KEGG   ENZYME: 1.14.99.1
Entry
EC 1.14.99.1                Enzyme                                 
Name
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O [RN:R01599]
Reaction(KEGG)
R01599;
(other) R00073 R01590
Substrate
arachidonate [CPD:C00219];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
prostaglandin H2 [CPD:C00427];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
This enzyme acts both as a dioxygenase and as a peroxidase.
History
EC 1.14.99.1 created 1972, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00509  prostaglandin-endoperoxide synthase 1
K11987  prostaglandin-endoperoxide synthase 2
Genes
HSA5742(PTGS1) 5743(PTGS2)
PTR464713(PTGS1) 469616(PTGS2)
PPS100985650(PTGS2) 100993705(PTGS1)
GGO101141060(PTGS1) 101146681(PTGS2)
PON100436566(PTGS2) 100437175(PTGS1)
NLE100585600(PTGS1) 100591090(PTGS2)
MCC698213(PTGS1) 716671(PTGS2)
MCF102143028(PTGS2) 102144094(PTGS1)
CSAB103218890(PTGS1) 103230420(PTGS2)
CATY105579902(PTGS2) 105599950(PTGS1)
PANU101023112(PTGS1) 101025796(PTGS2)
TGE112608352(PTGS1) 112611851(PTGS2)
RRO104655861(PTGS1) 104664377(PTGS2)
RBB108523178(PTGS2) 108537103(PTGS1)
TFN117074573(PTGS2) 117098720(PTGS1)
PTEH111531359(PTGS1) 111536921(PTGS2)
CJC100393715(PTGS1) 100407639(PTGS2)
SBQ101027603(PTGS2) 101033759(PTGS1)
CSYR103259123(PTGS1) 103275362(PTGS2)
MMUR105855505(PTGS2) 105875149(PTGS1)
OGA100944482(PTGS2) 100965277(PTGS1)
MMU19224(Ptgs1) 19225(Ptgs2)
MCAL110285189(Ptgs1) 110288090 110288092 110288093 110292340
MPAH110315297 110318148(Ptgs1) 110321554(Ptgs2)
RNO24693(Ptgs1) 29527(Ptgs2)
MCOC116070506(Ptgs2) 116090081(Ptgs1)
MUN110553489(Ptgs2) 110560752(Ptgs1)
CGE100751220(Ptgs2) 100770867(Ptgs1)
PLEU114696775(Ptgs2) 114704719(Ptgs1)
NGI103726651(Ptgs2) 103734478(Ptgs1)
HGL101698854(Ptgs1) 101704771(Ptgs2)
CPOC100135607(Ptgs2) 100714030(Ptgs1)
CCAN109685138(Ptgs2) 109692474(Ptgs1)
DORD105989626(Ptgs2) 105996185(Ptgs1)
DSP122103768(Ptgs2) 122107132(Ptgs1)
NCAR124962420 124964706
OCU100009248(PTGS2) 100009407(PTGS1)
OPI101534818(PTGS1) 101536557(PTGS2)
TUP102478264(PTGS2) 102497535(PTGS1)
CFA403544(PTGS1) 442942(PTGS2)
VVP112921830(PTGS2) 112927848(PTGS1)
VLG121474119(PTGS1) 121497643(PTGS2)
AML100481235(PTGS1) 100481615(PTGS2)
UMR103668648(PTGS2) 103670355(PTGS1)
UAH113262761(PTGS2) 113266374(PTGS1)
UAR123788000(PTGS1) 123801412(PTGS2)
ELK111145816 111150791
LLV125083798 125086360
MPUF101672803(PTGS1) 101688096(PTGS2)
ORO101370362(PTGS1) 101375484(PTGS2)
EJU114212724(PTGS1) 114222880(PTGS2)
ZCA113933515(PTGS2) 113935079(PTGS1)
MLX118013715(PTGS2) 118017727(PTGS1)
FCA100126581(PTGS2) 101092557(PTGS1)
