KEGG   ENZYME: 1.14.11.65
Entry
EC 1.14.11.65               Enzyme                                 
Name
[histone H3]-dimethyl-L-lysine9 demethylase;
KDM3A (gene name);
KDM3B (gene name);
JMJD1A (gene name);
JMJD1B (gene name);
JHDM2A (gene name);
JHDM2B (gene name);
KDM7B (gene name);
PHF8 (gene name);
HR (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With 2-oxoglutarate as one donor, and incorporation of one atom of oxygen into each donor
Sysname
[histone H3]-N6,N6-dimethyl-L-lysine9,2-oxoglutarate:oxygen oxidoreductase
Reaction(IUBMB)
a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2 2-oxoglutarate + 2 O2 = a [histone H3]-L-lysine9 + 2 succinate + 2 formaldehyde + 2 CO2 (overall reaction) [RN:R10056];
(1a) a [histone H3]-N6,N6-dimethyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-N6-methyl-L-lysine9 + succinate + formaldehyde + CO2 [RN:R09510];
(1b) a [histone H3]-N6-methyl-L-lysine9 + 2-oxoglutarate + O2 = a [histone H3]-L-lysine9 + succinate + formaldehyde + CO2 [RN:R09511]
Reaction(KEGG)
Substrate
[histone H3]-N6,N6-dimethyl-L-lysine9;
2-oxoglutarate [CPD:C00026];
O2 [CPD:C00007];
[histone H3]-N6-methyl-L-lysine9
Product
[histone H3]-L-lysine9;
succinate [CPD:C00042];
formaldehyde [CPD:C00067];
CO2 [CPD:C00011];
[histone H3]-N6-methyl-L-lysine9
Comment
Requires iron(II). This entry describes a group of enzymes that demethylate N-methylated Lys-9 residues in the tail of the histone protein H3 (H3K9). This lysine residue can exist in three methylation states (mono-, di- and trimethylated), but this group of enzymes only act on the the di- and mono-methylated forms. The enzymes are dioxygenases and act by hydroxylating the methyl group, forming an unstable hemiaminal that leaves as formaldehyde. cf. EC 1.14.11.66, [histone H3]-trimethyl-L-lysine9 demethylase.
History
EC 1.14.11.65 created 2019
Orthology
K00478  [histone H3]-dimethyl-L-lysine9 demethylase
K11445  [histone H3]-dimethyl-L-lysine9 demethylase
K15601  [histone H3]-dimethyl-L-lysine9 demethylase
K19415  [histone H3]-dimethyl-L-lysine9 demethylase
Genes
HSA23133(PHF8) 51780(KDM3B) 55806(HR) 55818(KDM3A) 80853(KDM7A)
PTR462095(KDM3B) 464040(HR) 465652(PHF8) 470424(KDM3A) 472532(KDM7A)
PPS100971462(KDM3A) 100973092(PHF8) 100974528(KDM7A) 100980801(HR) 100989674(KDM3B)
GGO101130195(KDM3A) 101132441(HR) 101133194(PHF8) 101143613(KDM7A) 101152151(KDM3B)
PON100439361(KDM7A) 100451474(HR) 100453519(KDM3A) 100461475(PHF8) 103890727(KDM3B)
NLE100580058(KDM3B) 100594054(HR) 100601220(PHF8) 100602763(KDM7A) 100602862(KDM3A)
MCC574164(HR) 697775(KDM3A) 703633(PHF8) 711830(KDM7A) 716648(KDM3B)
MCF101864801(KDM3A) 102126923(KDM3B) 102128432(PHF8) 102130334(KDM7A) 102146603(HR)
CSAB103215441(HR) 103219924(KDM3A) 103227008(KDM7A) 103232021(PHF8) 103244610(KDM3B)
CATY105579239(HR) 105587671(KDM3A) 105589663(KDM7A) 105598631(PHF8) 105599838(KDM3B)
PANU100999980(KDM3A) 101015006(PHF8) 101017364(KDM3B) 101019014(KDM7A) 101019424(HR)
TGE112604827(KDM3A) 112615507(PHF8) 112621806(KDM7A) 112625734(KDM3B) 112630704(HR)
RRO104656599(KDM7A) 104663955(HR) 104677068(KDM3A) 104681854(KDM3B) 104682297(PHF8)
RBB108521323(HR) 108521720 108523299(KDM3A) 108534836(KDM7A) 108541694(KDM3B)
TFN117062158(KDM3A) 117065804(KDM3B) 117073660(KDM7A) 117078480(PHF8) 117093091(HR)
PTEH111521469(KDM7A) 111528659(KDM3B) 111536168(PHF8) 111545675(HR) 111551109(KDM3A)
CJC100400684(HR) 100402409(KDM3A) 100405152(KDM7A) 100405431(KDM3B) 100405966(PHF8) 103791420
SBQ101036878(KDM3B) 101038744(PHF8) 101041467(HR) 101048409(KDM3A) 101051188(KDM7A)
CSYR103255240 103255583(KDM3A) 103260535(KDM7A) 103261710(KDM3B) 103265897(HR)
MMUR105857133(HR) 105862588(KDM3B) 105867068(PHF8) 105873230(KDM7A) 105876617(KDM3A)
OGA100944740(HR) 100948971(KDM3A) 100955977(KDM7A) 100964099(KDM3B) 100965601(PHF8)
MMU104263(Kdm3a) 15460(Hr) 277250(Kdm3b) 320595(Phf8) 338523(Kdm7a)
MCAL110284500(Kdm3b) 110286584(Phf8) 110295891(Kdm3a) 110296568(Kdm7a) 110309466(Hr)
MPAH110313305(Phf8) 110314829(Kdm3a) 110316394(Kdm7a) 110325567(Hr) 110333384(Kdm3b) 110335393
RNO299557(RGD1310212) 312440(Kdm3a) 317425(Phf8) 60563(Hr) 682469(Kdm3b) 684297(Kdm7a)
MCOC116084764(Hr) 116086978(Kdm3b) 116089734(Phf8) 116098765(Kdm7a) 116099061(Kdm3a)
MUN110539603 110545785(Kdm7a) 110551667(Hr) 110558460(Kdm3b) 110563696(Kdm3a)
CGE100752012(Kdm3b) 100756628(Phf8) 100765886(Hr) 100771108(Kdm3a) 100773228(Kdm7a) 100774109
PLEU114685573(Kdm3a) 114698778(Hr) 114702881(Phf8) 114705111(Kdm3b) 114706841(Kdm7a)
