| Entry |
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| Name |
glutaryl-CoA dehydrogenase (ETF);
glutaryl coenzyme A dehydrogenase;
glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating);
glutaryl-CoA dehydrogenase
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| Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With a flavin as acceptor
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| Sysname |
glutaryl-CoA:electron-transfer flavoprotein 2,3-oxidoreductase (decarboxylating)
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| Reaction(IUBMB) |
glutaryl-CoA + electron-transfer flavoprotein = crotonyl-CoA + CO2 + reduced electron-transfer flavoprotein (overall reaction) [RN: R02488];
(1a) glutaryl-CoA + electron-transfer flavoprotein = (E)-glutaconyl-CoA + reduced electron-transfer flavoprotein [RN: R10074];
(1b) (E)-glutaconyl-CoA = crotonyl-CoA + CO2 [RN: R03028]
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| Reaction(KEGG) |
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| Substrate |
glutaryl-CoA [CPD: C00527];
electron-transfer flavoprotein [CPD: C04253];
(E)-glutaconyl-CoA [CPD: C02411]
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| Product |
crotonyl-CoA [CPD: C00877];
CO2 [CPD: C00011];
reduced electron-transfer flavoprotein [CPD: C04570];
(E)-glutaconyl-CoA [CPD: C02411]
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| Comment |
Contains FAD. The enzyme catalyses the oxidation of glutaryl-CoA to glutaconyl-CoA (which remains bound to the enzyme), and the decarboxylation of the latter to crotonyl-CoA (cf. EC 4.1.1.70, glutaconyl-CoA decarboxylase). FAD is the electron acceptor in the oxidation of the substrate, and its reoxidation by electron-transfer flavoprotein completes the catalytic cycle. The anaerobic, sulfate-reducing bacterium Desulfococcus multivorans contains two glutaryl-CoA dehydrogenases: a decarboxylating enzyme (this entry), and a non-decarboxylating enzyme that only catalyses the oxidation to glutaconyl-CoA (EC 1.3.99.32).
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| History |
EC 1.3.8.6 created 1972 as EC 1.3.99.7, transferred 2012 to EC 1.3.8.6, modified 2013
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
| ec01130 | Biosynthesis of antibiotics |
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| Orthology |
| K00252 | glutaryl-CoA dehydrogenase |
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| Genes |
» show all
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| Reference |
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| Authors |
Besrat A, Polan CE, Henderson LM. |
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| Title |
Mammalian metabolism of glutaric acid. |
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| Journal |
J Biol Chem 244:1461-7 (1969) |
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| Reference |
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| Authors |
Hartel U, Eckel E, Koch J, Fuchs G, Linder D, Buckel W |
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| Title |
Purification of glutaryl-CoA dehydrogenase from Pseudomonas sp., an enzyme involved in the anaerobic degradation of benzoate. |
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| Journal |
Arch Microbiol 159:174-81 (1993) |
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| Reference |
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| Authors |
Dwyer TM, Zhang L, Muller M, Marrugo F, Frerman F |
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| Title |
The functions of the flavin contact residues, alphaArg249 and betaTyr16, in human electron transfer flavoprotein. |
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| Journal |
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| Reference |
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| Authors |
Rao KS, Albro M, Dwyer TM, Frerman FE |
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| Title |
Kinetic mechanism of glutaryl-CoA dehydrogenase. |
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| Journal |
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| Sequence |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 1.3.8.6 |
| ExPASy - ENZYME nomenclature database: | 1.3.8.6 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 1.3.8.6 |
| BRENDA, the Enzyme Database: | 1.3.8.6 |
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