PYU121011859(PTGS2) 121034945(PTGS1)
PBG122475362(PTGS1) 122475760(PTGS2)
PTG102948685(PTGS2) 102964670(PTGS1)
PPAD109253602(PTGS2) 109269849(PTGS1)
AJU106967086(PTGS2) 106986637(PTGS1)
HHV120226939(PTGS1) 120248734(PTGS2)
BTA282022(PTGS1) 282023(PTGS2)
BOM102271174(PTGS2) 102287995(PTGS1)
BIU109566428(PTGS1) 109570734(PTGS2)
BBUB102395640(PTGS1) 102416528(PTGS2)
CHX100860905(PTGS2) 102170328(PTGS1)
OAS443460(PTGS2) 443551(PTGS1)
ODA120851948(PTGS1) 120880449(PTGS2)
CCAD122442118(PTGS1) 122452326(PTGS2)
SSC397541(PTGS1) 397590(PTGS2)
CFR102507716(PTGS1) 102509586(PTGS2)
CBAI105069938(PTGS1) 105083396(PTGS2)
CDK105099289(PTGS2) 105104317(PTGS1)
VPC102536038(PTGS2) 102537567(PTGS1)
BACU102999195(PTGS2) 103003952(PTGS1)
LVE103070077(PTGS1) 103088613(PTGS2)
OOR101270299(PTGS2) 101274585(PTGS1)
DLE111177249(PTGS1) 111184673(PTGS2)
PCAD102982708(PTGS2) 102996994(PTGS1)
PSIU116755244(PTGS1) 116759534(PTGS2)
ECB100034087(PTGS1) 791253(PTGS2)
EPZ103547078(PTGS2) 103555394(PTGS1)
EAI106842002(PTGS1) 106846783(PTGS2)
MYB102259554(PTGS1) 102259598(PTGS2)
MYD102755037(PTGS1) 102774808(PTGS2)
MMYO118667138(PTGS1) 118673371(PTGS2)
MLF102422987(PTGS1) 102423775(PTGS2)
MNA107535587(PTGS1) 107546245(PTGS2)
PKL118716130(PTGS1) 118721470(PTGS2)
HAI109374968(PTGS1) 109379092(PTGS2)
DRO112296707(PTGS2) 112306427(PTGS1)
SHON118979157(PTGS2) 118995997(PTGS1)
AJM119046910 119046915 119059729(PTGS2)
PDIC114508591(PTGS1) 114511915(PTGS2)
PHAS123818377(PTGS2) 123820187(PTGS1)
MMF118630133(PTGS1) 118637857(PTGS2)
RFQ117014281(PTGS2) 117032421(PTGS1)
PALE102886561(PTGS2) 102889003(PTGS1)
PGIG120605750(PTGS1) 120617547(PTGS2)
PVP105292679(PTGS1) 105295029(PTGS2)
RAY107516332(PTGS1) 107521616(PTGS2)
MJV108405277(PTGS1) 108406216(PTGS2)
TOD119231807(PTGS1) 119241194(PTGS2)
SARA101543763(PTGS2) 101550346(PTGS1)
LAV100653633(PTGS1) 100666359(PTGS2)
TMU101345018 101353557
DNM101411709(PTGS1) 101438934(PTGS2)
MDO100016779(PTGS1) 100016853 100024802(PTGS2)
GAS123233706 123233707 123233708 123244793(PTGS2)
SHR100914094(PTGS1) 100926756(PTGS2)
PCW110194982 110194994 110206875(PTGS2)
OAA100081492(PTGS1) 100086096(PTGS2)
GGA396451(PTGS2) 427752(PTGS1)
PCOC116234371(PTGS1) 116238667(PTGS2)
MGP100549847(PTGS1) 100550092(PTGS2)
CJO107317330(PTGS2) 107321839(PTGS1)
NMEL110402447(PTGS2) 110406986(PTGS1)
APLA101790135(PTGS2) 101798526(PTGS1)
ACYG106034056(PTGS2) 106040639(PTGS1)
AFUL116491944(PTGS2) 116496998(PTGS1)
TGU100221909(PTGS2) 100226968(PTGS1)
LSR110467832(PTGS2) 110477714(PTGS1)
SCAN103814802(PTGS2) 103818937(PTGS1)
PMOA120510474(PTGS2) 120512453(PTGS1)
OTC121337092(PTGS1) 121344623(PTGS2)
