KEGG   ENZYME: 1.2.1.31
Entry
EC 1.2.1.31                 Enzyme                                 

Name
L-aminoadipate-semialdehyde dehydrogenase;
aminoadipate semialdehyde dehydrogenase;
2-aminoadipate semialdehyde dehydrogenase;
alpha-aminoadipate-semialdehyde dehydrogenase;
alpha-aminoadipate reductase;
2-aminoadipic semialdehyde dehydrogenase;
L-alpha-aminoadipate delta-semialdehyde oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:NAD+ oxidoreductase;
L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase;
L-2-aminoadipate 6-semialdehyde:NAD(P)+ 6-oxidoreductase
Class
Oxidoreductases;
Acting on the aldehyde or oxo group of donors;
With NAD+ or NADP+ as acceptor
Sysname
(S)-2-amino-6-oxohexanoate:NAD(P)+ 6-oxidoreductase
Reaction(IUBMB)
(S)-2-amino-6-oxohexanoate + NAD(P)+ + H2O = L-2-aminoadipate + NAD(P)H + H+ (overall reaction) [RN:R03102 R03103];
(1a) (S)-2-amino-6-oxohexanoate = (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + H2O (spontaneous) [RN:R02317];
(1b) (S)-2,3,4,5-tetrahydropyridine-2-carboxylate + NAD(P)+ + 2 H2O = L-2-aminoadipate + NAD(P)H + H+ [RN:R11231 R11232]
Reaction(KEGG)
Substrate
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NAD+ [CPD:C00003];
NADP+ [CPD:C00006];
H2O [CPD:C00001];
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate [CPD:C00450]
Product
L-2-aminoadipate [CPD:C00956];
NADH [CPD:C00004];
NADPH [CPD:C00005];
H+ [CPD:C00080];
(S)-2,3,4,5-tetrahydropyridine-2-carboxylate [CPD:C00450];
H2O [CPD:C00001]
Comment
(S)-2-amino-6-oxohexanoate undergoes a spontaneous dehydration forming the cyclic (S)-2,3,4,5-tetrahydropyridine-2-carboxylate, which serves as a substrate for the hydrogenation reaction.
History
EC 1.2.1.31 created 1972, modified 2011
Pathway
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K14085  aldehyde dehydrogenase family 7 member A1
Genes
HSA: 501(ALDH7A1)
PTR: 462033(ALDH7A1)
PPS: 100970731(ALDH7A1)
GGO: 101148545(ALDH7A1)
PON: 100461726(ALDH7A1)
NLE: 100583462(ALDH7A1)
MCC: 702749(ALDH7A1)
MCF: 102120771(ALDH7A1)
CSAB: 103245164(ALDH7A1)
RRO: 104677423(ALDH7A1)
RBB: 108537700(ALDH7A1)
CJC: 100401828(ALDH7A1) 100410565(ALDH7A1)
SBQ: 101045920(ALDH7A1)
MMU: 110695(Aldh7a1)
MCAL: 110285158(Aldh7a1)
MPAH: 110333007(Aldh7a1)
RNO: 291450(Aldh7a1)
MUN: 110562122(Aldh7a1)
CGE: 100756509(Aldh7a1)
NGI: 103740420(Aldh7a1)
HGL: 101711696(Aldh7a1)
CCAN: 109699996(Aldh7a1)
OCU: 100344302(ALDH7A1)
TUP: 102495542(ALDH7A1)
CFA: 481486(ALDH7A1)
VVP: 112917127(ALDH7A1)
AML: 100475712(ALDH7A1)
UMR: 103670577(ALDH7A1)
UAH: 113261663(ALDH7A1)
ORO: 101372739(ALDH7A1)
ELK: 111148305
FCA: 101086623(ALDH7A1)
PTG: 102951788(ALDH7A1)
PPAD: 109250945(ALDH7A1)
AJU: 106970741(ALDH7A1)
BTA: 507477(ALDH7A1)
BOM: 102285292(ALDH7A1)
BIU: 109561847(ALDH7A1)
BBUB: 102391870(ALDH7A1)
CHX: 102187125(ALDH7A1)
OAS: 101108127(ALDH7A1)
SSC: 106504110(ALDH7A1)
CFR: 102512958(ALDH7A1)
CDK: 105089785(ALDH7A1)
BACU: 103018812 103019170(ALDH7A1)
LVE: 103087111(ALDH7A1)
OOR: 101279003(ALDH7A1)
DLE: 111182376(ALDH7A1)
PCAD: 102990841(ALDH7A1)
