KEGG   ENZYME: 1.12.1.5Help
Entry
EC 1.12.1.5                 Enzyme                                 

Name
hydrogen dehydrogenase [NAD(P)+];
hydrogenase II (ambiguous)
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
hydrogen:NAD(P)+ oxidoreductase
Reaction(IUBMB)
H2 + NAD(P)+ = H+ + NAD(P)H [RN:R00700 R07181]
Reaction(KEGG)
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
H+ [CPD:C00080];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
History
EC 1.12.1.5 created 2013
Orthology
K17993  sulfhydrogenase subunit alpha
K17994  sulfhydrogenase subunit delta
Genes
DES: DSOUD_2750
DEU: DBW_2713 DBW_2714
PHO: PH1292(PH1292) PH1294(PH1294)
PAB: PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787
PFU: PF0893 PF0894 PF1331 PF1332
PFI: PFC_03675 PFC_03680 PFC_05870 PFC_05875
PYN: PNA2_1551 PNA2_1553 PNA2_1665 PNA2_1666
PYA: PYCH_00040 PYCH_00050 PYCH_08370 PYCH_08380
PYS: Py04_0892 Py04_0893 Py04_1129 Py04_1130
PYC: TQ32_02785 TQ32_02790 TQ32_03115 TQ32_03120
BARB: AOA66_1503(shyD) AOA66_1504(hydA)
 » show all
Taxonomy
Reference
1  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J Bacteriol 182:1864-71 (2000)
DOI:10.1128/JB.182.7.1864-1871.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.5
IUBMB Enzyme Nomenclature: 1.12.1.5
ExPASy - ENZYME nomenclature database: 1.12.1.5
BRENDA, the Enzyme Database: 1.12.1.5

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