NGI103726099(Kdm7a) 103735156(Kdm3b) 103737052(Kdm3a) 103747314(Phf8) 103747778(Hr)
HGL101699351(Kdm7a) 101710794(Hr) 101713897(Kdm3b) 101716284(Phf8) 101723328(Kdm3a)
CPOC100718883(Kdm7a) 100721757(Phf8) 100726903(Hr) 100727212(Kdm3a) 100730299(Kdm3b)
CCAN109678510(Phf8) 109681363(Kdm3b) 109685469 109685470 109690461(Hr) 109695710(Kdm3a)
DORD105988644(Kdm3b) 105989466(Kdm7a) 105999425(Hr) 106000262(Kdm3a) 106000517(Phf8)
DSP122096642(Hr) 122105975(Kdm7a) 122112019(Phf8) 122116630(Kdm3a) 122118079(Kdm3b)
OCU100338358(KDM7A) 100344764(PHF8) 100346181(KDM3B) 100357019(HR) 100358329(KDM3A)
OPI101516112(KDM3B) 101521335(HR) 101524889(KDM3A) 101528834(PHF8) 101534335(KDM7A)
TUP102468331(KDM3B) 102482466(PHF8) 102483037(KDM7A) 102496564(KDM3A) 102497988(HR)
CFA474695(KDM3B) 475763(KDM3A) 482769(KDM7A) 486130(HR) 491897(PHF8)
VVP112907052(KDM7A) 112912465(PHF8) 112916661(KDM3A) 112921904(KDM3B) 112926824(HR)
VLG121490166(KDM7A) 121490857(KDM3A) 121495302(KDM3B) 121498074(HR)
AML100465004(KDM3B) 100478044(HR) 100481292(PHF8) 100482264(KDM3A) 100484484(KDM7A)
UMR103663948(KDM3B) 103669104(KDM7A) 103671466(KDM3A) 103673344(HR) 103681294(PHF8)
UAH113242954(KDM3A) 113247534(PHF8) 113261789(KDM3B) 113265016(KDM7A) 113270010(HR)
UAR123777452(HR) 123788883(KDM7A) 123790306(KDM3B) 123793526(PHF8) 123799703(KDM3A)
ELK111139928 111140753 111147968 111151896 111155178
LLV125080612 125091686 125092848 125100774 125108614
MPUF101674550(KDM7A) 101677720(KDM3B) 101679605(HR) 101680792(PHF8) 101682431(KDM3A)
ORO101366569(KDM3B) 101368265(PHF8) 101374851(KDM7A) 101375149(KDM3A) 101381177(HR)
EJU114200637(PHF8) 114209440(KDM3B) 114211741(KDM7A) 114217504(HR) 114223432(KDM3A)
ZCA113910907(KDM7A) 113925989(HR) 113928910(KDM3B) 113930714(PHF8) 113937471(KDM3A)
MLX117999051(PHF8) 118007892(KDM3A) 118016684(KDM3B) 118021153(KDM7A) 118022071(HR)
FCA101087899(KDM3B) 101090097(HR) 101091609(KDM7A) 101092337(PHF8) 101094014(KDM3A)
PYU121010766(KDM3B) 121024724(PHF8) 121028981(KDM7A) 121039884(HR) 121044494(KDM3A)
PBG122472509(HR) 122476885(PHF8) 122487923(KDM3B) 122488396(KDM7A) 122497137(KDM3A)
PTG102949083(KDM3B) 102951883(PHF8) 102952247(KDM7A) 102967684(KDM3A) 102971648(HR)
PPAD109252129(KDM3B) 109261301(PHF8) 109264121(KDM3A) 109269100(KDM7A) 109277357(HR)
AJU106968509(KDM3B) 106970395(KDM7A) 106978152(KDM3A) 106981121(HR) 106985228(PHF8)
HHV120220746(KDM3B) 120225764(PHF8) 120232962(KDM7A) 120239457(HR) 120245537(KDM3A)
BTA100848816(KDM3B) 513959(PHF8) 521504(KDM7A) 536073(KDM3A) 785815(HR)
BOM102268445(KDM3A) 102271352(KDM7A) 102283438(PHF8) 102284413(HR) 102288360(KDM3B)
BIU109554894(PHF8) 109557955(KDM7A) 109561075(KDM3B) 109563100(HR) 109566155(KDM3A)
BBUB102399076(KDM3B) 102402096(PHF8) 102404623(KDM7A) 102411447(HR) 102411697(KDM3A)
CHX102171151(HR) 102178793(KDM7A) 102184056(KDM3B) 102185576(KDM3A) 102186671
OAS101106756(KDM3A) 101111280(KDM3B) 101111627(KDM7A) 101118668(PHF8) 443241(HR)
ODA120851486(KDM3A) 120863609(KDM3B) 120865379(HR) 120877650(KDM7A) 120882172(PHF8)
CCAD122431899(HR) 122434784(PHF8) 122438716(KDM7A) 122439871(KDM3B) 122441759(KDM3A)
SSC100515632(KDM7A) 100515884(KDM3B) 100517522(KDM3A) 100520413(PHF8) 397617(HR)
CFR102504168(KDM3A) 102517611(KDM3B) 102517929(HR) 102518453(PHF8) 102522822(KDM7A)
CBAI105063028(KDM7A) 105068989(HR) 105072118(KDM3A) 105081541(PHF8) 105082169(KDM3B)
CDK105091085(KDM3B) 105091644(KDM7A) 105093683(PHF8) 105102729(HR) 105104170(KDM3A)
VPC102524777(HR) 102524782(KDM3A) 102527192(PHF8) 102527237(KDM7A) 102533658(KDM3B)
BACU103000070(KDM3A) 103000580(PHF8) 103013150(KDM7A) 103014592(HR) 103014807(KDM3B)
LVE103071419(PHF8) 103072442(KDM3A) 103077313(KDM7A) 103089463(KDM3B) 103089845(HR)
OOR101275638(KDM3B) 101278897(KDM7A) 101281085(KDM3A) 101287099(PHF8) 101289157(HR)
DLE111165409(KDM3A) 111169011(HR) 111169400(PHF8) 111177710(KDM7A) 111182496(KDM3B)
PCAD102977831(KDM3B) 102979345(PHF8) 102984422(KDM3A) 102990432(KDM7A) 102993125(HR)
PSIU116747525(PHF8) 116752322(KDM3B) 116756044(HR) 116759289(KDM7A) 116764099(KDM3A)
ECB100053727(HR) 100060410(PHF8) 100062288(KDM3B) 100066113(KDM7A) 100066939(KDM3A)
EPZ103544040 103551355(KDM3B) 103555339(KDM7A) 103562057(KDM3A) 103566264(HR)
EAI106827349(PHF8) 106838584(KDM3A) 106839246(KDM3B) 106842580(KDM7A) 106847718(HR)
MYB102241201(PHF8) 102254444(KDM3A) 102258695(HR) 102259727(KDM7A) 102262860(KDM3B)
MYD102752154(KDM7A) 102755445(HR) 102757708(KDM3A) 102759691(PHF8) 102770711(KDM3B)
MMYO118653685(PHF8) 118658930(KDM3B) 118658994(HR) 118666349(KDM7A) 118668778(KDM3A)
