KEGG   ENZYME: 1.14.14.112
Entry
EC 1.14.14.112              Enzyme                                 

Name
ent-cassa-12,15-diene 11-hydroxylase;
ent-cassadiene C11alpha-hydroxylase;
CYP76M7
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
Sysname
ent-cassa-12,15-diene,[reduced NADPH---hemoprotein reductase]:oxygen 11-oxidoreductase
Reaction(IUBMB)
ent-cassa-12,15-diene + O2 + [reduced NADPH---hemoprotein reductase] = ent-11beta-hydroxycassa-12,15-diene + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R09866]
Reaction(KEGG)
R09866
Substrate
ent-cassa-12,15-diene [CPD:C18226];
O2 [CPD:C00007];
[reduced NADPH---hemoprotein reductase] [CPD:C03024]
Product
ent-11beta-hydroxycassa-12,15-diene [CPD:C20150];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
A cytochrome P-450 (heme-thiolate) protein. The enzyme from rice (Oryza sativa) is involved in the biosynthesis of the antifungal phytocassanes.
History
EC 1.14.14.112 created 2012 as EC 1.14.13.145, transferred 2018 to EC 1.14.14.112
Pathway
ec00904  Diterpenoid biosynthesis
ec01110  Biosynthesis of secondary metabolites
Orthology
K16084  ent-cassa-12,15-diene 11-hydroxylase / oryzalexin D synthase
Genes
OSA: 4329722 4329723 4341447
DOSA: Os02t0569400-01(Os02g0569400) Os02t0569900-01(Os02g0569900) Os06t0599200-01(Os06g0599200)
Reference
1  [PMID:19825834]
  Authors
Swaminathan S, Morrone D, Wang Q, Fulton DB, Peters RJ
  Title
CYP76M7 is an ent-cassadiene C11alpha-hydroxylase defining a second multifunctional diterpenoid biosynthetic gene cluster in rice.
  Journal
Plant Cell 21:3315-25 (2009)
DOI:10.1105/tpc.108.063677
  Sequence
[osa:4329723]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.112
IUBMB Enzyme Nomenclature: 1.14.14.112
ExPASy - ENZYME nomenclature database: 1.14.14.112
BRENDA, the Enzyme Database: 1.14.14.112

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