KEGG   ENZYME: 1.14.99.1
Entry
EC 1.14.99.1                Enzyme                                 

Name
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O [RN:R01599]
Reaction(KEGG)
R01599;
(other) R00073 R01590
Substrate
arachidonate [CPD:C00219];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
prostaglandin H2 [CPD:C00427];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
This enzyme acts both as a dioxygenase and as a peroxidase.
History
EC 1.14.99.1 created 1972, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00509  prostaglandin-endoperoxide synthase 1
K11987  prostaglandin-endoperoxide synthase 2
Genes
HSA: 5742(PTGS1) 5743(PTGS2)
PTR: 464713(PTGS1) 469616(PTGS2)
PPS: 100985650(PTGS2) 100993705(PTGS1)
GGO: 101141060(PTGS1) 101146681(PTGS2)
PON: 100436566(PTGS2) 100437175(PTGS1)
NLE: 100585600(PTGS1) 100591090(PTGS2)
MCC: 698213(PTGS1) 716671(PTGS2)
MCF: 102143028(PTGS2) 102144094(PTGS1)
CSAB: 103218890(PTGS1) 103230420(PTGS2)
RRO: 104655861(PTGS1) 104664377(PTGS2)
RBB: 108523178(PTGS2) 108537103(PTGS1)
CJC: 100393715(PTGS1) 100407639(PTGS2)
SBQ: 101027603(PTGS2) 101033759(PTGS1)
MMU: 19224(Ptgs1) 19225(Ptgs2)
MCAL: 110285189(Ptgs1) 110288090 110288092 110288093 110292340
MPAH: 110315297 110318148(Ptgs1) 110321554(Ptgs2)
RNO: 24693(Ptgs1) 29527(Ptgs2)
MUN: 110553489(Ptgs2) 110560752(Ptgs1)
CGE: 100751220(Ptgs2) 100770867(Ptgs1)
NGI: 103726651(Ptgs2) 103734478(Ptgs1)
HGL: 101698854(Ptgs1) 101704771(Ptgs2)
CCAN: 109685138(Ptgs2) 109692474(Ptgs1)
OCU: 100009248(PTGS2) 100009407(PTGS1)
TUP: 102478264(PTGS2) 102497535(PTGS1)
CFA: 403544(PTGS1) 442942(PTGS2)
VVP: 112921830(PTGS2) 112927848(PTGS1)
AML: 100481235(PTGS1) 100481615(PTGS2)
UMR: 103668648(PTGS2) 103670355(PTGS1)
UAH: 113262761(PTGS2) 113266374(PTGS1)
ORO: 101370362(PTGS1) 101375484(PTGS2)
ELK: 111145816 111150791
FCA: 100126581(PTGS2) 101092557(PTGS1)
PTG: 102948685(PTGS2) 102964670(PTGS1)
PPAD: 109253602(PTGS2) 109269849(PTGS1)
AJU: 106967086(PTGS2) 106986637(PTGS1)
BTA: 282022(PTGS1) 282023(PTGS2)
BOM: 102271174(PTGS2) 102287995(PTGS1)
BIU: 109566428(PTGS1) 109570734(PTGS2)
BBUB: 102395640(PTGS1) 102416528(PTGS2)
CHX: 100860905(PTGS2) 102170328(PTGS1)
OAS: 443460(PTGS2) 443551(PTGS1)
SSC: 397541(PTGS1) 397590(PTGS2)
CFR: 102507716(PTGS1) 102509586(PTGS2)
CDK: 105099289(PTGS2) 105104317(PTGS1)
BACU: 102999195(PTGS2) 103003952(PTGS1)
LVE: 103070077(PTGS1) 103088613(PTGS2)
OOR: 101270299(PTGS2) 101274585(PTGS1)
DLE: 111177249(PTGS1) 111184673(PTGS2)
PCAD: 102982708(PTGS2) 102996994(PTGS1)
ECB: 100034087(PTGS1) 791253(PTGS2)
EPZ: 103547078(PTGS2) 103555394(PTGS1)
EAI: 106842002(PTGS1) 106846783(PTGS2)
MYB: 102259554(PTGS1) 102259598(PTGS2)
MYD: 102755037(PTGS1) 102774808(PTGS2)
MNA: 107535587(PTGS1) 107546245(PTGS2)
HAI: 109374968(PTGS1) 109379092(PTGS2)
DRO: 112296707(PTGS2) 112306427(PTGS1)
PALE: 102886561(PTGS2) 102889003(PTGS1)
RAY: 107516332(PTGS1) 107521616(PTGS2)
MJV: 108405277(PTGS1) 108406216(PTGS2)
