KEGG   ENZYME: 1.5.5.3
Entry
EC 1.5.5.3                  Enzyme                                 
Name
hydroxyproline dehydrogenase;
HYPDH;
OH-POX;
hydroxyproline oxidase;
PRODH2 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a quinone or similar compound as acceptor
Sysname
trans-4-hydroxy-L-proline:quinone oxidoreductase
Reaction(IUBMB)
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol [RN:R03295]
Reaction(KEGG)
R03295
Substrate
trans-4-hydroxy-L-proline [CPD:C01157];
quinone [CPD:C00472]
Product
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate [CPD:C04281];
quinol [CPD:C00530]
Comment
A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).
History
EC 1.5.5.3 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K11394  hydroxyproline dehydrogenase
Genes
HSA58510(PRODH2)
PTR469076(PRODH2)
PPS100988900(PRODH2)
GGO101154315(PRODH2)
PON100441645(PRODH2)
PPYG129019526(PRODH2)
NLE100582687(PRODH2)
HMH116479635(PRODH2)
MCC718914(PRODH2)
MCF102119447(PRODH2)
MTHB126941910
MNI105495496(PRODH2)
CSAB103235488(PRODH2)
CATY105578193(PRODH2)
PANU101016659(PRODH2)
TGE112611985(PRODH2)
MLEU105543103(PRODH2)
RRO104667131(PRODH2)
TFN117092378
PTEH111529920(PRODH2)
CANG105516704(PRODH2)
CJC100409353(PRODH2)
SBQ101051757(PRODH2)
CIMI108298522(PRODH2)
ANAN105707000(PRODH2)
CSYR103249678(PRODH2)
MMUR105876908(PRODH2)
LCAT123624454(PRODH2)
PCOQ105816146(PRODH2)
OGA105887642(PRODH2)
MMU56189(Prodh2)
MCAL110297695(Prodh2)
MPAH110335390(Prodh2)
RNO361538(Prodh2)
MCOC116100441(Prodh2)
ANU117721570(Prodh2)
MUN110550901(Prodh2)
CGE100773901(Prodh2)
MAUA106022088(Prodh2)
PROB127238421(Prodh2)
PLEU114681696(Prodh2)
MORG121449990(Prodh2)
MFOT126486731
AAMP119820680(Prodh2)
NGI103729941(Prodh2)
HGL101703531(Prodh2)
CPOC100736006(Prodh2)
CCAN109689445(Prodh2)
DORD105993097(Prodh2)
DSP122097495(Prodh2)
PLOP125368012(Prodh2)
NCAR124966378
MMMA107151783(Prodh2)
OCU100354740
OPI101536287(PRODH2)
TUP102492745(PRODH2)
GVR103592829(PRODH2)
CFA484572(PRODH2)
CLUD112643571(PRODH2)
VVP112928512(PRODH2)
VLG121484394(PRODH2)
NPO129500989(PRODH2)
AML100474293(PRODH2)
UMR103682563(PRODH2)
UAR123793900(PRODH2)
ELK111161589
LLV125088416
MPUF101671462(PRODH2)
MNP132006160(PRODH2)
MLK131818468(PRODH2)
NVS122911569(PRODH2)
ORO101380565(PRODH2)
EJU114224383(PRODH2)
ZCA113935606(PRODH2)
MLX118022832(PRODH2)
NSU110590134(PRODH2)
LWW102738808(PRODH2)
FCA101087368(PRODH2)
PYU121011544(PRODH2)
PCOO112851027(PRODH2)
PBG122495009(PRODH2)
PVIV125153574(PRODH2)
LRUF124511931
PTG102963452(PRODH2)
PPAD109251455(PRODH2)
PUC125915107
AJU106974672
HHV120243503(PRODH2)
BTA508542(PRODH2)
BOM102278759(PRODH2)
BIU109572365(PRODH2)
BBUB102409119(PRODH2)
BBIS104995257(PRODH2)
CHX102176816(PRODH2)
OAS101105181(PRODH2)
BTAX128063762(PRODH2)
ODA120872535(PRODH2)
CCAD122421420(PRODH2)
MBEZ129546106(PRODH2)
CFR102508280(PRODH2)
CBAI105065057(PRODH2)
CDK105088061(PRODH2)
VPC102527118(PRODH2)
BACU103020530(PRODH2)
BMUS118884847(PRODH2)
LVE103075818(PRODH2)
OOR101279871(PRODH2)