MLF102418079(HR) 102418268(PHF8) 102418498(KDM7A) 102425534 102440155(KDM3B)
MNA107528676(KDM3A) 107530125(KDM3B) 107531081(KDM7A) 107538839(PHF8) 107543545(HR)
PKL118711715(KDM3B) 118713727(KDM7A) 118714031(PHF8) 118717626(KDM3A) 118725837(HR)
HAI109375925(KDM3A) 109382348(HR) 109388530(KDM7A) 109393019(KDM3B) 109396386(PHF8)
DRO112299785(KDM7A) 112302945(KDM3A) 112305232(HR) 112308159(PHF8) 112318036(KDM3B)
SHON118975073(HR) 118982081(KDM3A) 118989082(KDM7A) 118997565(KDM3B) 118997788(PHF8)
AJM119044436(KDM7A) 119050998(KDM3B) 119054763(HR) 119055472(PHF8) 119059857(KDM3A)
PDIC114498541(KDM3A) 114504175(HR) 114505471(PHF8) 114507876(KDM7A) 114509521(KDM3B)
PHAS123806415(KDM3B) 123811623(KDM3A) 123814866(PHF8) 123828336(HR) 123829671(KDM7A)
MMF118615912(KDM3B) 118616017(HR) 118620108(KDM7A) 118630476(KDM3A) 118635658(PHF8)
RFQ117016630(KDM3B) 117018068(KDM7A) 117026358(PHF8) 117033059(KDM3A) 117037581(HR)
PALE102880246(KDM7A) 102882413(KDM3A) 102893538(KDM3B) 102894028(PHF8) 102895975(HR)
PGIG120581350(KDM3B) 120593556(PHF8) 120594601(KDM3A) 120601248(KDM7A) 120606618(HR)
PVP105291611(KDM7A) 105293619(KDM3B) 105296542(HR) 105298533(KDM3A) 105307799(PHF8)
RAY107506006(KDM3A) 107506610(PHF8) 107509236(HR) 107518719(KDM3B) 107519345(KDM7A)
MJV108385294(KDM3B) 108393188(HR) 108396206 108402258(KDM3A) 108405197(KDM7A)
TOD119234300(HR) 119243427(KDM3B) 119245659(PHF8) 119247734(KDM7A) 119259144(KDM3A)
SARA101543749(KDM3B) 101550151(KDM7A) 101554490(KDM3A) 101555528(PHF8) 101557443(HR)
LAV100654829(KDM3A) 100660627(PHF8) 100665548(KDM7A) 100671524(KDM3B) 100675014(HR)
TMU101354693 101357906 101359737 101359931 101360722
DNM101432750(KDM3A) 101443365(HR) 101443377(PHF8) 101444806(KDM7A) 101447752(KDM3B)
MDO100017835(KDM7A) 100018142(KDM3A) 100019755(PHF8) 100025115(KDM3B) 100033094(HR)
GAS123233860(KDM3B) 123236688(KDM3A) 123236960(HR) 123250358(KDM7A) 123253723(PHF8)
SHR100913734(HR) 100914942(PHF8) 100917474(KDM3A) 100924702(KDM3B) 100933752(KDM7A)
PCW110196286(KDM3A) 110200432(HR) 110203535(PHF8) 110216227(KDM7A) 110220805(KDM3B)
OAA100076728(KDM7A) 100078761(PHF8) 100080666(KDM3A) 100088813(HR) 100092204(KDM3B)
GGA100859412(KDM3B) 107049623(HR) 418110(KDM7A) 422917(KDM3A)
PCOC116225707(KDM3A) 116226804(KDM7A) 116232280(KDM3B) 116238568(HR)
MGP100540242 100548885(KDM7A) 100550281(KDM3A) 104913311
CJO107313921(KDM3A) 107316012(KDM7A) 107320032(KDM3B)
NMEL110394301(KDM7A) 110398700(KDM3A) 110405432(KDM3B)
APLA101792656(KDM3A) 101799682(KDM3B) 101802308(KDM7A)
ACYG106031048(KDM7A) 106032716(KDM3B) 106034003(KDM3A)
AFUL116489129(KDM3A) 116494728(KDM3B) 116495114(KDM7A) 116499326(HR)
TGU100223451(KDM7A) 100226128(KDM3B) 100226356(KDM3A) 115492034(PHF8) 115498188(HR)
LSR110473305(KDM3A) 110477356(KDM3B) 110479416(HR) 110480571(PHF8) 110482623(KDM7A)
SCAN103817543(KDM3B) 103819605(KDM7A) 103823538(KDM3A) 103825198 108963604
PMOA120497171(HR) 120498734(KDM3B) 120501538(KDM7A) 120503083(PHF8) 120509406(KDM3A)
OTC121332505(KDM3B) 121332744(KDM7A) 121335228(KDM3A) 121336826(PHF8) 121346700(HR)
PRUF121352152(KDM3A) 121357335(PHF8) 121364304(KDM7A) 121365569(KDM3B) 121366008(HR)
GFR102033931(KDM3B) 102033961(KDM7A) 102038017(KDM3A)
FAB101812676(KDM3B) 101812948(KDM7A) 101820866(KDM3A)
PHI102101072(KDM3A) 102106638(KDM7A) 102106682(KDM3B) 102114626(HR)
PMAJ107202896(KDM3A) 107204765(KDM7A) 107210627(KDM3B) 107213805(HR)
CCAE111928304(KDM3A) 111935420(KDM3B) 111936971(KDM7A)
CCW104689460(KDM3B) 104690808(KDM3A) 104696183(KDM7A) 120411152(HR)
ETL114056173(KDM7A) 114058529(KDM3A) 114067189(KDM3B) 114070083 114072159
ZAB102067560(KDM3B) 102071485(KDM3A) 102074396(KDM7A)
FPG101918015(KDM3A) 101919240(HR) 101921419(KDM3B) 101923116(PHF8) 101924888(KDM7A)
FCH102045971(KDM3B) 102050963(HR) 102058181(KDM3A) 102058196(KDM7A) 102059772(PHF8)
CLV102084952(KDM7A) 102085459(KDM3A) 102092569(KDM3B) 102095540(HR)
EGZ104123613(KDM3B) 104135249(KDM3A) 104135567(KDM7A)
NNI104012063(KDM3B) 104012378(KDM7A) 104016037 104018538(KDM3A)
ACUN113479415(KDM3A) 113485115(KDM3B) 113488583(KDM7A)
TALA104363984(KDM3B) 104364991(KDM3A) 104366160(KDM7A) 116965504(HR)
PADL103923118(KDM3B) 103923511(KDM3A) 103924516(KDM7A)
ACHC115334286(KDM3B) 115338232(PHF8) 115344269(KDM3A) 115349784(HR) 115352493(KDM7A)
AAM106484895(KDM3A) 106487160(KDM3B) 106488270(KDM7A)
AROW112964857(KDM3B) 112965512(KDM3A) 112972632(PHF8) 112973611(HR) 112974653(KDM7A)
NPD112943029(KDM3A) 112945630(KDM7A) 112952800(KDM3B)
DNE112990767(KDM3A) 112994081(KDM3B) 112995031(KDM7A)
