KEGG   ENZYME: 1.14.99.1
Entry
EC 1.14.99.1                Enzyme                                 

Name
prostaglandin-endoperoxide synthase;
prostaglandin synthase;
prostaglandin G/H synthase;
(PG)H synthase;
PG synthetase;
prostaglandin synthetase;
fatty acid cyclooxygenase;
prostaglandin endoperoxide synthetase
Class
Oxidoreductases;
Acting on paired donors, with incorporation or reduction of molecular oxygen;
Miscellaneous
Sysname
(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase
Reaction(IUBMB)
arachidonate + reduced acceptor + 2 O2 = prostaglandin H2 + acceptor + H2O [RN:R01599]
Reaction(KEGG)
R01599;
(other) R00073 R01590
Substrate
arachidonate [CPD:C00219];
reduced acceptor [CPD:C00030];
O2 [CPD:C00007]
Product
prostaglandin H2 [CPD:C00427];
acceptor [CPD:C00028];
H2O [CPD:C00001]
Comment
This enzyme acts both as a dioxygenase and as a peroxidase.
History
EC 1.14.99.1 created 1972, modified 1990
Pathway
ec00590  Arachidonic acid metabolism
ec01100  Metabolic pathways
Orthology
K00509  prostaglandin-endoperoxide synthase 1
K11987  prostaglandin-endoperoxide synthase 2
Genes
HSA: 5742(PTGS1) 5743(PTGS2)
PTR: 464713(PTGS1) 469616(PTGS2)
PPS: 100985650(PTGS2) 100993705(PTGS1)
GGO: 101141060(PTGS1) 101146681(PTGS2)
PON: 100436566(PTGS2) 100437175(PTGS1)
NLE: 100585600(PTGS1) 100591090(PTGS2)
MCC: 698213(PTGS1) 716671(PTGS2)
MCF: 102143028(PTGS2) 102144094(PTGS1)
CSAB: 103218890(PTGS1) 103230420(PTGS2)
RRO: 104655861(PTGS1) 104664377(PTGS2)
RBB: 108523178(PTGS2) 108537103(PTGS1)
CJC: 100393715(PTGS1) 100407639(PTGS2)
SBQ: 101027603(PTGS2) 101033759(PTGS1)
MMU: 19224(Ptgs1) 19225(Ptgs2)
MCAL: 110285189(Ptgs1) 110288090 110288092 110288093 110292340
MPAH: 110315297 110318148(Ptgs1) 110321554(Ptgs2)
RNO: 24693(Ptgs1) 29527(Ptgs2)
MUN: 110553489(Ptgs2) 110560752(Ptgs1)
CGE: 100751220(Ptgs2) 100770867(Ptgs1)
NGI: 103726651(Ptgs2) 103734478(Ptgs1)
HGL: 101698854(Ptgs1) 101704771(Ptgs2)
CCAN: 109685138(Ptgs2) 109692474(Ptgs1)
OCU: 100009248(PTGS2) 100009407(PTGS1)
TUP: 102478264(PTGS2) 102497535(PTGS1)
CFA: 403544(PTGS1) 442942(PTGS2)
VVP: 112921830(PTGS2) 112927848(PTGS1)
AML: 100481235(PTGS1) 100481615(PTGS2)
UMR: 103668648(PTGS2) 103670355(PTGS1)
UAH: 113262761(PTGS2) 113266374(PTGS1)
ORO: 101370362(PTGS1) 101375484(PTGS2)
ELK: 111145816 111150791
FCA: 100126581(PTGS2) 101092557(PTGS1)
PTG: 102948685(PTGS2) 102964670(PTGS1)
PPAD: 109253602(PTGS2) 109269849(PTGS1)
AJU: 106967086(PTGS2) 106986637(PTGS1)
BTA: 282022(PTGS1) 282023(PTGS2)
BOM: 102271174(PTGS2) 102287995(PTGS1)
BIU: 109566428(PTGS1) 109570734(PTGS2)
BBUB: 102395640(PTGS1) 102416528(PTGS2)
CHX: 100860905(PTGS2) 102170328(PTGS1)
OAS: 443460(PTGS2) 443551(PTGS1)
SSC: 397541(PTGS1) 397590(PTGS2)
CFR: 102507716(PTGS1) 102509586(PTGS2)
CDK: 105099289(PTGS2) 105104317(PTGS1)
BACU: 102999195(PTGS2) 103003952(PTGS1)
LVE: 103070077(PTGS1) 103088613(PTGS2)
OOR: 101270299(PTGS2) 101274585(PTGS1)
DLE: 111177249(PTGS1) 111184673(PTGS2)
PCAD: 102982708(PTGS2) 102996994(PTGS1)
ECB: 100034087(PTGS1) 791253(PTGS2)
EPZ: 103547078(PTGS2) 103555394(PTGS1)
EAI: 106842002(PTGS1) 106846783(PTGS2)
MYB: 102259554(PTGS1) 102259598(PTGS2)
MYD: 102755037(PTGS1) 102774808(PTGS2)