DLE111181175(PRODH2)
PCAD102988845(PRODH2)
PSIU116744597(PRODH2)
NASI112392264(PRODH2)
ECB100630262(PRODH2)
EPZ103566804(PRODH2)
EAI106829258(PRODH2)
MYB102243035(PRODH2)
MYD102760255(PRODH2)
MMYO118674658(PRODH2)
MLF102420802(PRODH2)
PKL118720660(PRODH2)
EFUS103284519(PRODH2)
MNA107543420(PRODH2)
DRO112320057(PRODH2)
SHON118982564(PRODH2)
AJM119044201(PRODH2)
PDIC114511204(PRODH2)
PHAS123823819(PRODH2)
MMF118638631(PRODH2)
PPAM129083102(PRODH2)
HAI109372033(PRODH2)
RFQ117034953(PRODH2)
PALE102881173(PRODH2)
PGIG120592449(PRODH2)
PVP105306655(PRODH2)
RAY107497651(PRODH2)
MJV108401524(PRODH2)
TOD119250206(PRODH2)
SARA101538488(PRODH2)
SETR126027622(PRODH2)
LAV100665466(PRODH2)
TMU101347296
ETF101657990(PRODH2)
DNM101424361(PRODH2)
MDO100016428(PRODH2)
GAS123243033(PRODH2)
SHR111719924(PRODH2)
AFZ127556084
PCW110201606(PRODH2)
TVP118839038(PRODH2)
OAA114812117(PRODH2)
GGA107050361(PRODH2)
CATA118261618
LSR116184746
PRUF121364410
PHI102108371(PRODH2)
AGEN126036653
SHAB115602951
ASN102378835(PRODH2)
AMJ102567357(PRODH2)
CMY119566296(PRODH2)
CCAY125637978(PRODH2)
DCC119856739(PRODH2)
CPIC103306964(PRODH2)
CABI116826185(PRODH2)
MRV120404560(PRODH2)
ACS100555092(prodh2)
ASAO132779394(PRODH2)
PVT110078478(PRODH2)
SUND121932668(PRODH2)
PBI103056447(PRODH2)
PMUR107282463
CTIG120304571(PRODH2)
TSR106555418
PGUT117669155(PRODH2)
APRI131198602(PRODH2)
PTEX113443488(PRODH2)
NSS113418577(PRODH2)
VKO123032097(PRODH2)
PMUA114582127(PRODH2)
PRAF128401066(PRODH2)
ZVI118095866(PRODH2)
HCG128330949(PRODH2)
GJA107116343(PRODH2)
EMC129338259(PRODH2)
XLA398760(prodh2.L)
XTR101734436(prodh2)
NPR108789185(PRODH2)
RTEM120943083(PRODH2)
BBUF121007568(PRODH2)
BGAR122945283(PRODH2)
MUO115474312(PRODH2)
GSH117361299(PRODH2)
DRE436664(zgc:92040)
SRX107708971(prodh2)
SANH107693688(prodh2)
SGH107562014
CCAR109052804
CAUA113112084(prodh2)
CGIB127968710
PTET122333364(prodh2)
LROH127174616(prodh2)
OMC131551143(prodh2)
PPRM120469022(prodh2)
RKG130080601(prodh2)
MAMB125255611(prodh2)
CIDE127523442
MASI127422819 127427392
TROS130568787(prodh2)
TDW130438579(prodh2)
MANU129420497(prodh2)
IPU108273642
IFU128617398(prodh2)
PHYP113527045(prodh2)
SMEO124388555(prodh2)
TFD113653517(prodh2)
TVC132841530(prodh2)
TRN134321739(prodh2)
AMEX103022862(prodh2)
CMAO118809756(prodh2)
EEE113587524(prodh2)
CHAR105909097(prodh2)
TRU101078218(prodh2)
TFS130522305(prodh2)
TNGGSTEN00028317G001
LCO104926870(prodh2)
NCC104953237(prodh2)
TBEN117473940(prodh2)
CGOB115024870(prodh2)
PGEO117464422(prodh2)
GACU117545004(prodh2)
EMAC134870598(prodh2)
ELY117246798(prodh2)
EFO125880413(prodh2)
PLEP121958569(prodh2)
SLUC116061559(prodh2)
ECRA117937303(prodh2)
ESP116671297(prodh2)
PFLV114548408(prodh2)
GAT120819101(prodh2)
PPUG119212632(prodh2)
AFB129091288(prodh2)
PSWI130203323(prodh2)
MSAM119916307(prodh2)
SCHU122868155(prodh2)
CUD121528303(prodh2)
ALAT119009899(prodh2)
MZE101487644(prodh2)
ONL100703669(prodh2)
OAU116327639(prodh2)
OLA101155724(prodh2)
OML112154696(prodh2)
CSAI133419346(prodh2)
XMA102226277(prodh2)