ECB: 100063766(ALDH7A1)
EPZ: 103557440(ALDH7A1)
EAI: 106842819(ALDH7A1)
MYB: 102247575(ALDH7A1)
MYD: 102754535(ALDH7A1)
MNA: 107540928(ALDH7A1)
HAI: 109379078(ALDH7A1)
DRO: 112314805(ALDH7A1)
PALE: 102880590(ALDH7A1)
RAY: 107498603(ALDH7A1)
MJV: 108401917(ALDH7A1)
LAV: 100656260(ALDH7A1)
TMU: 101361542
MDO: 100009965(ALDH7A1)
SHR: 100930576(ALDH7A1)
PCW: 110223911(ALDH7A1)
OAA: 100074256(ALDH7A1)
GGA: 426812(ALDH7A1)
MGP: 104915364(ALDH7A1)
CJO: 107306701(ALDH7A1)
NMEL: 110389971(ALDH7A1)
APLA: 101793275(ALDH7A1)
ACYG: 106046528(ALDH7A1)
TGU: 100223716(ALDH7A1)
LSR: 110467766(ALDH7A1)
SCAN: 103821480(ALDH7A1)
GFR: 102042249(ALDH7A1)
FAB: 101806923(ALDH7A1)
PHI: 102106824(ALDH7A1)
PMAJ: 107198296(ALDH7A1)
CCAE: 111941214(ALDH7A1)
CCW: 104690506(ALDH7A1)
ETL: 114069037(ALDH7A1)
FPG: 101917601(ALDH7A1)
FCH: 102052577(ALDH7A1)
CLV: 102091436(ALDH7A1)
EGZ: 104124248(ALDH7A1)
NNI: 104016339(ALDH7A1)
ACUN: 113489748(ALDH7A1)
PADL: 103914477(ALDH7A1)
ASN: 102368427(ALDH7A1)
AMJ: 102563610(ALDH7A1)
PSS: 102458471(ALDH7A1)
CMY: 102940167(ALDH7A1)
CPIC: 101937973(ALDH7A1)
ACS: 100560663(aldh7a1)
PVT: 110077534(ALDH7A1)
PBI: 103049565(ALDH7A1)
PMUR: 107283290(ALDH7A1)
TSR: 106537542(ALDH7A1)
GJA: 107112391(ALDH7A1)
XLA: 108707197(aldh7a1.S) 447522(aldh7a1.L)
XTR: 549131(aldh7a1)
NPR: 108799792(ALDH7A1)
DRE: 334197(aldh7a1)
SRX: 107715563(aldh7a1)
SANH: 107657454(aldh7a1)
SGH: 107573911(aldh7a1)
CCAR: 109097311(aldh7a1)
IPU: 108277325(aldh7a1)
PHYP: 113543635(aldh7a1)
AMEX: 103034062(aldh7a1)
EEE: 113589019(aldh7a1)
TRU: 101066288(aldh7a1)
LCO: 104931924(aldh7a1)
NCC: 104947674(aldh7a1)
MZE: 101482988(aldh7a1)
ONL: 100699093(aldh7a1)
OLA: 101157525(aldh7a1)
XMA: 102233064(aldh7a1)
XCO: 114150635(aldh7a1)
PRET: 103464136(aldh7a1)
CVG: 107103171(aldh7a1)
NFU: 107392683(aldh7a1)
KMR: 108230647(aldh7a1)
ALIM: 106511506(aldh7a1)
AOCE: 111565984(aldh7a1)
CSEM: 103393055(aldh7a1)
POV: 109625620(aldh7a1)
LCF: 108881294(aldh7a1)
SDU: 111217230(aldh7a1)
SLAL: 111650170(aldh7a1)
HCQ: 109522068(aldh7a1)
BPEC: 110160079(aldh7a1)
MALB: 109958202(aldh7a1)
SASA: 100194754(aldh7a1)
OTW: 112220006(aldh7a1)
SALP: 111961923(aldh7a1)
ELS: 105021749(aldh7a1)
SFM: 108929860(aldh7a1)
PKI: 111861025(aldh7a1)
LCM: 102356888(ALDH7A1)
CMK: 103182361(aldh7a1)
RTP: 109914520(aldh7a1)
BFO: 118409632
CIN: 100184485
SPU: 588376
APLC: 110981183
SKO: 100370075
DME: Dmel_CG9629(Aldh7A1)
DER: 6543557
DSE: 6618402
DSI: Dsimw501_GD12292(Dsim_GD12292)
DAN: 6493640
DSR: 110190220
DPE: 6602384
DMN: 108151959
DWI: 6643070
DNV: 108651977
DHE: 111604532
DVI: 6622382
MDE: 101888197
LCQ: 111687514
AALB: 109412183
AME: 411140
BIM: 100747121
BTER: 100648169
CCAL: 108627760
OBB: 114876201
MPHA: 105833498
AEC: 105151044
ACEP: 105619807
PBAR: 105422187
VEM: 105566549
HST: 105181543
DQU: 106746805
CFO: 105258160
LHU: 105668398
PGC: 109862314
OBO: 105285166
PCF: 106790004
NVI: 100499205
CSOL: 105366902
MDL: 103568681
TCA: 658395
ATD: 109609044
NVL: 108564650
BMOR: 101735616
BMAN: 114249252
PRAP: 110996914
HAW: 110372538
TNL: 113491734