LAV: 100653633(PTGS1) 100666359(PTGS2)
TMU: 101345018 101353557
MDO: 100016779(PTGS1) 100016853 100024802(PTGS2)
SHR: 100914094(PTGS1) 100926756(PTGS2)
PCW: 110194982 110194994 110206875(PTGS2)
OAA: 100081492(PTGS1) 100086096(PTGS2)
GGA: 396451(PTGS2) 427752(PTGS1)
MGP: 100549847(PTGS1) 100550092(PTGS2)
CJO: 107317330(PTGS2) 107321839(PTGS1)
NMEL: 110402447(PTGS2) 110406986(PTGS1)
APLA: 101790135(PTGS2) 101798526(PTGS1)
ACYG: 106034056(PTGS2) 106040639(PTGS1)
TGU: 100221909(PTGS2) 100226968(PTGS1)
LSR: 110467832(PTGS2) 110477714(PTGS1)
SCAN: 103814802(PTGS2) 103818937(PTGS1)
GFR: 102035566(PTGS1) 102045242(PTGS2)
FAB: 101806256(PTGS1) 101816125(PTGS2)
PHI: 102105209(PTGS2) 102109794(PTGS1)
PMAJ: 107208209(PTGS2) 107211923(PTGS1)
CCAE: 111932522(PTGS2) 111937099(PTGS1)
CCW: 104688375(PTGS1) 104693603(PTGS2)
ETL: 114058501(PTGS1) 114066906(PTGS2)
FPG: 101918755(PTGS2) 101919862(PTGS1)
FCH: 102046609(PTGS1) 102050356(PTGS2)
CLV: 102088222(PTGS1) 102088650(PTGS2)
EGZ: 104124553(PTGS2) 104135209(PTGS1)
NNI: 104011302(PTGS2) 104023317(PTGS1)
ACUN: 113483094(PTGS2) 113486560(PTGS1)
PADL: 103922182(PTGS2) 103923309(PTGS1)
AAM: 106486027 106495973(PTGS1)
ASN: 102369126(PTGS2) 102386481(PTGS1)
AMJ: 102567925(PTGS1) 106736995(PTGS2)
PSS: 102456040(PTGS1) 102459102(PTGS2)
CMY: 102933336(PTGS1) 102934690(PTGS2)
CPIC: 101941281(PTGS2) 101945575(PTGS1)
ACS: 100558584(ptgs1) 100560130(ptgs2)
PVT: 110078807(PTGS1) 110079773(PTGS2)
PBI: 103060436(PTGS1) 103063043(PTGS2)
PMUR: 107285158(PTGS2) 107293024(PTGS1)
TSR: 106542642(PTGS2)
PMUA: 114589186 114589394 114589395 114598627 114598628
GJA: 107116524(PTGS1) 107121970(PTGS2)
XLA: 100037245(ptgs1.S) 108714508 446781(ptgs2.S)
XTR: 100493073(ptgs1) 595089(ptgs2)
NPR: 108798706(PTGS2) 108805018(PTGS1)
DRE: 246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
SRX: 107718138 107720239 107722606 107726413 107731054 107732418
SANH: 107672577 107677761 107693741 107696154 107698381 107699776
SGH: 107552613 107553505 107587657 107589869 107594645 107599092
CCAR: 109071632(ptgs2) 109077984 109081129 109090204
IPU: 108255976 108257974(PTGS2) 108277762 108277763
PHYP: 113537039 113539247 113546811
AMEX: 103025268(ptgs1) 103032345 103034574
EEE: 113585124 113587050 113588667
TRU: 101064817(ptgs2) 101070781 101071202
TNG: GSTEN00012293G001 GSTEN00029010G001 GSTEN00033631G001
LCO: 104921828(ptgs2) 104923661 104924489
NCC: 104951901 104951902 104955130(ptgs2)
MZE: 101472557(ptgs2) 101475411 101479420
ONL: 100698573(ptgs2) 100699955 100704809
OLA: 100359365(ptgs2) 101161174 101173634
XMA: 102224819 102228898(ptgs2) 102233495
XCO: 114149351 114150821(ptgs2) 114155241
PRET: 103468244(ptgs2) 103469906 103473446
CVG: 107085952(ptgs2) 107088990 107098100
NFU: 107374754 107386307 107392885(ptgs2)
KMR: 108231052 108233679 108238364(ptgs2)
ALIM: 106516263 106516825(ptgs2) 106528924
AOCE: 111569804 111580397 111585762(ptgs2)
CSEM: 103390448 103395284(ptgs2) 103397598
POV: 109626319 109636696(ptgs2) 109636984
