Entry |
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Name |
2'-dehydrokanamycin reductase;
kanK (gene name, ambiguous)
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Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
 |
Sysname |
kanamycin A:NADP+ oxidoreductase
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Reaction(IUBMB) |
kanamycin A + NADP+ = 2'-dehydrokanamycin A + NADPH + H+ [RN: R10417]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
Found in the bacterium Streptomyces kanamyceticus where it is involved in the conversion of kanamycin B to kanamycin A.
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History |
EC 1.1.1.355 created 2013
|
Pathway |
ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
ec01130 | Biosynthesis of antibiotics |
|
Orthology |
K20152 | 2'-dehydrokanamycin reductase |
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Reference |
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Authors |
Sucipto H, Kudo F, Eguchi T |
Title |
The last step of kanamycin biosynthesis: unique deamination reaction catalyzed by the alpha-ketoglutarate-dependent nonheme iron dioxygenase KanJ and the NADPH-dependent reductase KanK. |
Journal |
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Sequence |
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Other DBs |
ExPASy - ENZYME nomenclature database: | 1.1.1.355 |
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