ASN102367801(PHF8) 102369743(KDM3A) 102375877(HR) 102384419(KDM7A) 102385873(KDM3B)
AMJ102561002(HR) 102564045(KDM3A) 102565368(KDM7A) 102572481(KDM3B) 102576916(PHF8)
CPOO109310262(KDM3B) 109315928(KDM7A) 109317449(HR) 109322275(KDM3A)
GGN109289732(KDM3B) 109296413(KDM7A) 109304003(KDM3A)
PSS102451224(KDM3A) 102452179(KDM7A) 102459230(KDM3B)
CMY102934784(KDM3A) 102936854(KDM7A) 102938050(HR) 102942689(KDM3B) 119564919(PHF8)
CPIC101931208 101938224(KDM3B) 101943939(KDM3A) 101944418(HR)
TST117872980(HR) 117877955(KDM3A) 117881685(KDM7A) 117882292(KDM3B)
CABI116818902(PHF8) 116822781(KDM3A) 116826436(KDM7A) 116828118(KDM3B) 116836899(HR)
MRV120369548(KDM7A) 120370723(KDM3B) 120388512(PHF8) 120399369(HR) 120406610(KDM3A)
ACS100558799(kdm7a) 100565622(kdm3b) 100566919(phf8)
PVT110077141(KDM3B) 110078613(PHF8) 110082708(KDM7A)
SUND121921582(KDM3B) 121922074(PHF8) 121932272(KDM7A)
PBI103049534(KDM3B) 103057322(PHF8) 103057981(KDM7A)
PMUR107286551(PHF8) 107289184(KDM3B) 107291326(KDM7A)
TSR106545401(KDM3B) 106549042(PHF8) 106557367(KDM7A)
PGUT117655556(KDM7A) 117675459(PHF8) 117679493(KDM3B)
VKO123028950(KDM7A) 123029951(PHF8) 123034077(KDM3B)
PMUA114587329(PHF8) 114591477(KDM3B) 114604965(KDM7A)
ZVI118075479(PHF8) 118080535(KDM3B) 118090639(KDM7A)
GJA107107150(KDM3B) 107108788(KDM7A) 107120718(PHF8)
XLA108699998(phf8.S) 108710732 108711000(kdm3b.L) 108713217(kdm3b.S) 398683(phf8.L) 432112(kdm3a.L) 444005(kdm7a.S) 496351(kdm3a.S)
XTR100135177(kdm3b) 100379807(kdm3a) 733740(phf8) 780121(kdm7a)
NPR108790443(PHF8) 108798114(KDM3B) 108798478(KDM7A) 108799576(KDM3A)
RTEM120913173(PHF8) 120924339(KDM3A) 120932159(KDM3B) 120932906(KDM7A)
BBUF120977166(PHF8) 120978707(KDM3B) 120990371 120990372 120990373 121006000(KDM7A)
BGAR122921758(KDM7A) 122928122(KDM3B) 122939812 122939823 122939830 122946058 122946085
DRE321248(kdm7aa) 326643(kdm3b) 503902(kdm7ab) 566534(phf8)
SRX107707470 107710674 107716077 107732814 107742679 107745465 107754509 107755881
SANH107665263 107665704 107679597 107680036 107681973 107694190 107695732 107703655
SGH107557668 107563633 107570386 107572692 107575156 107588407(kdm3b) 107590789 107590966
CCAR109050707 109050828 109050914 109058285 109071593 109075367 109081251(phf8) 109107655
CAUA113043252 113048207 113061837 113065491 113066726 113069575 113070542 113113599
IPU108268841(kdm3b) 108268891(kdm7ab) 108276206(phf8) 108279642(kdm7aa)
PHYP113523883 113530637(phf8) 113542755(kdm3b) 113546643(kdm7a)
SMEO124385909(kdm3b) 124385935(kdm7ab) 124401165(kdm7aa)
AMEX103031714(kdm7a) 103035987(kdm3b) 103038657(phf8) 103040257
EEE113569278(kdm7a) 113570716(kdm3b) 113583350 113584437(phf8)
TRU101063341(phf8) 101066593(kdm3b) 101076981(kdm7a)
TNGGSTEN00019907G001 GSTEN00021511G001
LCO104922718(kdm3b) 104925311(kdm7a) 104932735(phf8)
NCC104954674(kdm3b) 104956848(phf8) 104968057(kdm7a)
CGOB115010619(phf8) 115014380 115028242(kdm7a)
ELY117249393(kdm7aa) 117258513(phf8) 117260664(kdm3b)
PLEP121946905(phf8) 121947733(kdm3b) 121961637(kdm7aa)
SLUC116039152(phf8) 116060087(kdm7aa) 116064303(kdm3b)
ECRA117938969(kdm7aa) 117947756(phf8) 117951196(kdm3b)
PFLV114550332(kdm7a) 114558895(phf8) 114562653(kdm3b)
GAT120817238(kdm3b) 120818311(kdm7aa) 120829087(phf8)
PPUG119210088(kdm3b) 119210342(kdm7aa) 119221933(phf8)
MSAM119888193 119905498(phf8) 119918234(kdm7aa) 119919361
CUD121505556(kdm7aa) 121516036(kdm3b) 121517595(phf8)
MZE101478139(phf8) 101482566(kdm3b) 101484672(kdm7a)
ONL100690767(kdm3b) 100699317(kdm7a) 100707999(phf8)
OAU116325803(phf8) 116329048(kdm3b) 116334660(kdm7aa)
OLA101156787(kdm7a) 101158953(kdm3b) 101166128(phf8)
OML112152985(kdm3b) 112155849(kdm7aa) 112159175(phf8)
XMA102222440(phf8) 102233421(kdm7a) 102236626(kdm3b)
XCO114139068(kdm3b) 114145833(phf8) 114160655(kdm7a)
XHE116714213 116727017(phf8) 116736575(kdm7a)
PRET103459110(kdm7a) 103467329(phf8) 103471239(kdm3b)
PFOR103135554(kdm3b) 103140218(kdm7a) 103141155(phf8)
PLAI106935046(phf8) 106957552(kdm7a) 106962568(kdm3b)
PMEI106904331(phf8) 106924672(kdm7a) 106933999(kdm3b)
GAF122826613(kdm7aa) 122837403(kdm3b) 122844097(phf8)
CVG107086788(phf8) 107095910(kdm7a) 107101767(kdm3b)
CTUL119782202(phf8) 119791158(kdm7aa) 119792495(kdm3b)
GMU124860246(kdm3b) 124873673(phf8) 124883260(kdm7aa)
NFU107375406(kdm3b) 107386380(kdm7a) 107390865(phf8)
KMR108233298(kdm7aa) 108240570(kdm3b) 108244610(phf8)
ALIM106514823(kdm7a) 106517661(kdm3b) 106534448(phf8)
NWH119408497(kdm3b) 119417631(phf8) 119428319(kdm7aa)
AOCE111569066(kdm7a) 111573437(kdm3b) 111576533(phf8)
CSEM103382718(kdm7a) 103384580(phf8) 103391012(kdm3b)