XCO114151741(prodh2)
XHE116726804(prodh2)
PRET103481397(prodh2)
PFOR103152334(prodh2)
PLAI106956243(prodh2)
PMEI106904144
GAF122823377(prodh2)
PPRL129377768(prodh2)
CVG107097212(prodh2)
CTUL119796745(prodh2)
GMU124874790(prodh2)
NFU107387966(prodh2)
KMR108247131(prodh2)
ALIM106521389(prodh2)
NWH119423598(prodh2)
AOCE111581595(prodh2)
MCEP125022425(prodh2)
CSEM103381976(prodh2)
POV109642723(prodh2)
SSEN122759684(prodh2)
HHIP117752768(prodh2)
HSP118100647(prodh2)
PPLT128426661(prodh2)
SMAU118287419(prodh2)
LCF108884464
SDU111219983(prodh2)
SLAL111658668(prodh2)
XGL120794641(prodh2)
HCQ109523978(prodh2)
SSCV125990918
SBIA133496028(prodh2)
PEE133395254(prodh2)
PTAO133469695(prodh2)
BPEC110159594(prodh2)
MALB109973598(prodh2)
BSPL114845927(prodh2)
SJO128381410(prodh2)
SASA106578328(prodh2)
STRU115200976(prodh2)
OTW112232855(prodh2)
OMY110498805(prodh2)
OGO124039926(prodh2)
ONE115143935(prodh2)
OKI109881735(prodh2)
OKE118357763(prodh2)
SALP111976348(prodh2)
SNH120060911(prodh2)
CCLU121547167(prodh2)
ELS105024364(prodh2)
SFM108933021(prodh2)
PKI111835827(prodh2)
AANG118220234(prodh2)
PSPA121306794(prodh2)
ARUT117398777(prodh2)
PSEX120536561(prodh2)
LCM102354203(PRODH2)
BFO118417335 118426280
BBEL109467218 109482107
CIN100180610
SCLV120330165
SPU576696
APLC110986277
SKO100377930 102805849 102805974
CSEC111870040
BROR134529400
IEL124155633
DPXDAPPUDRAFT_204241
DMK116931073
DPZ124349686
PVM113809427
PJA122250188
PCHN125030369
HAME121871864
PCLA123756392
CQD128694649
PTRU123520676
ESN126998472
MNZ135202330
HAZT108677818
EAF111711121 111717152
TCF131883838 131886973
PPOI119094904 119094914 119095844 119110169
DSV119440384
RSAN119386917
RMP119178297
CSCU111619182
PTEP107456183
ABRU129980899
UDV129227683
SDM118192813
LPOL106459347 106464159
PVUL126824415
PCAN112562444
BGT106070289
HRF124141689
HRJ124278048
CRG105335584 117680326
CVN111132312 111136064
CANU128190697
OED125664753
MYI110443255 110443384
PMAX117332253 117333133 117333135
MMER123530308
DPOL127877427
MAEA128216660
OBI106869190
OSN115221635 115221636 115229811 115231961
LJP135476916
LAK106181047
LLON135482803
NVE5511574
EPA110253348
ATEN116290773
ADF107336175 107352366
AMIL114959075
PDAM113673699
SPIS111329332
DGT114523876
XEN124434978
HMG100204778
HSY130656712
RES135683123
 » show all
Reference
1  [PMID:18287100]
  Authors
Cooper SK, Pandhare J, Donald SP, Phang JM
  Title
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
  Journal
J Biol Chem 283:10485-92 (2008)
DOI:10.1074/jbc.M702181200
  Sequence
[hsa:58510]
Reference
2  [PMID:25697095]
  Authors
Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT
  Title
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
  Journal
Biochem J 466:273-81 (2015)
DOI:10.1042/BJ20141159
  Sequence
[hsa:58510]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.5.3
IUBMB Enzyme Nomenclature: 1.5.5.3
ExPASy - ENZYME nomenclature database: 1.5.5.3
BRENDA, the Enzyme Database: 1.5.5.3

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