| Entry |
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| Name |
[histone H3]-dimethyl-L-lysine9 demethylase;
KDM3A (gene name);
KDM3B (gene name);
JMJD1A (gene name);
JMJD1B (gene name);
JHDM2A (gene name);
JHDM2B (gene name);
KDM7B (gene name);
PHF8 (gene name);
HR (gene name)
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| Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
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| Sysname |
[histone H3]-N6,N6-dimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase
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| Reaction(IUBMB) |
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN: R10056];
(1a) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 [RN: R09510];
(1b) a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 [RN: R09511]
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| Reaction(KEGG) |
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| Substrate |
[histone H3]-N6,N6-dimethyl-L-lysine9;
2-oxoglutarate [CPD: C00026];
O2 [CPD: C00007];
[histone H3]-N6-methyl-L-lysine9
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| Product |
[histone H3]-L-lysine9;
succinate [CPD: C00042];
formaldehyde [CPD: C00067];
CO2 [CPD: C00011];
[histone H3]-N6-methyl-L-lysine9
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| Comment |
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the di- and mono-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase.
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| History |
EC 1.14.11.65 created 2019
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| Orthology |
| K00478 | [histone H3]-dimethyl-L-lysine9 demethylase |
| K11445 | [histone H3]-dimethyl-L-lysine9 demethylase |
| K15601 | [histone H3]-dimethyl-L-lysine9 demethylase |
| K19415 | [histone H3]-dimethyl-L-lysine9 demethylase |
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| Genes |
» show all
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| Reference |
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| Authors |
Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y |
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| Title |
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Loh YH, Zhang W, Chen X, George J, Ng HH |
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| Title |
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells. |
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| Journal |
Genes Dev 21:2545-57 (2007) |
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| Reference |
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| Authors |
Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I |
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| Title |
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation. |
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| Journal |
Nat Struct Mol Biol 17:445-50 (2010) |
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| Sequence |
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| Reference |
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| Authors |
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M |
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| Title |
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a. |
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| Journal |
Science 341:1106-9 (2013) |
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| Sequence |
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| Reference |
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| Authors |
Liu L, Kim H, Casta A, Kobayashi Y, Shapiro LS, Christiano AM |
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| Title |
Hairless is a histone H3K9 demethylase. |
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| Journal |
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| Sequence |
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| Other DBs |
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