POV109630635(phf8) 109639123(kdm3b) 109642794(kdm7a)
SSEN122766563(kdm7aa) 122777424(phf8) 122778291(kdm3b)
HHIP117756996(kdm7aa) 117764736(phf8) 117769111(kdm3b)
LCF108876399(phf8) 108886202(kdm7a) 108899237
SDU111219101(phf8) 111224552(kdm7a) 111226425(kdm3b)
SLAL111646547(kdm3b) 111660050(kdm7a) 111670732(phf8)
XGL120785119(kdm3b) 120799884(kdm7aa) 120804106(phf8)
HCQ109518753(kdm3b) 109520217(phf8) 109523662(kdm7a)
BPEC110157613(kdm3b) 110161650(kdm7a) 110164574(phf8)
MALB109969690(kdm7a) 109971338(phf8) 109973152(kdm3b)
SASA106561353 106567021 106572710 106573199 106576355 106604924 106609399 106611934
OTW112216368 112217057 112218787 112220739 112221678 112252586(kdm7ab) 112256067 112267822
OMY110488590 110490481 110498407 110499986 110504800 110523495(kdm7ab) 110532714 118939533
OGO123993233 123994442 124003165(kdm7ab) 124010974 124014440 124032299 124040372 124046112
ONE115102683 115109602 115118341 115129319 115130508 115132508 115132989 115134043
SALP111952426 111955724 111962630 111965374 111966133 111967112 111977024 112067883
SNH120031903 120042006 120048212 120050080 120054110(kdm7ab) 120059087 120061008 120062556
ELS105013526(phf8) 105018223 105023448 105030321(kdm3b)
SFM108918571 108918762 108931562 108936838(kdm3b) 108939360
PKI111850514 111851237(kdm7a) 111855168(kdm3b) 111857050(phf8)
AANG118207776(phf8) 118222820(kdm3b) 118231709(kdm7ab) 118236331
LOC102683241(kdm3a) 102683929(kdm3b) 102684829 102686620(kdm7a)
PSPA121297437 121319566(kdm7ab) 121324136 121329054(phf8) 121331054
ARUT117401790 117408576 117413212 117415966 117419857 117431502 117970892 117973818
LCM102357423(KDM3B) 102358546(KDM3A) 102360659(PHF8) 102364075(KDM7A)
CMK103177263 103181484 103181879
RTP109916970 109918863(kdm7a) 109931051
BFO118416788
BBEL109478506 109486459
CIN100186291
SCLV120338873
SPU584837
APLC110974246
DMEDmel_CG8165(JHDM2)
DER6551800
DSE6607100
DYADyak_GE25957
DAN6501701
DSR110186612
DPODpse_GA20859
DPE6592144
DMN108154097
DWI6650461
DGR6563007
DMODmoj_GI10155
DAZ108620885
DNV108659609
DHE111593343
DVI6633093
CCAT101454483
BOD106618076
MDE101898867
SCAC106087866
LCQ111690288
AGAAgaP_AGAP002682
ACOZ120952772
AARA120893886
AAG5568859
AALB109404484 109406317 115261474 115261483
CQUCpipJ_CPIJ002903
CNS116339040
AME408944 410796
ACER107992465 107998431
ALAB122716040 122719388
BIM100741021 100748410
BBIF117208390 117216270
BVK117235299 117237734
BVAN117158116 117161169
BTER100643532 100648008
BPYO122570159 122577838
CCAL108623775 108627296
OBB114873724 114876184
MGEN117222022 117229680
NMEA116427677 116427701
CGIG122396356 122397985
SOC105197632 105207370
MPHA105831467 105836569
AEC105154009 105154695
ACEP105618013 105618554
PBAR105422686 105430127
VEM105564380 105566650
HST105182611 105191947
DQU106746513 106752044
CFO105256483 105259356
FEX115236527 115237891
LHU105671081 105671723
PGC109853673 109858121
OBO105280996 105285579
PCF106787737 106793424
PFUC122513374 122525475
VPS122632902 122637149
NVI100118316 100120387
CSOL105365650 105368368
TPRE106652030
MDL103569985 103576549
CGLO123258473 123271298
FAS105269662 105273831
DAM107038331 107045117
AGIF122848945 122853403
CCIN107267325 107274361
TCA655414 657601
DPA109537928 109539240
SOY115875040 115882916
ATD109608452 109608524
CSET123318836 123321404
AGB108906265 108917842
LDC111511070
NVL108566691 108567468
APLN108737574 108741242
PPYR116166465 116177968
OTU111414184 111428176
BMOR101737516 101746803
BMAN114240782 114253592
MSEX115440849 115442295
DPLKGM_212259 KGM_213911
BANY112047018 112051327
PMAC106707738 106719698
PPOT106111432
PXU106118485 106122068
PRAP110992579 111002389
ZCE119834076 119837706
HAW110371995 110372396 110373012
TNL113497978 113498243 113507849
OFU114356710 114365917
PXY105395210
API100165271 100167724
DNX107162056 107171901 107172987
AGS114121429 114121430 114122201
RMD113554458 113555953
BTAB109034424
DCI103512616
CLEC106661667 106664092 106670702
HHAL106679085 106681312
NLU111043754 111049355 111055104 120354604
PHUPhum_PHUM511870
FOC113203801 113210250
ZNE110831744 110833658
CSEC111863110 111864611
FCD110851159 110851649
DPXDAPPUDRAFT_302352 DAPPUDRAFT_44746
DMK116921174 116929829
PVM113829036 113829195
PJA122247997
HAME121853687 121868047
PCLA123766737
PTRU123520311
HAZT108680138
EAF111695647 111699073 111718409
ISCIscW_ISCW016174 IscW_ISCW018588
DSV119459688 119461183
RSAN119379177 119396367
RMP119174580 119175870 119176631 119176633 119181576
VDE111247505 111251560
VJA111265419 111272752
TUT107369786
DFR124493353
CSCU111630442 111641655