PRUF121360112(PTGS2) 121362456(PTGS1)
GFR102035566(PTGS1) 102045242(PTGS2)
FAB101806256(PTGS1) 101816125(PTGS2)
PHI102105209(PTGS2) 102109794(PTGS1)
PMAJ107208209(PTGS2) 107211923(PTGS1)
CCAE111932522(PTGS2) 111937099(PTGS1)
CCW104688375(PTGS1) 104693603(PTGS2)
ETL114058501(PTGS1) 114066906(PTGS2)
ZAB102067802(PTGS1) 102075122(PTGS2)
FPG101918755(PTGS2) 101919862(PTGS1)
FCH102046609(PTGS1) 102050356(PTGS2)
CLV102088222(PTGS1) 102088650(PTGS2)
EGZ104124553(PTGS2) 104135209(PTGS1)
NNI104011302(PTGS2) 104023317(PTGS1)
ACUN113483094(PTGS2) 113486560(PTGS1)
TALA104357859(PTGS2) 104368122(PTGS1)
PADL103922182(PTGS2) 103923309(PTGS1)
ACHC115335327(PTGS1) 115348714(PTGS2)
AAM106486027 106495973(PTGS1)
AROW112964272(PTGS1) 112964578(PTGS2)
NPD112951111(PTGS2) 112955867(PTGS1)
DNE112983639(PTGS1) 112983769(PTGS2)
ASN102369126(PTGS2) 102386481(PTGS1)
AMJ102567925(PTGS1) 106736995(PTGS2)
CPOO109307218(PTGS2) 109314140(PTGS1)
GGN109286913(PTGS2) 109293064(PTGS1)
PSS102456040(PTGS1) 102459102(PTGS2)
CMY102933336(PTGS1) 102934690(PTGS2)
CPIC101941281(PTGS2) 101945575(PTGS1)
TST117882058(PTGS2) 117889536(PTGS1)
CABI116817463(PTGS1) 116826611(PTGS2)
MRV120370233(PTGS2) 120386922(PTGS1)
ACS100558584(ptgs1) 100560130(ptgs2)
PVT110078807(PTGS1) 110079773(PTGS2)
SUND121930072(PTGS2) 121936238(PTGS1)
PBI103060436(PTGS1) 103063043(PTGS2)
PMUR107285158(PTGS2) 107293024(PTGS1)
TSR106542642(PTGS2)
PGUT117661093(PTGS2) 117678050(PTGS1)
VKO123027906(PTGS2) 123028351(PTGS1)
PMUA114589186 114589394 114589395 114598627 114598628
ZVI118078562(PTGS1) 118089145 118089253
GJA107116524(PTGS1) 107121970(PTGS2)
STOW125425043(PTGS2) 125441521(PTGS1)
XLA100037245(ptgs1.S) 108714508(ptgs2.L) 446781(ptgs2.S)
XTR100493073(ptgs1) 595089(ptgs2)
NPR108798706(PTGS2) 108805018(PTGS1)
RTEM120913067(PTGS1) 120945540(PTGS2)
BBUF120977235(PTGS1) 120979010(PTGS2)
BGAR122919494(PTGS1) 122943666(PTGS2)
DRE246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
SRX107718138 107720239 107722606 107726413 107731054 107732418
SANH107672577 107677761 107693741 107696154 107698381 107699776
SGH107552613 107553505 107587657 107589869 107594645 107599092
CCAR109071632(ptgs2) 109077984 109081129 109090204
CAUA113045805 113049679 113062963 113072624 113079489 113115972 113120750
PPRM120477480(ptgs1) 120483023(ptgs2a) 120493605(ptgs2b)
MAMB125250692(ptgs2a) 125267551(ptgs1) 125278201(ptgs2b)
IPU108255976(ptgs1) 108257974(ptgs2b) 108277762 108277763
PHYP113537039 113539247 113546811
SMEO124377272(ptgs2b) 124380760(ptgs1) 124394956(ptgs2a)
TFD113637684(ptgs1) 113642216(ptgs2a) 113647522(ptgs2b)
