Entry |
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Name |
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
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Class |
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
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Sysname |
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
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Reaction(IUBMB) |
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O [RN: R01599]
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Reaction(KEGG) |
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Substrate |
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Product |
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Comment |
This enzyme acts both as a dioxygenase and as a peroxidase.
|
History |
EC 1.14.99.1 created 1972, modified 1990
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Pathway |
ec00590 | Arachidonic acid metabolism |
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Orthology |
K00509 | prostaglandin-endoperoxide synthase 1 |
K11987 | prostaglandin-endoperoxide synthase 2 |
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Genes |
» show all
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Reference |
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Authors |
DeWitt DL, Smith WL |
Title |
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence. |
Journal |
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Sequence |
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Reference |
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Authors |
Ohki S, Ogino N, Yamamoto S, Hayaishi O. |
Title |
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes. |
Journal |
J Biol Chem 254:829-36 (1979) |
Other DBs |
ExPASy - ENZYME nomenclature database: | 1.14.99.1 |
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