PTEP107443848 107452613 107454948
SDM118186252 118197349 118199711
CELCELE_F29B9.2(jmjd-1.2)
CBRCBG_00502 CBG_01727(Cbr-jmjd-1.2) CBG_17159
LOALOAG_16418
NAINECAME_07829
TSPTsp_10659
HROHELRODRAFT_191270 HELRODRAFT_66280 HELRODRAFT_84338
LGILOTGIDRAFT_125461 LOTGIDRAFT_214375
PCAN112563891 112572205
BGT106074056
GAE121367629 121382781
HRF124123466 124136309
HRJ124261112
CRG105339941 105349098
MYI110457157 110460958
PMAX117331432 117339459
MMER123529570 123547522
OBI106875029 106883140
OSN115210477 115219521
LAK106168307 106176703
SMMSmp_161400
OVIT265_09128
EGLEGR_01790
NVE5511144
EPA110232045 110239832
ATEN116296338 116303077
ADF107340963
AMIL114969021
SPIS111335348
DGT114530640
XEN124435194 124444950
HMG101240623
AQU100639981
ATHAT1G09060 AT1G11950 AT1G62310 AT3G07610(IBM1) AT4G00990 AT4G21430(B160)
ALY9299864 9303920 9308986 9320727 9322542 9325796 9328728
CRB17877965 17881740 17890836 17893860 17895764 17896740 17898507
CSAT104705181 104707982 104712706 104714565 104718190 104722919 104731398 104739495 104739846 104744953 104746941 104752888 104755094 104755458 104764486 104767299 104770809 104783015 104784876 104793410
EUSEUTSA_v10006723mg EUTSA_v10006772mg EUTSA_v10020080mg EUTSA_v10023846mg EUTSA_v10024332mg EUTSA_v10028389mg EUTSA_v10029199mg
BRP103836196 103836361 103836863 103838408 103848169 103858823 103859003 103861230 103870649
BNA106362179 106362338 106362531 106365638 106365732 106382408 106384149 106391149 106397011 106401349 106407809 106417203 106420968 106420969 106438634 106440150 106452609 106452943 106453173 111211859 111212007
BOE106295854 106307025 106312486 106312888 106314441 106318121 106320549 106335168 106342895
RSZ108815526 108821948 108822691 108822894 108827618 108827827 108831834 108836671 108841898 108844796 108845708 108845709 108850104 108854937 108857932 108863230
THJ104802301 104805886 104806269 104809481
CPAP110808037 110815324 110817837 110817842 110823553
CIT102608274 102618372 102627530 102628262 102630420 112498587
CICCICLE_v10000178mg CICLE_v10014405mg CICLE_v10018309mg CICLE_v10018464mg CICLE_v10030129mg CICLE_v10030567mg
PVY116105794 116111837 116118247 116120916 116127730 116145560
MINC123193660 123203107 123216179 123219186 123221013 123221611 123222771 123224033 123224326 123229211
TCC18594898 18594944 18596980 18597208 18600456 18605773 18608484 18613967
GRA105764144 105765441 105776528 105776893 105792513 105796000 105798928 105802803
GHI107886373 107886889 107888974 107891819 107893542 107894236 107899094 107909028 107909805 107920142 107922997 107925048 107925205 107935390 107937768 107946103 107947242
GAB108456686 108458513 108462003 108464033 108470050 108470506 108470810 108475988 108479413 108489158
DZI111275118 111275220 111276660 111277308 111278223 111278287 111282335 111291322 111293855 111304844 111308098
EGR104422002 104424512 104432297 104441103 104441424 104456270
GMX100780803 100787798 100792166 100797799 100797860 100799234 100801287 100801772 100802129 100805723 100806419 100808936 100810673
GSJ114372006 114372354 114374498 114377657 114385667 114388143 114393753 114400039 114400181 114402667 114403732 114419476 114420197 114421319
PVUPHAVU_002G220900g PHAVU_003G0315000 PHAVU_003G081400g PHAVU_006G146500g PHAVU_006G193200g PHAVU_007G016300g PHAVU_007G196300g PHAVU_009G044500g
VRA106764357 106769172 106769293 106770921 106772037 106775239 106777829
VAR108319082 108326030 108326042 108326469 108335790 108336764 108341633 108343467
VUN114173692 114177024 114178232 114179197 114186619 114188594 114189879 114190673 114190936
CCAJ109791350 109792867 109795965 109803836 109804071 109805638 109809401 109812025 109814285
APRC113846017 113846373 113850353 113857849 113870828 113871360
MTRMTR_0020s0100 MTR_1g008060 MTR_1g069565 MTR_1g083120 MTR_1g114070 MTR_1g114130 MTR_1g114150 MTR_2g011630 MTR_2g024140 MTR_2g024270 MTR_4g091520 MTR_4g132540 MTR_5g047620 MTR_5g065200 MTR_7g117445
CAM101491141 101492686 101499864 101500129 101504299 101508582 101510147 101510800 101512170
LJALj0g3v0183709.1(Lj0g3v0183709.1) Lj0g3v0226069.1(Lj0g3v0226069.1) Lj0g3v0266619.1(Lj0g3v0266619.1) Lj0g3v0359099.1(Lj0g3v0359099.1) Lj1g3v5035010.1(Lj1g3v5035010.1) Lj3g3v2443330.1(Lj3g3v2443330.1) Lj4g3v0134600.1(Lj4g3v0134600.1) Lj4g3v0134600.2(Lj4g3v0134600.2) Lj5g3v2258440.1(Lj5g3v2258440.1) Lj6g3v1812130.1(Lj6g3v1812130.1) Lj6g3v2115770.1(Lj6g3v2115770.1)
ADU107465322 107467388 107468654 107480557 107481935 107491941 107494945
AIP107605295 107617672 107617904 107623244 107626237 107628195 107635922 107645693
