C00006]
Product
2'-dehydrokanamycin A [CPD:C20509];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
History
EC 1.1.1.355 created 2013
Pathway
ec00524  Neomycin, kanamycin and gentamicin biosynthesis
ec01130  Biosynthesis of antibiotics
Orthology
K20152  2'-dehydrokanamycin reductase
Reference
1  [PMID:22374809]
  Authors
Sucipto H, Kudo F, Eguchi T
  Title
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK.
  Journal
Angew Chem Int Ed Engl 51:3428-31 (2012)
DOI:10.1002/anie.201108122
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.355
IUBMB Enzyme Nomenclature: 1.1.1.355
ExPASy - ENZYME nomenclature database: 1.1.1.355
BRENDA, the Enzyme Database: 1.1.1.355

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (5)   
   KEGG COMPOUND (5)   
Chemical reaction (2)   
   KEGG REACTION (1)   
   KEGG RCLASS (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
Protein sequence (21)   
   UniProt (20)   
   SWISS-PROT (1)   
DNA sequence (6)   
   GenBank (3)   
   EMBL (3)   
All databases (40)   

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