KEGG   ENZYME: 1.5.5.3Help
Entry
EC 1.5.5.3                  Enzyme                                 

Name
hydroxyproline dehydrogenase;
HYPDH;
OH-POX;
hydroxyproline oxidase;
PRODH2 (gene name)
Class
Oxidoreductases;
Acting on the CH-NH group of donors;
With a quinone or similar compound as acceptor
BRITE hierarchy
Sysname
trans-4-hydroxy-L-proline:quinone oxidoreductase
Reaction(IUBMB)
trans-4-hydroxy-L-proline + a quinone = (3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate + a quinol [RN:R03295]
Reaction(KEGG)
Substrate
trans-4-hydroxy-L-proline [CPD:C01157];
quinone [CPD:C00472]
Product
(3R,5S)-3-hydroxy-1-pyrroline-5-carboxylate [CPD:C04281];
quinol [CPD:C00530]
Comment
A flavoprotein (FAD). The enzyme from human also has low activity with L-proline (cf. EC 1.5.5.2, proline dehydrogenase).
History
EC 1.5.5.3 created 2017
Pathway
ec00330  Arginine and proline metabolism
ec01100  Metabolic pathways
Orthology
K11394  hydroxyproline dehydrogenase
Genes
HSA: 58510(PRODH2)
PTR: 469076(PRODH2)
PPS: 100988900(PRODH2)
GGO: 101154315(PRODH2)
PON: 100441645(PRODH2)
NLE: 100582687(PRODH2)
MCC: 718914(PRODH2)
MCF: 102119447(PRODH2)
CSAB: 103235488(PRODH2)
RRO: 104667131(PRODH2) 104670156
RBB: 108524887(PRODH2)
CJC: 100409353(PRODH2)
SBQ: 101051757(PRODH2)
MMU: 56189(Prodh2)
MCAL: 110297695(Prodh2)
MPAH: 110335390(Prodh2)
RNO: 361538(Prodh2)
MUN: 110550901(Prodh2)
CGE: 100773901(Prodh2)
NGI: 103729941(Prodh2)
HGL: 101703531(Prodh2)
CCAN: 109689445(Prodh2)
OCU: 100354740(PRODH2)
TUP: 102492745(PRODH2)
CFA: 484572(PRODH2)
VVP: 112928512(PRODH2)
AML: 100474293(PRODH2)
UMR: 103682563(PRODH2)
UAH: 113244794(PRODH2)
ORO: 101380565(PRODH2)
FCA: 101087368(PRODH2)
PTG: 102963452(PRODH2)
AJU: 106974672(PRODH2)
BTA: 508542(PRODH2)
BOM: 102278759(PRODH2)
BIU: 109572365(PRODH2)
BBUB: 102409119(PRODH2)
PHD: 102343804(PRODH2)
CHX: 102176816(PRODH2)
OAS: 101105181(PRODH2)
SSC: 106510519(PRODH2)
CFR: 102508280(PRODH2)
CDK: 105088061(PRODH2)
BACU: 103020530(PRODH2)
LVE: 103075818(PRODH2)
OOR: 101279871(PRODH2)
DLE: 111181175(PRODH2)
ECB: 100630262(PRODH2)
EPZ: 103566804(PRODH2)
EAI: 106829258(PRODH2)
MYB: 102243035(PRODH2)
MYD: 102760255(PRODH2)
MNA: 107543420(PRODH2)
HAI: 109372033(PRODH2)
RSS: 109457244(PRODH2)
DRO: 112320057(PRODH2)
PALE: 102881173(PRODH2)
LAV: 100665466(PRODH2)
TMU: 101347296
MDO: 100016428(PRODH2)
SHR: 111719924(PRODH2)
PCW: 110201606(PRODH2)
OAA: 114812117(PRODH2)
GGA: 107050361(PRODH2)
CJO: 107307868
PHI: 102108371(PRODH2)
ASN: 102378835(PRODH2)
AMJ: 102567357(PRODH2)
CPIC: 103306964(PRODH2)
ACS: 100555092(prodh2)
PVT: 110078478(PRODH2)
PBI: 103056447(PRODH2)
PMUR: 107282463
GJA: 107116343(PRODH2)
XLA: 398760(prodh2.L)
XTR: 496774(prodh2)
NPR: 108789185(PRODH2)
DRE: 436664(zgc:92040)
SRX: 107708971(prodh2)
SANH: 107693688(prodh2)
CCAR: 109052804
IPU: 108273642(prodh2)
PHYP: 113527045(prodh2)
AMEX: 103022862(prodh2)
EEE: 113587524(prodh2)
TRU: 101078218(prodh2)
LCO: 104926870(prodh2)
NCC: 104953237(prodh2)
MZE: 101487644(prodh2)
OLA: 101155724(prodh2)
XMA: 102226277(prodh2)
XCO: 114151741(prodh2)
PRET: 103481397(prodh2)
NFU: 107387966(prodh2)
KMR: 108247131(prodh2)
CSEM: 103381976(prodh2)
LCF: 108884464(prodh2)
SDU: 111219983(prodh2)
HCQ: 109523978(prodh2)
BPEC: 110159594(prodh2)
MALB: 109973598(prodh2)
SASA: 106578328(prodh2)
OTW: 112232855
SALP: 111976348(prodh2)
ELS: 105024364(prodh2)
SFM: 108933021(prodh2)
PKI: 111835827(prodh2)
LCM: 102354203(PRODH2)
CIN: 100180610
SPU: 576696
APLC: 110986277
ZNE: 110826864
FCD: 110850723
PCAN: 112562444
CRG: 105335584
OBI: 106869190
LAK: 106181047
EPA: 110253348
SPIS: 111329332
HMG: 100204778
 » show all
Taxonomy
Reference
1  [PMID:18287100]
  Authors
Cooper SK, Pandhare J, Donald SP, Phang JM.
  Title
A novel function for hydroxyproline oxidase in apoptosis through generation of reactive oxygen species.
  Journal
J Biol Chem 283:10485-92 (2008)
DOI:10.1074/jbc.M702181200
  Sequence
[hsa:58510]
Reference
2  [PMID:25697095]
  Authors
Summitt CB, Johnson LC, Jonsson TJ, Parsonage D, Holmes RP, Lowther WT
  Title
Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria.
  Journal
Biochem J 466:273-81 (2015)
DOI:10.1042/BJ20141159
  Sequence
[hsa:58510]
Other DBs
ExplorEnz - The Enzyme Database: 1.5.5.3
IUBMB Enzyme Nomenclature: 1.5.5.3
ExPASy - ENZYME nomenclature database: 1.5.5.3
BRENDA, the Enzyme Database: 1.5.5.3

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