KEGG   ENZYME: 1.3.98.6
Entry
EC 1.3.98.6                 Enzyme                                 

Name
AdoMet-dependent heme synthase;
ahbD (gene name);
SAM-dependent heme synthase
Class
Oxidoreductases;
Acting on the CH-CH group of donors;
With other, known, physiological acceptors
Sysname
Fe-coproporphyrin III:S-adenosyl-L-methionine oxidoreductase (decarboxylating)
Reaction(IUBMB)
Fe-coproporphyrin III + 2 S-adenosyl-L-methionine = protoheme + 2 CO2 + 2 5'-deoxyadenosine + 2 L-methionine [RN:R12002]
Reaction(KEGG)
R12002
Substrate
Fe-coproporphyrin III [CPD:C21284];
S-adenosyl-L-methionine [CPD:C00019]
Product
protoheme [CPD:C00032];
CO2 [CPD:C00011];
5'-deoxyadenosine [CPD:C05198];
L-methionine [CPD:C00073]
Comment
This radical AdoMet enzyme participates in a heme biosynthesis pathway found in archaea and sulfur-reducing bacteria. cf. EC 1.3.98.5, hydrogen peroxide-dependent heme synthase.
History
EC 1.3.98.6 created 2019
Pathway
ec00860  Porphyrin and chlorophyll metabolism
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K22227  AdoMet-dependent heme synthase
Genes
ECQ: ECED1_2305 ECED1_2306
KLW: DA718_15700
CIE: AN232_20810 AN232_20815
EBC: C2U52_19010 C2U52_19015
PBRA: B5S52_09360
SOD: Sant_1066
BRB: EH207_06110
PRAG: EKN56_18750
LRI: NCTC12151_00948(ydeM)
XHR: XJ27_04600
PSEN: PNC201_17690(albA1) PNC201_17715(albA2)
FTN: FTN_0761
FTX: AW25_1260
FTD: AS84_1779
FTY: CH70_1281
FPH: Fphi_1658
FPT: BZ13_338
FPI: BF30_1936
FPM: LA56_513
FPX: KU46_1639
FPZ: LA55_1131
FPJ: LA02_1355
FRC: KX01_139
MEJ: Q7A_2389
TIG: THII_3654
CVI: CV_3886
AMAH: DLM_4558
BTQ: BTQ_4994
BTJ: BTJ_3621
BTZ: BTL_4468
BTV: BTHA_5750
BTHE: BTN_4118
BTHM: BTRA_3975
BTHA: DR62_4154
BTHL: BG87_4450
AZA: AZKH_1433
HEBR: AEBR_2323
SMUL: SMUL_1795
GSU: GSU3454
GLO: Glov_3122
GBM: Gbem_0015
GEB: GM18_0014
DVU: DVU0855
DVL: Dvul_2128
DVM: DvMF_2901
DDE: Dde_2577
DDS: Ddes_0287
DEF: CNY67_13555(ahbD)
DTR: RSDT_0965(ahbD)
DFL: DFE_1924
DPI: BN4_20515
PPRF: DPRO_4012(albA)
PSEL: GM415_11940(ahbD)
LIP: LI0206
LIR: LAW_00209
DRT: Dret_1955
DOL: Dole_1223
DML: Dmul_12470(pqqE)
DAL: Dalk_3856
DAT: HRM2_28000(ppqE2)
MXA: MXAN_3928
SCL: sce1829(nirJ)
HOH: Hoch_6508
DAX: FDQ92_08380(ahbD)
DBR: Deba_0779
RPD: RPD_4322
XAU: Xaut_1935
MEX: Mext_2406
MPO: Mpop_2365
MNO: Mnod_2953
META: Y590_11625
BLI: BL01169
BLD: BLi02077
BAN: BA_1875
BAR: GBAA_1875
BAT: BAS1737
BAI: BAA_1941
BANT: A16_19100
BANR: A16R_19310
BANS: BAPAT_1787
BANV: DJ46_683
BCX: BCA_1941
BCF: bcf_09195
BTL: BALH_1651
BTW: BF38_3097
BMYC: DJ92_2126
BGY: BGLY_2377
BKW: BkAM31D_11655(albA)
BBEV: BBEV_0800(pqqE-1) BBEV_2001(pqqE-2)
GKA: GK0765
GTN: GTNG_0647(pqqE) GTNG_3498
GEA: GARCT_00740(albA_2) GARCT_03097
AFL: Aflv_1204
AAMY: GFC30_1118
MCAK: MCCS_00980(albA)
BLR: BRLA_c027150(albA_1)
PPO: PPM_3629(M1_4008) PPM_4326(pqqE)
PPOL: X809_34115
PMW: B2K_23550
PSAB: PSAB_13045
BTS: Btus_2569
LLW: kw2_2217
STC: str0920
STL: stu0920
STE: STER_0937
STN: STND_0886
STW: Y1U_C0961
STHE: T303_05705
SSI: SSU1788
SUP: YYK_08615
SEQU: Q426_01850
SIU: SII_0673
CAC: CA_C2795
CAE: SMB_G2831(albA)
CAY: CEA_G2803
CBY: CLM_0614
CBE: Cbei_2008
CBZ: Cbs_2008
CBEI: LF65_02177
CKL: CKL_0376
CKR: CKR_0326
CSR: Cspa_c47280(nirJ)
CBV: U729_1548
CSQ: CSCA_2640
CTYK: CTK_C24960
CDY: F3K33_10010(nirJ2)
HSC: HVS_15565(albA)
CCEL: CCDG5_1961
CAPR: EQM14_11210(acgM)
