Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors

tetracycline:coenzyme F420 dehydrogenase

tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420 [RN:R05459]

R05459;
(other) R09192

tetracycline [CPD:C06570];
oxidized coenzyme F420 [CPD:C00876]

The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.

EC 1.3.98.4 created 2016

1

McCormick, J.R.D., Hirsch, U., Sjolander, N.O. and Doerschuk, A.P.

Cosynthesis of tetracyclines by pairs of Streptomyces aureofaciens mutants.

J Am Chem Soc 82:5006-5007 (1960)

2

Miller, P.A., Sjolander, N.O., Nalesnyk, S., Arnold, N., Johnson, S., Doerschuk, A.P. and McCormick, J.R.D.

Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens.

J Am Chem Soc 82:5002-5003 (1960)

3

McCormick, J.R.D. and Morton, G.O.

Identity of cosynthetic factor I of Streptomyces aureofaciens and fragment FO from coenzyme F420 of Methanobacterium species.

J Am Chem Soc 104:4014-4015 (1982)

4  [PMID:23621493]

Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y

Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis.

J Am Chem Soc 135:7138-41 (2013)
DOI:10.1021/ja403516u