Entry
Name
L-aminoadipate-semialdehyde dehydrogenase;
aminoadipate semialdehyde dehydrogenase;
2-aminoadipate semialdehyde dehydrogenase;
alpha-aminoadipate-semialdehyde dehydrogenase;
alpha-aminoadipate reductase;
2-aminoadipic semialdehyde dehydrogenase;
L-alpha-aminoadipate delta-semialdehyde oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase;
L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
BRITE hierarchy
Sysname
(S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ (overall reaction) [RN:
R03102 R03103 ];
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) [RN:
R02317 ];
(1b) (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD(P)+ + 2 H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:
R11231 R11232 ]
Reaction(KEGG)
Substrate
(S)-2-amino-6-oxohexanoate [CPD:
C04076 ];
NAD+ [CPD:
C00003 ];
NADP+ [CPD:
C00006 ];
H2O [CPD:
C00001 ];
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate [CPD:
C00450 ]
Product
Comment
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
History
EC 1.2.1.31 created 1972, modified 2011
Pathway
ec01110 Biosynthesis of secondary metabolites
ec01120 Microbial metabolism in diverse environments
Orthology
K14085 aldehyde dehydrogenase family 7 member A1
Genes
PPS : 100970644 100970731(ALDH7A1)
GGO : 101148545(ALDH7A1) 101149382
PON : 100451192 100461726(ALDH7A1)
PPYG : 129036711(ALDH7A1) 129037528
MCF : 102115022 102120771(ALDH7A1)
MTHB : 126935059 126957101
MNI : 105463163(ALDH7A1) 105468632
TFN : 117065947(ALDH7A1) 117083919
CANG : 105511908(ALDH7A1) 105519793
CIMI : 108284323(ALDH7A1) 108301874
ANAN : 105712290 105715808(ALDH7A1)
MORG : 121440676 121443639
CCAD : 122423739 122440104(ALDH7A1)
BACU : 103018812 103019170(ALDH7A1)
BMUS : 118892669 118893577(ALDH7A1)
PMUA : 114606883 114606885
XLA : 108707197(aldh7a1.S) 447522(aldh7a1.L)
PGEO : 117445293 117445447
CSAI : 133457811 133458463
PSPA : 121302406(aldh7a1) 121315548
ARUT : 117409000 117418586
DME : Dmel_CG9629(Aldh7A1)
DSI : Dsimw501_GD12292(Dsim_GD12292)
DYA : Dyak_GE22513 Dyak_GE22917
SOC : 105195464 105206389 120356859
MSEX : 115442380 119191946
PMAC : 106720155 106720340
SGRE : 126266840 126350022
DPX : DAPPUDRAFT_242599 DAPPUDRAFT_302712
CSCU : 111632173 111632185
CBR : CBG_09070(Cbr-alh-9)
MAEA : 128228037 128228762
AQU : 100634152 100639963 100640016
CSAT : 104742930 104758760 104778346
MINC : 123211867 123218758
GMX : 100811186(ALDH7B2) 547717(ALDH7B1)
TPRA : 123884286 123884287
VVO : 131594999 131595000 131626561 131632545 131632546
QSA : O6P43_002655 O6P43_022502
MDM : 103400922(MF-60) 103406954
MSYL : 126604407 126607185
MESC : 110613709 110626659 110626662
PALZ : 118034844 118037985
INI : 109176332 109187725 109192542(PnG13-12)
SSPL : 121769176 121772143 121789974 121797122 121801193
SHIS : 125207407 125208530
PSOM : 113328159 113337233
TAES : 100682438 123111970 123121538
MFLO : 136535291 136541987 136549888
PVIR : 120660777 120679927
ZOF : 121988679 121997609 122041536 122046049
SMO : SELMODRAFT_164276 SELMODRAFT_230941
CDEP : 91089011(L203_104802)
KMG : 30166501(I203_100779)
KNE : 92181557(IAR55_004299)
CCAC : CcaHIS019_0510190(CcaverHIS019_0510190)
DSQ : DICSQDRAFT_71439 DICSQDRAFT_71492
ABP : AGABI1DRAFT114711(AGABI1DRAFT_114711)
ABV : AGABI2DRAFT194900(AGABI2DRAFT_194900)
SCM : SCHCO_02629080(SCHCODRAFT_02629080)
PTM : GSPATT00002104001 GSPATT00006572001
BLAC : 94346165(CCR75_002397) 94350386(CCR75_006647)
» show all
Taxonomy
Reference
Authors
Calvert AF, Rodwell VW.
Title
Metabolism of pipecolic acid in a Pseudomonas species. 3. L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase.
Journal
J Biol Chem 241:409-14 (1966)
Reference
2
Authors
Rodwell VW.
Title
Delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde.
Journal
Method Enzymol 17B:188-199 (1971)
Reference
Authors
de La Fuente JL, Rumbero A, Martin JF, Liras P
Title
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing actinomycetes.
Journal
Biochem J 327 ( Pt 1):59-64 (1997)
Reference
Authors
Fujii T, Narita T, Agematu H, Agata N, Isshiki K
Title
Cloning and characterization of pcd encoding delta'-piperideine-6-carboxylate dehydrogenase from flavobacterium lutescens IFO3084.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.31
ExPASy - ENZYME nomenclature database: 1.2.1.31