BHU: bhn_I0331
BPRL: CL2_24440
ERT: EUR_00470
ERA: ERE_25610
PHX: KGNDJEFE_01686(mftC_2)
STH: STH1619
SWO: Swol_0691
SLP: Slip_1423
SALQ: SYNTR_0462
DRM: Dred_2159
DAE: Dtox_1255
PTH: PTH_0976
DAU: Daud_1343
SGY: Sgly_1408
HMO: HM1_1969
HCV: FTV88_1673(nirJ2)
CTHM: CFE_1685
TIT: Thit_0938
CHY: CHY_1211
MTA: Moth_1245
MTHO: MOTHE_c12260(albA1)
MTHZ: MOTHA_c13120(albA1)
ATE: Athe_1970
PHAR: NCTC13077_00312(ydeM_1)
MED: MELS_1054
MFUN: GXM21_11860(nirJ2)
MANA: MAMMFC1_00500(albA_1) MAMMFC1_02771(albA_3) MAMMFC1_03439(albA_5)
STED: SPTER_13400(pqqE_2) SPTER_14960(mftC_3)
LPIL: LIP_0128
NFA: NFA_49430
SRW: TUE45_04043(albA_2)
SLX: SLAV_34295(moaA3)
XCE: Xcel_3125
PAUS: NCTC13651_02438(moaA_2)
SRO: Sros_7439
FAL: FRAAL3004
AHG: AHOG_19765(albA3)
ALO: CRK55207
ACTN: L083_5080
ELE: Elen_2079
GPA: GPA_20660
AEQ: AEQU_0715
SYND: KR52_03395
MPK: VL20_5627
TER: Tery_4990
NSP: BMF81_00288(mftC)
RCA: Rcas_1583
HAU: Haur_4646
STI: Sthe_3103
TSC: TSC_c17570(pqqE)
TAQ: TO73_0343
TTF: THTE_4233
KST: KSMBR1_0056 KSMBR1_0789(moaA_nirJ_pqqE_1) KSMBR1_1925(nirJ_3) KSMBR1_3784(nirJ_4) KSMBR1_3882
PBU: L21SP3_00060(moaA1)
PBP: STSP1_01298(albA)
ALUS: STSP2_00887(albA_1) STSP2_00943(albA_3)
ACA: ACP_2694
ABAS: ACPOL_1935
ABAC: LuPra_05322(albA_2)
SBR: SY1_16520
BTH: BT_0510
BTHO: Btheta7330_02005(albA)
BFR: BF4492
PMUC: ING2E5A_0801(mftC)
PDI: BDI_2426
PSAC: PSM36_3132
AFD: Alfi_2914
ASH: AL1_03110
CTE: CT1749
CPC: Cpar_2038
CLI: Clim_1914
PPH: Ppha_0808
TTK: TST_1454
TMA: TM0825
TMW: THMA_0846
TMQ: THMB_0846
TMX: THMC_0846
TPT: Tpet_0102
TRQ: TRQ2_0101
TNA: CTN_1751
TNP: Tnap_0102
TME: Tmel_0095
TAF: THA_327
THER: Y592_01650
FNO: Fnod_0862
PMO: Pmob_1519
CEX: CSE_01250
NDE: NIDE0561
NJA: NSJP_1591
CTHI: THC_1234
TAV: G4V39_06175(ahbD)
TMAI: FVE67_06070(ahbD)
MOX: DAMO_0982
MVO: Mvol_0698
MSI: Msm_1497
MMIL: sm9_1371
MOL: YLM1_1580
AFU: AF_2413
FPL: Ferp_2134
GAC: GACE_0004
GAH: GAH_00348
PAB: PAB1702
TEU: TEU_08115
MAC: MA_0573(nirJ) MA_0794 MA_1302
MMA: MM_1726(nirJ) MM_1737(nirJ)
MMAC: MSMAC_1492
MPI: Mpet_2494
MBN: Mboo_0958
RCI: RCIX1164
HAL: VNG_1185G(pqqE)
HSL: OE_2700F(ahbD)
HHB: Hhub_2684(ahbD)
HHSR: HSR6_1793
HMA: rrnAC3489(pqqE)
HHI: HAH_0709(pqqE)
NPH: NP_1546A(ahbD)
HUT: Huta_0031
HMU: Hmuk_1679
HALL: LC1Hm_0720
HVO: HVO_2144(ahbD)
HME: HFX_2185(cmo_1)
HLA: Hlac_1215
HTU: Htur_1728
NAT: NJ7G_3377
SALI: L593_14195
IHO: Igni_1107
IIS: EYM_03160
HBU: Hbut_0256
MSE: Msed_0512
MCN: Mcup_1584
STEP: IC006_2192
KCR: Kcr_0374
CCAI: NAS2_0910
LOKI: Lokiarch_30590(albA_7)
 » show all
Reference
1  [PMID:21969545]
  Authors
Bali S, Lawrence AD, Lobo SA, Saraiva LM, Golding BT, Palmer DJ, Howard MJ, Ferguson SJ, Warren MJ
  Title
Molecular hijacking of siroheme for the synthesis of heme and d1 heme.
  Journal
Proc Natl Acad Sci U S A 108:18260-5 (2011)
DOI:10.1073/pnas.1108228108
Reference
2  [PMID:24669201]
  Authors
Kuhner M, Haufschildt K, Neumann A, Storbeck S, Streif J, Layer G.
  Title
The alternative route to heme in the methanogenic archaeon Methanosarcina barkeri.
  Journal
Archaea 2014:327637 (2014)
DOI:10.1155/2014/327637
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.3.98.6
IUBMB Enzyme Nomenclature: 1.3.98.6
ExPASy - ENZYME nomenclature database: 1.3.98.6
BRENDA, the Enzyme Database: 1.3.98.6

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