| Entry |
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| Name |
6'''-hydroxyneomycin C oxidase;
neoG (gene name);
neoQ (obsolete gene name)
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| Class |
Oxidoreductases;
Acting on the CH-OH group of donors;
With oxygen as acceptor
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| Sysname |
6'''-deamino-6'''-hydroxyneomycin C:oxygen 6'''-oxidoreductase
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| Reaction(IUBMB) |
6'''-deamino-6'''-hydroxyneomycin C + O2 = 6'''-deamino-6'''-oxoneomycin C + H2O2 [RN: R08902]
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| Reaction(KEGG) |
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| Substrate |
6'''-deamino-6'''-hydroxyneomycin C [CPD: C17588];
O2 [CPD: C00007]
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| Product |
6'''-deamino-6'''-oxoneomycin C [CPD: C17589];
H2O2 [CPD: C00027]
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| Comment |
Contains FAD. Involved in the biosynthetic pathway of aminoglycoside antibiotics of the neomycin family. Works in combination with EC 2.6.1.95, neomycin C transaminase, to replace the 6'''-hydroxy group of 6'''-hydroxyneomycin C with an amino group.
Also catalyses EC 1.1.3.43, paromamine 6'-oxidase.
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| History |
EC 1.1.3.44 created 2012
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| Pathway |
| ec00524 | Neomycin, kanamycin and gentamicin biosynthesis |
| ec01110 | Biosynthesis of secondary metabolites |
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| Orthology |
| K20565 | paromamine 6'-oxidase / 6'''-hydroxyneomycin C oxidase |
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| Genes |
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| Reference |
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| Authors |
Huang F, Spiteller D, Koorbanally NA, Li Y, Llewellyn NM, Spencer JB |
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| Title |
Elaboration of neosamine rings in the biosynthesis of neomycin and butirosin. |
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| Journal |
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| Reference |
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| Authors |
Clausnitzer D, Piepersberg W, Wehmeier UF |
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| Title |
The oxidoreductases LivQ and NeoQ are responsible for the different 6'-modifications in the aminoglycosides lividomycin and neomycin. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.1.3.44 |
| ExPASy - ENZYME nomenclature database: | 1.1.3.44 |
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