Entry |
|
Name |
5a,11a-dehydrotetracycline reductase;
oxyR (gene name);
12-dehydrotetracycline dehydrogenase;
dehydrooxytetracycline dehydrogenase;
12-dehydrotetracycline reductase
|
Class |
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
|
Sysname |
tetracycline:coenzyme F420 dehydrogenase
|
Reaction(IUBMB) |
tetracycline + oxidized coenzyme F420 = 5a,11a-dehydrotetracycline + reduced coenzyme F420 [RN: R05459]
|
Reaction(KEGG) |
|
Substrate |
tetracycline [CPD: C06570];
oxidized coenzyme F420 [CPD: C00876]
|
Product |
5a,11a-dehydrotetracycline [CPD: C03206];
reduced coenzyme F420 [CPD: C01080]
|
Comment |
The enzyme, characterized from the bacteria Streptomyces aureofaciens and Streptomyces rimosus, catalyses the last step in the biosynthesis of the tetracycline antibiotics tetracycline and oxytetracycline.
|
History |
EC 1.3.98.4 created 2016
|
Pathway |
ec01057 | Biosynthesis of type II polyketide products |
ec01110 | Biosynthesis of secondary metabolites |
|
Orthology |
K21301 | 5a,11a-dehydrotetracycline reductase |
|
Genes |
|
Reference |
1 |
Authors |
McCormick, J.R.D., Hirsch, U., Sjolander, N.O. and Doerschuk, A.P. |
Title |
Cosynthesis of tetracyclines by pairs of Streptomyces aureofaciens mutants. |
Journal |
J Am Chem Soc 82:5006-5007 (1960) |
Reference |
2 |
Authors |
Miller, P.A., Sjolander, N.O., Nalesnyk, S., Arnold, N., Johnson, S., Doerschuk, A.P. and McCormick, J.R.D. |
Title |
Cosynthetic factor I, a factor involved in hydrogen-transfer in Streptomyces aureofaciens. |
Journal |
J Am Chem Soc 82:5002-5003 (1960) |
Reference |
3 |
Authors |
McCormick, J.R.D. and Morton, G.O. |
Title |
Identity of cosynthetic factor I of Streptomyces aureofaciens and fragment FO from coenzyme F420 of Methanobacterium species. |
Journal |
J Am Chem Soc 104:4014-4015 (1982) |
Reference |
|
Authors |
Wang P, Bashiri G, Gao X, Sawaya MR, Tang Y |
Title |
Uncovering the enzymes that catalyze the final steps in oxytetracycline biosynthesis. |
Journal |
|
Other DBs |
ExplorEnz - The Enzyme Database: | 1.3.98.4 |
ExPASy - ENZYME nomenclature database: | 1.3.98.4 |
|