MNA: 107535587(PTGS1) 107546245(PTGS2)
HAI: 109374968(PTGS1) 109379092(PTGS2)
DRO: 112296707(PTGS2) 112306427(PTGS1)
PALE: 102886561(PTGS2) 102889003(PTGS1)
RAY: 107516332(PTGS1) 107521616(PTGS2)
MJV: 108405277(PTGS1) 108406216(PTGS2)
LAV: 100653633(PTGS1) 100666359(PTGS2)
TMU: 101345018 101353557
MDO: 100016779(PTGS1) 100016853 100024802(PTGS2)
SHR: 100914094(PTGS1) 100926756(PTGS2)
PCW: 110194982 110194994 110206875(PTGS2)
OAA: 100081492(PTGS1) 100086096(PTGS2)
GGA: 396451(PTGS2) 427752(PTGS1)
MGP: 100549847(PTGS1) 100550092(PTGS2)
CJO: 107317330(PTGS2) 107321839(PTGS1)
NMEL: 110402447(PTGS2) 110406986(PTGS1)
APLA: 101790135(PTGS2) 101798526(PTGS1)
ACYG: 106034056(PTGS2) 106040639(PTGS1)
TGU: 100221909(PTGS2) 100226968(PTGS1)
LSR: 110467832(PTGS2) 110477714(PTGS1)
SCAN: 103814802(PTGS2) 103818937(PTGS1)
GFR: 102035566(PTGS1) 102045242(PTGS2)
FAB: 101806256(PTGS1) 101816125(PTGS2)
PHI: 102105209(PTGS2) 102109794(PTGS1)
PMAJ: 107208209(PTGS2) 107211923(PTGS1)
CCAE: 111932522(PTGS2) 111937099(PTGS1)
CCW: 104688375(PTGS1) 104693603(PTGS2)
ETL: 114058501(PTGS1) 114066906(PTGS2)
FPG: 101918755(PTGS2) 101919862(PTGS1)
FCH: 102046609(PTGS1) 102050356(PTGS2)
CLV: 102088222(PTGS1) 102088650(PTGS2)
EGZ: 104124553(PTGS2) 104135209(PTGS1)
NNI: 104011302(PTGS2) 104023317(PTGS1)
ACUN: 113483094(PTGS2) 113486560(PTGS1)
PADL: 103922182(PTGS2) 103923309(PTGS1)
AAM: 106486027 106495973(PTGS1)
ASN: 102369126(PTGS2) 102386481(PTGS1)
AMJ: 102567925(PTGS1) 106736995(PTGS2)
PSS: 102456040(PTGS1) 102459102(PTGS2)
CMY: 102933336(PTGS1) 102934690(PTGS2)
CPIC: 101941281(PTGS2) 101945575(PTGS1)
ACS: 100558584(ptgs1) 100560130(ptgs2)
PVT: 110078807(PTGS1) 110079773(PTGS2)
PBI: 103060436(PTGS1) 103063043(PTGS2)
PMUR: 107285158(PTGS2) 107293024(PTGS1)
TSR: 106542642(PTGS2)
PMUA: 114589186 114589394 114589395 114598627 114598628
GJA: 107116524(PTGS1) 107121970(PTGS2)
XLA: 100037245(ptgs1.S) 108714508 446781(ptgs2.S)
XTR: 100493073(ptgs1) 595089(ptgs2)
NPR: 108798706(PTGS2) 108805018(PTGS1)
DRE: 246226(ptgs1) 246227(ptgs2a) 559020(ptgs2b)
SRX: 107718138 107720239 107722606 107726413 107731054 107732418
SANH: 107672577 107677761 107693741 107696154 107698381 107699776
SGH: 107552613 107553505 107587657 107589869 107594645 107599092
CCAR: 109071632(ptgs2) 109077984 109081129 109090204
IPU: 108255976 108257974(PTGS2) 108277762 108277763
PHYP: 113537039 113539247 113546811
AMEX: 103025268(ptgs1) 103032345 103034574
EEE: 113585124 113587050 113588667
TRU: 101064817(ptgs2) 101070781 101071202
TNG: GSTEN00012293G001 GSTEN00029010G001 GSTEN00033631G001
LCO: 104921828(ptgs2) 104923661 104924489
NCC: 104951901 104951902 104955130(ptgs2)
MZE: 101472557(ptgs2) 101475411 101479420
ONL: 100698573(ptgs2) 100699955 100704809
OLA: 100359365(ptgs2) 101161174 101173634
XMA: 102224819 102228898(ptgs2) 102233495
XCO: 114149351 114150821(ptgs2) 114155241
PRET: 103468244(ptgs2) 103469906 103473446
CVG: 107085952(ptgs2) 107088990 107098100
NFU: 107374754 107386307 107392885(ptgs2)
KMR: 108231052(pdcl) 108233679(ptgs1) 108238364(ptgs2b)
ALIM: 106516263 106516825(ptgs2) 106528924
AOCE: 111569804 111580397 111585762(ptgs2)
CSEM: 103390448 103395284(ptgs2) 103397598