AMEX103025268(ptgs1) 103032345 103034574
EEE113585124 113587050 113588667
TRU101064817(ptgs2) 101070781 101071202
TNGGSTEN00012293G001 GSTEN00029010G001 GSTEN00033631G001
LCO104921828(ptgs2) 104923661 104924489
NCC104951901 104951902 104955130(ptgs2)
CGOB115006753(ptgs2) 115013092 115017043 115017044
ELY117252052(ptgs1) 117254034(ptgs2b) 117269916(pdcl)
PLEP121944804(ptgs1) 121959668 121965412(ptgs2b)
SLUC116054323(ptgs1) 116060361(ptgs2b) 116063024(pdcl)
ECRA117945264(ptgs1) 117949850(ptgs2b) 117959716(pdcl)
PFLV114555363(ptgs1) 114561193(ptgs2) 114571366
GAT120823991(ptgs2b) 120831124(ptgs1) 120832175(pdcl)
PPUG119216828(ptgs2b) 119225664(ptgs1) 119227031(pdcl)
MSAM119890902 119892019(ptgs1) 119900433(ptgs2b) 119914980
CUD121509844(ptgs1) 121511973(ptgs2b) 121524824(pdcl)
MZE101472557(ptgs2) 101475411 101479420
ONL100698573(ptgs2) 100699955 100704809
OAU116326159(ptgs1) 116331813 116335047(ptgs2b)
OLA100359365(ptgs2) 101161174 101173634
OML112148723(ptgs1) 112150839(ptgs2b) 112163152
XMA102224819 102228898(ptgs2) 102233495
XCO114149351 114150821(ptgs2) 114155241
XHE116724919 116726213(ptgs2) 116730499
PRET103468244(ptgs2) 103469906 103473446
PFOR103137256(ptgs2) 103141975 103151447(ptgs1)
PLAI106936158(ptgs2) 106954300 106963319(ptgs1)
PMEI106913887(ptgs2) 106923731 106931073(ptgs1)
GAF122819447(pdcl) 122828438(ptgs1) 122838735(ptgs2b)
CVG107085952(ptgs2) 107088990 107098100
CTUL119776568(pdcl) 119787704(ptgs2b) 119793110(ptgs1)
GMU124873023(pdcl) 124874136(ptgs2b) 124878065(ptgs1)
NFU107374754 107386307 107392885(ptgs2)
KMR108231052(pdcl) 108233679(ptgs1) 108238364(ptgs2b)
ALIM106516263 106516825(ptgs2) 106528924
NWH119413821(ptgs1) 119424504 119430565(ptgs2b)
AOCE111569804 111580397 111585762(ptgs2)
CSEM103390448 103395284(ptgs2) 103397598
POV109626319 109636696(ptgs2) 109636984
SSEN122758638 122769128(ptgs1) 122780440 122780441
HHIP117760688(ptgs2b) 117768144(ptgs1) 117772197(pdcl)
LCF108874033 108875662 108896773(ptgs2)
SDU111219627(ptgs2) 111236442 111239897
SLAL111645378(ptgs2) 111656786 111663044
XGL120791019(ptgs2b) 120805594(ptgs1) 120806708(pdcl)
HCQ109519080(ptgs2) 109520402 109525209
BPEC110157308 110164382 110167945(ptgs2)
MALB109959089 109961724(ptgs2) 109972312
SASA100136456(cox-2) 100195345(pgh1) 106560558 106583970 106585418 106599098
OTW112227066 112232804(ptgs1) 112250956 112251388(ptgs2b) 112260348 112263114
OMY100136025(cox-2) 100136038(cox-1) 110508862 110521832 110523034(ptgs2b) 110525466(ptgs1)
OGO123997083(ptgs2b) 124009489 124034459(ptgs1) 124036129 124037149 124041979
ONE115103206 115111434 115114277 115118188 115139855 115145304
