Entry
Name
4-methylaminobutanoate oxidase (formaldehyde-forming);
mabO (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With oxygen as acceptor
BRITE hierarchy
Sysname
4-methylaminobutanoate:oxygen oxidoreductase (formaldehyde-forming)
Reaction(IUBMB)
4-methylaminobutanoate + O2 + H2O = 4-aminobutanoate + formaldehyde + H2O2 [RN:
R10102 ]
Reaction(KEGG)
Substrate
Product
Comment
A flavoprotein (FAD). In the enzyme from the soil bacterium Arthrobacter nicotinovorans the cofactor is covalently bound. Participates in the nicotine degradation pathway of this organism.
History
EC 1.5.3.19 created 2012
Pathway
ec00760 Nicotinate and nicotinamide metabolism
ec01120 Microbial metabolism in diverse environments
Orthology
K19191 4-methylaminobutanoate oxidase (formaldehyde-forming)
Genes
Taxonomy
Reference
Authors
Chiribau CB, Sandu C, Fraaije M, Schiltz E, Brandsch R
Title
A novel gamma-N-methylaminobutyrate demethylating oxidase involved in catabolism of the tobacco alkaloid nicotine by Arthrobacter nicotinovorans pAO1.
Journal
Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.5.3.19
ExPASy - ENZYME nomenclature database: 1.5.3.19
UM-BBD (Biocatalysis/Biodegradation Database): 1.5.3.19