POV: 109626319 109636696(ptgs2) 109636984
LCF: 108874033 108875662 108896773(ptgs2)
SDU: 111219627(ptgs2) 111236442 111239897
SLAL: 111645378(ptgs2) 111656786 111663044
HCQ: 109519080(ptgs2) 109520402 109525209
BPEC: 110157308 110164382 110167945(ptgs2)
MALB: 109959089 109961724(ptgs2) 109972312
SASA: 100136456(cox-2) 100195345(pgh1) 106560558 106583970 106585418 106599098
OTW: 112227066 112232804 112250956 112251388(ptgs2) 112260348 112263114
SALP: 111956708 111971482 111974856 111974857 111975404(ptgs2) 111979383
ELS: 105014126 105028801 105029082(ptgs2)
SFM: 108935147 108935314(ptgs2) 108936098(ptgs1) 108938933
PKI: 111833721 111840107 111841020 111841845
LCM: 102352257(PTGS2) 102361862(PTGS1)
CMK: 103179983(ptgs2) 103184666(ptgs1)
RTP: 109933769(ptgs2) 109938472(ptgs1)
BFO: 118421716 118427666
CIN: 100183010 100183175
API: 100568622 100571465 100571889 103308129
RMD: 113560185
PHU: Phum_PHUM212290
DPX: DAPPUDRAFT_313427(COX)
PVM: 113810970
LGI: LOTGIDRAFT_139178
PCAN: 112575294
CRG: 105337232 105344258
MYI: 110451344
OBI: 106867682 106867683
DGT: 114537549
MGR: MGG_10859
CEG: D0C16_00335
AJP: AMJAP_1341
RHY: RD110_14310
NEU: NE1240(Ptgs1)
NCO: AAW31_14550
NMU: Nmul_A0533 Nmul_A0615
REI: IE4771_PB00086
STAR: G3545_15735
MET: M446_1624
MNO: Mnod_6498
BBAR: RHAL1_00763
LAGG: B0E33_11870
LABT: FIU93_05445
RSH: Rsph17029_3626
RSK: RSKD131_4262
RDE: RD1_1072
RLI: RLO149_c002730
PYE: A6J80_02260
LMD: METH_17860
TOM: BWR18_00745
OCD: FHY55_19620
MALU: KU6B_22370
HDH: G5B40_10195
PALG: HFP57_15525
MVA: Mvan_3099
MCB: Mycch_2784
MPSC: MPSYJ_36270
SRW: TUE45_00459
SFIC: EIZ62_02380
SRO: Sros_8745
NOW: GBF35_15120
GOB: Gobs_1219
LEN: LEP3755_10380
HHG: XM38_035770
GLP: Glo7428_2177
MIC: Mic7113_3623
ONI: Osc7112_4273
MPRO: BJP34_21525
NPU: Npun_R5469
NOS: Nos7107_2301
CSG: Cylst_1559
NCN: BZZ01_08105
 » show all
Reference
1  [PMID:3125548]
  Authors
DeWitt DL, Smith WL
  Title
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
  Journal
Proc Natl Acad Sci U S A 85:1412-6 (1988)
DOI:10.1073/pnas.85.5.1412
  Sequence
[oas:443551]
Reference
2  [PMID:104998]
  Authors
Ohki S, Ogino N, Yamamoto S, Hayaishi O.
  Title
Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.
  Journal
J Biol Chem 254:829-36 (1979)
Other DBs
ExplorEnz - The Enzyme Database: 1.14.99.1
IUBMB Enzyme Nomenclature: 1.14.99.1
ExPASy - ENZYME nomenclature database: 1.14.99.1
BRENDA, the Enzyme Database: 1.14.99.1
CAS: 39391-18-9

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Pathway (4)   
   KEGG PATHWAY (4)   
Chemical substance (7)   
   KEGG COMPOUND (7)   
Chemical reaction (6)   
   KEGG REACTION (3)   
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Gene (1305)   
   KEGG ORTHOLOGY (2)   
   KEGG GENES (425)   
   KEGG MGENES (339)   
   RefGene (539)   
Protein sequence (1859)   
   UniProt (1536)   
   SWISS-PROT (17)   
   RefSeq(pep) (58)   
   PDBSTR (210)   
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DNA sequence (249)   
   RefSeq(nuc) (66)   
   GenBank (95)   
   EMBL (88)   
3D Structure (86)   
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Protein domain (7)   
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