Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
vinorine,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (21alpha-hydroxylating)
vinorine + [reduced NADPH---hemoprotein reductase] + O2 = vomilenine + [oxidized NADPH---hemoprotein reductase] + H2O [RN:
[reduced NADPH---hemoprotein reductase] [CPD:
[oxidized NADPH---hemoprotein reductase] [CPD:
A cytochrome P-450 (heme-thiolate) protein from the plant Rauvolfia serpentina. Forms a stage in the biosynthesis of the indole alkaloid ajmaline.
EC 18.104.22.168 created 2002 as EC 22.214.171.124, transferred 2018 to EC 126.96.36.199
ec00901 Indole alkaloid biosynthesis
ec01110 Biosynthesis of secondary metabolites
Falkenhagen, H. and Stockligt, J.
Enzymatic biosynthesis of vomilenine, a key intermediate of the ajmaline pathway, catalysed by a novel cytochrome P-450-dependent enzyme from plant cell cultures of Rauwolfia serpentina.
Z Naturforsch C: Biosci 50:45-53 (1995)