KEGG   ENZYME: 1.5.1.10
Entry
EC 1.5.1.10                 Enzyme                                 
Name
saccharopine dehydrogenase (NADP+, L-glutamate-forming);
saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase;
aminoadipic semialdehyde-glutamic reductase;
aminoadipate semialdehyde-glutamate reductase;
aminoadipic semialdehyde-glutamate reductase;
epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming);
saccharopine reductase;
6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)
Reaction(IUBMB)
N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + (S)-2-amino-6-oxohexanoate + NADPH + H+ [RN:R02315]
Reaction(KEGG)
R02315
Substrate
N6-(L-1,3-dicarboxypropyl)-L-lysine [CPD:C00449];
NADP+ [CPD:C00006];
H2O [CPD:C00001]
Product
L-glutamate [CPD:C00025];
(S)-2-amino-6-oxohexanoate [CPD:C04076];
NADPH [CPD:C00005];
H+ [CPD:C00080]
History
EC 1.5.1.10 created 1972, modified 2011
Pathway
ec00300  Lysine biosynthesis
ec00310  Lysine degradation
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K00293  saccharopine dehydrogenase (NADP+, L-glutamate forming)
K24034  spermidine synthase / saccharopine dehydrogenase (NADP+, L-glutamate-forming)
Genes
SHON118994002
AJM119046515
NLU111060998
NVE116616792
QSU111989186 112001276
SCEYNR050C(LYS9)
SEUBDI49_4783
SPAOSPAR_N03520
AGOAGOS_ABR116C
ERCEcym_7008
KLAKLLA0_C18744g
KMXKLMA_40016(LYS9)
LTHKLTH0A07590g
VPOKpol_1028p12
ZROZYRO0D17578g
CGRCAGL0C03443g
NCSNCAS_0A05670(NCAS0A05670)
NDINDAI_0K02690(NDAI0K02690)
TPFTPHA_0M02120(TPHA0M02120)
TBLTBLA_0F00190(TBLA0F00190)
TDLTDEL_0A07910(TDEL0A07910)
TGBHG536_0A09500
KAFKAFR_0C04810(KAFR0C04810)
KNGKNAG_0D00180(KNAG0D00180)
ZMKHG535_0F00210
PPAPAS_chr3_0528
DHADEHA2F17424g
PICPICST_70210(LYS9)
PGUPGUG_04239
SPAASPAPADRAFT_62366
LELLELG_02987
CALCAALFM_C306590WA(LYS9)
CTPCTRG_05710
COTCORT_0C00740
CDUCD36_86570
CTENCANTEDRAFT_117343
YLIYALI0D22891g
CLUCLUG_04206
CLUSA9F13_04g03179
CAURCJI97_001920
PKZC5L36_0E03900
BNNFOA43_001036(LYS9)
BBRXBRETT_003666(LYS9)
OPAHPODL_04616
NCRNCU03748
NTENEUTE1DRAFT58317(NEUTE1DRAFT_58317)
SMPSMAC_02595
PANPODANSg8147
TTTTHITE_2050253 THITE_2107047
MTMMYCTH_2300877
CTHRCTHT_0065790
MGRMGG_17041
TMNUCRPA7_3100
SSCKSPSK_03190
FGRFGSG_00346
FPUFPSE_00004 FPSE_09212
FVRFVEG_00801
FOXFOXG_00713
NHENECHADRAFT_101578 NECHADRAFT_92326
TRETRIREDRAFT_123631
TRRM419DRAFT_88293
MAWMAC_01390
MAJMAA_08309
CMTCCM_00396
PLJVFPFJ_07841
VALVDBG_04207
VDAVDAG_01433
CFJCFIO01_01988 CFIO01_06768
CHIGCH63R_03270 CH63R_08861
SAPOSAPIO_CDS0514
ELAUCREL1_7945 UCREL1_8042
PFYPFICI_12081
SSLSS1G_13213
BFUBCIN_03g09280(Bclys9)
MBEMBM_03741
PSCOLY89DRAFT_705797
GLZGLAREA_00865 GLAREA_05240
ANIAN5601.2
AFMAFUA_4G11340
ACTACLA_003400 ACLA_050430
NFINFIA_105250
AORAO090001000233 AO090003001086
ANGANI_1_3268014(An01g13590) ANI_1_878184(An04g05260)
AFVAFLA_000585 AFLA_008579
ALUCAKAW2_10277A AKAW2_51500S(LYS3)
ACHEACHE_10568A(LYS3)
APUUAPUU_40960S(LYS3)
PCSPc22g05800(Lys7)
PDPPDIP_34140
TMFPMAA_041310
TRGTRUGW13939_02837
CIMCIMG_01555
CPWCPC735_049050
UREUREG_05275
PBLPAAG_02693
PBNPADG_01718
ABEARB_02329
TVETRV_04693
AJEHCAG_01575
BGHBDBG_07199
PNOSNOG_09324
PTEPTT_10655
BZECOCCADRAFT_8652
BSCCOCSADRAFT_188437
BORCOCMIDRAFT_39282
AALTCC77DRAFT_143741
ZTRMYCGRDRAFT_110462(LYS9)
PFJMYCFIDRAFT_49608 MYCFIDRAFT_54301
FFUCLAFUR5_07080
BCOMBAUCODRAFT_33041
NPAUCRNP2_5529
TMLGSTUM_00000988001
SPOSPBC3B8.03
CNECNG01150
CNBCNBG3640
CNGCNAG_03476
CGICGB_G5220C
TMSTREMEDRAFT_74272
TASAA1Q1_06672
TVSTRAVEDRAFT_53623
DSQDICSQDRAFT_85486
PCOPHACADRAFT_187523 PHACADRAFT_262714
SHSSTEHIDRAFT_129850 STEHIDRAFT_76391
HIRHETIRDRAFT_471805
PSQPUNSTDRAFT_145068
ADLAURDEDRAFT_115750
FMEFOMMEDRAFT_112965
GTRGLOTRDRAFT_139895
LBCLACBIDRAFT_177008
MRRMoror_16977
MOREE1B28_013447
CCICC1G_05582
SCMSCHCODRAFT_257151 SCHCODRAFT_257519
ABPAGABI1DRAFT64147(AGABI1DRAFT_64147)
ABVAGABI2DRAFT184364(AGABI2DRAFT_184364)
CPUTCONPUDRAFT_168017 CONPUDRAFT_84267
SLASERLADRAFT_362472
WSEWALSEDRAFT_31404
WICJ056_002184
UMAUMAG_05818
PFPPFL1_02581
MGLMGL_1529
MRTMRET_3829
MSYMMSY001_2438
PGRPGTG_06954
MLRMELLADRAFT_73077 MELLADRAFT_91581
MBRMONBRDRAFT_34020
DDIDDB_G0285267(sdh)
PTMGSPATT00022932001
KKOKkor_1620
KPDCW740_04755
MTTFtrac_3732
 » show all
Reference
1  [PMID:4380448]
  Authors
Jones EE, Broquist HP.
  Title
Saccharopine, an intermediate of the aminoadipic acid pathway of lysine biosynthesis. 3. Aminoadipic semialdehyde-glutamate reductase.
  Journal
J Biol Chem 241:3430-4 (1966)
Other DBs
ExplorEnz - The Enzyme Database: 1.5.1.10
IUBMB Enzyme Nomenclature: 1.5.1.10
ExPASy - ENZYME nomenclature database: 1.5.1.10
BRENDA, the Enzyme Database: 1.5.1.10
CAS: 9033-55-0

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