API: 100159019
DNX: 107173527
AGS: 114122915
RMD: 113550006
BTAB: 109031859
CLEC: 106664902
ZNE: 110841255
FCD: 110857963
PVM: 113805908
TUT: 107369629
DPTE: 113798509
PTEP: 107453898
CEL: CELE_F01F1.6(alh-9)
CBR: CBG09070(Cbr-alh-9)
PCAN: 112553791
CRG: 105327683
MYI: 110455019
OBI: 106871909
NVE: 5502556
EPA: 110236278
ADF: 107348248
AMIL: 114950886
PDAM: 113675597
SPIS: 111337300
HMG: 100198995(aldh7a1)
ATH: AT1G54100(ALDH7B4)
ALY: 9327851
CRB: 17897673
BRP: 103832634
THJ: 104815620
CPAP: 110818468
CIT: 102620491
TCC: 18596241
GRA: 105773235
GHI: 107900603
GAB: 108473666
EGR: 104450978
GMX: 100811186 547717(TP55)
VRA: 106762243
VAR: 108331606
VUN: 114163305
CCAJ: 109817465
CAM: 101513733
LJA: Lj6g3v1177340.1(Lj6g3v1177340.1)
ADU: 107479115
AIP: 107630450
LANG: 109326919
FVE: 101298824
RCN: 112187805
PPER: 18770979
PMUM: 103340601
PAVI: 110749149
MDM: 103400922(MF-60) 103406954
ZJU: 107423905
CSV: 101205436
CMO: 103500684
MCHA: 111021324
CMAX: 111488616
CMOS: 111455986
CPEP: 111807264
JCU: 105631377
JRE: 109009030
QSU: 111996661
SLY: 101252968
SPEN: 107014931
SOT: 102598345
CANN: 107861672
NSY: 104236891
NTO: 104107938
NAU: 109212832
INI: 109176332 109187725 109192542(PnG13-12)
SIND: 105157813
OEU: 111402278
HAN: 110886479
LSV: 111910340
CCAV: 112516483
DCR: 108228021
BVG: 104899742
SOE: 110804032
NNU: 104600531
OSA: 4347172
DOSA: Os09t0440300-01(Os09g0440300)
OBR: 102721194
BDI: 100831288
ATS: 109774117(LOC109774117)
SBI: 8080995
ZMA: 100282748
SITA: 101759802
PDA: 103709342
EGU: 105042090
MUS: 103995197
DCT: 110096635
PEQ: 110026035
AOF: 109845011
ATR: 18439499
PPP: 112278756
CNE: CNA07130
CNB: CNBA6940
TASA: A1Q1_08027
ABP: AGABI1DRAFT114711(AGABI1DRAFT_114711)
ABV: AGABI2DRAFT194900(AGABI2DRAFT_194900)
DFA: DFA_02437
SPAR: SPRG_06143
 » show all
Reference
1  [PMID:4285660]
  Authors
Calvert AF, Rodwell VW.
  Title
Metabolism of pipecolic acid in a Pseudomonas species. 3. L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase.
  Journal
J Biol Chem 241:409-14 (1966)
Reference
2
  Authors
Rodwell, V.W.
  Title
Delta1-piperideine-6-carboxylic acid and alpha-aminoadipic acid delta-semialdehyde.
  Journal
Method Enzymol 17B:188-199 (1971)
Reference
3  [PMID:9355735]
  Authors
de La Fuente JL, Rumbero A, Martin JF, Liras P
  Title
Delta-1-piperideine-6-carboxylate dehydrogenase, a new enzyme that forms alpha-aminoadipate in Streptomyces clavuligerus and other cephamycin C-producing  actinomycetes.
  Journal
Biochem J 327 ( Pt 1):59-64 (1997)
Reference
4  [PMID:11098140]
  Authors
Fujii T, Narita T, Agematu H, Agata N, Isshiki K
  Title
Cloning and characterization of pcd encoding delta'-piperideine-6-carboxylate dehydrogenase from flavobacterium lutescens IFO3084.
  Journal
J Biochem 128:975-82 (2000)
DOI:10.1093/oxfordjournals.jbchem.a022849
Other DBs
ExplorEnz - The Enzyme Database: 1.2.1.31
IUBMB Enzyme Nomenclature: 1.2.1.31
ExPASy - ENZYME nomenclature database: 1.2.1.31
BRENDA, the Enzyme Database: 1.2.1.31
CAS: 9067-87-2

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