AHF112695306 112697376 112710820 112712232 112714676 112720584 112728632 112741247 112755284 112758460 112776580 112779524 112783249 112791371 112800837
LANG109333240 109334446 109335964 109336286 109346541 109349310 109354502 109362924
FVE101291294 101293935 101296675 101297357 101298267 101304554 101311232 101313813 101314963 105350308
RCN112165154 112167797 112175938 112175955 112175956 112176495 112176556 112182020 112183165 112192158 112202312
PPER18774933 18775974 18778157 18780819 18785058 18785228
PMUM103324432 103324621 103331520 103332197 103333767 103336696 103344581
PAVI110745954 110755359 110755425 110757606 110757978 110761507 110767149
PDUL117617200 117617278 117623937 117624950 117629215 117629612
MDM103410099 103419652 103434093 103434479 103434663 103436763 103443682 103446492 103446740 103450924
PXB103929317 103939628 103941479 103943437 103948209 103948381 103955549 103963072 103965329
ZJU107412028 107414789 107420983 107421868 107422024 107423648
MNT21384327 21385972 21396700 21397315 21404458 21406261 21406437
CSV101205548 101212609 101213201 101221956
CMO103483181 103484564 103494803 103501341
BHJ120067115 120074191 120079380 120083001
MCHA111011805 111012394 111016257 111018800
CMAX111465429 111478370 111479552 111489241 111497046
CMOS111431944 111433811 111444156 111444677 111453694
CPEP111781587 111791913 111798542 111804142 111809358
RCU8272423 8275377 8279765 8287067
JCU105634571 105641053 105644045 105647520 105649444 110008625
HBR110636361 110640309 110640311 110652189 110659337 110659751 110659841 110666717 110671140 110673841
MESC110600303 110603091 110603589 110605221 110609603 110620614 110626432
POP112323367 18097336 18098686 7473273 7475185 7477121 7484535 7486369 7494328 7496997
PEU105108522 105109539 105119259 105123855 105123935 105125065 105134208 105138797 105139757
PALZ118031276 118038675 118039404 118042793 118047634 118050884 118057135 118060765
JRE108987281 108993135 108994046 109003678 109008549
QSU111989488 111995675 112003991 112018887 112019937 112020902 112030617 112030626
QLO115979542 115983630 115984353 115989638 115991978
TWL119983099 119984887 119987701 119987804 119988588 119989036 120000947 120004943 120009158
VVI100244450 100249389 100250303 100258626 100261347
VRI117913221 117922968 117924153 117924278 117930285 117932242
SLY101244102 101252668 101254269 101260929 101261570 101265193 101266484 101268515
SPEN107008917 107010511 107010872 107011550 107014353 107017980 107028609 107030481
SOT102579305 102579336 102592630 102600140 102601383 102601654 102602507
CANN107853986 107859430 107859487 107859618 107859758 107863125 107870654
NTA107760914 107762636 107763131 107781452 107783445 107790961 107792489 107801811 107807497 107811127 107816625 107817667 107819356 107820201 107823214 107826305 107827619
NSY104210645 104216911 104220079 104223604 104229368 104230525 104233138 104236192 104247108
NTO104085787 104086546 104089625 104089740 104092962 104107374 104113677 104120641
NAU109210238 109210393 109210417 109221321 109225259 109226670 109240176 109240531
INI109146533 109165748 109167226 109167549 109170062 109170488 109189206 109190745
ITR115999033 116014530 116019870 116022145 116028446 116028592 116029499 116032231
SIND105160354 105164507 105167913 105167942 105175293 105178010 105178012 105179295
OEU111367462 111367707 111368321 111395941 111401080 111402317 111402932 111407153 111407210
EGT105951478 105954987 105954988 105954989 105954992 105962268 105962291 105962292 105968855 105971139 105971720 105973384 105976354
SSPL121741356 121744023 121774592 121775413 121777273 121782215 121784962 121787820 121799331 121804812 121809575
HAN110864993 110891504 110891505 110897732 110908467 110911634 110911863 110911866 110918305 110922488 110937904 110939759 110940261
ECAD122578794 122581287 122582194 122592486 122593272 122593617 122593626 122594611 122595845 122598373 122598400 122600266 122600681 122601645 122604737
LSV111876199 111891028 111897129 111897591 111897596 111897599 111897601 111897616 111897624 111897637 111899281 111906700 111906844
CCAV112509058 112519070 112519826 112520797 112523406 112524134 112526359 112526634
DCR108196439 108198168 108199584 108199761 108200418 108200872 108204525 108204753 108208940 108210880 108218474 108218680 108218781 108219993 108220736 108220782 108221020 108221768 108223011
CSIN114264142 114264287 114266443 114268310 114268347 114280817 114293695 114297156 114299718 114313129 114317079
