| Entry |
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| Name |
2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
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| Sysname |
kanamycin A:NADP+ oxidoreductase
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| Reaction(IUBMB) |
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN: R10417]
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| Reaction(KEGG) |
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| Substrate |
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| Product |
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| Comment |
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
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| History |
EC 1.1.1.355 created 2013
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| Pathway |
| ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K20152 | 2'-dehydrokanamycin reductase |
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| Reference |
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| Authors |
Sucipto H, Kudo F, Eguchi T |
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| Title |
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExPASy - ENZYME nomenclature database: | 1.1.1.355 |
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