SALP111956708 111971482 111974856 111974857 111975404(ptgs2) 111979383
SNH120020058(ptgs2a) 120051921 120055021 120055825 120057811(ptgs1) 120063119
ELS105014126 105028801 105029082(ptgs2)
SFM108935147 108935314(ptgs2) 108936098(ptgs1) 108938933
PKI111833721 111840107 111841020 111841845
AANG118213010 118224852(ptgs2b) 118230093(ptgs2a)
LOC102685083(ptgs1) 102685668(ptgs2)
PSPA121307469 121307517 121327167 121330673
ARUT117413155(ptgs2b) 117416604 117422616 117964719
LCM102352257(PTGS2) 102361862(PTGS1)
CMK103179983(ptgs2b) 103184666
RTP109933769(ptgs2) 109938472(ptgs1)
BFO118421716 118427666
BBEL109462019 109463842
CIN100183010 100183175
SCLV120331187 120340042 120348034 120348654 120348658
API100568622 100571465 100571889 103308129
RMD113560185
HHAL106689310
PHUPhum_PHUM212290
FOC113206724
DPXDAPPUDRAFT_313427(COX)
DMK116931895
PVM113810970
PJA122249372
PCHN125029591
HAME121854255
PCLA123764014
PTRU123502583
HAZT108668991
LGILOTGIDRAFT_139178
PCAN112575294
BGT106074919
GAE121382972
HRF124144833
HRJ124271085
CRG105337232 105344258
MYI110451344
PMAX117321998
MMER123553411
OBI106867682 106867683
OSN115225592 115225784
DGT114537549
MGRMGG_10859
CEGD0C16_00335
AJPAMJAP_1341
RHYRD110_14310
NEUNE1240(Ptgs1)
NCOAAW31_14550
NMUNmul_A0533 Nmul_A0615
REIIE4771_PB00086
STARG3545_15735
METM446_1624
MNOMnod_6498
BBARRHAL1_00763
LABTFIU93_05445
LAGGB0E33_11870
CAULKCG34_20200
RDERD1_1072
RLIRLO149_c002730
LMDMETH_17860
TOMBWR18_00745
OCDFHY55_19620
MALUKU6B_22370
RSHRsph17029_3626
RSKRSKD131_4262
PYEA6J80_02260
HDHG5B40_10195
PALGHFP57_15525
PHAOHF685_06845
MRFMJO55_14090
MVAMvan_3099
MCBMycch_2784
MPSCMPSYJ_36270
SPINKV203_19175
SRWTUE45_00459
SFICEIZ62_02380
SHUNDWB77_00529
SDDD9753_02420
SROSros_8745
NOWGBF35_15120
NCXNocox_13215
GOBGobs_1219
LENLEP3755_10380
HHGXM38_035770
GLPGlo7428_2177
MICMic7113_3623
ONIOsc7112_4273
MPROBJP34_21525
NPUNpun_R5469
NOSNos7107_2301
CSGCylst_1559
NCNBZZ01_08105
 » show all
Reference
1  [PMID:3125548]
  Authors
DeWitt DL, Smith WL
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc Natl Acad Sci U S A 85:1412-6 (1988)
DOI:10.1073/pnas.85.5.1412
  Sequence
[oas:443551]
Reference
2  [PMID:104998]
  Authors
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
  Title
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
  Journal
J Biol Chem 254:829-36 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.1
IUBMB Enzyme Nomenclature: 1.14.99.1
ExPASy - ENZYME nomenclature database: 1.14.99.1
BRENDA, the Enzyme Database: 1.14.99.1
CAS: 39391-18-9

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