BVG104888238 104890817 104894116 104900526 104900951 104902560 104902561 104902562
SOE110776892 110782183 110782184 110782215 110783111 110786898 110790482 110791310
CQI110687212 110687400 110693506 110696129 110700529 110702095 110702096 110708655 110716258 110716390 110716391 110726512 110731303 110736881
NNU104586476 104588030 104594066 104610850 104612247
MING122071557 122078449 122078741 122082724 122082866 122094085
TSS122640764 122644562 122645932 122646059 122652471 122665823 122665826 122668049 122671675
PSOM113275863 113281752 113282767 113284362 113287766 113288027 113295951 113296009 113303396 113303421 113305551 113313020 113313133 113313961 113317849 113319150 113323573 113331285 113331302 113355522
NCOL116254572 116258349 116260149 116264174
OSA4328036 4331234 4332818 4333174 4346966
DOSAOs02t0109501-00(Os02g0109501) Os02t0828900-01(Os02g0828900) Os03t0346700-01(Os03g0346700) Os03t0430400-01(Os03g0430400) Os09t0393200-01(Os09g0393200)
OBR102700407 102704400 102706545 102715972 102720417
BDI100822574 100824316 100827690 100830519 100839939 100840043
ATS109735815 109751030 109762874 109778383
TDC119282505 119285652 119292670 119301485 119303548 119309301 119319373 119323379 119366488
TAES123039062 123066751 123085844 123088655 123097453 123103666 123111890 123121446 123131680 123135497 123143072 123180586
SBI8055790 8056244 8064531 8066494 8075376 8082299
ZMA100280238 103639146 103643664 103654986 115072891
SITA101770150 101773812 101776595 101782484 101785162
SVS117835064 117837736 117838147 117841672 117842084 117849487
PVIR120650419 120650691 120652383 120654389 120657702 120677648 120678814 120681947 120693259
PHAI112875134 112875831 112879069 112882015 112889370
PDA103716776 103722119 103722435
EGU105039109 105045269 105055437 105058958
MUS103973768 103977644 103978241 103980677
DCT110092432 110094082 110094528 110094529 110096451 110099337
PEQ110020896 110023871 110026107 110029163 110033089 110037200
AOF109819530 109824870 109828027 109840026 109846237 109851265
ATR18426427 18437573 18442343 18445315 18445708
PPP112281307 112291212 112293817 112294516
CSLCOCSUDRAFT_58661 COCSUDRAFT_60531
CVRCHLNCDRAFT_139911
MISMICPUN_56249
MPPMICPUCDRAFT_67662
TMLGSTUM_00002399001
CNECNB00050
CNBCNBB5640
CGICGB_B9660W
TMSTREMEDRAFT_62039
TASAA1Q1_05278
TVSTRAVEDRAFT_70056
DSQDICSQDRAFT_103145
PCOPHACADRAFT_249898
SHSSTEHIDRAFT_146372
HIRHETIRDRAFT_312843
PSQPUNSTDRAFT_142322
ADLAURDEDRAFT_96661
FMEFOMMEDRAFT_21365
GTRGLOTRDRAFT_109823
LBCLACBIDRAFT_303733
MRRMoror_11511
CCICC1G_08208
SCMSCHCODRAFT_103341
ABPAGABI1DRAFT79449(AGABI1DRAFT_79449)
ABVAGABI2DRAFT184322(AGABI2DRAFT_184322)
CPUTCONPUDRAFT_103614
SLASERLADRAFT_446408
PFPPFL1_00870
PGRPGTG_14479
MLRMELLADRAFT_102214 MELLADRAFT_108548 MELLADRAFT_77276 MELLADRAFT_94186
MBRMONBRDRAFT_17694
SREPTSG_03313
EHXEMIHUDRAFT_108224
 » show all
Reference
1  [PMID:16603237]
  Authors
Yamane K, Toumazou C, Tsukada Y, Erdjument-Bromage H, Tempst P, Wong J, Zhang Y
  Title
JHDM2A, a JmjC-containing H3K9 demethylase, facilitates transcription activation by androgen receptor.
  Journal
Cell 125:483-95 (2006)
DOI:10.1016/j.cell.2006.03.027
  Sequence
[hsa:55818]
Reference
2  [PMID:17938240]
  Authors
Loh YH, Zhang W, Chen X, George J, Ng HH
  Title
Jmjd1a and Jmjd2c histone H3 Lys 9 demethylases regulate self-renewal in embryonic stem cells.
  Journal
Genes Dev 21:2545-57 (2007)
DOI:10.1101/gad.1588207
Reference
3  [PMID:20208542]
  Authors
Feng W, Yonezawa M, Ye J, Jenuwein T, Grummt I
  Title
PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2  demethylation.
  Journal
Nat Struct Mol Biol 17:445-50 (2010)
DOI:10.1038/nsmb.1778
  Sequence
[hsa:23133]
Reference
4  [PMID:24009392]
  Authors
Kuroki S, Matoba S, Akiyoshi M, Matsumura Y, Miyachi H, Mise N, Abe K, Ogura A, Wilhelm D, Koopman P, Nozaki M, Kanai Y, Shinkai Y, Tachibana M
  Title
Epigenetic regulation of mouse sex determination by the histone demethylase Jmjd1a.
  Journal
Science 341:1106-9 (2013)
DOI:10.1126/science.1239864
  Sequence
[mmu:104263]
Reference
5  [PMID:24334705]
  Authors
Liu L, Kim H, Casta A, Kobayashi Y, Shapiro LS, Christiano AM
  Title
Hairless is a histone H3K9 demethylase.
  Journal
FASEB J 28:1534-42 (2014)
DOI:10.1096/fj.13-237677
  Sequence
[hsa:55806]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.11.65
IUBMB Enzyme Nomenclature: 1.14.11.65
ExPASy - ENZYME nomenclature database: 1.14.11.65
BRENDA, the Enzyme Database: 1.14.11.65

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