KEGG   ENZYME: 1.14.14.74Help
Entry
EC 1.14.14.74               Enzyme                                 

Name
albendazole monooxygenase (hydroxylating);
CYP2J2 (gene name)
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
BRITE hierarchy
Sysname
albendazole,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (hydroxylating)
Reaction(IUBMB)
albendazole + [reduced NADPH---hemoprotein reductase] + O2 = hydroxyalbendazole + [oxidized NADPH---hemoprotein reductase] + H2O [RN:R12070]
Reaction(KEGG)
Substrate
albendazole [CPD:C01779];
[reduced NADPH---hemoprotein reductase] [CPD:C03024];
O2 [CPD:C00007]
Product
hydroxyalbendazole [CPD:C21883];
[oxidized NADPH---hemoprotein reductase] [CPD:C03161];
H2O [CPD:C00001]
Comment
CYP2J2 is a microsomal cytochrome P-450 monooxygenase that catalyses the hydroxylation of the terminal carbon of the propylsulfanyl chain in albendazole, a broad-spectrum anthelmintic used against gastrointestinal nematodes and the larval stages of cestodes. cf. EC 1.14.14.73, albendazole monooxygenase (sulfoxide-forming).
History
EC 1.14.14.74 created 2018
Orthology
K07418  cytochrome P450 family 2 subfamily J
Genes
HSA: 1573(CYP2J2)
PTR: 456896(CYP2J2)
PPS: 100984148
GGO: 101148349
PON: 100447634
NLE: 100589053
MCC: 693631
MCF: 102119662(CYP2J2)
CSAB: 103224719(CYP2J2)
RRO: 104668045
RBB: 108532916
CJC: 100397287(CYP2J2)
SBQ: 101041470
MMU: 100066(Cyp2j11) 13109(Cyp2j5) 13110(Cyp2j6) 230459(Cyp2j13) 242546(Cyp2j12) 665095(Cyp2j8) 74519(Cyp2j9)
RNO: 100912642 313373(Cyp2j10) 313375(Cyp2j3) 502969(Cyp2j16) 65210(Cyp2j4)
CCAN: 109684284
OCU: 100301544(CYP2J1)
CFA: 610195(CYP2J2)
VVP: 112926087
AML: 100482335
UMR: 103663082
UAH: 113254606
ORO: 101382939
FCA: 101097746
PTG: 102958105
PPAD: 109266776
AJU: 106974984
BIU: 109556228
OAS: 101121820 768095(CYP2J)
LVE: 103072875
OOR: 101287985
DLE: 111175878
PCAD: 102995526
ECB: 100067247
EPZ: 103564165
EAI: 106833456
MYB: 102259820
MYD: 102765527
MNA: 107531748
HAI: 109389708
DRO: 112297490
PALE: 102885276
RAY: 107518358
TMU: 101350163
MDO: 100031975
SHR: 100921692
OAA: 100087745
GGA: 101750603(CYP2J21) 424676(CYP2J23) 424677(CYP2J22)
CJO: 107317691
APLA: 101792912
ACYG: 106033102
TGU: 100224220(CYP2J40)
SCAN: 103815060 103815209(CYP2J19)
GFR: 102039653
FAB: 101817417
PHI: 102112918
PMAJ: 107208256
CCW: 104695151
FPG: 101919387
FCH: 102056779
EGZ: 104123941
AMJ: 102557714(CYP2P10)
CMY: 102940076(CYP2J19)
PBI: 103061770
DRE: 100034366(cyp2p8) 100034406(cyp2p7)
SANH: 107665313
IPU: 108257767
PHYP: 113530771
MZE: 112429716
OLA: 100302452(cyp2p3)
CSEM: 103383190
BPEC: 110173990
SASA: 106584062
CMK: 103185273
RTP: 109921744
CIN: 100181884
SKO: 100374154
CCAL: 108625699
MPHA: 105830628
VEM: 105569042
HST: 105190954
ATD: 109595197
NVL: 108561496
BMOR: 101743283(CYP303A1)
PMAC: 106717103
PRAP: 111003399
HAW: 110376552
CLEC: 106665205
FCD: 110852911
MYI: 110454048
OBI: 106870255
CPEP: 111802054
QSU: 111998475
CCAV: 112510946
CQI: 110715534
PSOM: 113343088
MUS: 103995680
DFA: DFA_07281(CYP513C1)
 » show all
Taxonomy
Reference
1  [PMID:23959307]
  Authors
Wu Z, Lee D, Joo J, Shin JH, Kang W, Oh S, Lee DY, Lee SJ, Yea SS, Lee HS, Lee T, Liu KH
  Title
CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.
  Journal
Antimicrob Agents Chemother 57:5448-56 (2013)
DOI:10.1128/AAC.00843-13
  Sequence
[hsa:1573]
Other DBs
ExplorEnz - The Enzyme Database: 1.14.14.74
IUBMB Enzyme Nomenclature: 1.14.14.74
ExPASy - ENZYME nomenclature database: 1.14.14.74
BRENDA, the Enzyme Database: 1.14.14.74

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