LCF: 108874033 108875662 108896773(ptgs2)
SDU: 111219627(ptgs2) 111236442 111239897
SLAL: 111645378(ptgs2) 111656786 111663044
HCQ: 109519080(ptgs2) 109520402 109525209
BPEC: 110157308 110164382 110167945(ptgs2)
MALB: 109959089 109961724(ptgs2) 109972312
SASA: 100136456(cox-2) 100195345(pgh1) 106560558 106583970 106585418 106599098
OTW: 112227066 112232804 112250956 112251388(ptgs2) 112260348 112263114
SALP: 111956708 111971482 111974856 111974857 111975404(ptgs2) 111979383
ELS: 105014126 105028801 105029082(ptgs2)
SFM: 108935147 108935314(ptgs2) 108936098(ptgs1) 108938933
PKI: 111833721 111840107 111841020 111841845
LCM: 102352257(PTGS2) 102361862(PTGS1)
CMK: 103179983(ptgs2) 103184666(ptgs1)
RTP: 109933769(ptgs2) 109938472(ptgs1)
BFO: 118421716 118427666
CIN: 100183010 100183175
API: 100568622 100571465 100571889 103308129
RMD: 113560185
PHU: Phum_PHUM212290
DPX: DAPPUDRAFT_313427(COX)
PVM: 113810970
LGI: LOTGIDRAFT_139178
PCAN: 112575294
CRG: 105337232 105344258
MYI: 110451344
OBI: 106867682 106867683
DGT: 114537549
MGR: MGG_10859
CEG: D0C16_00335
RHY: RD110_14310
NEU: NE1240(Ptgs1)
NCO: AAW31_14550
NMU: Nmul_A0533 Nmul_A0615
REI: IE4771_PB00086
STAR: G3545_15735
MET: M446_1624
MNO: Mnod_6498
BBAR: RHAL1_00763
RSH: Rsph17029_3626
RSK: RSKD131_4262
RDE: RD1_1072
RLI: RLO149_c002730
PYE: A6J80_02260
LMD: METH_17860
LAGG: B0E33_11870
LABT: FIU93_05445
TOM: BWR18_00745
OCD: FHY55_19620
MALU: KU6B_22370
HDH: G5B40_10195
PALG: HFP57_15525
MVA: Mvan_3099
MCB: Mycch_2784
SRW: TUE45_00459
SRO: Sros_8745
NOW: GBF35_15120
GOB: Gobs_1219
LEN: LEP3755_10380
HHG: XM38_035770
GLP: Glo7428_2177
MIC: Mic7113_3623
ONI: Osc7112_4273
MPRO: BJP34_21525
NPU: Npun_R5469
NOS: Nos7107_2301
CSG: Cylst_1559
NCN: BZZ01_08105
 » show all
Reference
1  [PMID:3125548]
  Authors
DeWitt DL, Smith WL
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc Natl Acad Sci U S A 85:1412-6 (1988)
DOI:10.1073/pnas.85.5.1412
  Sequence
[oas:443551]
Reference
2  [PMID:104998]
  Authors
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
  Title
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
  Journal
J Biol Chem 254:829-36 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.1
IUBMB Enzyme Nomenclature: 1.14.99.1
ExPASy - ENZYME nomenclature database: 1.14.99.1
BRENDA, the Enzyme Database: 1.14.99.1
CAS: 39391-18-9

  All links  
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (6)   
   KEGG REACTION (3)   
   KEGG RCLASS (3)   
Gene (1308)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (422)   
   KEGG MGENES (345)   
   RefGene (539)   
Protein sequence (1788)   
   UniProt (1465)   
   SWISS-PROT (17)   
   RefSeq(pep) (58)   
   PDBSTR (210)   
   PMD (38)   
DNA sequence (248)   
   RefSeq(nuc) (66)   
   GenBank (94)   
   EMBL (88)   
3D Structure (86)   
   PDB (86)   
Protein domain (7)   
   InterPro (6)   
   PROSITE(DOC) (1)   
All databases (3454)   

Download RDF
DBGET integrated database retrieval system