KEGG   ENZYME: 1.13.11.76
Entry
EC 1.13.11.76               Enzyme                                 
Name
2-amino-5-chlorophenol 1,6-dioxygenase;
cnbC (gene name);
2-amino-5-chlorophenol:oxygen 1,6-oxidoreductase (decyclizing)
Class
Oxidoreductases;
Acting on single donors with incorporation of molecular oxygen (oxygenases);
With incorporation of two atoms of oxygen
Sysname
2-amino-5-chlorophenol:oxygen 1,6-oxidoreductase (ring-opening)
Reaction(IUBMB)
2-amino-5-chlorophenol + O2 = 2-amino-5-chloromuconate 6-semialdehyde [RN:R10521]
Reaction(KEGG)
R10521
Substrate
2-amino-5-chlorophenol [CPD:C20669];
O2 [CPD:C00007]
Product
2-amino-5-chloromuconate 6-semialdehyde [CPD:C20670]
Comment
The enzyme, a member of the nonheme-iron(II)-dependent dioxygenase family, is an extradiol-type dioxygenase that utilizes a non-heme ferrous iron to cleave the aromatic ring at the meta position (relative to the hydroxyl substituent). The enzyme from the bacterium Comamonas testosteroni CNB-1 also has the activity of EC 1.13.11.74, 2-aminophenol 1,6-dioxygenase.
History
EC 1.13.11.76 created 2013
Orthology
K15059  2-aminophenol/2-amino-5-chlorophenol 1,6-dioxygenase subunit beta
Genes
PPWPputW619_2014
PKCPKB_3263(amnb1) PKB_3611(amnb3)
BXEBxe_A1145(amnB)
BXBDR64_3304(amnB)
BAVBAV0550(amnB)
BHZACR54_00822(cnbCb)
AXYAXYL_02641
AISBUW96_03280
ASWCVS48_11345
ACHBDVB37_23465
ADYHLG70_04300(cnbCb)
PIGEGT29_21585
SYBTZ53_02830
SUFLFIL70_13995
SBARH5V43_15190
VMAVAB18032_17825
MCRAID554_30935
VERHUT12_13600
PRYPrubr_10680
SCORJ3U87_09070
 » show all
Reference
1  [PMID:15580337]
  Authors
Wu JF, Sun CW, Jiang CY, Liu ZP, Liu SJ
  Title
A novel 2-aminophenol 1,6-dioxygenase involved in the degradation of p-chloronitrobenzene by Comamonas strain CNB-1: purification, properties, genetic cloning and expression in Escherichia coli.
  Journal
Arch Microbiol 183:1-8 (2005)
DOI:10.1007/s00203-004-0738-5
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.13.11.76
IUBMB Enzyme Nomenclature: 1.13.11.76
ExPASy - ENZYME nomenclature database: 1.13.11.76
BRENDA, the Enzyme Database: 1.13.11.76

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