KEGG   ENZYME: 1.12.1.5
Entry
EC 1.12.1.5                 Enzyme                                 

Name
hydrogen dehydrogenase [NAD(P)+];
hydrogenase II (ambiguous)
Class
Oxidoreductases;
Acting on hydrogen as donor;
With NAD+ or NADP+ as acceptor
Sysname
hydrogen:NAD(P)+ oxidoreductase
Reaction(IUBMB)
H2 + NAD(P)+ = H+ + NAD(P)H [RN:R00700 R07181]
Reaction(KEGG)
R00700 R07181
Substrate
H2 [CPD:C00282];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006]
Product
H+ [CPD:C00080];
NADH [CPD:C00004];
NADPH [CPD:C00005]
Comment
A nickel, iron, iron-sulfur protein. The enzyme from the archaeon Pyrococcus furiosus is part of a heterotetrameric complex where the alpha and delta subunits function as a hydrogenase while the beta and gamma subunits function as sulfur reductase (EC 1.12.98.4, sulfhydrogenase). Different from EC 1.12.1.3, hydrogen dehydrogenase (NADP+).
History
EC 1.12.1.5 created 2013
Orthology
K17993  sulfhydrogenase subunit alpha
K17994  sulfhydrogenase subunit delta
Genes
AVL: AvCA_04400(hoxH)
AVD: AvCA6_04400(hoxH)
ACX: Achr_4360(hoxY) Achr_4370(hoxH)
MSQ: BKP64_00955 BKP64_00960
MARA: D0851_07215 D0851_07220
MICC: AUP74_02543(hoxH) AUP74_02544(hoxY)
MII: BTJ40_11460 BTJ40_11465
MICT: FIU95_09940(hoxH) FIU95_09945(hoxY)
MHYD: GTQ55_08910 GTQ55_08915
ALG: AQULUS_13030(hoxH) AQULUS_13040(hoxY)
ASIP: AQUSIP_08270(hoxY) AQUSIP_08280(hoxH)
LPM: LP6_2497(hydA) LP6_2498
LPC: LPC_2010 LPC_2011(hydA)
LCJ: NCTC11976_02959(hoxY) NCTC11976_02962(hoxH_2)
FNA: OOM_1816
TNI: TVNIR_2169 TVNIR_2170(vhuG_[H])
TBD: Tbd_1263
SCL: sce4575(hoxH)
MGRY: MSR1_09580(hoxH) MSR1_09590(hoxY)
MGM: Mmc1_0883
AFR: AFE_0937(hoxH) AFE_0938(hoxY)
MTHN: 4412656_03554(hoxY) 4412656_03555(hoxH)
NSR: NS506_04373(hydA) NS506_04374(mvhG)
RER: RER_34040
REQ: REQ_15170
SLAU: SLA_6981
SGE: DWG14_00278(hoxY) DWG14_00279(hoxH)
SRO: Sros_4826
TBI: Tbis_1858
GPA: GPA_23180
MIN: Minf_2390(frhG) Minf_2391(frhA)
FMR: Fuma_01323(hoxH) Fuma_01324(hoxY)
GMR: GmarT_18740(hoxY) GmarT_18750(hoxH)
KST: KSMBR1_3673(hoxY) KSMBR1_3674(hoxH)
ALUS: STSP2_01452(hoxH) STSP2_01453(hoxY)
RMR: Rmar_2590
MGOT: MgSA37_01986(hoxY) MgSA37_01987(hoxH)
CCH: Cag_0245
PROC: Ptc2401_02008(hoxY) Ptc2401_02009(hoxH)
CTS: Ctha_0344
NIO: NITINOP_0586(hydA) NITINOP_0587(hydD)
PHO: PH1292(PH1292) PH1294(PH1294)
PAB: PAB0640(hydD-2) PAB0641(hydA-2) PAB1786 PAB1787
HTI: HTIA_2365
BARB: AOA66_1503(shyD) AOA66_1504(hydA)
PSYT: DSAG12_03219(shyD)
 » show all
Reference
1  [PMID:10714990]
  Authors
Ma K, Weiss R, Adams MW
  Title
Characterization of hydrogenase II from the hyperthermophilic archaeon Pyrococcus furiosus and assessment of its role in sulfur reduction.
  Journal
J Bacteriol 182:1864-71 (2000)
DOI:10.1128/JB.182.7.1864-1871.2000
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.12.1.5
IUBMB Enzyme Nomenclature: 1.12.1.5
ExPASy - ENZYME nomenclature database: 1.12.1.5
BRENDA, the Enzyme Database: 1.12.1.5

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